Experimental assessment of the importance of amino acid positions identified by an entropy-based correlation analysis of multiple-sequence alignments

Biochemistry

Volumn 51, Issue 28, 2012, Pages 5633-5641

  Dietrich, Susanne ^a   Borst, Nadine ^a   Schlee, Sandra ^a   Schneider, Daniel ^a   Janda, Jan Oliver ^a   Sterner, Reinhard ^a   Merkl, Rainer ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRANILATE; ARCHAEON; CATALYTIC EFFICIENCIES; CONFORMATIONAL STABILITIES; CORRELATION ANALYSIS; ENTROPY-BASED; ENZYME FUNCTIONS; EXPERIMENTAL ASSESSMENT; INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE; MUTANT PROTEINS; NON-CONSERVED RESIDUES; PHOSPHORIBOSYL TRANSFERASE; PROTEIN FUNCTIONS; SULFOLOBUS SOLFATARICUS; THERMAL UNFOLDING; WILD TYPES;

ALIGNMENT; AMINO ACIDS; CORRELATION METHODS; ENZYME KINETICS; GLYCEROL;

PROTEINS;

ALANINE; AMINO ACID; ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE; INDOLE 3 GLYCEROL PHOSPHATE SYNTHASE; MUTANT PROTEIN;

ALGORITHM; ARTICLE; CATALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; ENTROPY; ENZYME STABILITY; EXPERIMENTAL STUDY; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROBABILITY; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTEIN UNFOLDING; SEQUENCE ALIGNMENT; STEADY STATE; SULFOLOBUS SOLFATARICUS; TEMPERATURE; VALIDATION STUDY; WILD TYPE;

AMINO ACID SUBSTITUTION; AMINO ACIDS; ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE; ARCHAEAL PROTEINS; CATALYSIS; ENTROPY; ENZYME STABILITY; HOT TEMPERATURE; INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE; KINETICS; MODELS, MOLECULAR; MUTATION; PROTEIN CONFORMATION; PROTEIN UNFOLDING; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SULFOLOBUS SOLFATARICUS;

ARCHAEA; SULFOLOBUS SOLFATARICUS;

EID: 84863901189     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300747r     Document Type: Article

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