α-Biphenylsulfonylamino 2-methylpropyl phosphonates: Enantioselective synthesis and selective inhibition of MMPs

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 2, 2007, Pages 791-799

  Biasone, Alessandro ^a   Tortorella, Paolo ^b   Campestre, Cristina ^a   Agamennone, Mariangela ^a   Preziuso, Serena ^a   Chiappini, Marika ^a   Nuti, Elisa ^c   Carelli, Paolo ^c   Rossello, Armando ^c   Mazza, Fernando ^d   Gallina, Carlo ^a  

^a UNIVERSITY OF CHIETI   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

Dibenzyl phosphite stereoselective addition; Enantiopure sulfinimine; MMP phosphonate inhibitors; Suzuki coupling

Indexed keywords

4' METHOXYBIPHENYLSULFONYLAMINO 2 METHYLPROPYL PHOSPHONATE; COLLAGENASE 3; GELATINASE A; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRILYSIN; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE INHIBITOR; NEUTROPHIL COLLAGENASE; PHOSPHONIC ACID DERIVATIVE; STROMELYSIN;

ACYLATION; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; DRUG SCREENING; DRUG SYNTHESIS; ENANTIOSELECTIVITY; ENZYME INHIBITION; HYDROGENOLYSIS; IC 50; OXIDATION; STEREOCHEMISTRY; SUZUKI REACTION;

BIPHENYL COMPOUNDS; HUMANS; INDICATORS AND REAGENTS; ISOENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; MATRIX METALLOPROTEINASES; MODELS, MOLECULAR; PHOSPHONIC ACIDS; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; SPECTROPHOTOMETRY, ULTRAVIOLET; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33845283570     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.047     Document Type: Article

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