-
1
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nature Rev Cancer 2002 2 : 489 501.
-
(2002)
Nature Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
2
-
-
0034653608
-
The PI3K-PDK1 connection: More than just a road to PKB
-
Vanhaesebroeck B, Alessi DR. The PI3K-PDK1 connection: more than just a road to PKB. Biochem J 2000 346 : 561 76.
-
(2000)
Biochem J
, vol.346
, pp. 561-76
-
-
Vanhaesebroeck, B.1
Alessi, D.R.2
-
3
-
-
17144395975
-
The activation of Akt/PKB signaling pathway and cell survival
-
Song G, Ouyang G, Bao S. The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 2005 9 : 59 71.
-
(2005)
J Cell Mol Med
, vol.9
, pp. 59-71
-
-
Song, G.1
Ouyang, G.2
Bao, S.3
-
4
-
-
0034663568
-
Signal-dependent membrane targeting by pleckstrin homology (PH) domains
-
Lemmon MA, Ferguson KM. Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem J 2000 350 : 1 18.
-
(2000)
Biochem J
, vol.350
, pp. 1-18
-
-
Lemmon, M.A.1
Ferguson, K.M.2
-
5
-
-
0032590011
-
PIK3CA is implicated as an oncogene in ovarian cancer
-
Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet 1999 21 : 99 102.
-
(1999)
Nat Genet
, vol.21
, pp. 99-102
-
-
Shayesteh, L.1
Lu, Y.2
Kuo, W.L.3
Baldocchi, R.4
Godfrey, T.5
Collins, C.6
-
6
-
-
28244479028
-
Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells
-
Isakoff SJ, Engelman JA, Irie HY, Luo J, Brachmann SM, Pearline RV, et al. Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells. Cancer Res 2005 65 : 10992 1000.
-
(2005)
Cancer Res
, vol.65
, pp. 10992-1000
-
-
Isakoff, S.J.1
Engelman, J.A.2
Irie, H.Y.3
Luo, J.4
Brachmann, S.M.5
Pearline, R.V.6
-
7
-
-
33344462540
-
Mutation of the PIK3CA oncogene in human cancers
-
Karakas B, Bachman KE, Park BH. Mutation of the PIK3CA oncogene in human cancers. Br J Cancer 2006 94 : 455 9.
-
(2006)
Br J Cancer
, vol.94
, pp. 455-9
-
-
Karakas, B.1
Bachman, K.E.2
Park, B.H.3
-
8
-
-
0000440912
-
Transformation of chicken cells by the gene encoding the catalytic subunit of PI3K
-
Chang H, Aoki M, Fruman D, Auger K, Bellacosa A, Tsichlis P, et al. Transformation of chicken cells by the gene encoding the catalytic subunit of PI3K. Science 1997 276 : 1848 50.
-
(1997)
Science
, vol.276
, pp. 1848-50
-
-
Chang, H.1
Aoki, M.2
Fruman, D.3
Auger, K.4
Bellacosa, A.5
Tsichlis, P.6
-
9
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serine-threonine kinase containing a SH2-like region
-
Bellacosa A, Testa J, Staal S, Tsichlis P. A retroviral oncogene, akt, encoding a serine-threonine kinase containing a SH2-like region. Science 1991 254 : 274 7.
-
(1991)
Science
, vol.254
, pp. 274-7
-
-
Bellacosa, A.1
Testa, J.2
Staal, S.3
Tsichlis, P.4
-
10
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
Testa JR, Bellacosa A. AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 2001 98 : 10983 5.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10983-5
-
-
Testa, J.R.1
Bellacosa, A.2
-
11
-
-
0034742120
-
AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells
-
Sun M, Wang G, Paciga JE, Feldman RI, Yuan ZQ, Ma XL, et al. AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol 2001 159 : 431 7.
-
(2001)
Am J Pathol
, vol.159
, pp. 431-7
-
-
Sun, M.1
Wang, G.2
Paciga, J.E.3
Feldman, R.I.4
Yuan, Z.Q.5
Ma, X.L.6
-
12
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 2007 448 : 439 44.
-
(2007)
Nature
, vol.448
, pp. 439-44
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
Donoho, G.P.4
Briggs, S.L.5
Robbins, C.M.6
-
13
-
-
0033957661
-
The PTEN tumor suppressor protein: An antagonist of phosphoinositide 3-kinase signaling
-
Vazquez F, Sellers WR. The PTEN tumor suppressor protein: an antagonist of phosphoinositide 3-kinase signaling. Biochim Biophys Acta 2000 1470 : M21 35.
-
(2000)
Biochim Biophys Acta
, vol.1470
-
-
Vazquez, F.1
Sellers, W.R.2
-
14
-
-
0038459116
-
Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas
-
Wang JY, Huang TJ, Chen FM, Hsieh MC, Lin SR, Hou MF, et al. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in advanced gastric carcinomas. Virchows Arch 2003 442 : 437 43.
-
(2003)
Virchows Arch
, vol.442
, pp. 437-43
-
-
Wang, J.Y.1
Huang, T.J.2
Chen, F.M.3
Hsieh, M.C.4
Lin, S.R.5
Hou, M.F.6
-
15
-
-
0842308265
-
PTEN mutations are common in sporadic microsatellite stable colorectal cancer
-
Nassif NT, Lobo GP, Wu X, Henderson CJ, Morrison CD, Eng C, et al. PTEN mutations are common in sporadic microsatellite stable colorectal cancer. Oncogene 2004 23 : 617 28.
-
(2004)
Oncogene
, vol.23
, pp. 617-28
-
-
Nassif, N.T.1
Lobo, G.P.2
Wu, X.3
Henderson, C.J.4
Morrison, C.D.5
Eng, C.6
-
16
-
-
0037431435
-
Frequent monoallelic deletion of PTEN and its reciprocal association with PIK3CA amplification in gastric carcinoma
-
Byun DS, Cho K, Ryu BK, Lee MG, Park JI, Chae KS, et al. Frequent monoallelic deletion of PTEN and its reciprocal association with PIK3CA amplification in gastric carcinoma. Int J Cancer 2003 104 : 318 27.
-
(2003)
Int J Cancer
, vol.104
, pp. 318-27
-
-
Byun, D.S.1
Cho, K.2
Ryu, B.K.3
Lee, M.G.4
Park, J.I.5
Chae, K.S.6
-
17
-
-
0036094108
-
Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis
-
Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, et al. Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis. Mol Cell Biol 2002 22 : 3842 51.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3842-51
-
-
Stiles, B.1
Gilman, V.2
Khanzenzon, N.3
Lesche, R.4
Li, A.5
Qiao, R.6
-
18
-
-
33750285711
-
Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway
-
Meng Q, Xia C, Fang J, Rojanasakul Y, Jiang BH. Role of PI3K and AKT specific isoforms in ovarian cancer cell migration, invasion and proliferation through the p70S6K1 pathway. Cell Signal 2006 18 : 2262 71.
-
(2006)
Cell Signal
, vol.18
, pp. 2262-71
-
-
Meng, Q.1
Xia, C.2
Fang, J.3
Rojanasakul, Y.4
Jiang, B.H.5
-
19
-
-
34447125097
-
AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway
-
Liu LZ, Zhou XD, Qian G, Shi X, Fang J, Jiang BH. AKT1 amplification regulates cisplatin resistance in human lung cancer cells through the mammalian target of rapamycin/p70S6K1 pathway. Cancer Res 2007 67 : 6325 32.
-
(2007)
Cancer Res
, vol.67
, pp. 6325-32
-
-
Liu, L.Z.1
Zhou, X.D.2
Qian, G.3
Shi, X.4
Fang, J.5
Jiang, B.H.6
-
20
-
-
33947101019
-
Patterns of somatic mutation in human cancer genomes
-
Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, et al. Patterns of somatic mutation in human cancer genomes. Nature 2007 446 : 153 8.
-
(2007)
Nature
, vol.446
, pp. 153-8
-
-
Greenman, C.1
Stephens, P.2
Smith, R.3
Dalgliesh, G.L.4
Hunter, C.5
Bignell, G.6
-
21
-
-
33749993417
-
The consensus coding sequences of human breast and colorectal cancers
-
Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, et al. The consensus coding sequences of human breast and colorectal cancers. Science 2006 314 : 268 74.
-
(2006)
Science
, vol.314
, pp. 268-74
-
-
Sjoblom, T.1
Jones, S.2
Wood, L.D.3
Parsons, D.W.4
Lin, J.5
Barber, T.D.6
-
22
-
-
0031695171
-
A simple, precise and economical microdissection technique for analysis of genomic DNA from archival tissue sections
-
Lee JY, Dong SM, Kim SY, Yoo NJ, Lee SH, Park WS. A simple, precise and economical microdissection technique for analysis of genomic DNA from archival tissue sections. Virchows Arch 1998 433 : 305 9.
-
(1998)
Virchows Arch
, vol.433
, pp. 305-9
-
-
Lee, J.Y.1
Dong, S.M.2
Kim, S.Y.3
Yoo, N.J.4
Lee, S.H.5
Park, W.S.6
-
23
-
-
24944523611
-
Hypermethylation of the RUNX3 gene in hepatocellular carcinoma
-
Park WS, Cho YG, Kim CJ, Song JH, Lee YS, Kim SY, et al. Hypermethylation of the RUNX3 gene in hepatocellular carcinoma. Exp Mol Med 2005 37 : 276 81.
-
(2005)
Exp Mol Med
, vol.37
, pp. 276-81
-
-
Park, W.S.1
Cho, Y.G.2
Kim, C.J.3
Song, J.H.4
Lee, Y.S.5
Kim, S.Y.6
-
24
-
-
27744459507
-
Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers
-
Michl P, Downward J. Mechanisms of disease: PI3K/AKT signaling in gastrointestinal cancers. Z Gastroenterol 2005 43 : 1133 9.
-
(2005)
Z Gastroenterol
, vol.43
, pp. 1133-9
-
-
Michl, P.1
Downward, J.2
-
25
-
-
33847679524
-
Expression of phosphorylated Akt (pAkt) in gastric carcinoma predicts prognosis and efficacy of chemotherapy
-
Murakami D, Tsujitani S, Osaki T, Saito H, Katano K, Tatebe S, et al. Expression of phosphorylated Akt (pAkt) in gastric carcinoma predicts prognosis and efficacy of chemotherapy. Gastric cancer 2007 10 : 45 51.
-
(2007)
Gastric Cancer
, vol.10
, pp. 45-51
-
-
Murakami, D.1
Tsujitani, S.2
Osaki, T.3
Saito, H.4
Katano, K.5
Tatebe, S.6
-
26
-
-
12344289067
-
Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma
-
Nakanishi K, Sakamoto M, Yamasaki S, Todo S, Hirohashi S. Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma. Cancer 2005 103 : 307 12.
-
(2005)
Cancer
, vol.103
, pp. 307-12
-
-
Nakanishi, K.1
Sakamoto, M.2
Yamasaki, S.3
Todo, S.4
Hirohashi, S.5
-
27
-
-
0036195196
-
AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis
-
Roy HK, Olusola BF, Clemens DL, Karolski WJ, Ratashak A, Lynch HT, et al. AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis. Carcinogenesis 2002 23 : 201 5.
-
(2002)
Carcinogenesis
, vol.23
, pp. 201-5
-
-
Roy, H.K.1
Olusola, B.F.2
Clemens, D.L.3
Karolski, W.J.4
Ratashak, A.5
Lynch, H.T.6
-
28
-
-
0042316755
-
PTEN: One gene, many syndromes
-
Eng C. PTEN: One gene, many syndromes. Hum Mutat 2003 22 : 183 98.
-
(2003)
Hum Mutat
, vol.22
, pp. 183-98
-
-
Eng, C.1
-
29
-
-
0030943057
-
CAMP stimulates protein kinase B in a Wortmannininsensitive manner
-
Sable CL, Filippa N, Hemmings B, Van Obberghen E. cAMP stimulates protein kinase B in a Wortmannininsensitive manner. FEBS Lett 1997 409 : 253 7.
-
(1997)
FEBS Lett
, vol.409
, pp. 253-7
-
-
Sable, C.L.1
Filippa, N.2
Hemmings, B.3
Van Obberghen, E.4
-
30
-
-
0032997270
-
Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase
-
Filippa N, Sable CL, Filloux C, Hemmings BA, Van Obberghen E. Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase. Mol Cell Biol 1999 19 : 4989 5000.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4989-5000
-
-
Filippa, N.1
Sable, C.L.2
Filloux, C.3
Hemmings, B.A.4
Van Obberghen, E.5
-
31
-
-
0030785701
-
Activation of proteinkinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27
-
Konishi H, Matsuzaki H, Tanaka M, Takemura Y, Kuroda S, Ono Y, et al. Activation of proteinkinase B (Akt/RAC-protein kinase) by cellular stress and its association with heat shock protein Hsp27. FEBS Lett 1997 410 : 493 8.
-
(1997)
FEBS Lett
, vol.410
, pp. 493-8
-
-
Konishi, H.1
Matsuzaki, H.2
Tanaka, M.3
Takemura, Y.4
Kuroda, S.5
Ono, Y.6
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