-
1
-
-
2342496712
-
FoxOs at the crossroads of cellular metabolism, differentiation, and transformation
-
Accili D, Arden KC. 2004. FoxOs at the crossroads of cellular metabolism, differentiation, and transformation. Cell 117:421-426.
-
(2004)
Cell
, vol.117
, pp. 421-426
-
-
Accili, D.1
Arden, K.C.2
-
2
-
-
15244344356
-
A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities
-
Bellacosa A, Testa JR, Moore R, Larue L. 2004. A portrait of AKT kinases: human cancer and animal models depict a family with strong individualities. Cancer Biol Ther 3:268-275.
-
(2004)
Cancer Biol Ther
, vol.3
, pp. 268-275
-
-
Bellacosa, A.1
Testa, J.R.2
Moore, R.3
Larue, L.4
-
3
-
-
77957833800
-
The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane
-
Berndt N, Yang H, Trinczek B, Betzi S, Zhang Z, Wu B, Lawrence NJ, Pellecchia M, Schonbrunn E, Cheng JQ, et al. 2010. The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane. Cell Death Differ 17:1795-1804.
-
(2010)
Cell Death Differ
, vol.17
, pp. 1795-1804
-
-
Berndt, N.1
Yang, H.2
Trinczek, B.3
Betzi, S.4
Zhang, Z.5
Wu, B.6
Lawrence, N.J.7
Pellecchia, M.8
Schonbrunn, E.9
Cheng, J.Q.10
-
4
-
-
52149086562
-
AKT1(E17K) in human solid tumours
-
Bleeker FE, Felicioni L, Buttitta F, Lamba S, Cardone L, Rodolfo M, Scarpa A, Leenstra S, Frattini M, Barbareschi M, et al. 2008. AKT1(E17K) in human solid tumours. Oncogene 27:5648-5650.
-
(2008)
Oncogene
, vol.27
, pp. 5648-5650
-
-
Bleeker, F.E.1
Felicioni, L.2
Buttitta, F.3
Lamba, S.4
Cardone, L.5
Rodolfo, M.6
Scarpa, A.7
Leenstra, S.8
Frattini, M.9
Barbareschi, M.10
-
5
-
-
66249107937
-
Absence of AKT1 mutations in glioblastoma
-
Bleeker FE, Lamba S, Zanon C, van Tilborg AA, Leenstra S, Troost D, Hulsebos T, Vandertop WP, Bardelli A. 2009. Absence of AKT1 mutations in glioblastoma. PloS One 4:e5638.
-
(2009)
PloS One
, vol.4
-
-
Bleeker, F.E.1
Lamba, S.2
Zanon, C.3
van Tilborg, A.A.4
Leenstra, S.5
Troost, D.6
Hulsebos, T.7
Vandertop, W.P.8
Bardelli, A.9
-
6
-
-
49649116904
-
Absence of E17K mutation in the pleckstrin homology domain of AKT1 in gastrointestinal and liver cancers in the Korean population
-
Cao Z, Song JH, Kim CJ, Cho YG, Kim SY, Nam SW, Lee JY, Park WS. 2008. Absence of E17K mutation in the pleckstrin homology domain of AKT1 in gastrointestinal and liver cancers in the Korean population. APMIS 116:530-533.
-
(2008)
APMIS
, vol.116
, pp. 530-533
-
-
Cao, Z.1
Song, J.H.2
Kim, C.J.3
Cho, Y.G.4
Kim, S.Y.5
Nam, S.W.6
Lee, J.Y.7
Park, W.S.8
-
7
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, Hostetter G, Boguslawski S, Moses TY, Savage S, et al. 2007. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448:439-444.
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
Hostetter, G.7
Boguslawski, S.8
Moses, T.Y.9
Savage, S.10
-
9
-
-
33847314539
-
The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer
-
Dillon RL, White DE, Muller WJ. 2007. The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer. Oncogene 26:1338-1345.
-
(2007)
Oncogene
, vol.26
, pp. 1338-1345
-
-
Dillon, R.L.1
White, D.E.2
Muller, W.J.3
-
10
-
-
68549083200
-
Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting
-
Do H, Solomon B, Mitchell PL, Fox SB, Dobrovic A. 2008. Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting. BMC Res Notes 1:14.
-
(2008)
BMC Res Notes
, vol.1
, pp. 14
-
-
Do, H.1
Solomon, B.2
Mitchell, P.L.3
Fox, S.B.4
Dobrovic, A.5
-
11
-
-
77950691967
-
Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma
-
Dunlap J, Le C, Shukla A, Patterson J, Presnell A, Heinrich MC, Corless CL, Troxell ML. 2010. Phosphatidylinositol-3-kinase and AKT1 mutations occur early in breast carcinoma. Breast Cancer Res Treat 120:409-418.
-
(2010)
Breast Cancer Res Treat
, vol.120
, pp. 409-418
-
-
Dunlap, J.1
Le, C.2
Shukla, A.3
Patterson, J.4
Presnell, A.5
Heinrich, M.C.6
Corless, C.L.7
Troxell, M.L.8
-
12
-
-
79955401117
-
Membrane Recruitment as a Cancer Mechanism: a case study of Akt PH domain
-
Falke JJ. 2007. Membrane Recruitment as a Cancer Mechanism: a case study of Akt PH domain. Cellscience 4:25-30.
-
(2007)
Cellscience
, vol.4
, pp. 25-30
-
-
Falke, J.J.1
-
13
-
-
1642617693
-
PI3K/Akt signalling pathway and cancer
-
Fresno Vara JA, Casado E, de Castro J, Cejas P, Belda-Iniesta C, Gonzalez-Baron M. 2004. PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 30:193-204.
-
(2004)
Cancer Treat Rev
, vol.30
, pp. 193-204
-
-
Fresno Vara, J.A.1
Casado, E.2
de Castro, J.3
Cejas, P.4
Belda-Iniesta, C.5
Gonzalez-Baron, M.6
-
14
-
-
4444346646
-
AKT involvement in cisplatin chemoresistance of human uterine cancer cells
-
Gagnon V, Mathieu I, Sexton E, Leblanc K, Asselin E. 2004. AKT involvement in cisplatin chemoresistance of human uterine cancer cells. Gynecol Oncol 94:785-795.
-
(2004)
Gynecol Oncol
, vol.94
, pp. 785-795
-
-
Gagnon, V.1
Mathieu, I.2
Sexton, E.3
Leblanc, K.4
Asselin, E.5
-
15
-
-
34247339936
-
Exploring the specificity of the PI3K family inhibitor LY294002
-
Gharbi SI, Zvelebil MJ, Shuttleworth SJ, Hancox T, Saghir N, Timms JF, Waterfield MD. 2007. Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J 404:15-21.
-
(2007)
Biochem J
, vol.404
, pp. 15-21
-
-
Gharbi, S.I.1
Zvelebil, M.J.2
Shuttleworth, S.J.3
Hancox, T.4
Saghir, N.5
Timms, J.F.6
Waterfield, M.D.7
-
16
-
-
17144387901
-
PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways
-
Grandage VL, Gale RE, Linch DC, Khwaja A. 2005. PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. Leukemia 19:586-594.
-
(2005)
Leukemia
, vol.19
, pp. 586-594
-
-
Grandage, V.L.1
Gale, R.E.2
Linch, D.C.3
Khwaja, A.4
-
17
-
-
0032933182
-
New model of ErbB-2 over-expression in human mammary luminal epithelial cells. International journal of cancer
-
Harris RA, Eichholtz TJ, Hiles ID, Page MJ, O'Hare MJ. 1999. New model of ErbB-2 over-expression in human mammary luminal epithelial cells. International journal of cancer. J Int Cancer 80:477-484.
-
(1999)
J Int Cancer
, vol.80
, pp. 477-484
-
-
Harris, R.A.1
Eichholtz, T.J.2
Hiles, I.D.3
Page, M.J.4
O'Hare, M.J.5
-
18
-
-
32644447756
-
Post-transcriptional nucleotide modification and alternative folding of RNA
-
Helm M. 2006. Post-transcriptional nucleotide modification and alternative folding of RNA. Nucleic Acids Res 34:721-733.
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 721-733
-
-
Helm, M.1
-
19
-
-
43749124236
-
c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21
-
Holmstrom TH, Mialon A, Kallio M, Nymalm Y, Mannermaa L, Holm T, Johansson H, Black E, Gillespie D, Salminen TA, et al. 2008. c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21. J Biol Chem 283:7046-7053.
-
(2008)
J Biol Chem
, vol.283
, pp. 7046-7053
-
-
Holmstrom, T.H.1
Mialon, A.2
Kallio, M.3
Nymalm, Y.4
Mannermaa, L.5
Holm, T.6
Johansson, H.7
Black, E.8
Gillespie, D.9
Salminen, T.A.10
-
20
-
-
34547566701
-
Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes
-
Ince TA, Richardson AL, Bell GW, Saitoh M, Godar S, Karnoub AE, Iglehart JD, Weinberg RA. 2007. Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell 12:160-170.
-
(2007)
Cancer Cell
, vol.12
, pp. 160-170
-
-
Ince, T.A.1
Richardson, A.L.2
Bell, G.W.3
Saitoh, M.4
Godar, S.5
Karnoub, A.E.6
Iglehart, J.D.7
Weinberg, R.A.8
-
21
-
-
79955572687
-
Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination
-
Jo H, Lo PK, Li Y, Loison F, Green S, Wang J, Silberstein LE, Ye K, Chen H, Luo HR. 2011. Deactivation of Akt by a small molecule inhibitor targeting pleckstrin homology domain and facilitating Akt ubiquitination. Proc Natl Acad Sci USA 108:6486-6491.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 6486-6491
-
-
Jo, H.1
Lo, P.K.2
Li, Y.3
Loison, F.4
Green, S.5
Wang, J.6
Silberstein, L.E.7
Ye, K.8
Chen, H.9
Luo, H.R.10
-
22
-
-
34249301918
-
Akt1 governs breast cancer progression in vivo
-
Ju X, Katiyar S, Wang C, Liu M, Jiao X, Li S, Zhou J, Turner J, Lisanti MP, Russell RG, et al. 2007. Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci USA 104:7438-7443.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 7438-7443
-
-
Ju, X.1
Katiyar, S.2
Wang, C.3
Liu, M.4
Jiao, X.5
Li, S.6
Zhou, J.7
Turner, J.8
Lisanti, M.P.9
Russell, R.G.10
-
23
-
-
43249115083
-
Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias
-
Kim MS, Jeong EG, Yoo NJ, Lee SH. 2008. Mutational analysis of oncogenic AKT E17K mutation in common solid cancers and acute leukaemias. Br J Cancer 98:1533-1535.
-
(2008)
Br J Cancer
, vol.98
, pp. 1533-1535
-
-
Kim, M.S.1
Jeong, E.G.2
Yoo, N.J.3
Lee, S.H.4
-
24
-
-
77950906170
-
A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation
-
Kim D, Sun M, He L, Zhou QH, Chen J, Sun XM, Bepler G, Sebti SM, Cheng JQ. 2010. A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J Biol Chem 285:8383-8394.
-
(2010)
J Biol Chem
, vol.285
, pp. 8383-8394
-
-
Kim, D.1
Sun, M.2
He, L.3
Zhou, Q.H.4
Chen, J.5
Sun, X.M.6
Bepler, G.7
Sebti, S.M.8
Cheng, J.Q.9
-
25
-
-
26044443105
-
AKT activation predicts outcome in breast cancer patients treated with tamoxifen
-
Kirkegaard T, Witton CJ, McGlynn LM, Tovey SM, Dunne B, Lyon A, Bartlett JM. 2005. AKT activation predicts outcome in breast cancer patients treated with tamoxifen. J Pathol 207:139-146.
-
(2005)
J Pathol
, vol.207
, pp. 139-146
-
-
Kirkegaard, T.1
Witton, C.J.2
McGlynn, L.M.3
Tovey, S.M.4
Dunne, B.5
Lyon, A.6
Bartlett, J.M.7
-
26
-
-
0037945211
-
HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells
-
Knuefermann C, Lu Y, Liu B, Jin W, Liang K, Wu L, Schmidt M, Mills GB, Mendelsohn J, Fan Z. 2003. HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells. Oncogene 22:3205-3212.
-
(2003)
Oncogene
, vol.22
, pp. 3205-3212
-
-
Knuefermann, C.1
Lu, Y.2
Liu, B.3
Jin, W.4
Liang, K.5
Wu, L.6
Schmidt, M.7
Mills, G.B.8
Mendelsohn, J.9
Fan, Z.10
-
27
-
-
0032694152
-
Genetic alterations in 'normal' luminal and myoepithelial cells of the breast
-
Lakhani SR, Chaggar R, Davies S, Jones C, Collins N, Odel C, Stratton MR, O'Hare MJ. 1999. Genetic alterations in 'normal' luminal and myoepithelial cells of the breast. J Pathol 189:496-503.
-
(1999)
J Pathol
, vol.189
, pp. 496-503
-
-
Lakhani, S.R.1
Chaggar, R.2
Davies, S.3
Jones, C.4
Collins, N.5
Odel, C.6
Stratton, M.R.7
O'Hare, M.J.8
-
28
-
-
56749168073
-
Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain
-
Landgraf KE, Pilling C, Falke JJ. 2008. Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain. Biochemistry 47:12260-12269.
-
(2008)
Biochemistry
, vol.47
, pp. 12260-12269
-
-
Landgraf, K.E.1
Pilling, C.2
Falke, J.J.3
-
29
-
-
77950664407
-
Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3
-
Larance M, Rowland AF, Hoehn KL, Humphreys DT, Preiss T, Guilhaus M, James DE. 2010. Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3. Mol Cell Proteomics 9:682-694.
-
(2010)
Mol Cell Proteomics
, vol.9
, pp. 682-694
-
-
Larance, M.1
Rowland, A.F.2
Hoehn, K.L.3
Humphreys, D.T.4
Preiss, T.5
Guilhaus, M.6
James, D.E.7
-
30
-
-
77951586944
-
Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations
-
Lauring J, Cosgrove DP, Fontana S, Gustin JP, Konishi H, Abukhdeir AM, Garay JP, Mohseni M, Wang GM, Higgins MJ, et al. 2010. Knock in of the AKT1 E17K mutation in human breast epithelial cells does not recapitulate oncogenic PIK3CA mutations. Oncogene 29:2337-2345.
-
(2010)
Oncogene
, vol.29
, pp. 2337-2345
-
-
Lauring, J.1
Cosgrove, D.P.2
Fontana, S.3
Gustin, J.P.4
Konishi, H.5
Abukhdeir, A.M.6
Garay, J.P.7
Mohseni, M.8
Wang, G.M.9
Higgins, M.J.10
-
31
-
-
42149159986
-
Akt1 inhibition by RNA interference sensitizes human non-small cell lung cancer cells to cisplatin
-
Lee MW, Kim DS, Min NY, Kim HT. 2008. Akt1 inhibition by RNA interference sensitizes human non-small cell lung cancer cells to cisplatin. Int J Cancer 122:2380-2384.
-
(2008)
Int J Cancer
, vol.122
, pp. 2380-2384
-
-
Lee, M.W.1
Kim, D.S.2
Min, N.Y.3
Kim, H.T.4
-
32
-
-
0042399368
-
Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy
-
Liang K, Jin W, Knuefermann C, Schmidt M, Mills GB, Ang KK, Milas L, Fan Z. 2003. Targeting the phosphatidylinositol 3-kinase/Akt pathway for enhancing breast cancer cells to radiotherapy. Mol Cancer Ther 2:353-360.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 353-360
-
-
Liang, K.1
Jin, W.2
Knuefermann, C.3
Schmidt, M.4
Mills, G.B.5
Ang, K.K.6
Milas, L.7
Fan, Z.8
-
33
-
-
84860389181
-
A mosaic activating mutation in AKT1 associated with the Proteus syndrome
-
Lindhurst MJ, Sapp JC, Teer JK, Johnston JJ, Finn EM, Peters K, Turner J, Cannons JL, Bick D, Blakemore L, et al. 2011. A mosaic activating mutation in AKT1 associated with the Proteus syndrome. N Engl J Med 365:611-619.
-
(2011)
N Engl J Med
, vol.365
, pp. 611-619
-
-
Lindhurst, M.J.1
Sapp, J.C.2
Teer, J.K.3
Johnston, J.J.4
Finn, E.M.5
Peters, K.6
Turner, J.7
Cannons, J.L.8
Bick, D.9
Blakemore, L.10
-
34
-
-
33645213629
-
Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2
-
Liu H, Radisky DC, Nelson CM, Zhang H, Fata JE, Roth RA, Bissell MJ. 2006. Mechanism of Akt1 inhibition of breast cancer cell invasion reveals a protumorigenic role for TSC2. Proc Natl Acad Sci USA 103:4134-419.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 4134-4419
-
-
Liu, H.1
Radisky, D.C.2
Nelson, C.M.3
Zhang, H.4
Fata, J.E.5
Roth, R.A.6
Bissell, M.J.7
-
35
-
-
48349131028
-
The transforming mutation E17K/AKT1 is not a major event in B-cell-derived lymphoid leukaemias
-
Mahmoud IS, Sughayer MA, Mohammad HA, Awidi AS, Ismail SI. 2008. The transforming mutation E17K/AKT1 is not a major event in B-cell-derived lymphoid leukaemias. Br J Cancer 99:488-490.
-
(2008)
Br J Cancer
, vol.99
, pp. 488-490
-
-
Mahmoud, I.S.1
Sughayer, M.A.2
Mohammad, H.A.3
Awidi, A.S.4
Ismail, S.I.5
-
36
-
-
41849132829
-
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung
-
Malanga D, Scrima M, De Marco C, Fabiani F, De Rosa N, De Gisi S, Malara N, Savino R, Rocco G, Chiappetta G, et al. 2008. Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. Cell Cycle 7:665-669.
-
(2008)
Cell Cycle
, vol.7
, pp. 665-669
-
-
Malanga, D.1
Scrima, M.2
De Marco, C.3
Fabiani, F.4
De Rosa, N.5
De Gisi, S.6
Malara, N.7
Savino, R.8
Rocco, G.9
Chiappetta, G.10
-
37
-
-
34250788809
-
AKT/PKB signaling: navigating downstream
-
Manning BD, Cantley LC. 2007. AKT/PKB signaling: navigating downstream. Cell 129:1261-1274.
-
(2007)
Cell
, vol.129
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
38
-
-
53549123296
-
AKT1 (E17K) mutation in pancreatic cancer
-
Mohamedali A, Lea NC, Feakins RM, Raj K, Mufti GJ, Kocher HM. 2008. AKT1 (E17K) mutation in pancreatic cancer. Technol Cancer Res Treat 7:407-408.
-
(2008)
Technol Cancer Res Treat
, vol.7
, pp. 407-408
-
-
Mohamedali, A.1
Lea, N.C.2
Feakins, R.M.3
Raj, K.4
Mufti, G.J.5
Kocher, H.M.6
-
39
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
Nicholson KM, Anderson NG. 2002. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal 14:381-395.
-
(2002)
Cell Signal
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
40
-
-
13844273087
-
PI3K-Akt pathway: its functions and alterations in human cancer
-
Osaki M, Oshimura M, Ito H. 2004. PI3K-Akt pathway: its functions and alterations in human cancer. Apoptosis 9:667-676.
-
(2004)
Apoptosis
, vol.9
, pp. 667-676
-
-
Osaki, M.1
Oshimura, M.2
Ito, H.3
-
41
-
-
0038335334
-
PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling
-
Paez J, Sellers WR. 2003. PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling. Cancer Treat Res 115:145-167.
-
(2003)
Cancer Treat Res
, vol.115
, pp. 145-167
-
-
Paez, J.1
Sellers, W.R.2
-
42
-
-
13044312108
-
Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties
-
Page MJ, Amess B, Townsend RR, Parekh R, Herath A, Brusten L, Zvelebil MJ, Stein RC, Waterfield MD, Davies SC, et al. 1999. Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties. Proc Natl Acad Sci USA 96:12589-12594.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 12589-12594
-
-
Page, M.J.1
Amess, B.2
Townsend, R.R.3
Parekh, R.4
Herath, A.5
Brusten, L.6
Zvelebil, M.J.7
Stein, R.C.8
Waterfield, M.D.9
Davies, S.C.10
-
43
-
-
0034680102
-
Molecular portraits of human breast tumours
-
Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al. 2000. Molecular portraits of human breast tumours. Nature 406:747-752.
-
(2000)
Nature
, vol.406
, pp. 747-752
-
-
Perou, C.M.1
Sorlie, T.2
Eisen, M.B.3
van de Rijn, M.4
Jeffrey, S.S.5
Rees, C.A.6
Pollack, J.R.7
Ross, D.T.8
Johnsen, H.9
Akslen, L.A.10
-
44
-
-
80755141307
-
The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P(3)
-
Pilling C, Landgraf KE, Falke JJ. 2011. The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3, 4, 5)P(3). Biochemistry 50:9845-9856.
-
(2011)
Biochemistry
, vol.50
, pp. 9845-9856
-
-
Pilling, C.1
Landgraf, K.E.2
Falke, J.J.3
-
45
-
-
46249116675
-
DAnTE: a statistical tool for quantitative analysis of -omics data
-
Polpitiya AD, Qian WJ, Jaitly N, Petyuk VA, Adkins JN, Camp DG, 2nd, Anderson GA, Smith RD. 2008. DAnTE: a statistical tool for quantitative analysis of -omics data. Bioinformatics 24:1556-1558.
-
(2008)
Bioinformatics
, vol.24
, pp. 1556-1558
-
-
Polpitiya, A.D.1
Qian, W.J.2
Jaitly, N.3
Petyuk, V.A.4
Adkins, J.N.5
Camp 2nd, D.G.6
Anderson, G.A.7
Smith, R.D.8
-
46
-
-
57149120776
-
The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma
-
Salhia B, Tran NL, Chan A, Wolf A, Nakada M, Rutka F, Ennis M, McDonough WS, Berens ME, Symons M, et al. 2008. The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. Am J Pathol 173:1828-1838.
-
(2008)
Am J Pathol
, vol.173
, pp. 1828-1838
-
-
Salhia, B.1
Tran, N.L.2
Chan, A.3
Wolf, A.4
Nakada, M.5
Rutka, F.6
Ennis, M.7
McDonough, W.S.8
Berens, M.E.9
Symons, M.10
-
47
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle T, Hall MN. 2000. TOR, a central controller of cell growth. Cell 103:253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
48
-
-
0142150204
-
Involvement of the Akt/PKB signaling pathway with disease processes
-
Sen P, Mukherjee S, Ray D, Raha S. 2003. Involvement of the Akt/PKB signaling pathway with disease processes. Mol Cell Biochem 253:241-246.
-
(2003)
Mol Cell Biochem
, vol.253
, pp. 241-246
-
-
Sen, P.1
Mukherjee, S.2
Ray, D.3
Raha, S.4
-
49
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
-
Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al. 2001. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 98:10869-10874.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10869-10874
-
-
Sorlie, T.1
Perou, C.M.2
Tibshirani, R.3
Aas, T.4
Geisler, S.5
Johnsen, H.6
Hastie, T.7
Eisen, M.B.8
van de Rijn, M.9
Jeffrey, S.S.10
-
50
-
-
51049118140
-
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer
-
Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A, et al. 2008. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res 68:6084-6091.
-
(2008)
Cancer Res
, vol.68
, pp. 6084-6091
-
-
Stemke-Hale, K.1
Gonzalez-Angulo, A.M.2
Lluch, A.3
Neve, R.M.4
Kuo, W.L.5
Davies, M.6
Carey, M.7
Hu, Z.8
Guan, Y.9
Sahin, A.10
-
51
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
Testa JR, Bellacosa A. 2001. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 98:10983-10985.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10983-10985
-
-
Testa, J.R.1
Bellacosa, A.2
-
52
-
-
12444345515
-
Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS
-
Thompson A, Schafer J, Kuhn K, Kienle S, Schwarz J, Schmidt G, Neumann T, Johnstone R, Mohammed AK, Hamon C. 2003. Tandem mass tags: a novel quantification strategy for comparative analysis of complex protein mixtures by MS/MS. Anal Chem 75:1895-1904.
-
(2003)
Anal Chem
, vol.75
, pp. 1895-1904
-
-
Thompson, A.1
Schafer, J.2
Kuhn, K.3
Kienle, S.4
Schwarz, J.5
Schmidt, G.6
Neumann, T.7
Johnstone, R.8
Mohammed, A.K.9
Hamon, C.10
-
53
-
-
73949156234
-
High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast
-
Troxell ML, Levine J, Beadling C, Warrick A, Dunlap J, Presnell A, Patterson J, Shukla A, Olson NR, Heinrich MC, et al. 2010. High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast. Mod Pathol 23:27-37.
-
(2010)
Mod Pathol
, vol.23
, pp. 27-37
-
-
Troxell, M.L.1
Levine, J.2
Beadling, C.3
Warrick, A.4
Dunlap, J.5
Presnell, A.6
Patterson, J.7
Shukla, A.8
Olson, N.R.9
Heinrich, M.C.10
-
55
-
-
34347230544
-
Sulforhodamine B colorimetric assay for cytotoxicity screening
-
Vichai V, Kirtikara K. 2006. Sulforhodamine B colorimetric assay for cytotoxicity screening. Nat Protoc 1:1112-1116.
-
(2006)
Nat Protoc
, vol.1
, pp. 1112-1116
-
-
Vichai, V.1
Kirtikara, K.2
-
56
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. 2002. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2:489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
57
-
-
27944446105
-
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT
-
Yoeli-Lerner M, Yiu GK, Rabinovitz I, Erhardt P, Jauliac S, Toker A. 2005. Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell 20:539-550.
-
(2005)
Mol Cell
, vol.20
, pp. 539-550
-
-
Yoeli-Lerner, M.1
Yiu, G.K.2
Rabinovitz, I.3
Erhardt, P.4
Jauliac, S.5
Toker, A.6
-
58
-
-
43449092194
-
Chronic lymphocytic leukaemia and acute myeloid leukaemia are not associated with AKT1 pleckstrin homology domain (E17K) mutations
-
Zenz T, Dohner K, Denzel T, Dohner H, Stilgenbauer S, Bullinger L. 2008. Chronic lymphocytic leukaemia and acute myeloid leukaemia are not associated with AKT1 pleckstrin homology domain (E17K) mutations. Br J Haematol 141:742-743.
-
(2008)
Br J Haematol
, vol.141
, pp. 742-743
-
-
Zenz, T.1
Dohner, K.2
Denzel, T.3
Dohner, H.4
Stilgenbauer, S.5
Bullinger, L.6
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