Group B streptococcal β-hemolysin/cytolysin activates neutrophil signaling pathways in brain endothelium and contributes to development of meningitis

Journal of Clinical Investigation

Volumn 112, Issue 5, 2003, Pages 736-744

  Doran, Kelly S ^a,b   Liu, George Y ^a   Nizet, Victor ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA HEMOLYSIN; CYTOLYSIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROALPHA PROTEIN; GROBETA PROTEIN; HEMOLYSIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; INTERLEUKIN 8; MELANOMA GROWTH STIMULATORY ACTIVITY FACTOR; MYELOID CELL LEUKEMIA SEQUENCE 1; PROTEIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR; BACTERIAL PROTEIN; STREPTOCOCCAL GROUP B HEMOLYSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; BLOOD BRAIN BARRIER; BRAIN TISSUE; CONTROLLED STUDY; CYTOKINE RELEASE; DNA MICROARRAY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; MENINGITIS; MORTALITY; MOUSE; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STREPTOCOCCUS AGALACTIAE; BACTERIAL MENINGITIS; BIOSYNTHESIS; BRAIN; CELL MOTION; DISEASE MODEL; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; METABOLISM; PATHOGENICITY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM; VASCULARIZATION;

BACTERIAL PROTEINS; BLOOD-BRAIN BARRIER; BRAIN; CELL MOVEMENT; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION PROFILING; HEMOLYSIN PROTEINS; HUMANS; INTERLEUKIN-8; MENINGITIS, BACTERIAL; NEUTROPHILS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STREPTOCOCCUS AGALACTIAE;

EID: 0141723665     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200317335     Document Type: Article

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