Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapy

Nature Medicine

Volumn 7, Issue 11, 2001, Pages 1202-1208

  Wielockx, Ben ^a   Lannoy, Katrien ^a   Shapiro, Steven D ^b   Itoh, Takeshi ^c   Itohara, Shigeyoshi ^d   Vandekerckhove, Joël ^a   Libert, Claude ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b BARNES JEWISH HOSPITAL   (United States)

^c SHIONOGI AND CO LTD   (Japan)

^d RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BATIMASTAT; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; STROMELYSIN; TUMOR NECROSIS FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER THERAPY; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; HEPATITIS; LIVER CELL; LIVER NECROSIS; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; TUMOR;

ANIMALS; APOPTOSIS; HEPATITIS, ANIMAL; HUMANS; INTERFERON-GAMMA, RECOMBINANT; MATRIX METALLOPROTEINASES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASMS; PHENYLALANINE; PROTEASE INHIBITORS; THIOPHENES; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 0035170255     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1101-1202     Document Type: Article

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