Assessment of 5-HT 7 receptor agonists selectivity using nociceptive and thermoregulation tests in knockout versus wild-type mice

Advances in Pharmacological Sciences

Volumn 2012, Issue , 2012, Pages

  Brenchat, Alex ^a   Rocasalbas, Maria ^a   Zamanillo, Daniel ^a   Hamon, Michel ^b   Vela, José Miguel ^a   Romero, Luz ^a  

^a Drug Discovery and Preclinical Development   (Spain)

^b SORBONNE UNIVERSITÉ   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; AS 19; E 55888; E 57431; FORMALDEHYDE; SEROTONIN 7 RECEPTOR; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; BASAL BODY TEMPERATURE; BEHAVIOR; BODY TEMPERATURE; CONTROLLED STUDY; GENE INACTIVATION; GENOTYPE; HOT PLATE TEST; HYPERALGESIA; KNOCKOUT MOUSE; LICKING; MOUSE; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; TAIL FLICK TEST; THERMOREGULATION;

EID: 84863673513     PISSN: 16876334     EISSN: 16876342     Source Type: Journal    
DOI: 10.1155/2012/312041     Document Type: Article

References (48)

1. Hedlund P. B., The 5-HT 7 receptor and disorders of the nervous system: an overview Psychopharmacology 2009 206 3 345 354
2. Leopoldo M., Lacivita E., Berardi F., Perrone R., Hedlund P. B., Serotonin 5-HT 7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders Pharmacology and Therapeutics 2011 129 2 120 148
3. Cushing D. J., Zgombick J. M., Nelson D. L., Cohen M. L., LY215840, a high-affinity 5-HT 7 receptor ligand, blocks serotonin-induced relaxation in canine coronary artery Journal of Pharmacology and Experimental Therapeutics 1996 277 3 1560 1566
4. Forbes I. T., Dabbs S., Duckworth D. M., Jennings A. J., King F. D., Lovell P. J., Brown A. M., Collin L., Hagan J. J., Middlemiss D. N., Riley G. J., Thomas D. R., Upton N., (R)-3,N-Dimethyl-N-[1-methyl-3-(4-methyl-piperidin- 1- yl)propyl]benzenesulfonamide: the first selective 5-HT 7 receptor antagonist Journal of Medicinal Chemistry 1998 41 5 655 657 (Pubitemid 28114873)
5. Kikuchi C., Nagaso H., Hiranuma T., Koyama M., Tetrahydrobenzindoles: selective antagonists of the 5-HT 7 receptor Journal of Medicinal Chemistry 1999 42 4 533 535 (Pubitemid 29110768)
6. Lovell P. J., Bromidge S. M., Dabbs S., Duckworth D. M., Forbes I. T., Jennings A. J., King F. D., Middlemiss D. N., Rahman S. K., Saunders D. V., Collin L. L., Hagan J. J., Riley G. J., Thomas D. R., A novel, potent, and selective 5-HT 7 antagonist: (R)-3-(2-(2-(4- methylpiperidin-1-yl)- ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970) Journal of Medicinal Chemistry 2000 43 3 342 345
7. Forbes I. T., Douglas S., Gribble A. D., Ife R. J., Lightfoot A. P., Garner A. E., Riley G. J., Jeffrey P., Stevens A. J., Stean T. O., Thomas D. R., SB-656104-A: a novel 5-HT 7 receptor antagonist with improved in vivo properties Bioorganic and Medicinal Chemistry Letters 2002 12 22 3341 3344 (Pubitemid 35248245)
8. Johansson A. M., Brisander M., Sanin A., Rosqvist S., Mohell N., Malmberg A., 5-Aryl substituted (S)-2-(dimethylamino)-tetralins: novel serotonin 5-HT 7 receptor ligands Proceedings of the 226th American Chemical Society National Meeting 2003 New York, NY, USA
9. Sanin A., Brisander M., Rosqvist S., Mohell N., Malberg A., Johansson A., 5-Aryl substituted (S)-2-(dimethylamino)-tetralins novel serotonin 5HT 7 receptor ligands Proceedings of the 14th Camerino-Noord Symposium 2003 Camerino, Italy Ongoing Progress in the Receptor Chemistry
10. Thomson C. G., Beer M. S., Curtis N. R., Diggle H. J., Handford E., Kulagowski J. J., Thiazoles and thiopyridines: novel series of high affinity h5HT 7 ligands Bioorganic and Medicinal Chemistry Letters 2004 14 3 677 680 (Pubitemid 38114851)
11. Leopoldo M., Berardi F., Colabufo N. A., Contino M., Lacivita E., Niso M., Perrone R., Tortorella V., Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine 7 receptor agents Journal of Medicinal Chemistry 2004 47 26 6616 6624 (Pubitemid 39657323)
12. Leopoldo M., Lacivita E., De Giorgio P., Fracasso C., Guzzetti S., Caccia S., Contino M., Colabufo N. A., Berardi F., Perrone R., Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1- piperazinehexanamides: Influence on lipophilicity and 5-HT 7 receptor activity. Part III Journal of Medicinal Chemistry 2008 51 18 5813 5822
13. Brenchat A., Romero L., Garca M., Pujol M., Burgueo J., Torrens A., Hamon M., Baeyens J. M., Buschmann H., Zamanillo D., Vela J. M., 5-HT 7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice Pain 2009 141 3 239 247
14. Brenchat A., Nadal X., Romero L., Ovalle S., Muro A., Snchez-Arroyos R., Portillo-Salido E., Pujol M., Montero A., Codony X., Burgueo J., Zamanillo D., Hamon M., Maldonado R., Vela J. M., Pharmacological activation of 5-HT 7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity Pain 2010 149 3 483 494
15. Leopoldo M., Lacivita E., Contino M., Colabufo N. A., Berardi F., Perrone R., Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1- yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT 7 receptor agents Journal of Medicinal Chemistry 2007 50 17 4214 4221 (Pubitemid 47301752)
16. Hedlund P. B., Leopoldo M., Caccia S., Sarkisyan G., Fracasso C., Martelli G., Lacivita E., Berardi F., Perrone R., LP-211 is a brain penetrant selective agonist for the serotonin 5-HT 7 receptor Neuroscience Letters 2010 481 1 12 16
17. Brenchat A., Zamanillo D., Hamon M., Romero L., Vela J. M., Role of peripheral versus spinal 5-HT 7 receptors in the modulation of pain under sensitizing conditions European Journal of Pain 2012 16 1 72 81
18. Diaz-Reval M. I., Ventura-Martinez R., Deciga-Campos M., Terron J. A., Cabre F., Lopez-Munoz F. J., Evidence for a central mechanism of action of S-(+)-ketoprofen European Journal of Pharmacology 2004 483 23 241 248 (Pubitemid 38068406)
19. Doly S., Fischer J., Brisorgueil M. J., Vergé D., Conrath M., Pre- and postsynaptic localization of the 5-HT 7 receptor in rat dorsal spinal cord: immunocytochemical evidence Journal of Comparative Neurology 2005 490 3 256 269 (Pubitemid 41140992)
20. Harte S. E., Kender R. G., Borszcz G. S., Activation of 5-H T 1 A and 5-HT 7 receptors in the parafascicular nucleus suppresses the affective reaction of rats to noxious stimulation Pain 2005 113 3 405 415 (Pubitemid 40127524)
21. Meuser T., Pietruck C., Gabriel A., Xie G. X., Lim K. J., Pierce Palmer P., 5-HT 7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons Life Sciences 2002 71 19 2279 2289 (Pubitemid 35246216)
22. Neumaier J. F., Sexton T. J., Yracheta J., Diaz A. M., Brownfield M., Localization of 5-HT 7 receptors in rat brain by immunocytochemistry, in situ hybridization, and agonist stimulated cFos expression Journal of Chemical Neuroanatomy 2001 21 1 63 73 (Pubitemid 32155392)
23. Rocha-Gonzlez H. I., Meneses A., Carlton S. M., Granados-Soto V., Pronociceptive role of peripheral and spinal 5-HT 7 receptors in the formalin test Pain 2005 117 1-2 182 192 (Pubitemid 41764786)
24. Guscott M. R., Egan E., Cook G. P., Stanton J. A., Beer M. S., Rosahl T. W., Hartmann S., Kulagowski J., McAllister G., Fone K. C. F., Hutson P. H., The hypothermic effect of 5-CT in mice is mediated through the 5-HT 7 receptor Neuropharmacology 2003 44 8 1031 1037 (Pubitemid 36570427)
25. Guscott M., Bristow L. J., Hadingham K., Rosahl T. W., Beer M. S., Stanton J. A., Bromidge F., Owens A. P., Huscroft I., Myers J., Rupniak N. M., Patel S., Whiting P. J., Hutson P. H., Fone K. C., Biello S. M., Kulagowski J. J., McAllister G., Genetic knockout and pharmacological blockade studies of the 5-HT 7 receptor suggest therapeutic potential in depression Neuropharmacology 2005 48 4 492 502 (Pubitemid 40332407)
26. Hagan J. J., Price G. W., Jeffrey P., Deeks N. J., Stean T., Piper D., Smith M. I., Upton N., Medhurst A. D., Middlemiss D. N., Riley G. J., Lovell P. J., Bromidge S. M., Thomas D. R., Characterization of SB-269970-A, a selective 5-HT 7 receptor antagonist British Journal of Pharmacology 2000 130 3 539 548 (Pubitemid 30332971)
27. Hedlund P. B., Danielson P. E., Thomas E. A., Slanina K., Carson M. J., Sutcliffe J. G., No hypothermic response to serotonin in 5-HT 7 receptor knockout mice Proceedings of the National Academy of Sciences of the United States of America 2003 100 3 1375 1380 (Pubitemid 36184009)
28. Hedlund P. B., Kelly L., Mazur C., Lovenberg T., Sutcliffe J. G., Bonaventure P., 8-OH-DPAT acts on both 5-H T 1 A and 5-HT 7 receptors to induce hypothermia in rodents European Journal of Pharmacology 2004 487 13 125 132 (Pubitemid 38368989)
29. Zimmermann M., Ethical guidelines for investigations of experimental pain in conscious animals Pain 1983 16 2 109 110 (Pubitemid 13058546)
30. DAmour F. E., Smith D. L., A method for determining loss of pain sensation Journal of Pharmacology and Experimental Therapeutics 1941 72 1 74 79
31. Ramabadran K., Bansinath M., Turndorf H., Puig M. M., Tail immersion test for the evaluation of a nociceptive reaction in mice. Methodological considerations Journal of Pharmacological Methods 1989 21 1 21 31 (Pubitemid 19064683)
32. Woolfe G., MacDonald A. D., The evaluation of the analgesic action of pethidine hydrochloride (Demerol) Journal of Pharmacology and Experimental Therapeutics 1944 80 3 300 307
33. Hunskaar S., Hole K., The formalin test in mice: dissociation between inflammatory and non-inflammatory pain Pain 1987 30 1 103 114 (Pubitemid 17094194)
34. Galici R., Boggs J. D., Miller K. L., Bonaventure P., Atack J. R., Effects of SB-269970, a 5-HT 7 receptor antagonist, in mouse models predictive of antipsychotic-like activity Behavioural Pharmacology 2008 19 2 153 159 (Pubitemid 351365693)
35. Hedlund P. B., Huitron-Resendiz S., Henriksen S. J., Sutcliffe J. G., 5-HT 7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern Biological Psychiatry 2005 58 10 831 837 (Pubitemid 41677422)
36. Liu J., Akay T., Hedlund P. B., Pearson K. G., Jordan L. M., Spinal 5-HT 7 receptors are critical for alternating activity during locomotion: In vitro neonatal and in vivo adult studies using 5-HT 7 receptor knockout mice Journal of Neurophysiology 2009 102 1 337 348
37. Shelton J., Bonaventure P., Li X., Yun S., Lovenberg T., Dugovic C., 5-HT 7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-H T 1 A receptor Neuropharmacology 2009 56 448 454
38. Roberts A. J., Krucker T., Levy C. L., Slanina K. A., Sutcliffe J. G., Hedlund P. B., Mice lacking 5-HT 7 receptors show specific impairments in contextual learning European Journal of Neuroscience 2004 19 7 1913 1922 (Pubitemid 38482579)
39. Sarkisyan G., Hedlund P. B., The 5-HT 7 receptor is involved in allocentric spatial memory information processing Behavioural Brain Research 2009 202 1 26 31
40. Semenova S., Geyer M. A., Sutcliffe J. G., Markou A., Hedlund P. B., Inactivation of the 5-HT 7 receptor partially blocks phencyclidine-induced disruption of prepulse inhibition Biological Psychiatry 2008 63 1 98 105 (Pubitemid 350234877)
41. Coderre T. J., Melzack R., The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury Journal of Neuroscience 1992 12 9 3665 3670
42. Tjlsen A., Berge O. G., Hunskaar S., Rosland J. H., Hole K., The formalin test: an evaluation of the method Pain 1992 51 1 5 17
43. Vissers K., Hoffmann V., Geenen F., Biermans R., Meert T., Is the second phase of the formalin test useful to predict activity in chronic constriction injury models? A pharmacological comparison in different species Pain Practice 2003 3 298 309
44. Brenchat A., Ejarque M., Zamanillo D., Vela J. M., Romero L., Potentiation of morphine analgesia by adjuvant activation of 5-HT 7 receptors Journal of Pharmacological Sciences 2011 116 4 388 391
45. Dogrul A., Ossipov M. H., Porreca F., Differential mediation of descending pain facilitation and inhibition by spinal 5HT 3 and 5HT 7 receptors Brain Research 2009 1280 52 59
46. Dogrul A., Seyrek M., Systemic morphine produce antinociception mediated by spinal 5-HT 7, but not 5-H T 1 A and 5-HT 2 receptors in the spinal cord British Journal of Pharmacology 2006 149 5 498 505 (Pubitemid 44658510)
47. Yanarates O., Dogrul A., Yildirim V., Sahin A., Sizlan A., Seyrek M., Akgl.., Kozak O., Kurt E., Aypar U., Spinal 5-HT 7 receptors play an important role in the antinociceptive and antihyperalgesic effects of tramadol and its metabolite, o-desmethyltramadol, via activation of descending serotonergic pathways Anesthesiology 2010 112 3 696 710
48. Kalkman H. O., Neumann V., Evidence for a 5-H T 1 D receptor-mediated hypothermic effect of the 1-adrenoceptor agonist, SDZ NVI-085, in guinea-pigs European Journal of Pharmacology 1995 285 3 313 315