Nonspecific prion protein-nucleic acid interactions lead to different aggregates and cytotoxic species

Biochemistry

Volumn 51, Issue 27, 2012, Pages 5402-5413

  MacEdo, Bruno ^a   Millen, Thiago A ^a   Braga, Carolina A C A ^a   Gomes, Mariana P B ^a   Ferreira, Priscila S ^a   Kraineva, Julia ^b   Winter, Roland ^b   Silva, Jerson L ^a   Cordeiro, Yraima ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b TU DORTMUND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOPHYSICAL PROPERTIES; CELL DYSFUNCTION; CELLULAR ASSAYS; CELLULAR EFFECTS; CULTURED CELL; CYTOTOXIC SPECIES; GC CONTENTS; MISFOLDING; NUCLEOTIDE SEQUENCES; PRION DISEASE; PRION PROTEIN; PROTEIN-NUCLEIC ACID INTERACTION; SECONDARY STRUCTURES; SEQUENCE SPECIFICITY; SPECTROSCOPIC TECHNIQUE; STRUCTURAL CHANGE;

AGGREGATES; BIOMOLECULES; DNA SEQUENCES; MAMMALS; NEURODEGENERATIVE DISEASES; OLIGONUCLEOTIDES; PROTEINS; TOXICITY;

NUCLEIC ACIDS;

DNA; DOUBLE STRANDED DNA; OLIGONUCLEOTIDE; PRION PROTEIN;

ANIMAL CELL; ARTICLE; CELL AGGREGATION; CYTOTOXICITY; DNA BASE COMPOSITION; DNA BINDING; DNA SEQUENCE; NEUROBLASTOMA CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SPECTROSCOPY;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL LINE, TUMOR; CYTOTOXINS; DNA; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PRIONS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; SOLUBILITY;

MAMMALIAN PRION;

EID: 84863755561     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300440e     Document Type: Article

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