Modified single-stranded oligonucleotides inhibit aggregate formation and toxicity induced by expanded polyglutamine

Journal of Molecular Neuroscience

Volumn 24, Issue 2, 2004, Pages 257-267

  Parekh Olmedo, Hetal ^a   Wang, Jin ^b   Gusella, James F ^b   Kmiec, Eric B ^a  

^a UNIVERSITY OF DELAWARE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Aggregation inhibition; HD; Htt; Modified single stranded oligonucleotides

Indexed keywords

HUNTINGTIN; OLIGONUCLEOTIDE; PHOSPHOROTHIOIC ACID; POLYGLUTAMINE; RNA; HDH PROTEIN, RAT; HYBRID PROTEIN; NERVE PROTEIN; NUCLEAR PROTEIN; PEPTIDE; REPETITIVE DNA;

ANIMAL CELL; ARTICLE; BIOASSAY; CELL ASSAY; CELL LINE; CELL STRAIN; CELL SURVIVAL; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; INHIBITION KINETICS; MOLECULE; NERVE CELL; NONHUMAN; PROTEIN AGGREGATION; RAT; STANDARDIZATION; TOXICITY; ANIMAL; CELL INCLUSION; CYTOLOGY; GENETICS; HUNTINGTON CHOREA; METABOLISM; RANDOMIZATION; RISK;

ANIMALS; CELL LINE; CELL SURVIVAL; DNA REPEAT EXPANSION; HUNTINGTON DISEASE; INCLUSION BODIES; NERVE TISSUE PROTEINS; NEURONS; NUCLEAR PROTEINS; ODDS RATIO; OLIGONUCLEOTIDES; PC12 CELLS; PEPTIDES; RANDOM ALLOCATION; RATS; RECOMBINANT FUSION PROTEINS;

EID: 25444456100     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:24:2:257     Document Type: Article

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