MicroRNA-mediated upregulation of integrin-linked kinase promotes Src-induced tumor progression

Oncogene

Volumn 31, Issue 13, 2012, Pages 1623-1635

  Oneyama, C ^a   Morii, E ^b   Okuzaki, D ^a   Takahashi, Y ^a   Ikeda, J ^b   Wakabayashi, N ^a   Akamatsu, H ^c   Tsujimoto, M ^c   Nishida, T ^c   Aozasa, K ^b   Okada, M ^a  

^a OSAKA UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA POLICE HOSPITAL   (Japan)

Author keywords

c Src; ILK; miRNA; tumor progression

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; FOCAL ADHESION KINASE INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; INTEGRIN LINKED KINASE; K RAS PROTEIN; MICRORNA; MICRORNA 542 3P; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER GROWTH; CANCER TISSUE; CELL ADHESION; CELL INVASION; COLON CANCER; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; ONCOGENE; PRIORITY JOURNAL; UPREGULATION;

ANIMALS; CELL ADHESION; CELL LINE; COLONIC NEOPLASMS; DISEASE PROGRESSION; FOCAL ADHESION KINASE 1; HUMANS; MICE; MICRORNAS; NEOPLASM INVASIVENESS; NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; UP-REGULATION;

EID: 84860390475     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.367     Document Type: Article

References (43)

1. Abboud ER, Coffelt SB, Figueroa YG, Zwezdaryk KJ, Nelson AB, Sullivan DE et al. (2007). Integrin-linked kinase: a hypoxia-induced anti-apoptotic factor exploited by cancer cells. Int J Oncol 30: 113-122.
2. Ambros V. (2004). The functions of animal microRNAs. Nature 431: 350-355.
3. Attwell S, Mills J, Troussard A, Wu C, Dedhar S. (2003). Integration of cell attachment, cytoskeletal localization, and signaling by integrin-linked kinase (ILK), CH-ILKBP, and the tumor suppressor PTEN. Mol Biol Cell 14: 4813-4825. (Pubitemid 37484798)
4. Bartel DP. (2004). MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
5. Bartel DP. (2009). MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
6. Brown M, Cooper J. (1996). Regulation, substrates and functions of src. Biochim Biophys Acta 1287: 121-149. (Pubitemid 26189191)
7. Cabodi S, del Pilar Camacho-Leal M, Di Stefano P, Defilippi P. (2010a). Integrin signalling adaptors: not only figurants in the cancer story. Nat Rev Cancer 10: 858-870.
8. Cabodi S, Di Stefano P, Leal Mdel P, Tinnirello A, Bisaro B, Morello V et al. (2010b). Integrins and signal transduction. Adv Exp Med Biol 674: 43-54.
9. Calin GA, Croce CM. (2006). MicroRNA signatures in human cancers. Nat Rev Cancer 6: 857-866. (Pubitemid 44629897)
10. Di-Poi N, Tan NS, Michalik L, Wahli W, Desvergne B. (2002). Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway. Mol Cell 10: 721-733. (Pubitemid 35335629)
11. Esquela-Kerscher A, Slack FJ. (2006). Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 6: 259-269.
12. Frame M. (2002). Src in cancer: deregulation and consequences for cell behaviour. Biochim Biophy Acta 1602: 114-130.
13. Hannigan G, Troussard AA, Dedhar S. (2005). Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat Rev Cancer 5: 51-63. (Pubitemid 40052325)
14. Hannigan GE, Leung-Hagesteijn C, Fitz-Gibbon L, Coppolino MG, Radeva G, Filmus J et al. (1996). Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase. Nature 379: 91-96. (Pubitemid 26008142)
15. He L, Hannon GJ. (2004). MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5: 522-531. (Pubitemid 38868508)
16. Hehlgans S, Haase M, Cordes N. (2007). Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta 1775: 163-180. (Pubitemid 44881199)
17. Iliopoulos D, Jaeger SA, Hirsch HA, Bulyk ML, Struhl K. (2010). STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell 39: 493-506.
18. Ingley E. (2008). Src family kinases: regulation of their activities, levels and identification of new pathways. Biochim Biophys Acta 1784: 56-65.
19. Irby R, Mao W, Coppola D, Kang J, Loubeau J, Trudeau W et al. (1999). Activating SRC mutation in a subset of advanced human colon cancers. Nat Genet 21: 187-190. (Pubitemid 29070364)
20. Irby R, Yeatman T. (2000). Role of Src expression and activation in human cancer. Oncogene 19: 5636-5642.
21. Ishizawar R, Parsons S. (2004). c-Src and cooperating partners in human cancer. Cancer Cell 6: 209-214. (Pubitemid 39222033)
22. Kim M, Lee KT, Jang HR, Kim JH, Noh SM, Song KS et al. (2008a). Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion. Mol Cancer Res 6: 222-230. (Pubitemid 351342410)
23. Kim YB, Choi S, Choi MC, Oh MA, Lee SA, Cho M et al. (2008b). Cell adhesion-dependent cofilin serine 3 phosphorylation by the integrin-linked kinase.c-Src complex. J Biol Chem 283: 10089-10096.
24. Legate KR, Montanez E, Kudlacek O, Fassler R. (2006). ILK, PINCH and parvin: the tIPP of integrin signalling. Nat Rev Mol Cell Biol 7: 20-31. (Pubitemid 43361569)
25. Li X, Shen Y, Ichikawa H, Antes T, Goldberg GS. (2009). Regulation of miRNA expression by Src and contact normalization: effects on nonanchored cell growth and migration. Oncogene 28: 4272-4283.
26. McDonald PC, Fielding AB, Dedhar S. (2008). Integrin-linked kinase - essential roles in physiology and cancer biology. J Cell Sci 121: 3121-3132.
27. Mitra SK, Schlaepfer DD. (2006). Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol 18: 516-523. (Pubitemid 44332916)
28. Okada M, Nada S, Yamanashi Y, Yamamoto T, Nakagawa H. (1991). CSK: a protein-tyrosine kinase involved in regulation of src family kinases. J Biol Chem 266: 24249-24252. (Pubitemid 21908933)
29. Oneyama C, Hikita T, Nada S, Okada M. (2008). Functional dissection of transformation by c-Src and v-Src. Genes Cells 13: 1-12.
30. Oneyama C, Ikeda J, Okuzaki D, Suzuki K, Kanou T, Shintani Y et al. (2011). MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways. Oncogene 30: 3489-3501.
31. Persad S, Dedhar S. (2003). The role of integrin-linked kinase (ILK) in cancer progression. Cancer Metast Rev 22: 375-384. (Pubitemid 36791893)
32. Pontier SM, Huck L, White DE, Rayment J, Sanguin-Gendreau V, Hennessy B et al. (2010). Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer. Oncogene 29: 3374-3385.
33. Radeva G, Petrocelli T, Behrend E, Leung-Hagesteijn C, Filmus J, Slingerland J et al. (1997). Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression. J Biol Chem 272: 13937-13944. (Pubitemid 27224838)
34. Shenouda SK, Alahari SK. (2009). MicroRNA function in cancer: oncogene or a tumor suppressor? Cancer Metast Rev 28: 369-378.
35. Toloubeydokhti T, Pan Q, Luo X, Bukulmez O, Chegini N. (2008). The expression and ovarian steroid regulation of endometrial micro- RNAs. Reprod Sci 15: 993-1001.
36. Troussard AA, McDonald PC, Wederell ED, Mawji NM, Filipenko NR, Gelmon KA et al. (2006). Preferential dependence of breast cancer cells versus normal cells on integrin-linked kinase for protein kinase B/Akt activation and cell survival. Cancer Res 66: 393-403. (Pubitemid 43166047)
37. Ventura A, Jacks T. (2009). MicroRNAs and cancer: short RNAs go a long way. Cell 136: 586-591.
38. White DE, Cardiff RD, Dedhar S, Muller WJ. (2001). Mammary epithelial-specific expression of the integrin-linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice. Oncogene 20: 7064-7072. (Pubitemid 33052198)
39. Yang L, Olsson B, Pfeifer D, Jonsson JI, Zhou ZG, Jiang X et al. (2010). Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell-fibronectin adhesion of colon cancer cells. Oncogene 29: 516-526.
40. Yau CY, Wheeler JJ, Sutton KL, Hedley DW. (2005). Inhibition of integrin-linked kinase by a selective small molecule inhibitor, QLT0254, inhibits the PI3K/PKB/mTOR, Stat3, and FKHR pathways and tumor growth, and enhances gemcitabine-induced apoptosis in human orthotopic primary pancreatic cancer xenografts. Cancer Res 65: 1497-1504. (Pubitemid 40270179)
41. Yeatman TJ. (2004). A renaissance for SRC. Nat Rev Cancer 4: 470-480.
42. Yoganathan TN, Costello P, Chen X, Jabali M, Yan J, Leung D et al. (2000). Integrin-linked kinase (ILK): a 'hot' therapeutic target. Biochem Pharmacol 60: 1115-1119.
43. Yoon S, Choi YC, Lee S, Jeong Y, Yoon J, Baek K. (2010). Induction of growth arrest by miR-542-3p that targets survivin. FEBS Lett 584: 4048-4052.