Traditional Chinese medicine as dual guardians against hypertension and cancer?

Journal of Biomolecular Structure and Dynamics

Volumn 30, Issue 3, 2012, Pages 299-317

  Tou, Weng Ieong ^a,b   Chen, Calvin Yu Chian ^b,c,d,e  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d ASIA UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY BEIGANG HOSPITAL   (Taiwan)

Author keywords

Cancer; Docking; Molecular dynamics (MD); QSAR; Src; Traditional chinese medicine (TCM)

Indexed keywords

2' HYDROXY 3',4' DIMETHOXYISOFLAVAN 7 O BETA DEXTRO GLUCOSIDE; 3 [2',6 DIHYDROXY 5' (2 PROPENYL)(1,1' BIPHENYL) 3YL] 2 PROPENOIC ACID; ANGELIFERULATE; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HEAT SHOCK PROTEIN 90; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SARACATINIB; UNCLASSIFIED DRUG;

ANGELICA SINENSIS; ARTICLE; COMPLEX FORMATION; DATA BASE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; HYPERTENSION; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MULTIPLE LINEAR REGRESSION ANALYSIS; NEOPLASM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; SUPPORT VECTOR MACHINE;

ANTIHYPERTENSIVE AGENTS; ANTINEOPLASTIC AGENTS; BENZODIOXOLES; DATABASES, FACTUAL; LIGANDS; MEDICINE, CHINESE TRADITIONAL; MOLECULAR DYNAMICS SIMULATION; PROTEIN KINASE INHIBITORS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINAZOLINES; SRC-FAMILY KINASES;

ANGELICA SINENSIS;

EID: 84863867013     PISSN: 07391102     EISSN: None     Source Type: Journal    
DOI: 10.1080/07391102.2012.680030     Document Type: Article

References (115)

1. Al Moustafa, A.E., Yasmeen, A., & Achkhar, A. (2011). Src inhibitors are promising therapy molecules for human cervical carcinomas. Medical Hypotheses, 77, 812-814.
2. Bartholomeusz, C., Itamochi, H., Yuan, L.X., Esteva, F.J., Wood, C.G., Terakawa, N., ... Ueno, N.T. (2005). Bcl-2 antisense oligonucleotide overcomes resistance to E1A gene therapy in a low HER2-expressing ovarian cancer xenograft model. Cancer Research, 65, 8406-8413. (Pubitemid 41330607)
3. Bernier, A.J., Zhang, J., Lillehoj, E., Shaw, A.R., Gunasekara, N., & Hugh, J.C. (2011). Non-cysteine linked MUC1 cytoplasmic dimers are required for Src recruitment and ICAM-1 binding induced cell invasion. Molecular Cancer, 10, 93.
4. Bhargavi, K., Kalyan Chaitanya, P., Ramasree, D., Vasavi, M., Murthy, D.K., & Uma, V. (2010). Homology modeling and docking studies of human Bcl-2L10 protein. Journal of Biomolecular Structure & Dynamics, 28, 379-391.
5. Bjorge, J.D., Pang, A.S., Funnell, M., Chen, K.Y., Diaz, R., Magliocco, A.M., & Fujita, D.J. (2011). Simultaneous siRNA targeting of Src and downstream signaling molecules inhibit tumor formation and metastasis of a human model breast cancer cell line. PLoS ONE, 6, e19309.
6. Blair, J.A., Rauh, D., Kung, C., Yun, C.H., Fan, Q.W., Rode, H., ... Shokat, K.M. (2007). Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nature Chemical Biology, 3, 229-238. (Pubitemid 46440537)
7. Boschelli, D.H., Wang, D., Wang, Y., Wu, B., Honores, E. E., Barrios Sosa, A.C., ... Boschelli, F. (2010). Optimization of 7-alkene-3- quinolinecarbonitriles as Src kinase inhibitors. Bioorganic & Medicinal Chemistry Letters, 20, 2924-2927.
8. Brady, R.R., Loveridge, C.J., Dunlop, M.G., & Stark, L.A. (2011). c-Src dependency of NSAID-induced effects on NF-kappaB-mediated apoptosis in colorectal cancer cells. Carcinogenesis, 32, 1069-1077.
9. Brooks, B.R., Brooks, C.L.3rd, Mackerell, A.D.Jr., Nilsson, L., Petrella, R.J., Roux, B., ... Karplus, M. (2009). CHARMM: The biomolecular simulation program. Journal of Computational Chemistry, 30, 1545-1614.
10. Burbidge, R., Trotter, M., Buxton, B., & Holden, S. (2001). Drug design by machine learning: Support vector machines for pharmaceutical data analysis. Computers & Chemistry, 26, 5-14. (Pubitemid 33034554)
11. Cai, Y.D., He, J.F., & Lu, L. (2011). Predicting sumoylation site by feature selection method. Journal of Biomolecular Structure & Dynamics, 28, 797-804.
12. Cambria, M.T., Di Marino, D., Falconi, M., Garavaglia, S., & Cambria, A. (2010). Docking simulation and competitive experiments validate the interaction between the 2, 5-xylidine inhibitor and Rigidoporus lignosus laccase. Journal of Biomolecular Structure & Dynamics, 27, 501-509.
13. Casimiro, M., Rodriguez, O., Pootrakul, L., Aventian, M., Lushina, N., Cromelin, C., ... Albanese, C. (2007). ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo. Cancer Research, 67, 4364-4372. (Pubitemid 46815085)
14. Chang, T.T., Chen, K.C., Chang, K.W., Chen, H.Y., Tsai, F.J., Sun, M.F., & Chen, C.Y.C. (2011). In silico pharmacology suggests ginger extracts may reduce stroke risks. Molecular BioSystems, 7, 2702-2710.
15. Chang, T.T., Huang, H.J., Lee, K.J., Yu, H.W., Chen, H.Y., Tsai, F.J., ... Chen, C.Y.C. (2010). Key features for designing phosphodiesterase-5 inhibitors. Journal of Biomolecular Structure & Dynamics, 28, 309-321.
16. Chang, S.S., Huang, H.J., & Chen, C.Y.C. (2011a). High performance screening, structural and molecular dynamics analysis to identify H1 inhibitors from TCM Database@Taiwan. Molecular BioSystems, 7, 3366-3374.
17. Chang, S.S., Huang, H.J., & Chen, C.Y.C. (2011b). Two birds with one stone? Possible dual-targeting H1N1 inhibitors from traditional Chinese medicine. PLoS Computational Biology, 7, e1002315.
18. Chang, C.-C., & Lin, C.-J. (2011). LIBSVM: A library for support vector machines. ACM Transactions on Intelligent Systems and Technology, 2, 27:21-27:27.
19. Chang, T.T., Sun, M.F., Chen, H.Y., Tsai, F.J., Fisher, M., Lin, J.G., & Chen, C.Y.C. (2011). Screening from the world's largest TCM database against H1N1 virus. Journal of Biomolecular Structure & Dynamics, 28, 773-786.
20. Chang, K.W., Tsai, T.Y., Chen, K.C., Yang, S.C., Huang, H.J., Chang, T.T., ... Chen, C.Y.C. (2011). iSMART: An integrated cloud computing web server for traditional chinese medicine for online virtual screening, de novo evolution and drug design. Journal of Biomolecular Structure & Dynamics, 29, 243-250.
21. Chang, P.C., Wang, J.D., Lee, M.M., Chang, S.S., Tsai, T.Y., Chang, K.W., ... Chen, C.Y.C. (2011). Lose weight with traditional chinese medicine? Potential suppression of fat mass and obesity-associated protein. Journal of Biomolecular Structure & Dynamics, 29, 471-483.
22. Charoenfuprasert, S., Yang, Y.Y., Lee, Y.C., Chao, K.C., Chu, P.Y., Lai, C.R., ... Shih, N.Y. (2011). Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer. Oncogene, 30, 3570-3584.
23. Chen, C.Y.C. (2007). The molecular dynamic simulation of zolpidem interaction with gamma aminobutyric acid type A receptor. Journal of the Chinese Chemical Society-Taipei, 54, 653-658.
24. Chen, C.Y.C. (2008a). A novel perspective on designing the inhibitor of HER2 receptor. Journal of the Chinese Institute of Chemical Engineers, 39, 291-299.
25. Chen, C.Y.C. (2008b). Insights into the suanzaoren mechanism- From constructing the 3D structure of GABA-A receptor to its binding interaction analysis. Journal of the Chinese Institute of Chemical Engineers, 39, 663-671.
26. Chen, C.Y.C. (2009a). De novo design of novel selective COX-2 inhibitors: From virtual screening to pharmacophore analysis. Journal of the Taiwan Institute of Chemical Engineers, 40, 55-69.
27. Chen, C.Y.C. (2009b). Pharmacoinformatics approach for mPGES-1 in anti-inflammation by 3D-QSAR pharmacophore mapping. Journal of the Taiwan Institute of Chemical Engineers, 40, 155-161.
28. Chen, C.Y.C. (2010a). Virtual screening and drug design for PDE-5 receptor from traditional Chinese medicine database. Journal of Biomolecular Structure & Dynamics, 27, 627-640.
29. Chen, C.Y.C. (2010b). Bioinformatics, chemoinformatics, and pharmainformatics analysis of HER2/HSP90 dual-targeted inhibitors. Journal of the Taiwan Institute of Chemical Engineers, 41, 143-149.
30. Chen, C.Y.C. (2011). TCM Database@Taiwan: The world's largest traditional chinese medicine database for drug screening in silico. The PLoS ONE, 6, e15939.
31. Chen, C.Y., Chang, Y.H., Bau, D.T., Huang, H.J., Tsai, F.J., Tsai, C.H., & Chen, C.Y.C. (2009). Discovery of potent inhibitors for phosphodiesterase 5 by virtual screening and pharmacophore analysis. Acta Pharmacologica Sinica, 30, 1186-1194.
32. Chen, C.Y., & Chen, C.Y.C. (2010). Insights into designing the dual-targeted HER2/HSP90 inhibitors. Journal of Molecular Graphics and Modelling, 29, 21-31.
33. Chen, K.C., & Chen, C.Y.C. (2011). Stroke prevention by traditional Chinese medicine? A genetic algorithm, support vector machine and molecular dynamics approach. Soft Matter, 7, 4001-4008.
34. Chen, C.Y.C., Chen, G.W., & Chen, W.Y.C. (2008). Molecular simulation of HER2/neu degradation by inhibiting HSP90. Journal of the Chinese Chemical Society-Taipei, 55, 297-302.
35. Chen, C.Y., Huang, H.J., Tsai, F.J., & Chen, C.Y.C. (2010). Drug design for influenza A virus subtype H1N1. Journal of the Chinese Chemical Society-Taipei, 41, 8-15.
36. Chen, P.C., Muo, C.H., Lee, Y.T., Yu, Y.H., & Sung, F.C. (2011). Lung cancer and incidence of stroke: A population-based cohort study. Stroke, 42, 3034-3039.
37. Chen, K.C., Sun, M.F., Yang, S.C., Chang, S.S., Chen, H.Y., Tsai, F.J., & Chen, C.Y.C. (2011). Investigation into potent inflammation inhibitors from traditional Chinese medicine. Chemical Biology & Drug Design, 78, 679-688.
38. Cramer, R.D.3rd, Patterson, D.E., & Bunce, J.D. (1989). Recent advances in comparative molecular field analysis (CoMFA). Progress in Clinical and Biological Research, 291, 161-165.
39. da Cunha, E.F.F., Barbosa, E.F., Oliveira, A.A., & Ramalho, T. C. (2010). Molecular modeling of Mycobacterium tuberculosis DNA gyrase and its molecular docking study with gatifloxacin inhibitors. Journal of Biomolecular Structure & Dynamics, 27, 619-625.
40. DaSilva, J., Gioeli, D., Weber, M.J., & Parsons, S.J. (2009). The neuroendocrine-derived peptide parathyroid hormone-related protein promotes prostate cancer cell growth by stabilizing the androgen receptor. Cancer Research, 69, 7402-7411.
41. Ding, Y., Wang, X., Xu, A., Xu, X., Tian, K., Young, C.Y., & Yuan, H. (2011). Associations of saposin C, Src, and androgen receptor upregulate the expression and function of androgen receptor in human prostate cancer cells. Journal of Cellular Biochemistry, 112, 818-828.
42. Ferrandi, M., Molinari, I., Torielli, L., Padoani, G., Salardi, S., Rastaldi, M.P., ... Bianchi, G. (2010). Adducin- and ouabain- related gene variants predict the antihypertensive activity of rostafuroxin, part 1: Experimental studies. Science Translational Medicine, 2, 59ra86.
43. Ferrari, P. (2010). Rostafuroxin: An ouabain-inhibitor counteracting specific forms of hypertension. Biochimica et Biophysica Acta, 1802, 1254-1258.
44. Ferrari, P., Ferrandi, M., Valentini, G., & Bianchi, G. (2006). Rostafuroxin: An ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin- dependent hypertension. American Journal of Physiology- Regulatory, I(290), R529-R535.
45. Ferrarini, M., Heltai, S., Zocchi, M.R., & Rugarli, C. (1992). Unusual expression and localization of heat-shock proteins in human tumor cells. International Journal of Cancer, 51, 613-619.
46. Ghose, A.K., & Crippen, G.M. (1987). Atomic physicochemical parameters for three-dimensional-structure-directed quantitative structure-activity relationships. 2. Modeling dispersive and hydrophobic interactions. Journal of Chemical Information and Computer Sciences, 27, 21-35.
47. Gianni, D., Taulet, N., DerMardirossian, C., & Bokoch, G.M. (2010). c-Src-mediated phosphorylation of NoxA1 and Tks4 induces the reactive oxygen species (ROS)-dependent formation of functional invadopodia in human colon cancer cells. Molecular Biology of the Cell, 21, 4287-4298.
48. Gillespie, R.J., Bayles, D., Platts, J., Heard, G.L., & Bader, R. F.W. (1998). The Lennard-Jones function: A quantitative description of the spatial correlation of electrons as determined by the exclusion principle. Journal of Physical Chemistry A, 102, 3407-3414. (Pubitemid 128578061)
49. Guimaraes, A.P., Oliveira, A.A., da Cunha, E.F., Ramalho, T. C., & Franca, T.C. (2011). Design of new chemotherapeutics against the deadly anthrax disease. Docking and molecular dynamics studies of inhibitors containing pyrrolidine and riboamidrazone rings on nucleoside hydrolase from Bacillus anthracis. Journal of Biomolecular Structure & Dynamics, 28, 455-469.
50. Haenssen, K.K., Caldwell, S.A., Shahriari, K.S., Jackson, S.R., Whelan, K.A., Klein-Szanto, A.J., & Reginato, M.J. (2010). ErbB2 requires integrin alpha5 for anoikis resistance via Src regulation of receptor activity in human mammary epithelial cells. Journal of Cell Science, 123, 1373-1382.
51. Hennequin, L.F., Allen, J., Breed, J., Curwen, J., Fennell, M., Green, T.P., ... Costello, G. (2006). N-(5-chloro-1, 3-benzodioxol- 4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5-(tetrahydro-2H-pyran-4-yloxy) quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. Journal of Medicinal Chemistry, 49, 6465-6488. (Pubitemid 44657442)
52. Hou, Z., Falcone, D.J., Subbaramaiah, K., & Dannenberg, A.J. (2011). Macrophages induce COX-2 expression in breast cancer cells: Role of IL-1beta autoamplification. Carcinogenesis, 32, 695-702.
53. Huang, H.J., Lee, K.J., Yu, H.W., Chen, H.Y., Tsai, F.J., & Chen, C.Y.C. (2010). A novel strategy for designing the selective PPAR agonist by the "sum of activity" model. Journal of Biomolecular Structure & Dynamics, 28, 187-200.
54. Huang, H.J., Lee, K.J., Yu, H.W., Hsu, C.H., Chen, H.Y., Tsai, F.J., & Chen, C.Y.C. (2010). Structure-based and ligand-based drug design for HER 2 receptor. Journal of Biomolecular Structure & Dynamics, 28, 23-37.
55. Huang, J., Yao, L., Xu, R., Wu, H., Wang, M., White, B.S., ...Zheng, X. (2011). Activation of Src and transformation by an RPTP alpha splice mutant found in human tumours. The EMBO Journal, 30, 3200-3211.
56. Irwin, M.E., Bohin, N., & Boerner, J.L. (2011). Src family kinases mediate epidermal growth factor receptor signaling from lipid rafts in breast cancer cells. Cancer Biology & Therapy, 12, 718-726.
57. Ivanciuc, O. (2007). Applications of support vector machines in chemistry. Reviews in Computational Chemistry, 23, 291-400.
58. Jameel, A., Law, M., Coombes, R., & Luqmani, Y. (1993). Significance of heat-shock protein-90 as a prognostic indicator in breast-cancer. International Journal of Oncology, 2, 1075-1080. (Pubitemid 23178418)
59. Jian, J., Yang, Q., & Huang, X. (2011). Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival. Journal of Biological Chemistry, 286, 35708-35715.
60. Kawata, M., & Mikami, M. (1999). Acceleration of the canonical molecular dynamics simulation by the particle mesh Ewald method combined with the multiple time-step integrator algorithm. Chemical Physics Letters, 313, 261-266. (Pubitemid 129556651)
61. Kearney, P.M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P.K., & He, J. (2005). Global burden of hypertension: Analysis of worldwide data. Lancet, 365, 217-223. (Pubitemid 40138015)
62. Kim, H.S., Han, H.D., Armaiz-Pena, G.N., Stone, R.L., Nam, E.J., Lee, J.W., ... Sood, A.K. (2011). Functional roles of Src and Fgr in ovarian carcinoma. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research, 17, 1713-1721.
63. Klebe, G., Abraham, U., & Mietzner, T. (1994). Molecular similarity indices in a comparative analysis (CoMSIA) of drug molecules to correlate and predict their biological activity. Journal of Medicinal Chemistry, 37, 4130-4146. (Pubitemid 24379702)
64. Kobayashi, T., Inoue, T., Shimizu, Y., Terada, N., Maeno, A., Kajita, Y., ... Nakamura, E. (2010). Activation of Rac1 is closely related to androgen-independent cell proliferation of prostate cancer cells both in vitro and in vivo. Molecular Endocrinology, 24, 722-734.
65. Kung, P.P., Huang, B., Zhang, G., Zhou, J.Z., Wang, J., Digits, J.A., ... Gehring, M.R. (2010). Dihydroxyphenylisoindoline amides as orally bioavailable inhibitors of the heat shock protein 90 (hsp90) molecular chaperone. Journal of Medicinal Chemistry, 53, 499-503.
66. Langer, T., & Bryant, S.D. (2008).C.G. Wermuth (Ed.), The practice of medicinal chemistry (pp. 587-604). Burlington, MA: Academic Press.
67. Laskowski, R.A., & Swindells, M.B. (2011). LigPlot+: Multiple ligand-protein interaction diagrams for drug discovery. Journal of Chemical Information and Modeling, 51, 2778-2786.
68. Le, X.F., Mao, W., He, G., Claret, F.X., Xia, W., Ahmed, A.A., ... Bast, R.C.Jr. (2011). The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells. Journal of the Natural Cancer, I(103), 1403-1422.
69. Lee, J.C., Maa, M.C., Yu, H.S., Wang, J.H., Yen, C.K., Wang, S.T., ... Leu, T.H. (2005). Butyrate regulates the expression of c-Src and focal adhesion kinase and inhibits cell invasion of human colon cancer cells. Molecular Carcinogenesis, 43, 207-214.
70. Leu, T.H., & Maa, M.C. (2003). Functional implication of the interaction between EGF receptor and c-Src. Frontiers in Bioscience, 8, s28-s38.
71. Leung, E.L., Wong, J.C., Johlfs, M.G., Tsang, B.K., & Fiscus, R.R. (2010). Protein kinase G type Ialpha activity in human ovarian cancer cells significantly contributes to enhanced Src activation and DNA synthesis/cell proliferation. Molecular Cancer Research, 8, 578-591.
72. Leve, F., Marcondes, T.G., Bastos, L.G., Rabello, S.V., Tanaka, M.N., & Morgado-Diaz, J.A. (2011). Lysophosphatidic acid induces a migratory phenotype through a crosstalk between RhoA-Rock and Src-FAK signalling in colon cancer cells. European Journal of Pharmacology, 671, 7-17.
73. Lin, C.H., Chang, T.T., Sun, M.F., Chen, H.Y., Tsai, F.J., Chang, K.L., ... Chen, C.Y.C. (2011). Potent inhibitor design against H1N1 swine influenza: Structure-based and molecular dynamics analysis for M2 inhibitors from traditional chinese medicine database. Journal of Biomolecular Structure & Dynamics, 28, 471-482.
74. Liu, X.G., Guo, Y., Yan, Z.Q., Guo, M.Y., Zhang, Z.G., & Guo, C.A. (2011). FAK/c-Src signaling pathway mediates the expression of cell surface HSP90 in cultured human prostate cancer cells and its association with their invasive capability. Zhonghua Zhong Liu Za Zhi, 33, 340-344.
75. Lo, H.W., Hsu, S.C., Ali-Seyed, M., Gunduz, M., Xia, W., Wei, Y., ... Hung, M.C. (2005). Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell, 7, 575-589. (Pubitemid 40799250)
76. Lo, H.W., Hsu, S.C., Xia, W., Cao, X., Shih, J.Y., Wei, Y., ...Hung, M.C. (2007). Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Research, 67, 9066-9076. (Pubitemid 47535891)
77. Mader, C.C., Oser, M., Magalhaes, M.A., Bravo-Cordero, J.J., Condeelis, J., Koleske, A.J., & Gil-Henn, H. (2011). An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Research, 71, 1730-1741.
78. Manning, G., Whyte, D.B., Martinez, R., Hunter, T., & Sudarsanam, S. (2002). The protein kinase complement of the human genome. Science, 298, 1912-1934. (Pubitemid 35425239)
79. Mei, Z.H., Liu, J., & Yu, H.W. (2011). Modeling of transition state by molecular dynamics. Prediction of catalytic efficiency of the mutants of mandelate racemase. Journal of Biomolecular Structure & Dynamics, 28, 871-879.
80. Migliaccio, A., Castoria, G., & Auricchio, F. (2011). Analysis of androgen receptor rapid actions in cellular signaling pathways: Receptor/Src association. Methods in Molecular Biology, 776, 361-370.
81. Miyake, T., & Parsons, S.J. (2011). Functional interactions between Choline kinase alpha, epidermal growth factor receptor and c-Src in breast cancer cell proliferation. Oncogene. doi:10.1038/onc.2011.1332
82. Ompraba, G., Velmurugan, D., Louis, P.A., & Rafi, Z.A. (2010). Molecular modeling of the additional inhibitor site located in secretory phospholipase A(2). Journal of Biomolecular Structure & Dynamics, 27, 489-499.
83. Oneyama, C., Morii, E., Okuzaki, D., Takahashi, Y., Ikeda, J., Wakabayashi, N., ... Okada, M. (2012). MicroRNA-mediated upregulation of integrin-linked kinase promotes Srcinduced tumor progression. Oncogene, 31, 1623-1635.
84. Pandini, G., Genua, M., Frasca, F., Vigneri, R., & Belfiore, A. (2009). Sex steroids upregulate the IGF-1R in prostate cancer cells through a nongenotropic pathway. Annals of the New York Academy of Sciences, 1155, 263-267.
85. Pohorelic, B., Singh, R., Parkin, S., Koro, K., Yang, A.D., Egan, C., & Magliocco, A. (2011). Role of Src in breast cancer cell migration and invasion in a breast cell/bone-derived cell microenvironment. Breast Cancer Research Treatment (Advanced Online Publication). doi:10.1007/s10549-10011- 11753-10542
86. Poole, E.M., Curtin, K., Hsu, L., Kulmacz, R.J., Duggan, D.J., ... Ulrich, C.M. (2011). Genetic variability in EGFR, Src and HER2 and risk of colorectal adenoma and cancer. International Journal of Molecular Epidemiology and Genetics, 2, 300-315.
87. Prinetti, A., Cao, T., Illuzzi, G., Prioni, S., Aureli, M., Gagliano, N., ... C, S. (2011). A glycosphingolipid/caveolin-1 signaling complex inhibits the motility of human ovarian carcinoma cells. The Journal of Biological Chemistry, 47, 40900-40910.
88. Ratushny, V., Pathak, H.B., Beeharry, N., Tikhmyanova, N., Xiao, F., Li, T., ... Golemis, E.A. (2012). Dual inhibition of SRC and Aurora kinases induces postmitotic attachment defects and cell death. Oncogene, 31, 1217-1227.
89. Reeder-Hayes, K.E., Carey, L.A., & Sikov, W.M. (2010). Clinical trials in triple negative breast cancer. Breast Disease, 32, 123-136.
90. Said, N., & Theodorescu, D. (2009). Pathways of metastasis suppression in bladder cancer. Cancer Metastasis Reviews, 28, 327-333.
91. Saini, S., Arora, S., Majid, S., Shahryari, V., Chen, Y., Deng, G., ... Dahiya, R. (2011). Curcumin modulates microRNA- 203-mediated regulation of the Src-Akt axis in bladder cancer. Cancer Prevention Research, 4, 1698-1709.
92. Sanderson, K. (2011). Databases aim to bridge the East-West divide of drug discovery. Nature Medicine, 17, 1531.
93. Semighini, E.P., Resende, J.A., de Andrade, P., Morais, P.A.B., Carvalho, I., Taft, C.A., & Silva, C.H.T.P. (2011). Using computer-aided drug design and medicinal chemistry strategies in the fight against diabetes. Journal of Biomolecular Structure & Dynamics, 28, 787-796.
94. Shackleford, T.J., Zhang, Q., Tian, L., Vu, T.T., Korapati, A.L., Baumgartner, A.M., ... Claret, F.X. (2011). Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells. Breast Cancer Research, 13, R65.
95. Slinker, B.K., & Glantz, S.A. (2008). Multiple linear regression - Accounting for multiple simultaneous determinants of a continuous dependent variable. Circulation, 117, 1732-1737. (Pubitemid 351482596)
96. Sturla, L.M., Zinn, P.O., Ng, K., Nitta, M., Kozono, D., Chen, C.C., & Kasper, E.M. (2011). Src homology domain-containing phosphatase 2 suppresses cellular senescence in glioblastoma. British Journal of Cancer, 105, 1235-1243.
97. Sun, M.F., Chang, T.T., Chang, K.W., Huang, H.J., Chen, H.Y., Tsai, F.J., ... Chen, C.Y.C. (2011). Blocking the DNA repair system by traditional chinese medicine? Journal of Biomolecular Structure & Dynamics, 28, 895-906.
98. Sun, M.F., Chen, H.Y., Tsai, F.J., Lui, S.H., & Chen, C.Y.C. (2011). Search for novel remedies to augment radiation resistance of inhabitants of Fukushima and Chernobyl disasters: Identifying DNA repair protein XRCC4 inhibitors. Journal of Biomolecular Structure & Dynamics, 29, 325-337.
99. Sun, M.F., Yang, S.C., Chang, K.W., Tsai, T.Y., Chen, H. Y., Tsai, F.J., ... Chen, C.Y.C. (2011). Screening from TCM Database@Taiwan and QSAR model for identifying HER2 inhibitors. Molecular Simulation, 37, 884-892.
100. Swaminathan, G., & Cartwright, C.A. (2012). Rack1 promotes epithelial cell-cell adhesion by regulating E-cadherin endocytosis. Oncogene, 31, 376-389.
101. Tang, G., & Ma, B.K. (2000). Dynamic scaling of growing surfaces with growth inhomogeneities of screened coulombic function. Chinese Physics, 9, 737-741. (Pubitemid 33715714)
102. Thomas, S.M., & Brugge, J.S. (1997). Cellular functions regulated by Src family kinases. Annual Review of Cell and Developmental Biology, 13, 513-609. (Pubitemid 28034534)
103. Thomas, S., Overdevest, J.B., Nitz, M.D., Williams, P.D., Owens, C.R., Sanchez-Carbayo, M., ... Theodorescu, D. (2011). Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer. Cancer Research, 71, 832-841.
104. Tikhmyanova, N., & Golemis, E.A. (2011). NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation. PLoS ONE, 6, e22102.
105. Tou, W.I., & Chen, C.Y.C. (2012). In silico investigation of potential Src kinase ligands from traditional Chinese medicine. PloS One, 7, e33728.
106. Tsai, T.Y., Chang, K.W., & Chen, C.Y.C. (2011). iScreen: World's first cloud-computing web server for virtual screening and de novo drug design based on TCM database@Taiwan. Journal of Computer-Aided Molecular Design, 25, 525-531.
107. Tufail, M., & Ormsbee, L.E. (2006). A fixed functional set genetic algorithm (FFSGA) approach for function approximation. Journal of Hydroinformatics, 8, 193-206.
108. Vapnik, V. (1995). The nature of statistical learning theory. New York, NY: Springer.
109. Vapnik, V., & Lerner, A. (1963). Pattern Recognition Using Generalized Portrait Method. Automation and Remote Control, 24, 774-780.
110. Whitesell, L., Mimnaugh, E.G., De Costa, B., Myers, C.E., & Neckers, L.M. (1994). Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation. Proceedings of the National Academy of Sciences United States of America, 91, 8324-8328.
111. Yang, S.C., Chang, S.S., & Chen, C.Y.C. (2011). Identifying HER2 inhibitors from natural products database. PLoS ONE, 6, e28793.
112. Yang, S.C., Chang, S.S., Chen, H.Y., & Chen, C.Y.C. (2011). Identification of potent EGFR inhibitors from TCM Database@ Taiwan. PLoS Computational Biology, 7, e1002189.
113. Yufu, Y., Nishimura, J., & Nawata, H. (1992). High constitutive expression of heat shock protein 90 alpha in human acute leukemia cells. Leukemia Research, 16, 597-605.
114. Yun, C.H., Boggon, T.J., Li, Y., Woo, M.S., Greulich, H., Meyerson, M., & Eck, M.J. (2007). Structures of lung cancer-derived EGFR mutants and inhibitor complexes: Mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell, 11, 217-227. (Pubitemid 46349842)
115. Zhang, S., Zhau, H.E., Osunkoya, A.O., Iqbal, S., Yang, X., Fan, S., ... Wu, D. (2010). Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells. Molecular Cancer, 9, 9.