Cytokines and defense and pathology of the CNS

Cytokines and the CNS

Volumn , Issue , 2005, Pages 243-267

  Combes, Valéry ^a   Grau, Georges E ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84863815691     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (118)

1. Mhlanga JD, Bentivoglio M, Kristensson K: Neurobiology of cerebral malaria and African sleeping sickness. Brain Res Bull 1997, 44:579-589.
2. Brown H, Rogerson S, Taylor T, Tembo M, Mwenechanya J, Molyneux M, Turner G: Blood-brain barrier function in cerebral malaria in Malawian children. Am J Trop Med Hyg 2001, 64:207-213.
3. Brown HC, Chau TT, Mai NT, Day NP, Sinh DX, White NJ, Hien TT, Farrar J, Turner GD: Blood-brain barrier function in cerebral malaria and CNS infections in Vietnam. Neurology 2000, 55:104-111.
4. Hunt NH, Grau GE: Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria. Trends Immunol 2003, 24:491-499.
5. Craig A: Malaria: a new gene family (clag) involved in adhesion. Parasitol Today 2000, 16:366-367; discussion 405.
6. Craig A, Scherf A: Molecules on the surface of the Plasmodium falciparum infected erythrocyte and their role in malaria pathogenesis and immune evasion. Mol Biochem Parasitol 2001, 115:129-143.
7. Rasti N, Wahlgren M, Chen Q: Molecular aspects of malaria pathogenesis. FEMS Immunol Med Microbiol 2004, 41:9-26.
8. Hatabu T, Kawazu S, Aikawa M, Kano S: Binding of Plasmodium falciparum-infected erythrocytes to the membrane-bound form of Fractalkine/CX3CL1. Proc Natl Acad Sci U.S.A 2003, 100:15942-15946.
9. de Souza JB, Riley EM: Cerebral malaria: the contribution of studies in animal models to our understanding of immunopathogenesis. Microbes Infect 2002, 4:291-300.
10. Medana IM, Chaudhri G, Chan-Ling T, Hunt NH: Central nervous system in cerebral malaria: ‘innocent bystander’ or active participant in the induction of immunopathology? Immunol Cell Biol 2001, 79:101-120.
11. Langhorne J, Quin SJ, Sanni LA: Mouse models of blood-stage malaria infections: immune responses and cytokines involved in protection and pathology. Chem Immunol 2002, 80:204-228.
12. Artavanis-Tsakonas K, Tongren JE, Riley EM: The war between the malaria parasite and the immune system: immunity, immunoregulation and immunopathology. Clin Exp Immunol 2003, 133:145-152.
13. Furlan R, Villa P, Senaldi G, Martino G: TNFalpha in experimental diseases of the CNS. Methods Mol Med 2004, 98:171-190.
14. Clark IA, Cowden WB: The pathophysiology of falciparum malaria. Pharmacol Ther 2003, 99:221-260.
15. Coltel N, Combes V, Hunt NH, Grau GE: Cerebral malaria-a neurovascular pathology with many riddles still to be solved. Curr Neurovasc Res 2004, 1:91-110.
16. Schluesener HJ, Kremsner PG, Meyermann R: Heme oxygenase-1 in lesions of human cerebral malaria. Acta Neuropathol (Berl) 2001, 101:65-68.
17. Tracey KJ, Czura CJ, Ivanova S: Mind over immunity. Faseb J 2001, 15:1575-1576.
18. Brown H, Turner G, Rogerson S, Tembo M, Mwenechanya J, Molyneux M, Taylor T: Cytokine expression in the brain in human cerebral malaria. J Infect Dis 1999, 180:1742-1746.
19. Sibson NR, Blamire AM, Perry VH, Gauldie J, Styles P, Anthony DC: TNF-alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelinand TNFR2-dependent pathway. Brain 2002, 125:2446-2459.
20. Lucas R, Juillard P, Decoster E, Redard M, Burger D, Donati Y, Giroud C, Monso-Hinard C, De Kesel T, Buurman WA, Moore MW, Dayer JM, Fiers W, Bluethmann H, Grau GE: Crucial role of tumor necrosis factor (TNF) receptor 2 and membranebound TNF in experimental cerebral malaria. Eur J Immunol 1997, 27:1719-1725.
21. Stoelcker B, Hehlgans T, Weigl K, Bluethmann H, Grau GE, Mannel DN: Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria. Infect Immun 2002, 70:5857-5859.
22. Dietrich JB: The adhesion molecule ICAM-1 and its regulation in relation with the blood-brain barrier. J Neuroimmunol 2002, 128:58-68.
23. Craig A, Fernandez-Reyes D, Mesri M, McDowall A, Altieri DC, Hogg N, Newbold C: A functional analysis of a natural variant of intercellular adhesion molecule-1 (ICAM-1Kilifi). Hum Mol Genet 2000, 9:525-530.
24. Lou J, Gasche Y, Zheng L, Critico B, Monso-Hinard C, Juillard P, Morel P, Buurman WA, Grau GE: Differential reactivity of brain microvascular endothelial cells to TNF reflects the genetic susceptibility to cerebral malaria. Eur J Immunol 1998, 28:3989-4000.
25. Dobbie MS, Hurst RD, Klein NJ, Surtees RA: Upregulation of intercellular adhesion molecule-1 expression on human endothelial cells by tumour necrosis factor-alpha in an In vitro model of the blood-brain barrier. Brain Res 1999, 830:330-336.
26. Li J, Chang WL, Sun G, Chen HL, Specian RD, Berney SM, Kimpel D, Granger DN, van der Heyde HC: Intercellular adhesion molecule 1 is important for the development of severe experimental malaria but is not required for leukocyte adhesion in the brain. J Investig Med 2003, 51:128-140.
27. Shear HL, Marino MW, Wanidworanun C, Berman JW, Nagel RL: Correlation of increased expression of intercellular adhesion molecule-1, but not high levels of tumor necrosis factor-alpha, with lethality of Plasmodium yoelii 17XL, a rodent model of cerebral malaria. Am J Trop Med Hyg 1998, 59:852-858.
28. Clark IA, Gray KM, Rockett EJ, Cowden WB, Rockett KA, Ferrante A, Aggarwal BB: Increased lymphotoxin in human malarial serum, and the ability of this cytokine to increase plasma interleukin-6 and cause hypoglycaemia in mice: implications for malarial pathology. Trans R Soc Trop Med Hyg 1992, 86:602-607.
29. Engwerda CR, Mynott TL, Sawhney S, De Souza JB, Bickle QD, Kaye PM: Locally up-regulated lymphotoxin alpha, not systemic tumor necrosis factor alpha, is the principle mediator of murine cerebral malaria. J Exp Med 2002, 195:1371-1377.
30. Rae C, McQuillan JA, Parekh SB, Bubb WA, Weiser S, Balcar VJ, Hansen AM, Ball HJ, Hunt NH: Brain gene expression, metabolism, and bioenergetics: interrelationships in murine models of cerebral and noncerebral malaria. Faseb J 2004, 18:499-510.
31. Clark I, Awburn M: Migration inhibitory factor in the cerebral and systemic endothelium in sepsis and malaria. Crit Care Med 2002, 30:S263-267.
32. Clark IA, Awburn MM, Whitten RO, Harper CG, Liomba NG, Molyneux ME, Taylor TE: Tissue distribution of migration inhibitory factor and inducible nitric oxide synthase in falciparum malaria and sepsis in African children. Malar J 2003, 2:6.
33. Tongren JE, Yang C, Collins WE, Sullivan JS, Lal AA, Xiao L: Expression of proinflammatory cytokines in four regions of the brain in Macaque mulatta (rhesus) monkeys infected with Plasmodium coatneyi. Am J Trop Med Hyg 2000, 62:530-534.
34. Maneerat Y, Wilairatana P, Udomsangpetch R, Looareesuwan S: Lack of association between CSF nitrate and sera nitrate in falciparum malaria infection. Southeast Asian J Trop Med Public Health 2001, 32:268-274.
35. Sanni LA: The role of cerebral oedema in the pathogenesis of cerebral malaria. Redox Rep 2001, 6:137-142.
36. Hansen AM, Driussi C, Turner V, Takikawa O, Hunt NH: Tissue distribution of indoleamine 2,3-dioxygenase in normal and malaria-infected tissue. Redox Rep 2000, 5:112-115.
37. Ball HJ, McParland B, Driussi C, Hunt NH: Isolating vessels from the mouse brain for gene expression analysis using laser capture microdissection. Brain Res Brain Res Protoc 2002, 9:206-213.
38. Hanum PS, Hayano M, Kojima S: Cytokine and chemokine responses in a cerebral malaria-susceptible or -resistant strain of mice to Plasmodium berghei ANKA infection: early chemokine expression in the brain. Int Immunol 2003, 15:633-640.
39. Chang WL, Li J, Sun G, Chen HL, Specian RD, Berney SM, Granger DN, van der Heyde HC: P-selectin contributes to severe experimental malaria but is not required for leukocyte adhesion to brain microvasculature. Infect Immun 2003, 71:1911-1918.
40. Combes V, Rosenkranz AR, Redard M, Pizzolato G, Lepidi H, Vestweber D, Mayadas TN, Grau GE: Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartment. Am J Pathol 2004, 164:781-786.
41. Combes V, Taylor TE, Juhan-Vague I, Mege JL, Mwenechanya J, Tembo M, Grau GE, Molyneux ME: Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma. Jama 2004, 291:2542-2544.
42. Mulenga C, Mhlanga JD, Kristensson K, Robertson B: Trypanosoma brucei brucei crosses the blood-brain barrier while tight junction proteins are preserved in a rat chronic disease model. Neuropathol Appl Neurobiol 2001, 27:77-85.
43. Deckert-Schluter M, Bluethmann H, Kaefer N, Rang A, Schluter D: Interferongamma receptor-mediated but not tumor necrosis factor receptor type 1-or type 2-mediated signaling is crucial for the activation of cerebral blood vessel endothelial cells and microglia in murine Toxoplasma encephalitis. Am J Pathol 1999, 154:1549-1561.
44. Mun HS, Aosai F, Norose K, Chen M, Piao LX, Takeuchi O, Akira S, Ishikura H, Yano A: TLR2 as an essential molecule for protective immunity against Toxoplasma gondii infection. Int Immunol 2003, 15:1081-1087.
45. Yap GS, Scharton-Kersten T, Charest H, Sher A: Decreased resistance of TNF receptor p55-and p75-deficient mice to chronic toxoplasmosis despite normal activation of inducible nitric oxide synthase in vivo. J Immunol 1998, 160:1340-1345.
46. Aliberti J, Serhan C, Sher A: Parasite-induced lipoxin A4 is an endogenous regulator of IL-12 production and immunopathology in Toxoplasma gondii infection. J Exp Med 2002, 196:1253-1262.
47. Sukumaran SK, Prasadarao NV: Escherichia coli K1 invasion increases human brain microvascular endothelial cell monolayer permeability by disassembling vascularendothelial cadherins at tight junctions. J Infect Dis 2003, 188:1295-1309.
48. Sukumaran SK, McNamara G, Prasadarao NV: Escherichia coli K-1 interaction with human brain micro-vascular endothelial cells triggers phospholipase C-gamma1 activation downstream of phosphatidylinositol 3-kinase. J Biol Chem 2003, 278:45753-45762.
49. Sukumaran SK, Quon MJ, Prasadarao NV: Escherichia coli K1 internalization via caveolae requires caveolin-1 and protein kinase Calpha interaction in human brain microvascular endothelial cells. J Biol Chem 2002, 277:50716-50724.
50. Grigsby RJ, Dobrowsky RT: Inhibition of ceramide production reverses TNF-induced insulin resistance. Biochem Biophys Res Commun 2001, 287:1121-1124.
51. Kim KS: Escherichia coli translocation at the blood-brain barrier. Infect Immun 2001, 69:5217-5222.
52. Kim KS: Strategy of Escherichia coli for crossing the blood-brain barrier. J Infect Dis 2002, 186 Suppl 2:S220-224.
53. Kita E, Yunou Y, Kurioka T, Harada H, Yoshikawa S, Mikasa K, Higashi N: Pathogenic mechanism of mouse brain damage caused by oral infection with Shiga toxin-producing Escherichia coli O157:H7. Infect Immun 2000, 68:1207-1214.
54. Johansson L, Rytkonen A, Bergman P, Albiger B, Kallstrom H, Hokfelt T, Agerberth B, Cattaneo R, Jonsson AB: CD46 in meningococcal disease. Science 2003, 301:373-375.
55. Eisenhauer PB, Chaturvedi P, Fine RE, Ritchie AJ, Pober JS, Cleary TG, Newburg DS: Tumor necrosis factor alpha increases human cerebral endothelial cell Gb3 and sensitivity to Shiga toxin. Infect Immun 2001, 69:1889-1894.
56. Doran KS, Liu GY, Nizet V: Group B streptococcal beta-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis. J Clin Invest 2003, 112:736-744.
57. Tsao N, Chang WW, Liu CC, Lei HY: Development of hematogenous pneumococcal meningitis in adult mice: the role of TNF-alpha. FEMS Immunol Med Microbiol 2002, 32:133-140.
58. Nassif X, Bourdoulous S, Eugene E, Couraud PO: How do extracellular pathogens cross the blood-brain barrier? Trends Microbiol 2002, 10:227-232.
59. Drevets DA, Leenen PJ: Leukocyte-facilitated entry of intracellular pathogens into the central nervous system. Microbes Infect 2000, 2:1609-1618.
60. Schroten H, Spors B, Hucke C, Stins M, Kim KS, Adam R, Daubener W: Potential role of human brain microvascular endothelial cells in the pathogenesis of brain abscess: inhibition of Staphylococcus aureus by activation of indoleamine 2,3-dioxygenase. Neuropediatrics 2001, 32:206-210.
61. Kielian T, Hickey WF: Proinflammatory cytokine, chemokine, and cellular adhesion molecule expression during the acute phase of experimental brain abscess development. Am J Pathol 2000, 157:647-658.
62. Kielian T, Barry B, Hickey WF: CXC chemokine receptor-2 ligands are required for neutrophil-mediated host defense in experimental brain abscesses. J Immunol 2001, 166:4634-4643.
63. Munoz FM, Hawkins EP, Bullard DC, Beaudet AL, Kaplan SL: Host defense against systemic infection with Streptococcus pneumoniae is impaired in E-, P-, and E-/Pselectin-deficient mice. J Clin Invest 1997, 100:2099-2106.
64. Charland N, Nizet V, Rubens CE, Kim KS, Lacouture S, Gottschalk M: Streptococcus suis serotype 2 interactions with human brain microvascular endothelial cells. Infect Immun 2000, 68:637-643.
65. Zwijnenburg PJ, van der Poll T, Florquin S, Roord JJ, Van Furth AM: IL-1 receptor type 1 gene-deficient mice demonstrate an impaired host defense against pneumococcal meningitis. J Immunol 2003, 170:4724-4730.
66. Zwijnenburg PJ, van der Poll T, Florquin S, Roord JJ, van Furth AM: Interleukin-10 negatively regulates local cytokine and chemokine production but does not influence antibacterial host defense during murine pneumococcal meningitis. Infect Immun 2003, 71:2276-2279.
67. Kayal S, Lilienbaum A, Poyart C, Memet S, Israel A, Berche P: Listeriolysin O-dependent activation of endothelial cells during infection with Listeria monocytogenes: activation of NF-kappa B and upregulation of adhesion molecules and chemokines. Mol Microbiol 1999, 31:1709-1722.
68. Wilson SL, Drevets DA: Listeria monocytogenes infection and activation of human brain microvascular endothelial cells. J Infect Dis 1998, 178:1658-1666.
69. Thwaites GE, Simmons CP, Than Ha Quyen N, Thi Hong Chau T, Phuong Mai P, Thi Dung N, Hoan Phu N, White NP, Tinh Hien T, Farrar JJ: Pathophysiology and prognosis in Vietnamese adults with tuberculous meningitis. J Infect Dis 2003, 188:1105-1115.
70. Lechner F, Sahrbacher U, Suter T, Frei K, Brockhaus M, Koedel U, Fontana A: Antibodies to the junctional adhesion molecule cause disruption of endothelial cells and do not prevent leukocyte influx into the meninges after viral or bacterial infection. J Infect Dis 2000, 182:978-982.
71. McQuaid S, Cosby SL: An immunohistochemical study of the distribution of the measles virus receptors, CD46 and SLAM, in normal human tissues and subacute sclerosing panencephalitis. Lab Invest 2002, 82:403-409.
72. Andres O, Obojes K, Kim KS, ter Meulen V, Schneider-Schaulies J: CD46-and CD150-independent endothelial cell infection with wild-type measles viruses. J Gen Virol 2003, 84:1189-1197.
73. Mukhtar M, Harley S, Chen P, BouHamdan M, Patel C, Acheampong E, Pomerantz RJ: Primary isolated human brain microvascular endothelial cells express diverse HIV/SIV-associated chemokine coreceptors and DC-SIGN and L-SIGN. Virology 2002, 297:78-88.
74. Annunziata P: Blood-brain barrier changes during invasion of the central nervous system by HIV-1. Old and new insights into the mechanism. J Neurol 2003, 250:901-906.
75. Liu NQ, Lossinsky AS, Popik W, Li X, Gujuluva C, Kriederman B, Roberts J, Pushkarsky T, Bukrinsky M, Witte M, Weinand M, Fiala M: Human immunodeficiency virus type 1 enters brain microvascular endothelia by macropinocytosis dependent on lipid rafts and the mitogen-activated protein kinase signaling pathway. J Virol 2002, 76:6689-6700.
76. Boven LA, Middel J, Breij EC, Schotte D, Verhoef J, Soderland C, Nottet HS: Interactions between HIV-infected monocyte-derived macrophages and human brain microvascular endothelial cells result in increased expression of CC chemokines. J Neurovirol 2000, 6:382-389.
77. Berger O, Gan X, Gujuluva C, Burns AR, Sulur G, Stins M, Way D, Witte M, Weinand M, Said J, Kim KS, Taub D, Graves MC, Fiala M: CXC and CC chemokine receptors on coronary and brain endothelia. Mol Med 1999, 5:795-805.
78. Becher B, Prat A, Antel JP: Brain-immune connection: immuno-regulatory properties of CNS-resident cells. Glia 2000, 29:293-304.
79. Tong N, Perry SW, Zhang Q, James HJ, Guo H, Brooks A, Bal H, Kinnear SA, Fine S, Epstein LG, Dairaghi D, Schall TJ, Gendelman HE, Dewhurst S, Sharer LR, Gelbard HA: Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. J Immunol 2000, 164:1333-1339.
80. Romero IA, Prevost MC, Perret E, Adamson P, Greenwood J, Couraud PO, Ozden S: Interactions between brain endothelial cells and human T-cell leukemia virus type 1-infected lymphocytes: mechanisms of viral entry into the central nervous system. J Virol 2000, 74:6021-6030.
81. Kurt-Jones EA, Chan M, Zhou S, Wang J, Reed G, Bronson R, Arnold MM, Knipe DM, Finberg RW: Herpes simplex virus 1 interaction with Toll-like receptor 2 contributes to lethal encephalitis. Proc Natl Acad Sci U.S.A 2004, 101:1315-1320.
82. Bi Z, Quandt P, Komatsu T, Barna M, Reiss CS: IL-12 promotes enhanced recovery from vesicular stomatitis virus infection of the central nervous system. J Immunol 1995, 155:5684-5689.
83. Jong AY, Chen SH, Stins MF, Kim KS, Tuan TL, Huang SH: Binding of Candida albicans enolase to plasmin(ogen) results in enhanced invasion of human brain microvascular endothelial cells. J Med Microbiol 2003, 52:615-622.
84. MacIntyre A, Abramov R, Hammond CJ, Hudson AP, Arking EJ, Little CS, Appelt DM, Balin BJ: Chlamydia pneumoniae infection promotes the transmigration of monocytes through human brain endothelial cells. J Neurosci Res 2003, 71:740-750.
85. MacIntyre A, Hammond CJ, Little CS, Appelt DM, Balin BJ: Chlamydia pneumoniae infection alters the junctional complex proteins of human brain microvascular endothelial cells. FEMS Microbiol Lett 2002, 217:167-172.
86. Kawakami K, Qureshi MH, Zhang T, Okamura H, Kurimoto M, Saito A: IL-18 protects mice against pulmonary and disseminated infection with Cryptococcus neoformans by inducing IFN-gamma production. J Immunol 1997, 159:5528-5534.
87. Kawakami K, Hossain Qureshi M, Zhang T, Koguchi Y, Xie Q, Kurimoto M, Saito A: Interleukin-4 weakens host resistance to pulmonary and disseminated cryptococcal infection caused by combined treatment with interferon-gamma-inducing cytokines. Cell Immunol 1999, 197:55-61.
88. Chretien F, Lortholary O, Kansau I, Neuville S, Gray F, Dromer F: Pathogenesis of cerebral Cryptococcus neoformans infection after fungemia. J Infect Dis 2002, 186:522-530.
89. Lipovsky MM, Gekker G, Hu S, Ehrlich LC, Hoepelman AI, Peterson PK: Cryptococcal glucuronoxylomannan induces interleukin (IL)-8 production by human microglia but inhibits neutrophil migration toward IL-8. J Infect Dis 1998, 177:260-263.
90. Walker DH, Valbuena GA, Olano JP: Pathogenic mechanisms of diseases caused by Rickettsia. Ann NY Acad Sci 2003, 990:1-11.
91. Walker DH, Popov VL, Feng HM: Establishment of a novel endothelial target mouse model of a typhus group rickettsiosis: evidence for critical roles for gamma interferon and CD8 T lymphocytes. Lab Invest 2000, 80:1361-1372.
92. Park J, Choi KS, Grab DJ, Dumler JS: Divergent interactions of Ehrlichia chaffeensisand Anaplasma phagocytophilum-infected leukocytes with endothelial cell barriers. Infect Immun 2003, 71:6728-6733.
93. Beutler B, Grau GE: The role of TNF in the pathogenesis of infectious disease. CritCareMed 1993, 21:S423-S435.
94. Dantzer R: Innate immunity at the forefront of psychoneuroimmunology. Brain Behav Immun 2004, 18:1-6.
95. Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, Wang H, Abumrad N, Eaton JW, Tracey KJ: Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000, 405:458-462.
96. Pavlov VA, Wang H, Czura CJ, Friedman SG, Tracey KJ: The cholinergic antiinflammatory pathway: a missing link in neuroimmunomodulation. Mol Med 2003, 9:125-134.
97. Franzen R, Bouhy D, Schoenen J: Nervous system injury: focus on the inflammatory cytokine ‘granulocyte-macrophage colony stimulating factor.' Neurosci Lett 2004, 361:76-78.
98. Straub RH, Pongratz G, Scholmerich J, Kees F, Schaible TF, Antoni C, Kalden JR, Lorenz HM: Long-term anti-tumor necrosis factor antibody therapy in rheumatoid arthritis patients sensitizes the pituitary gland and favors adrenal androgen secretion. Arthritis Rheum 2003, 48:1504-1512.
99. Bissonnette CJ, Klegeris A, McGeer PL, McGeer EG: Interleukin 1alpha and interleukin 6 protect human neuronal SH-SY5Y cells from oxidative damage. Neurosci Lett 2004, 361:40-43.
100. Wang J, Schreiber RD, Campbell IL: STAT1 deficiency unexpectedly and markedly exacerbates the pathophysiological actions of IFN-alpha in the central nervous system. Proc Natl Acad Sci U.S.A 2002, 99:16209-16214.
101. Becher B, Durell BG, Noelle RJ: IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis. J Clin Invest 2003, 112:1186-1191.
102. Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, Zurawski S, Wiekowski M, Lira SA, Gorman D, Kastelein RA, Sedgwick JD: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 2003, 421:744-748.
103. Glabinski AR, Bielecki B, Kolodziejski P, Han Y, Selmaj K, Ransohoff RM: TNFalpha microinjection upregulates chemokines and chemokine receptors in the central nervous system without inducing leukocyte infiltration. J Interferon Cytokine Res 2003, 23:457-466.
104. Mannel DN, Grau GE: Role of platelet adhesion in homeostasis and immunopathology. Mol Pathol 1997, 50:175-185.
105. Grau GE, Mackenzie CD, Carr RA, Redard M, Pizzolato G, Allasia C, Cataldo C, Taylor TE, Molyneux ME: Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria. J Infect Dis 2003, 187:461-466.
106. Piguet PF, Da Laperrousaz C, Vesin C, Tacchini-Cottier F, Senaldi G, Grau GE: Delayed mortality and attenuated thrombocytopenia associated with severe malaria in urokinase-and urokinase receptor-deficient mice. Infect Immun 2000, 68:3822-3829.
107. Akopov S, Sercombe R, Seylaz J: Cerebrovascular reactivity: role of endothelium/platelet/leukocyte interactions. Cerebrovasc Brain Metab Rev 1996, 8:11-94.
108. Oprica M, Eriksson C, Schultzberg M: Inflammatory mechanisms associated with brain damage induced by kainic acid with special reference to the interleukin-1 system. J Cell Mol Med 2003, 7:127-140.
109. Barone FC, Arvin B, White RF, Miller A, Webb CL, Willette RN, Lysko PG, Feuerstein GZ: Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury. Stroke 1997, 28:1233-1244.
110. Zhang W, Stanimirovic D: Current and future therapeutic strategies to target inflammation in stroke. Curr Drug Targets Inflamm Allergy 2002, 1:151-166.
111. Akassoglou K, Douni E, Bauer J, Lassmann H, Kollias G, Probert L: Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice. Proc Natl Acad Sci U.S.A 2003, 100:709-714.
112. Bruce AJ, Boling W, Kindy MS, Peschon J, Kraemer PJ, Carpenter MK, Holtsberg FW, Mattson MP: Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors. Nat Med 1996, 2:788-794.
113. Rothwell NJ, Luheshi GN: Brain TNF: damage limitation or damaged reputation? Nature Med 1996, 2:746-747.
114. Kolev K, Skopal J, Simon L, Csonka E, Machovich R, Nagy Z: Matrix metalloproteinase-9 expression in post-hypoxic human brain capillary endothelial cells: H2O2 as a trigger and NF-kappaB as a signal transducer. Thromb Haemost 2003, 90:528-537
115. Hurst RD, Azam S, Hurst A, Clark JB: Nitric-oxide-induced inhibition of glyceraldehyde-3-phosphate dehydrogenase may mediate reduced endothelial cell monolayer integrity in an in vitro model blood-brain barrier. Brain Res 2001, 894:181-188
116. Jinno-Oue A, Wilt SG, Hanson C, Dugger NV, Hoffman PM, Masuda M, Ruscetti SK: Expression of inducible nitric oxide synthase and elevation of tyrosine nitration of a 32-kilodalton cellular protein in brain capillary endothelial cells from rats infected with a neuropathogenic murine leukemia virus. J Virol 2003, 77:5145-5151
117. Bresgen N, Karlhuber G, Krizbai I, Bauer H, Bauer HC, Eckl PM: Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations, micronuclei, and apoptosis. J Neurosci Res 2003, 72:327-333
118. Riedel W, Lang U, Oetjen U, Schlapp U, Shibata M: Inhibition of oxygen radical formation by methylene blue, aspirin, or alpha-lipoic acid, prevents bacteriallipopolysaccharide-induced fever. Mol Cell Biochem 2003, 247:83-94.