A Rationally Designed Monomeric Variant of Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus is as Active as the Dimeric Wild-type Enzyme but Less Thermostable

Journal of Molecular Biology

Volumn 376, Issue 2, 2008, Pages 506-516

  Schwab, Thomas ^a   Skegro, Darko ^b   Mayans, Olga ^b   Sterner, Reinhard ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF BASEL   (Switzerland)

Author keywords

anthranilate phosphoribosyltransferase; hyperthermophile; rational protein design; Sulfolobus solfataricus; thermal stability

Indexed keywords

ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE; ENZYME VARIANT; MONOMER;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME PURIFICATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; SULFOLOBUS SOLFATARICUS; THERMOSTABILITY; WILD TYPE; X RAY ANALYSIS;

SULFOLOBUS SOLFATARICUS;

EID: 38349132546     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2007.11.078     Document Type: Article

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