Increase of functional diversity by alternative splicing

Trends in Genetics

Volumn 19, Issue 3, 2003, Pages 124-128

  Kriventseva, Evgenia V ^a   Koch, Ina ^b   Apweiler, Rolf ^a   Vingron, Martin ^b   Bork, Peer ^c,d   Gelfand, Mikhail S ^e   Sunyaev, Shamil ^c,f  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b MAX PLANCK INSTITUTE FOR MOLECULAR GENETICS   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^e STATE RESEARCH INSTITUTE OF GENETICS AND SELECTION OF INDUSTRIAL MICROORGANISMS   (Russian Federation)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA7 INTEGRIN; INTEGRIN; ISOPROTEIN; KALLIKREIN; KALLIKREIN 2; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; EVOLUTION; GENE DELETION; GENE INSERTION; PREDICTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN STRUCTURE; REVIEW; SEQUENCE ANALYSIS;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; INSERTION SEQUENCES; MELANOGASTER;

EID: 0345316714     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(03)00023-4     Document Type: Review

References (24)

1. Hanke J., et al. Alternative splicing of human genes: more the rule than the exception? Trends Genet. 15:1999;389-390.
2. Mironov A.A., et al. Frequent alternative splicing of human genes. Genome Res. 9:1999;1288-1293.
3. Brett D., et al. EST comparison indicates 38% of human mRNAs contain possible alternative splice forms. FEBS Lett. 474:2000;83-86.
4. Croft L., et al. ISIS, the intron information system, reveals the high frequency of alternative splicing in the human genome. Nat. Genet. 24:2000;340-341.
5. Kan Z., et al. Gene structure prediction and alternative splicing analysis using genomically aligned ESTs. Genome Res. 11:2001;889-900.
6. Modrek B., Lee C. A genomic view of alternative splicing. Nat. Genet. 30:2002;13-19.
7. Modrek B., et al. Genome-wide detection of alternative splicing in expressed sequences of human genes. Nucleic Acids Res. 29:2001;2850-2859.
8. Brett D., et al. Alternative splicing and genome complexity. Nat. Genet. 30:2002;29-30.
9. Graveley B.R. Alternative splicing: increasing diversity in the proteomic world. Trends Genet. 17:2001;100-107.
10. Lopez A.J. Alternative splicing of pre-mRNA: developmental consequences and mechanisms of regulation. Annu. Rev. Genet. 32:1998;279-305.
11. Roberts G.C., Smith C.W. Alternative splicing: combinatorial output from the genome. Curr. Opin. Chem. Biol. 6:2002;375-383.
12. Caceres J.F., Kornblihtt A.R. Alternative splicing: multiple control mechanisms and involvement in human disease. Trends Genet. 18:2002;186-193.
13. Bairoch A., Apweiler R. The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. Nucleic Acids Res. 28:2000;45-48.
14. Apweiler R., et al. The InterPro database, an integrated documentation resource for protein families, domains and functional sites. Nucleic Acids Res. 29:2001;37-40.
15. Peneff C., et al. Crystal structures of two human pyrophosphorylase isoforms in complexes with UDPGlc(Gal)NAc: role of the alternatively spliced insert in the enzyme oligomeric assembly and active site architecture. EMBO J. 20:2001;6191-6202.
16. Oakley A.J., et al. The crystal structures of glutathione S-transferases isozymes 1-3 and 1-4 from Anopheles dirus species B. Protein Sci. 10:2001;2176-2185.
17. Falquet L., et al. The PROSITE database, its status in 2002. Nucleic Acids Res. 30:2002;235-238.
18. Boise L.H., et al. bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death. Cell. 74:1993;597-608.
19. Leung E., et al. A novel extracellular domain variant of the human integrin alpha 7 subunit generated by alternative intron splicing. Biochem. Biophys. Res. Commun. 243:1998;317-325.
20. Liu X.F., et al. Identification of three new alternate human kallikrein 2 transcripts: evidence of long transcript and alternative splicing. Biochem. Biophys. Res. Commun. 264:1999;833-839.
21. Kersey P., et al. VARSPLIC: alternatively-spliced protein sequences derived from SWISS-PROT and TrEMBL. Bioinformatics. 16:2000;1048-1049.
22. Zdobnov E.M., Apweiler R. InterProScan - an integration platform for the signature-recognition methods in InterPro. Bioinformatics. 17:2001;847-848.
23. Letunic I., et al. Recent improvements to the SMART domain-based sequence annotation resource. Nucleic Acids Res. 30:2002;242-244.
24. Bateman A., et al. The Pfam protein families database. Nucleic Acids Res. 30:2002;276-280.