Reactive oxygen species stimulates epithelial mesenchymal transition in normal human epidermal keratinocytes via TGF-beta secretion

Experimental Cell Research

Volumn 318, Issue 15, 2012, Pages 1926-1932

  Fukawa, Teruhisa ^a   Kajiya, Hiroshi ^a   Ozeki, Satoru ^a   Ikebe, Tetsuro ^a   Okabe, Koji ^a  

^a FUKUOKA DENTAL COLLEGE   (Japan)

Author keywords

Epithelial cadherin; Epithelial to mesenchymal transition; Normal human epidermal keratinocyte; Reactive oxygen species; Transforming growth factor 1; smooth muscle actin

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BIOLOGICAL MARKER; CADHERIN; HYDROGEN PEROXIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUTRALIZING ANTIBODY; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR SNAIL; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL STIMULATION; CELL STRUCTURE; CYTOKINE RELEASE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; EPIDERMIS CELL; EPITHELIAL MESENCHYMAL TRANSITION; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIME; UPREGULATION;

EID: 84863781225     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2012.05.023     Document Type: Article

References (38)

1. Finkel T., Holbrook N.J. Oxidants, oxidative stress and biology of aging. Nature 2000, 408:239-247.
2. Radisky D.C., Levy D.D., Littlepage L.E., Liu H., Nelson C.M., Fata J.E., Leake D., Godden E.L., Albertson D.G., Nieto M.A., Werb Z., Bissell M.J. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005, 436:123-127.
3. Oft M., Peli J., Rudaz C., Schwarz H., Beug H., Reichmann E. TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev. 1996, 10:2462-2477.
4. Cannito S., Novo E., Compagnone A., Valfrè di Bonzo L., Busletta C., Zamara E., Paternostro C., Povero D., Bandino A., Bozzo F., Cravanzola C., Bravoco V., Colombatto S., Parola M. Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells. Carcinogenesis 2008, 29:2267-2278.
5. Law A.Y., Woung C.K. Stanniocalcin-2 promotes epithelial-mesenchymal transition and invasiveness in hypoxic human ovarian cancer cells. Exp. Cell Res 2010, 316:3425-3434.
6. Zhou B.P., Deng J., Xia W., Xu J., Li Y.M., Gunduz M., Hung M.C. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 2004, 10:931-940.
7. Mousakas A., Heldin C.H. Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci. 2007, 10:1512-1520.
8. Thiery J.P. Epithelial-mesenchymal transitions in tumor progression. Nat. Rev. Cancer 2002, 6:442-454.
9. Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
10. Nieto M.A. The snail superfamily of zinc-finger transcription factors. Nat. Rev. Mol. Cell Biol 2002, 3:155-166.
11. Cano A., Pérez-Moreno M.A., Rodrigo I., Locascio A., Blanco M.J., del Barrio M.G., Portillo F., Nieto M.A. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2000, 2:76-83.
12. Massagué J., Blain S.W., Lo R.S. TGF beta signaling in growth control, cancer, and heritable disorders. Cell 2000, 103:295-309.
13. Heldin C.H., Landström M., Moustakas A. Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. Curr. Opin. Cell Bio 2009, 21:166-176.
14. Ikushima H., Miyazono K. TGF beta signaling: a complex web in cancer progression. Nat. Rev 2010, 10:415-424.
15. Elenbaas B., Spirio L., Koerner F., Fleming M.D., Zimonjic D.B., Donaher J.L., Popescu N.C., Hahn W.C., Weinberg R.A. Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev. 2001, 15:50-65.
16. Nakayama S., Kajiya H., Okabe K., Ikebe T. Effects of oxidative stress on the expression of 8-oxoguanine and its eliminating enzymes in human keratinocytes and squqmous carcinoma cells. Oral Science Int 2011, 8:11-16.
17. Gupta A., Rosenberger S.F., Bowden G.T. Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines. Carcinogenesis 1999, 11:2063-2073.
18. Böttinger E.P. M. Bitzer, TGF-beta signaling in renal disease. J. Am. Soc. Nephrol. 2002, 10:2600-2610.
19. Xu Z., Shen M.X., Ma D.Z., Wang L.Y., Zha X.L. TGF-beta1-promoted epithelial-to-mesenchymal transformation and cell adhesion contribute to TGF-beta1-enhanced cell migration in SMMC-7721 cells. Cell Res. 2003, 13:343-350.
20. Larue L., Bellacosa A. Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene 2005, 50:7443-7454.
21. Huber M.A., Kraut N., Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 2005, 5:548-558.
22. Lee J.M., Dedhar S., Kalluri R., Thompson E.W. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J. Cell Biol. 2006, 172:973-981.
23. Bates R.C., Mercurio A.M. The epithelial-mesenchymal transition (EMT) and colorectal cancer progression. Cancer Biol. Ther 2005, 4:365-370.
24. Thiery J.P. Epithelial-mesenchymal transitions in development and pathologies. Curr. Opin. Cell Biol 2003, 6:740-746.
25. Thiery J.P., Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 2006, 2:131-142.
26. Prindull G. Hypothesis: cell plasticity, linking embryonal stem cells to adult stem cell reservoirs and metastatic cancer cells?. Exp. Hematol 2005, 7:738-746.
27. Shin I., Kim S., Song H., Kim H.R., Moon A. H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells. J. Biol. Chem 2005, 280:14675-14683.
28. Chemyavsky A.I., Arredondo J., Karlsson E., Wessler I., Grando S.A. The Ras/Raf-1/MEK1/ERK signaling pathway coupled to integrin expression mediates cholinergic regulation of keratinocyte directional migration. J. Biol. Chem 2005, 280:39220-39228.
29. Huang C., Jacobson K., Schaller M.D. MAP kinases and cell migration. J. Cell Science 2004, 117:4619-4628.
30. Lin S.J., Shyue S.K., Liu P.L, Chen Y.H., Ku H.H., Chen J.W., Tam K.B., Chen Y.L. Adenovirus-mediated overexpression of catalase attenuates oxLDL-induced apoptosis in human aortic endothelial cells via AP-1 and C-Jun N-terminal kinase/extracellular signal-regulated kinase mitogen-activated protein kinase pathways. J. Mol. Cell Cardiol. 2004, 36:129-139.
31. Greene E.L., Lu G., Zhang D., Egan B.M. Signaling events mediating the additive effects of oleic acid and angiotensin II on vascular smooth muscle cell migration. Hypertension 2001, 37:308-312.
32. Lo I.C., Shih J.M., Jiang M.J. Reactive oxygen species and ERK 1/2 mediate monocyte chemotactic protein-1-stimulated smooth muscle cell migration. J. Biomed. Science 2005, 12:377-388.
33. Herrera B., Fernández M., Roncero C., Ventura J.J., Porras A., Valladares A., Benito M., Fabregat I. Activation of p38MAPK by TGF-beta in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death. FEBS. Lett 2001, 499:225-229.
34. Zhang Y.E. Non-Smad pathways in TGF-beta signaling. Cell Res 2009, 19:128-139.
35. Rhyu D.Y., Yang Y., Ha H., Lee G.T., Song J.S., Uh S.T., Lee H.B. Role of reactive oxygen species in TGF-beta1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J. Am. Soc. Nephrol. 2005, 16:667-675.
36. Felton V.M., Borok Z., Willis B.C. N-acetylcysteine inhibits alveolar epithelial-mesenchymal transition. Am. J. Physiol. Lung Cell Mol. Physiol 2009, 297:L805-812.
37. Zhang A., Jia Z., Guo X., Yang T. Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin. Am. J. Physiol. Renal Physiol 2007, 293:723-731.
38. Zhou G., Dada L.A., Wu M., Kelly A., Trejo H., Zhou Q., Varga J., Sznajder J.I. Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1. Am. J. Physiol. Lung Cell Mol. Physiol 2009, 297:L1120-1130.