Pathway specificity by the bifunctional receptor frizzled is determined by affinity for Wingless

Molecular Cell

Volumn 6, Issue 1, 2000, Pages 117-126

  Rulifson, Eric J ^a   Wu, Chi Hwa ^a   Nusse, Roel ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CELL POLARITY; CHIMERA; CONTROLLED STUDY; DROSOPHILA; EMBRYO; EMBRYO DEVELOPMENT; FEMALE; GENETIC ANALYSIS; IN VIVO STUDY; LIGAND BINDING; MALE; NONHUMAN; PROTEIN DOMAIN; RECEPTOR AFFINITY; SIGNAL PROCESSING;

ANIMALIA;

EID: 0033636247     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(05)00018-3     Document Type: Article

References (49)

1. Mutations in the cadherin superfamily member gene dachsous cause a tissue polarity phenotype by altering frizzled signaling
2. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
3. Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways
4. A new member of the frizzled family from Drosophila functions as a Wingless receptor
5. Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development
6. Dishevelled: At the crossroads of divergent intracellular signaling pathways
7. Signaling specificity by frizzled receptors in drosophila
8. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
9. Pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila
10. Wnt signaling: A common theme in animal development
11. Wingless repression of Drosophila frizzled 2 expression shapes the Wingless morphogen gradient in the wing
12. The Drosophila tissue polarity gene starry night encodes a member of the protocadherin family
13. In vivo evidence that Patched and Smoothened constitute distinct binding and transducing components of a Hedgehog receptor complex
14. Wingless transduction by the frizzled and frizzled2 proteins of drosophila
15. Transmembrane kit ligand cleavage does not require a signal in the cytoplasmic domain and occurs at a site dependent on spacing from the membrane
16. The wingless signalling pathway and the patterning of the wing margin in Drosophila
17. The kit ligand: A cell surface molecule altered in steel mutant fibroblasts
18. A basic-helix-loop-helix protein expressed in precursors of Drosophila longitudinal visceral muscles
19. Genes controlling cellular polarity in Drosophila
20. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs
21. Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin
22. Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein
23. Patched overexpression alters wing disc size and pattern: Transcriptional and post-transcriptional effects on hedgehog targets
24. Molecular analysis of EMS-induced frizzled mutations in Drosophila melanogaster
25. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
26. A single frizzled protein has a dual function in tissue polarity
27. Dishevelled is a component of the frizzled signaling pathway in Drosophila
28. Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer
29. Wingless signaling in the Drosophila embryo: Zygotic requirements and the role of the frizzled genes
30. Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing
31. The Drosophila STE20-like kinase misshapen is required downstream of the Frizzled receptor in planar polarity signaling
32. Wingless expression mediates determination of peripheral nervous system elements in late stages of Drosophila wing disc development
33. Induction of Drosophila eye development by decapentaplegic
34. Activation and desensitization of beta-adrenergic receptor-coupled GTPase and adenylate cyclase of frog and turkey erythrocyte membranes
35. A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors
36. Genetic transformation of Drosophila with transposable element vectors
37. Wingless refines its own expression domain on the Drosophila wing margin
38. Dfrizzled-3, a new Drosophila Wnt receptor, acting as an attenuator of Wingless signaling in wingless hypomorphic mutants
39. Frizzled signaling and the developmental control of cell polarity
40. The Wingless target gene Dfz3 encodes a new member of the Drosophila Frizzled family
41. Wingless gradient formation in the drosophila wing
42. The role of RhoA in tissue polarity and Frizzled signaling
43. Van Gogh: A new Drosophila tissue polarity gene
44. Smoothened encodes a receptor-like serpentine protein required for hedgehog signaling
45. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF
46. A Drosophila Axin homolog, Daxin, inhibits Wnt signaling
47. Tissue polarity genes of Drosophila regulate the subcellular location for prehair initiation in pupal wing cells
48. Direct and long-range action of a wingless morphogen gradient
49. Interactions between Wingless and DFz2 during Drosophila wing development