Cerebral malaria: The contribution of studies in animal models to our understanding of immunopathogenesis

Microbes and Infection

Volumn 4, Issue 3, 2002, Pages 291-300

  Brian De Souza, J ^a   Riley, Eleanor M ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Cerebral malaria animal models

Indexed keywords

CD36 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN DERIVATIVE; THROMBOSPONDIN; TUMOR NECROSIS FACTOR ALPHA;

ANEMIA; ANIMAL MODEL; BRAIN MALARIA; CELL ADHESION; CELL INTERACTION; CLINICAL FEATURE; DISEASE PREDISPOSITION; DISEASE SEVERITY; GENETIC VARIABILITY; HISTOPATHOLOGY; HOST; HOST PARASITE INTERACTION; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; INCIDENCE; METABOLIC DISORDER; MONKEY; MOUSE STRAIN; NEUROLOGICAL COMPLICATION; NEUROPATHOLOGY; NONHUMAN; ORGAN DISTRIBUTION; PARASITE; PARASITEMIA; PARASITOSIS; PATHOPHYSIOLOGY; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; SPECIES DIFFERENCE; T LYMPHOCYTE;

ANIMALIA; PLASMODIUM FALCIPARUM;

EID: 0036213195     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1286-4579(02)01541-1     Document Type: Review

References (75)

1. Division of control of tropical diseases, severe and complicated malaria
2. The pathogenesis of severe malaria in African children
3. The incidence and outcome of neurological abnormalities in childhood cerebral malaria: A long-term follow-up of 62 survivors
4. Cytoadhesion of Plasmodium falciparum ring-stage-infected erythrocytes
5. Sequestration in Plasmodium falciparum malaria: Sticky cells and sticky problems
6. Possible importance of macrophage-derived mediators in acute malaria
7. Malarial parasites induce tumour necrosis factor production by macrophages
8. Early cytokine induction by Plasmodium falciparum is not a classical endotoxin-like process
9. Reversal of type 2 diabetes in mice by products of malaria parasites: I. Effect of inactivated parasites
10. Signal transduction in host cells by a glycosylphosphatidylinositol toxin of malaria parasites
11. Glycosylphosphatidylinositol anchors of Plasmodium falciparum: Molecular characterization and naturally elicited antibody response that may provide immunity to malaria pathogenesis
12. IgE and tumor necrosis factor in malaria infection
13. IgE deposition in brain microvessels and on parasitized erythrocytes from cerebral malaria patients
14. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria
15. The effect of monoclonal antibody to tumour necrosis factor on survival from childhood cerebral malaria
16. Polyclonal anti-tumor necrosis factor-alpha Fab used as an ancillary treatment for severe malaria
17. Variation in the TNF-alpha promotor region associated with susceptibility to cerebral malaria
18. Is T cell priming required for initiation of pathology in malaria infections?
19. Prediction of accelerated cure in Plasmodium falciparum malaria by the elevated capacity of tumor necrosis factor production
20. Maintaining the immunological balance in parasitic infections: A role for TGF-beta?
21. The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria
22. Low plasma concentrations of interleukin 10 in severe malarial anaemia compared with cerebral and uncomplicated malaria
23. Proposed link between cytokines, nitric oxide and human cerebral malaria
24. Inducible nitric oxide synthase expression is increased in the brain in fatal cerebral malaria
25. Multi-organ erythrocyte sequestration and ligand expression in rhesus monkeys infected with Plasmodium coatneyi malaria
26. A correlation of the sequestration rate of Plasmodium coatneyi-infected erythrocytes in cerebral and subcutaneous tissues of a rhesus monkey
27. Expression of proinflammatory cytokines in four regions of the brain in Macaque mulatta (rhesus) monkeys infected with Plasmodium coatneyi
28. A nonhuman primate model for human cerebral malaria: Rhesus monkeys experimentally infected with Plasmodium fragile
29. Ultrastructural aspects of Plasmodium falciparum-infected erythrocyte adherence to endothelial cells of Saimiri brain microvasculature
30. The effect of antithymocyte serum on golden hamsters and rats infected Plasmodium berghei
31. Cerebral malaria in inbred mice. I. A new model and its pathology
32. Virulent P. berghei malaria: Prolonged survival and decreased cerebral pathology in cell-dependent nude mice
33. Profiles of cytokine production in relation with susceptibility to cerebral malaria
34. Pathology of fatal and resolving Plasmodium berghei cerebral malaria in mice
35. Immunopathology of cerebral malaria: Morphological evidence of parasite sequestration in murine brain microvasculature
36. Cerebral malaria in mice: Demonstration of cytoadherence of infected red blood cells and microrheologic correlates
37. Cerebral malaria in mice: Interleukin-2 treatment induces accumulation of gammadelta T cells in the brain and alters resistant mice to susceptible-like phenotype
38. Immunization with heat-killed Toxoplasma gondii stimulates an early IFN-gamma response and induces protection against virulent murine malaria
39. Crucial role for tumour necrosis factor (TNF) receptor 2 and membrane bound TNF in experimental cerebral malaria
40. Cloned lines of Plasmodium berghei ANKA differ in their abilities to induce experimental cerebral malaria
41. Immunopathological changes in human cerebral malaria
42. Tumour necrosis factor (cachectin) as an essential mediator in murine cerebral malaria
43. Development of irreversible lesions in the brain, heart and kidney following acute and chronic murine malaria infection
44. Comparisons between microvascular changes in cerebral and non-cerebral malaria in mice, using the retinal whole-mount technique
45. Blood-brain barrier function in cerebral malaria in Malawian children
46. Prognostic indicators in adult cerebral malaria: A study in Burundi, an area of high prevalence of HIV infection
47. Immunological aspects of cerebral lesions in murine malaria
48. Participation of lymphocyte subpopulations in the pathogenesis of experimental murine cerebral malaria
49. Perturbation and proinflammatory type activation of V delta 1(+) gamma delta T cells in African children with Plasmodium falciparum malaria
50. Gamma delta T-cell function in pathogenesis of cerebral malaria in mice infected with Plasmodium berghei ANKA
51. Protection of mice against malaria by a killed vaccine: Differences in effectiveness against P. yoelii and P. berghei
52. Evidence for multiple pathologic and protective mechanisms of murine cerebral malaria
53. Tumour necrosis factor-alpha expression in the brain during fatal murine cerebral malaria: Evidence for production by microglia and astrocytes
54. Neutrophils play a critical role in the pathogenesis of experimental cerebral malaria
55. Cytokine expression in the brain in human cerebral malaria
56. Circulating tumour necrosis factor a is not involved in the development of cerebral malaria in Plasmodium berghei-infected C57Bl mice
57. Involvement of IFN-gamma receptor-medicated signaling in pathology and anti-malarial immunity induced by Plasmodium berghei infection
58. Crucial role for tumour necrosis factor (TNF) receptor 2 and membrane bound TNF in experimental cerebral malaria
59. Protection against the mortality associated with disease models mediated by TNF and IFN-gamma in mice lacking IFN regulatory factor-1
60. Pentoxifylline prevents murine cerebral malaria
61. Interleukin 6 production in experimental cerebral malaria: Modulation by anticytokine antibodies and possible role in hypergammaglobulinemia
62. A defect in interleukin-10 leads to enhanced malarial disease in Plasmodium chabaudi chabaudi infection in mice
63. Transforming growth factor beta production is inversely correlated with severity of murine malaria infection
64. Interleukin-10 modulates susceptibility in experimental cerebral malaria
65. Increased plasma levels of soluble ICAM-1 and ELAM-1 (E-selectin) during acute Plasmodium falciparum malaria
66. Increased plasma concentrations of sICAM-1, sVCAM-1 and sELAM-1 in patients with Plasmodium falciparum or P. vivax malaria and association with disease severity
67. Receptor-specific adhesion and clinical disease in Plasmodium falciparum
68. PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes
69. Chondroitin-4-sulphate impairs in vitro and in vivo cytoadherence of Plasmodium falciparum infected erythrocytes
70. Promiscuity of clinical Plasmodium falciparum isolates for multiple adhesion molecules under flow conditions
71. Role of platelet adhesion in homeostasis and immunopathology
72. Platelets play an important role in TNF-induced microvascular endothelial cell pathology
73. Role of ICAM-1 (CD54) in the development of murine cerebral malaria
74. Falciparum Malaria, Sticking up, standing out and out-standing