A novel role for matrix metalloproteinase-8 in sepsis

Critical Care Medicine

Volumn 40, Issue 2, 2012, Pages 379-387

  Solan, Patrick D ^a   Dunsmore, Katherine E ^a,b   Denenberg, Alvin G ^a,b   Odoms, Kelli ^a,b   Zingarelli, Basilia ^a,b   Wong, Hector R ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

Author keywords

inflammation; matrix metalloproteinase 8; multiorgan failure; nuclear factor B; sepsis; septic shock

Indexed keywords

ALPHA CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MATRIX METALLOPROTEINASE 8 INHIBITOR; MATRIX METALLOPROTEINASE INHIBITOR; MESSENGER RNA; NEUTROPHIL COLLAGENASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHILDHOOD MORTALITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; OBSERVATIONAL STUDY; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETROSPECTIVE STUDY; SEPTIC SHOCK; SURVIVAL;

ANIMALS; CELLS, CULTURED; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTENSIVE CARE UNITS, PEDIATRIC; LEUKOCYTES, MONONUCLEAR; MACROPHAGES, PERITONEAL; MALE; MATRIX METALLOPROTEINASE 8; MICE; MICE, INBRED C57BL; MULTIPLE ORGAN FAILURE; PROGNOSIS; RETROSPECTIVE STUDIES; SEPSIS; SEVERITY OF ILLNESS INDEX; SHOCK, SEPTIC; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84856183793     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318232e404     Document Type: Article

References (39)

1. Martin GS, Mannino DM, Eaton S, et al: The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003; 348:1546-1554
2. Watson RS, Carcillo JA, Linde-Zwirble WT, et al: The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med 2003; 167:695-701
3. Angus DC, Linde-Zwirble WT, Lidicker J, et al: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29:1303-1310
4. Dellinger RP, Levy MM, Carlet JM, et al: Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008; 36:296-327
5. Vanlaere I, Libert C: Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock. Clin Microbiol Rev 2009; 22:224-239, Table of Contents
6. Sternlicht MD, Werb Z: How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol 2001; 17:463-516
7. Stamenkovic I: Extracellular matrix remodelling: The role of matrix metalloproteinases. J Pathol 2003; 200:448-464
8. Nagase H, Woessner JF Jr: Matrix metalloproteinases. J Biol Chem 1999; 274:21491-21494
9. Manicone AM, McGuire JK: Matrix metalloproteinases as modulators of inflammation. Semin Cell Dev Biol 2008; 19:34-41
10. McQuibban GA, Butler GS, Gong JH, et al: Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1. J Biol Chem 2001; 276:43503-43508
11. Maitra SR, Bhaduri S, Valane PD, et al: Inhibition of matrix metalloproteinases by chemically modified tetracyclines in sepsis. Shock 2003; 20:280-285
12. Halter JM, Pavone LA, Steinberg JM, et al: Chemically modified tetracycline (COL-3) improves survival if given 12 but not 24 hours after cecal ligation and puncture. Shock 2006; 26:587-591
13. Steinberg J, Halter J, Schiller HJ, et al: Metalloproteinase inhibition reduces lung injury and improves survival after cecal ligation and puncture in rats. J Surg Res 2003; 111: 185-195
14. Hasty KA, Pourmotabbed TF, Goldberg GI, et al: Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases. J Biol Chem 1990; 265: 11421-11424
15. Hasty KA, Jeffrey JJ, Hibbs MS, et al: The collagen substrate specificity of human neutrophil collagenase. J Biol Chem 1987; 262: 10048-10052
16. Van Lint P, Libert C: Matrix metalloproteinase-8: Cleavage can be decisive. Cytokine Growth Factor Rev 2006; 17:217-223
17. Hanemaaijer R, Sorsa T, Konttinen YT, et al: Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells. Regulation by tumor necrosis factor-alpha and doxycycline. J Biol Chem 1997; 272:31504-31509
18. Van Den Steen PE, Wuyts A, Husson SJ, et al: Gelatinase B/MMP-9 and neutrophil collage-nase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities. Eur J Biochem 2003; 270:3739-3749
19. Shanley TP, Cvijanovich N, Lin R, et al: Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol Med 2007; 13:495-508
20. Wong HR, Cvijanovich N, Allen GL, et al: Genomic expression profiling across the pediatric systemic inflammatory response syndrome, sepsis, and septic shock spectrum. Crit Care Med 2009; 37:1558-1566
21. Goldstein B, Giroir B, Randolph A: International pediatric sepsis consensus conference: Definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med 2005; 6:2-8
22. Proulx F, Fayon M, Farrell CA, et al: Epidemiology of sepsis and multiple organ dysfunction syndrome in children. Chest 1996; 109:1033-1037
23. Cvijanovich N, Shanley TP, Lin R, et al: Validating the genomic signature of pediatric septic shock. Physiol Genomics 2008; 34: 127-134
24. Wong HR, Shanley TP, Sakthivel B, et al: Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics 2007; 30:146-155
25. Zingarelli B, Piraino G, Hake PW, et al: Peroxisome proliferator- activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis. Am J Pathol 2010; 177:1834-1847
26. Solan PD, Piraino G, Hake PW, et al: Liver X receptor á activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor êB pathway. Shock 2011; 35:367-374
27. Aneja R, Odoms K, Dunsmore K, et al: Extracellular heat shock protein-70 induces endotoxin tolerance in THP-1 cells. J Immunol 2006; 177:7184-7192
28. Wong HR, Cvijanovich N, Lin R, et al: Identification of pediatric septic shock subclasses based on genome-wide expression profiling. BMC Med 2009; 7:34
29. Fligiel SE, Standiford T, Fligiel HM, et al: Matrix metalloproteinases and matrix metalloproteinase inhibitors in acute lung injury. Hum Pathol 2006; 37:422-430
30. Kong MY, Gaggar A, Li Y, et al: Matrix metalloproteinase activity in pediatric acute lung injury. Int J Med Sci 2009; 6:9-17
31. Tester AM, Cox JH, Connor AR, et al: LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity. PLoS One 2007; 2:e312
32. Van Lint P, Wielockx B, Puimège L, et al: Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis. J Immunol 2005; 175: 7642-7649
33. Hu J, Van den Steen PE, Dillen C, et al: Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shock. Biochem Pharmacol 2005; 70:535-544
34. Folgueras AR, Fueyo A, García-Suárez O, et al: Collagenase-2 deficiency or inhibition impairs experimental autoimmune encephalomyelitis in mice. J Biol Chem 2008; 283: 9465-9474
35. Gueders MM, Balbin M, Rocks N, et al: Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammation. J Immunol 2005; 175:2589-2597
36. Quintero PA, Knolle MD, Cala LF, et al: Matrix metalloproteinase-8 inactivates macrophage inflammatory protein-1 alpha to reduce acute lung inflammation and injury in mice. J Immunol 2010; 184:1575-1588
37. Owen CA, Hu Z, Lopez-Otin C, et al: Membrane-bound matrix metalloproteinase-8 on activated polymorphonuclear cells is a potent, tissue inhibitor of metalloproteinaseresistant collagenase and serpinase. J Immunol 2004; 172:7791-7803
38. Zingarelli B: Nuclear factor-kappaB. Crit Care Med 2005; 33:S414-S416
39. Böhrer H, Qiu F, Zimmermann T, et al: Role of NFkappaB in the mortality of sepsis. J Clin Invest 1997; 100:972-985