AKT1 (E17K) mutation in pancreatic cancer

Technology in Cancer Research and Treatment

Volumn 7, Issue 5, 2008, Pages 407-408

  Mohamedali, Azim ^a   Lea, Nicholas C ^a   Feakins, Roger M ^b   Raj, Kavita ^a   Mufti, Ghulam J ^a   Kocher, Hemant M ^b,c  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b ROYAL LONDON HOSPITAL   (United Kingdom)

^c QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

AKT1; Pancreatic cancer; Pyrosequencing

Indexed keywords

PLECKSTRIN;

ADULT; AGED; ARTICLE; CANCER GROWTH; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; ONCOGENE K RAS; PANCREAS ADENOCARCINOMA; PANCREAS DUCT; PREVALENCE; PROTEIN DOMAIN; PYROSEQUENCING; SOMATIC MUTATION;

EID: 53549123296     PISSN: 15330346     EISSN: None     Source Type: Journal    
DOI: 10.1177/153303460800700509     Document Type: Article

References (5)

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2. Brugge, J., Hung, M. C., Mills, G. B. A new mutational AKTivation in the PI3K pathway. Cancer Cell 12, 104-107 (2007).
3. Carpten, J. D., Faber, A. L., Horn, C., et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 448, 439-444 (2007).
4. Kocher, H. M., Mears, L., Lea, N. C., Raj, K., Mufti, G. J. JAK V617F missense mutation is absent in pancreatic cancer. Gut 56, 1174-1175 (2007).
5. Almoguera, C., Shibata, D., Forrester, K., Martin, J., Arnheim, N., Perucho, M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell 53, 549-554 (1988).