Molecular mechanism of an oncogenic mutation that alters membrane targeting: Glu17Lys modifies the PIP lipid specificity of the AKT1 PH domain

Biochemistry

Volumn 47, Issue 47, 2008, Pages 12260-12269

  Landgraf, Kyle E ^a   Pilling, Carissa ^a   Falke, Joseph J ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; DISSOCIATION; MEMBRANES; MODULATION; PHOSPHOLIPIDS; PLASMAS; RATE CONSTANTS;

AFFINITY BINDINGS; CELL FUNCTIONS; DISSOCIATION RATES; ELECTROSTATIC MODULATIONS; HUMAN CANCERS; IN VITRO STUDIES; KEY ELEMENTS; KINETIC STUDIES; LIPID BINDINGS; LIVE CELLS; MOLECULAR MECHANISMS; ONCOGENESIS; PH DOMAINS; PHOSPHATIDYLINOSITOL; PLASMA MEMBRANES; PROTEIN KINASES; SIDE CHAINS; SIGNALING PATHWAYS; TRIS PHOSPHATES;

CELL MEMBRANES;

GLUTAMIC ACID; LYSINE; MEMBRANE LIPID; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; POLYPHOSPHOINOSITIDE; PROTEIN KINASE B;

ARTICLE; BINDING AFFINITY; CARCINOGENESIS; CELL MEMBRANE; CONTROLLED STUDY; DISSOCIATION; ELECTRICITY; GENE MUTATION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; KINETICS; ONCOGENE; PRIORITY JOURNAL; PROTEIN DOMAIN; WILD TYPE;

3T3 CELLS; ANIMALS; CATTLE; CELL MEMBRANE; CELL SURVIVAL; GLUTAMIC ACID; HUMANS; KINETICS; LYSINE; MICE; MICROSCOPY, FLUORESCENCE; MUTATION; NEOPLASMS; ONCOGENES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; SUBSTRATE SPECIFICITY;

EID: 56749168073     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi801683k     Document Type: Article

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