Delayed mortality and attenuated thrombocytopenia associated with severe malaria in urokinase- and urokinase receptor-deficient mice

Infection and Immunity

Volumn 68, Issue 7, 2000, Pages 3822-3829

  Piguet, Pierre Francois ^a,e   Da Laperrousaz, Chen ^a   Vesin, Christian ^a   Tacchini Cottier, Fabienne ^b   Senaldi, Giorgio ^c   Grau, Georges Emile ^d  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b WORLD HEALTH ORGANIZATION   (Switzerland)

^c AMGEN INC   (United States)

^d AIX MARSEILLE UNIVERSITY   (France)

^e SMU   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; TISSUE PLASMINOGEN ACTIVATOR DERIVATIVE; TUMOR NECROSIS FACTOR; UROKINASE; UROKINASE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE SEVERITY; MALARIA; MORTALITY; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM BERGHEI; PRIORITY JOURNAL; THROMBOCYTE KINETICS; THROMBOCYTOPENIA;

ANIMALS; APROTININ; BLOOD PLATELETS; BLOOD-BRAIN BARRIER; CELL SURVIVAL; FIBRINOGEN; KINETICS; LUNG; MALARIA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; ORGAN SIZE; PARASITEMIA; PLASMODIUM BERGHEI; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SPLEEN; THROMBOCYTOPENIA; TISSUE PLASMINOGEN ACTIVATOR; TUMOR NECROSIS FACTOR-ALPHA; URINARY PLASMINOGEN ACTIVATOR;

EID: 0033946223     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.7.3822-3829.2000     Document Type: Article

References (51)

1. Barazzone, C., S. Horowitz, Y. Donati, C. Vesin, A. Rochat, I. Rodriguez, and P. F. Piguet. 1998. Oxygen toxicity in mouse lung: pathways to cell death. Am. J. Respir. Cell Mol. Biol. 19:573-581.
2. Barry, O. P., D. Pratico, J. A. Lawson, and G. A. Fitzgerald. 1997. Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. J. Clin. Investig. 99:2118-2127.
3. Bugge, T. H., T. T. Suh, M. J. Flick, C. C. Daugherty, J. Romer, H. Solberg, V. Ellis, K. Dano, and J. L. Degen. 1995. The receptor for urokinase-type plasminogen activator is not essential for mouse development or fertility. J. Biol. Chem. 270:16886-16894.
4. Chapman, H. A. 1997. Plasminogen activators, integrins and the coordinated regulation of cell adhesion and migration. Curr. Opin. Cell Biol. 9:714-724.
5. Charoenpan, P., S. Indraprasit, S. Kiatboonsri, O. Suvachttanont, and S. Tanomsup. 1990. Pulmonary oedema in severe falciparum malaria. Hemodynamic study and clinicophysiologic correlation. Chest 97:1190-1197.
6. Clark, I. A., J. D. Macmicking, K. M. Gray, K. A. Rockett, and W. B. Cowden. 1992. Malaria mimicry with tumor necrosis factor. Contrasts between species of murine malaria and Plasmodium falciparum. Am. J. Pathol. 140:325-336.
7. Coquelin, F., Y. Boulard, E. Mora-Silvera, F. Richard, A. G. Chabaud, and I. Landau. 1999. Final stage maturation of the erythrocytic schizonts of rodent Plasmodium in the lungs. C. R. Acad. Sci. (III). 322:55-62.
8. Dewerchin, M., A. Van Nuffelen, G. Wallays, A. Bouché, L. Moons, and P. Carmeliet. 1996. Generation and characterization of urokinase receptor-deficient mice. J. Clin. Investig. 97:870-878.
9. Diacovo, T. G., M. D. Catalina, M. H. Siegelman, and U. H. von Andrian. 1998. Circulating activated platelets reconstitute lymphocyte homing and immunity in L-selectin-deficient mice. J. Exp. Med. 187:197-204.
10. Duarte, M. I. S., C. E. P. Corbett, M. Boulos, and A. Neto. 1985. Ultrastructure of the lung in falciparum malaria. Am. J. Trop. Med. Hyg. 34:31-35.
11. Falanga, P. B., and E. C. Butcher. 1991. Late treatment with anti-LFA-1(CD11a) antibody prevents cerebral malaria in a mouse model. Eur. J. Immunol. 21:2259-2263.
12. Favre, N., K. Willimann, B. Ryffel, N. Weiss, B. A. Imhof, W. Rudin, R. Lucas, and P. F. Piguet. 1999. Role of ICAM-1 in the development of murine cerebral malaria. Microbes Infect. 1:961-968.
13. Fujioka, H., P. Millet, Y. Maeno, S. Nakazawa, Y. Ito, R. J. Howard, W. E. Collins, and M. Aikawa. 1994. A nonhuman primate model for human cerebral malaria: rhesus monkeys experimentally infected with Plasmodium fragile. Exp. Parasitol. 78:371-376.
14. Grau, G. E., F. Tacchini-Cottier, C. Vesin, G. Milon, J. N. Lou, P. F. Piguet, and P. Juillard. 1993. TNF-induced microvascular pathology: active role for platelets and importance of the LFA-1/ICAM-1 interaction. Eur. Cyto. Net. 4:415-419.
15. Grau, G. E., L. F. Fajardo, P. F. Piguet, B. Allet, P. H. Lambert, and P. Vassalli. 1987. Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria. Science 237:1210-1212.
16. Grau, G. E., T. Taylor, M. E. Molyneux, J. J. Wirima, P. Vassalli, M. Hommel, and P. H. Lambert. 1989. Tumor necrosis factor and disease severity in children with falciparum malaria. New. Engl. J. Med. 24:1586-1591.
17. Grau, G. E., D. Gretener, and P. H. Lambert. 1987. Prevention of murine cerebral malaria by low-dose cyclosporin A. Immunology 61:521-525.
18. Grau, G. E., P. Pointaire, P. F. Piguet, C. Vesin, H. Rosen, I. Stamenkovic, F. Takei, and P. Vassalli. 1991. Late administration of monoclonal antibody to leukocyte function antigen 1 abrogates incipient murine cerebral malaria. Eur. J. Immunol. 21:2265-2267.
19. + T lymphocytes play a major role in the pathogenesis of murine cerebral malaria. J. Immunol. 137:2348-2354.
20. Grau, G. E., H. Heremans, P. F. Piguet, P. Pointaire, P. H. Lambert, A. Billiau, and P. Vassalli. 1989. Monoclonal antibody against interferon-gamma can prevent experimental cerebral malaria and its associated over-production of tumor necrosis factor. Proc. Natl. Acad. Sci. USA 86:5572-5574.
21. Grau, G. E., P. F. Piguet, D. Gretener, C. Vesin, and P. H. Lambert. 1988. Immunopathology of thrombocytopenia in experimental malaria. Immunology. 65:501-506.
22. Grau, G. E., and S. de Kossodo. 1994. Cerebral malaria: mediators, mechanical obstruction or more? Parasitol. Today 10:408-409.
23. Hawrylowicz, C. M., G. L. Howells, and M. Feldmann. 1991. Platelet-derived interleukin-1 induces human endothelial adhesion molecules expression and cytokine production. J. Exp. Med. 174:785-790.
24. Heffner, J. E., and J. E. Repine. 1997. Platelets, p. 947-960. In R. G. Crystal, J. B. West, E. R. Weibel, and P. J. Barnes (ed.), The lung: scientific foundations. Lippincott-Raven, Philadelphia, Pa.
25. Henn, V., J. R. Slupsky, M. Grate, I. Anagnostopoulos, R. Forster, G. Mueller-Berghaus, and R. Kroczek. 1998. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 391:591-594.
26. Imhof, B. A., and D. Dunon. 1995. Leukocyte migration and adhesion. Adv. Immunol. 58:345-416.
27. Lucas, R., J. N. Lou, P. Juillard, M. Moore, H. Bluethmann, and G. E. Grau. 1997. Respective role of TNF receptors in the development of experimental cerebral malaria. J. Neuroimmunol. 72:143-148.
28. MacPherson, G. G., M. J. Warrell, N. J. White, S. Looareesuwan, and D. A. Warrell. 1985. Human cerebral malaria. A quantitative ultrastructural analysis of parasitized erythrocyte sequestration. Am. J. Pathol. 119:385-401.
29. Mann, H. B., and D. R. Whitney. 1947. On a test of whether one or two random variables is stochastically larger than the other. Ann. Math Statist. 18:50-60.
30. Maennel, D., and G. E. Grau. 1997. Role of platelet adhesion in homeostasis and immunopathology. J. Clin. Pathol. Mol. Pathol. 50:175-185.
31. McGuire, W., V. S. Hill, C. E. M. Allsopp, B. M. Greewood, and D. Kwjatkowski. 1994. Variation in the TNF-a promoter region associated with susceptibility to cerebral malaria. Nature 371:508-511.
32. May, A. E., S. M. Kanse, L. R. Lund, R. H. Gisler, B. A. Imhof, and K. T. Preissner. 1998. Urokinase receptor (CD87) regulates leukocyte recruitment via beta-2 integrins in vivo. J. Exp. Med. 188:1029-1037.
33. Nakamura, M., M. Shibazaki, Y. Nitta, and V. Endo. 1998. Translocation of platelets into Disse spaces and their entry into hepatocytes in response to lipopolysaccharides, interleukin-1 and tumor necrosis factor: the role of Kupffer cells. J. Hepatol. 28:991-999.
34. Nieswandt, B., B. Echtenacher, F. P. Wachs, J. Schroder, J. E. Gessner, R. E. Schmidt, G. E. Grau, and D. N. Mannel. 1999. Acute systemic reaction and lung alterations induced by an antiplatelet integrin gpIIb/IIIa antibody in mice. Blood 94:684-693.
35. Nordenhem, A., and B. Wiman. 1997. Plasminogen activator inhibitor-1 (PAI-1) content in platelets from healthy individuals genotyped for the 4G/5G polymorphism in the PAI-1 gene. Scand. J. Clin. Lab. Investig. 57: 453-461.
36. Patnaik, J. K., B. S. Das, S. K. Mishra, S. Mohanty, S. K. Sapathy, and D. Mohanty. 1994. Vascular clogging, mononuclear cell margination, and enhanced vascular permeability in the pathogenesis of human cerebral malaria. Am. J. Trop. Med. Hyg. 51:642-647.
37. Piguet, P. F., M. A. Collart, G. E. Grau, Y. Kapanci, and P. Vassalli. 1989. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J. Exp. Med. 170:655-663.
38. Piguet, P. F., C. Vesin, C. D. Laperousaz, and A. Rochat. 2000. Role of plasminogen activators and of urokinase receptor (uPAR, CD87) in platelet kinetics in mice. J. Hematol., in press.
39. Piguet, P. F., C. Vesin, Y. Donati, F. Tacchini-Cottier, D. Belin, and C. Barazzone. 1999. Urokinase-receptor (uPAR, CD87) is a platelet receptor important for kinetics and TNF-induced endothelial adhesion in mice. Circulation 99:3315-3321.
40. Pliego Rivero, F. B., N. Bayatti, X. Giannakoulopoulos, V. Glover, H. F. Bradford, G. Stern, and M. Sandler. 1997. Brain-derived neurotrophic factor in human platelets. Biochem. Pharmacol. 54:207-209.
41. Roggwiller, E., A. C. Fricaud, T. Blisnick, and C. Braun Breton. 1997. Host urokinase-type plasminogen activator participates in the release of malaria merozoites from infected erythrocytes. Mol. Biochem. Parasitol. 86:49-59.
42. Royston, B. D., D. Royston, and J. D. Pearson. 1992. Aprotinin inhibits platelet adhesion to endothelial cells. Blood Coag. Fibrin. 3:737-742.
43. Rudin, W., H. P. Eugster, G. Bordmann, J. Bonato, M. Muller, M. Yamage, and B. Ryffel. 1997. Resistance to cerebral malaria in tumor necrosis factor-alpha/beta-deficient mice is associated with a reduction of intercellular adhesion molecule-1 up-regulation and T helper type 1 response. Am. J. Pathol. 150:257-266.
44. Schofield, L., and F. Hackett. 1993. Signal transduction in host cells by a glycosylphatidylinositol toxin of malaria parasites. J. Exp. Med 177:145-153.
45. Senaldi, G., and P. F. Piguet. 1998. Mortality and platelet depletion occur independently of fibrinogen consumption in murine models of tumor necrosis factor-mediated systemic inflammatory responses. Cytokine 10:382-389.
46. Senaldi, G., C. Vesin, R. Chang, G. Grau, and P. F. Piguet. 1994. An effector role of neutrophils in the pathogenesis of murine severe malaria. Infect. Immun. 62:1144-1149.
47. Sitrin, R. G., R. F. Todd III, H. R. Petty, T. G. Brock, S. B. Shollenberger, E. Albrecht, and M. R. Gyetko. 1996. The urokinase receptor (CD87) facilitates CD11b/CD18-mediated adhesion of human monocytes. J. Clin. Investig. 97:1942-1951.
48. Tacchini-Cottier, F., C. Vesin, M. Redard, W. Buurman, and P. F. Piguet. 1998. Role of TNF receptors I and II in TNF-induced platelets consumption in mice. J. Immunol. 160:6182-6186.
49. White, N. J., and M. Ho. 1992. The pathophysiology of malaria, p. 84-173. Academic Press, Inc., New York, N.Y.
50. World Health Organization Malaria Action Programme. 1986. Severe and complicated malaria. Trans. R. Soc. Trop. Med. Hyg. 80:3-50.
51. Wright, D. H. 1968. The effect of neonatal thymectomy on the survival of golden hamsters infected with Plasmodium berghei. Br. J. Exp. Pathol. 49: 379-384.