The toxicity of the PrP106-126 prion peptide on cultured photoreceptors correlates with the prion protein distribution in the mammalian and human retina

American Journal of Pathology

Volumn 170, Issue 4, 2007, Pages 1314-1324

  Gong, Jie ^a,b   Jellali, Abdeljelil ^c   Forster, Valérie ^a,b   Mutterer, Jérôme ^d   Dubus, Elisabeth ^a,b   Altrock, Wilko D ^e   Sahel, José A ^a,b,f,g   Rendon, Alvaro ^a,b   Picaud, Serge ^a,b,h  

^a INSERM   (France)

^b SORBONNE UNIVERSITÉ   (France)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d INST DE BIOL MOLEC DES PLANTES   (France)

^e LEIBNIZ INSTITUTE FOR NEUROBIOLOGY   (Germany)

^f FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD   (France)

^g CENTRE HOSPITALIER NATIONAL D OPHTALMOLOGIE DES QUINZE VINGTS   (France)

^h ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN; PEPTIDE FRAGMENT;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LABELING; CELL LOSS; CELL POPULATION; CONTROLLED STUDY; CYTOTOXICITY; GLIA CELL; HUMAN; HUMAN TISSUE; NEUROTOXICITY; NICK END LABELING; NONHUMAN; PHOTORECEPTOR CELL; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RETINA AMACRINE CELL; RETINA CELL; ANIMAL; CELL CULTURE; CHEMISTRY; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECT; GLIA; LONG EVANS RAT; METABOLISM; PHOTORECEPTOR; PRION; RETINA; RETINA CONE; SWINE; SYNAPSE;

AMACRINE CELLS; ANIMALS; APOPTOSIS; CELLS, CULTURED; CONES (RETINA); HUMANS; MICROSCOPY, CONFOCAL; NEUROGLIA; PEPTIDE FRAGMENTS; PHOTORECEPTORS; PRIONS; PRPC PROTEINS; RATS; RATS, LONG-EVANS; RETINA; SWINE; SYNAPSES;

EID: 34247868930     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2007.060340     Document Type: Article

References (39)

1. Prusiner SB: Prions. Proc Natl Acad Sci USA 1998, 95:13363-13383
2. Fraser H: Diversity in the neuropathology of scrapie-like diseases in animals. Br Med Bull 1993, 49:792-809
3. Renault F, Richard P: Early electroretinogram alterations in Creutzfeldt-Jakob disease after growth hormone treatment. Lancet 1991, 338:191
4. Katz BJ, Warner JE, Digre KB, Creel DJ: Selective loss of the electroretinogram B-wave in a patient with Creutzfeldt-Jakob disease. J Neuroophthalmol 2000, 20:116-118
5. de Seze J, Hache JC, Vermersch P, Arndt CF, Maurage CA, Pasquier F, Laplanche JL, Ruchoux MM, Leys D, Destee A, Petit H: Creutzfeldt-Jakob disease: neurophysiologic visual impairments. Neurology 1998, 51:962-967
6. Richard P, Renault F, Ostre C, Auzoux-Cheve M: Neurophysiological follow-up in two children with Creutzfeldt-Jakob disease after human growth hormone treatment. Electroencephalogr Clin Neurophysiol 1994, 91:100-107
7. Head MW, Northcott V, Rennison K, Ritchie D, McCardle L, Bunn TJ, McLennan NF, Ironside JW, Tullo AB, Bonshek RE: Prion protein accumulation in eyes of patients with sporadic and variant Creutzfeldt-Jakob disease. Invest Ophthalmol Vis Sci 2003, 44:342-346
8. Buyukmihci N, Rorvik M, Marsh RF: Replication of the scrapie agent in ocular neural tissues Proc Nat! Acad Sci USA 1980, 77:1169-1171
9. Curtis R, Fraser H, Foster JD, Scott JR: The correlation of electroreti-nographic and histopathological findings in the eyes of mice infected with the 79A strain of scrapie Neuropathol Appl Neurobiol 1989, 15:75-89
10. Russelakis-Carneiro M, Betmouni S, Perry VH: Inflammatory response and retinal ganglion cell degeneration following intraocular injection of ME7. Neuropathol Appl Neurobiol 1999, 25:196-206
11. Herms J, Tings T, Gall S, Madlung A, Giese A, Siebert H, Schurmann P, Windl O, Brose N, Kretzschmar H: Evidence of presynaptic location and function of the prion protein. J Neurosci 1999, 19:8866-8875
12. Ettaiche M, Pichot R, Vincent JP, Chabry J: In vivo cytotoxicity of the prion protein fragment 106-126. J Biol Chem 2000, 275:36487-36490
13. Chabry J, Ratsimanohatra C, Sponne I, Elena PP, Vincent JP, Pillot T: In vivo and in vitro neurotoxicity of the human prion protein (PrP) fragment P118-135 independently of PrP expression. J Neurosci 2003, 23:462-469
14. Brown DR, Schmidt B, Kretzschmar HA: Role of microglia and host prion protein in neurotoxicity of a prion protein fragment. Nature 1996, 380:345-347
15. Brown DR: Prion protein peptide neurotoxicity can be mediated by astrocytes. J Neurochem 1999, 73:1105-1113
16. Rymer DL, Good TA: The role of prion peptide structure and aggregation in toxicity and membrane binding. J Neurochem 2000, 75:2536-2545
17. Picaud S, Hicks D, Forster V, Sahel J, Dreyfus H: Adult human retinal neurons in culture: physiology of horizontal cells. Invest Ophthalmol Vis Sci 1998, 39:2637-2648
18. White AR, Guirguis R, Brazier MW, Jobling MF, Hill AF, Beyreuther K, Barrow CJ, Masters CL, Collins SJ, Cappai R: Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons. Neurobiol Dis 2001, 8:299-316
19. tom Dieck S, Sanmarti-Vila L, Langnaese K, Richter K, Kindler S, Soyke A, Wex H, Smalla KH, Kampf U, Franzer JT, Stumm M, Garner CC, Gundelfinger ED: Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals. J. Cell Biol 1998, 142:499-509
20. Demart S, Fournier JG, Creminon C, Frobert Y, Lamoury F, Marce D, Lasmezas C, Dormont D, Grassi J, Deslys JP: New insight into abnormal prion protein using monoclonal antibodies. Biochem Biophys Res Commun 1999, 265:652-657
21. Krasemann S, Groschup MH, Harmeyer S, Hunsmann G, Bodemer W: Generation of monoclonal antibodies against human prion proteins in PrP0/0 mice. Mol Med 1996, 2:725-734
22. Faure JP, Mirshahi M, Dorey C, Thillaye B, de Kozak Y, Boucheix C: Production and specificity of monoclonal antibodies to retinal S antigen. Curr Eye Res 1984, 3:867-872
23. von Schantz M, Szel A, van Veen T, Farber DB: Expression of soluble phototransduction-associated proteins in ground squirrel retina. Invest Ophthalmol Vis Sci 1994, 35:3922-3930
24. Mirshahi M, Boucheix C, Collenot G, Thillaye B, Faure JP: Retinal S-antigen epitopes in vertebrate and invertebrate photoreceptors. Invest Ophthalmol Vis Sci 1985, 26:1016-1021
25. Sameshima M, Uehara F, Ohba N: Specialization of the interphotoreceptor matrices around cone and rod photoreceptor cells in the monkey retina, as revealed by lectin cytochemistry. Exp Eye Res 1987, 45:845-863
26. Hageman GS, Johnson LV: Biochemical characterization of the major peanut-agglutinin-binding glycoproteins in vertebrate retinae. J Comp Neurol 1986, 249:499-510, 482-483
27. Wässle H, Yamashita M, Greferath U, Grunert U, Muller F: The rod bipolar cell of the mammalian retina. Vis Neurosci 1991, 7:99-112
28. Hamano K, Kiyama H, Emson PC, Manabe R, Nakauchi M, Tohyama M: Localization of two calcium binding proteins, calbindin (28 kD) and parvalbumin (12 kD), in the vertebrate retina. J Comp Neurol 1990, 302:417-424
29. Brandstätter JH, Fletcher EL, Garner CC, Gundelfinger ED, Wassle H: Differential expression of the presynaptic cytomatrix protein bassoon among ribbon synapses in the mammalian retina. Eur J Neurosci 1999, 11:3683-3693
30. Chishti MA, Strome R, Carlson GA, Westaway D: Syrian hamster prion protein (PrP(C)) is expressed in photoreceptor cells of the adult retina. Neurosci Lett 1997, 234:11-14
31. Herms JW, Madlung A, Brown DR, Kretzschmar HA: Increase of intracellular free Ca2+ in microglia activated by prion protein fragment. Glia 1997, 21:253-257
32. Kercher L, Favara C, Chan CC, Race R, Chesebro B: Differences in scrapie-induced pathology of the retina and brain in transgenic mice that express hamster prion protein in neurons, astrocytes, or multiple cell types. Am J Pathol 2004, 165:2055-2067
33. Head MW, Peden AH, Yull HM, Ritchie DL, Bonshek RE, Tullo AB, Ironside JW: Abnormal prion protein in the retina of the most commonly occurring subtype of sporadic Creutzfeldt-Jakob disease. Br J Ophthalmol 2005, 89:1131-1133
34. Bueler H, Aguzzi A, Sailer A, Greiner RA, Autenried P, Aguet M, Weissmann C: Mice devoid of PrP are resistant to scrapie. Cell 1993, 73:1339-1347
35. Kretzschmar HA, Giese A, Brown DR, Herms J, Keller B, Schmidt B, Groschup M: Cell death in prion disease. J Neural Transm Suppl 1997, 50:191-210
36. Marella M, Chabry J: Neurons and astrocytes respond to prion infection by inducing microglia recruitment. J Neurosci 2004, 24:620-627
37. Combs CK, Johnson DE, Cannady SB, Lehman TM, Landreth GE: Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins. J Neurosci 1999, 19:928-939
38. Lesser RL, Albert DM, Bobowick AR, O'Brien FH: Creutzfeldt-Jakob disease and optic atrophy. Am J Ophthalmol 1979, 87:317-321
39. Tsutsui J, Kawashima S, Kajikawa I, Shirabe T, Terao A: Electrophysiological and pathological studies on Creutzfeldt-Jakob disease with retinal involvement. Doc Ophthalmol 1986, 63:13-21