Functional modulation of choroid plexus epithelial clusters in vitro for tissue repair applications

Cell Transplantation

Volumn 20, Issue 11-12, 2011, Pages 1659-1672

  Thanos, C G ^a,b   Bintz, B E ^a,b   Goddard, Moses ^a   Boekelheide, K ^b   Hall, Susan ^b   Emerich, D F ^c  

^a CytoSolv Inc   (United States)

^b BROWN UNIVERSITY   (United States)

^c Glocester Institute of Regenerative Medicine   (United States)

Author keywords

3D culture; Choroid plexus (CP); Growth factors; Neuroprotection; Spheroid; Vascular endothelial growth factor (VEGF)

Indexed keywords

ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL STRUCTURE; CELL TRANSPLANTATION; CHOROID PLEXUS; CYTOSKELETON; DNA MICROARRAY; EPITHELIUM CELL; IN VITRO STUDY; LATERAL BRAIN VENTRICLE; NERVE DEGENERATION; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SWINE; TISSUE REPAIR; TRANSMISSION ELECTRON MICROSCOPY; WOUND HEALING;

ANIMALS; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; COLLAGEN; DERMIS; DRUG COMBINATIONS; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; LAMININ; LATERAL VENTRICLES; MODELS, ANIMAL; PREALBUMIN; PROTEOGLYCANS; REGENERATION; RNA, MESSENGER; SWINE; VASCULAR ENDOTHELIAL GROWTH FACTOR A; WOUND HEALING;

ANIMALIA; SUS;

EID: 84856999479     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368911X564985     Document Type: Article

References (27)

1. Borlongan, C. V.; Skinner, S. J.; Geaney, M.; Vasconcel-los, A. V.; Elliott, R. B.; Emerich, D. F. CNS grafts of rat choroid plexus protect against cerebral ischemia in adult rats. Neuroreport 15(10):1543-1547; 2004.
2. Borlongan, C. V.; Skinner, S. J.; Geaney, M.; Vasconcel-los, A. V.; Elliott, R. B.; Emerich, D. F. Intracerebral transplantation of porcine choroid plexus provides structural and functional neuroprotection in a rodent model of stroke. Stroke 35(9):2206-2210; 2004.
3. Borlongan, C. V.; Skinner, S. J.; Geaney, M.; Vasconcel-los, A. V.; Elliott, R. B.; Emerich, D. F. Neuroprotection by encapsulated choroid plexus in a rodent model of Hun-tington's disease. Neuroreport 15(16):2521-2525; 2004.
4. Borlongan, C. V.; Thanos, C. G.; Skinner, S. J.; Geaney, M.; Emerich, D. F. Transplants of encapsulated rat cho-roid plexus cells exert neuroprotection in a rodent model of Huntington's disease. Cell Transplant. 16(10):987-992; 2008.
5. Chodobski, A.; Szmydynger-Chodobska, J. Choroid plexus: Target for polypeptides and site of their synthesis. Microsc. Res. Techniq. 52:65-82; 2001.
6. Emerich, D. F.; Mooney, D. J.; Storrie, H.; Rangasamy, S. B.; Kordower, J. H. Injectable hydrogels providing sustained delivery of vascular endothelial growth factor are neuroprotective in a rat model of Huntington's disease. Neurotox. Res. 17:66-74; 2010.
7. Emerich, D. F.; Thanos, C. G.; Goddard, M. B.; Skinner, S. J.; Geaney, M.; Bell, W. J.; Bintz, B. E.; Schneider, P. A.; Chu, Y.; Babu, R. S.; Borlongan, C. V.; Boekel-heide, K.; Hall, S.; Bryant, B.; Kordower, J. H. Extensive neuroprotection by choroid plexus transplants in excito-toxin lesioned monkeys. Neurobiol. Dis. 23(2):471-480; 2006.
8. Ericsson, A.; Liu, C.; Hart, R. P.; Sawchenko, P. E. Type 1 interleukin-1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL-1-induced cellular activation. J. Comp. Neurol. 361(4):681-698; 1995.
9. Fischer, R. S.; Yarmola, E. G.; Weber, K. L.; Speicher, K. D.; Speicher, D. W.; Bubb, M. R.; Fowler, V. M. Tro-pomodulin 3 binds to actin monomers. J. Biol. Chem. 281(47):36454-36465; 2006.
10. Gard, A. L.; Gavin, E.; Solodushko, V.; Pennica, D. Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system. Neuroscience 127(1):43-52; 2004.
11. Greenwood, S.; Swetloff, A.; Wade, A. M.; Terasaki, T.; Ferretti, P. Fgf2 is expressed in human and murine embryonic choroid plexus and affects choroid plexus epithelial cell behaviour. Cerebrospinal Fluid Res. 5:20; 2008.
12. Huang, X.; Ketova, T.; Fleming, J. T.; Wang, H.; Dey, S. K.; Litingtung, Y.; Chiang, C. Sonic hedgehog signaling regulates a novel epithelial progenitor domain of the hindbrain choroid plexus. Development 136(15):2535-2543; 2009.
13. Mashayekhi, F.; Azari, M.; Moghadam, L. M.; Yazdank-hah, M.; Naji, M.; Salehi, Z. Changes in cerebrospinal fluid nerve growth factor levels during chick embryonic development. J. Clin. Neurosci. 16(10):1334-1337; 2009.
14. McLean, W. J.; Smith, K. A.; Glowatzki, E.; Pyott, S. J. Distribution of the Na,K-ATPase alpha subunit in the rat spiral ganglion and organ of corti. J. Assoc. Res. Otola-ryngol. 10(1):37-49; 2009.
15. Morkbak, A. L.; Poulsen, S. S.; Nexo, E. Haptocorrin in humans. Clin. Chem. Lab. Med. 45(12):1751-1759; 2007.
16. Nadeau, S.; Rivest, S. Effects of circulating tumor necrosis factor on the neuronal activity and expression of the genes encoding the tumor necrosis factor receptors (p55 and p75) in the rat brain: A view from the blood-brain barrier. Neuroscience 93(4):1449-1464; 1999.
17. Salehi, Z.; Mashayekhi, F.; Naji, M.; Pandamooz, S. Insulin-like growth factor-1 and insulin-like growth factor binding proteins in cerebrospinal fluid during the development of mouse embryos. J. Clin. Neurosci. 16(7):950-953; 2009.
18. Sharma, H. S.; Tang, Z. H.; Gho, B. C.; Verdouw, P. D. Nucleotide sequence and expression of the porcine vascular endothelial growth factor. Biochim. Biophys. Acta 1260(2):235-238; 1995.
19. Strazielle, N.; Ghersi-Egea, J. F. Demonstration of a coupled metabolism-efflux process at the choroid plexus as a mechanism of brain protection toward xenobiotics. J. Neu-rosci. 19(15):6275-6289; 1999.
20. Szmydynger-Chodobska, J.; Strazielle, N.; Zink, B. J.; Ghersi-Egea, J. F.; Chodobski, A. The role of the choroid plexus in neutrophil invasion after traumatic brain injury. J. Cereb. Blood Flow Metab. 29(9):1503-1516; 2009.
21. Thanos, C. G.; Bintz, B. E.; Emerich, D. F. Microencapsu-lated choroid plexus epithelial cell transplants for repair of the brain. Adv. Exp. Med. Biol. 670:80-91; 2010.
22. Thanos, C. G.; Emerich, D. F.; Bintz, B. E.; Goddard, M. B.; Mills, J.; Jensen, R.; Lombardi, M.; Hall, S.; Boekelheide, K. Secreted products from the porcine cho-roid plexus accelerate the healing of cutaneous wounds. Cell Transplant. 18(12):1395-1409; 2009.
23. Thanos, C. G.; Schneider, P. A.; Bintz, B. E.; Jensen, R.; Bryant, B.; Bell, W. J.; Hudak, J.; Emerich, D. F. The in vitro expression and secretion of vascular endothelial growth factor from free and alginate-polyornithine encapsulated choroid plexus epithelium. Tissue Eng. 13(4):747-756; 2007.
24. Thouvenot, E.; Lafon-Cazal, M.; Demettre, E.; Jouin, P.; Bockaert, J.; Marin, P. The proteomic analysis of mouse choroid plexus secretome reveals a high protein secretion capacity of choroidal epithelial cells. Proteomics 6:5941-5952; 2006.
25. Tobin, D.; Quinn, A. G.; Ito, S.; Thody, A. J. The presence of tyrosinase and related proteins in human epidermis and their relationship to melanin type. Pigment Cell Res. 7(4):204-209; 1994.
26. Tradtrantip, L.; Tajima, M.; Li, L.; Verkman, A. S. Aquaporin water channels in transepithelial fluid transport. J. Med. Invest. 56:179-184; 2009.
27. Villalobos, A. R.; Parmelee, J. T.; Pritchard, J. B. Functional characterization of choroid plexus epithelial cells in primary culture. J. Pharmacol. Exp. Ther. 282(2):1109-1116; 1997.