Prion protein complexed to N2a cellular RNAs through its N-terminal domain forms aggregates and is toxic to murine neuroblastoma cells

Journal of Biological Chemistry

Volumn 283, Issue 28, 2008, Pages 19616-19625

  Gomes, Mariana P B ^a   Millen, Thiago A ^a   Ferreira, Priscila S ^a   Cunha E Silva, Narcisa L ^a   Vieira, Tuane C R G ^a   Almeida, Marcius S ^a   Silva, Jerson L ^a,b   Cordeiro, Yraima ^a,c  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b Instituto de Bioquimica Medica   (Brazil)

^c Faculdade de Farmacia   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

AGGREGATES; BODY FLUIDS; FLOW INTERACTIONS; MAGNETIC RESONANCE; MOLECULES; NUCLEAR MAGNETIC RESONANCE; OLIGOMERS; ORGANIC ACIDS; POLYMERS; PORT TERMINALS; RNA; SCANDIUM;

CATALYTIC EFFECTS; CELL VIABILITIES; CELLULAR PRION PROTEINS; CULTURED CELLS; DELETION MUTANTS; ISOFORMS; NANOMOLAR AFFINITIES; NEUROBLASTOMA CELLS; POTENTIALLY MODULATE; PRION DISEASES; PRION PROTEINS; PROTECTIVE EFFECTS; RNA MOLECULES; RNA SEQUENCES; STRUCTURAL CHANGES; TERMINAL DOMAINS; TERMINAL REGIONS;

NUCLEIC ACIDS;

CELL PROTEIN; MUTANT PROTEIN; OLIGOMER; PRION PROTEIN; RECOMBINANT PROTEIN; RNA; DNA; RIBOZYME; RNA BINDING PROTEIN;

AFFINITY LABELING; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; DELETION MUTANT; GENE DELETION; HOMEOSTASIS; MOLECULAR INTERACTION; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; RNA EXTRACTION; RNA SEQUENCE; RNA SYNTHESIS; ANIMAL; CELL SURVIVAL; CHEMISTRY; GENETICS; METABOLISM; NEUROBLASTOMA; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; TUMOR CELL LINE;

MURINAE;

ANIMALS; CATALYSIS; CELL LINE, TUMOR; CELL SURVIVAL; DNA, NEOPLASM; HOMEOSTASIS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; NEUROBLASTOMA; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PRPC PROTEINS; PRPSC PROTEINS; RNA, CATALYTIC; RNA, NEOPLASM; RNA-BINDING PROTEINS;

EID: 50349086383     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802102200     Document Type: Article

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