The GRP1 PH domain, like the AKT1 PH domain, possesses a sentry glutamate residue essential for specific targeting to plasma membrane PI(3,4,5)P 3

Biochemistry

Volumn 50, Issue 45, 2011, Pages 9845-9856

  Pilling, Carissa ^a   Landgraf, Kyle E ^a,b   Falke, Joseph J ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATES; CELL PHYSIOLOGY; CHARGE REVERSAL; DOMAIN STRUCTURE; HIGH AFFINITY; HUMAN PATHOLOGIES; PHOSPHOINOSITIDES; PLECKSTRIN HOMOLOGY DOMAINS; PROTEIN KINASE B; SIGNALING LIPIDS; SIGNALING PROTEINS; SPECIFIC BINDING;

CELL MEMBRANES; CYTOLOGY; MEMBRANES; PHOSPHOLIPIDS; PHYSIOLOGY; SIGNALING;

PLASMAS;

GENERAL RECEPTOR FOR PHOSPHOINOSITIDE 1; GLUTAMIC ACID; MEMBRANE LIPID; MEMBRANE RECEPTOR; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CELL FUNCTION; CELL MEMBRANE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOPLASM; DISSOCIATION; HYDROLYSIS; LIPID COMPOSITION; MEMBRANE BINDING; MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CELL MEMBRANE; GLUTAMIC ACID; HUMANS; KINETICS; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NIH 3T3 CELLS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT PROTEINS; SINGLE-CELL ANALYSIS; TRANSFECTION;

EID: 80755141307     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi2011306     Document Type: Article

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