Pharmacological activation of 5-HT7 receptors reduces nerve injury-induced mechanical and thermal hypersensitivity

Pain

Volumn 149, Issue 3, 2010, Pages 483-494

  Brenchat, Alex ^a   Nadal, Xavier ^b   Romero, Luz ^a   Ovalle, Sergio ^a   Muro, Asunción ^a   Sánchez Arroyos, Ricard ^a   Portillo Salido, Enrique ^a   Pujol, Marta ^a   Montero, Ana ^a   Codony, Xavier ^a   Burgueño, Javier ^a   Zamanillo, Daniel ^a   Hamon, Michel ^c   Maldonado, Rafael ^b   Vela, José Miguel ^a  

^a Esteve ^*  (Spain)

^b UNIVERSITAT POMPEU FABRA   (Spain)

^c INSERM   (France)

Author keywords

Allodynia; Hyperalgesia; Hypersensitivity; Neuropathic pain; Pain; Serotonin 5 HT7 receptor; Spinal cord

Indexed keywords

2 [2 (DIMETHYLAMINO)ETHYL] 4 (1,3,5 TRIMETHYL 1H PYRAZOL 4 YL)PHENOL; 3,N DIMETHYL N [1 METHYL 3 (4 METHYL 1 PIPERIDINYL)PROPYL]BENZENESULFONAMIDE; AS 19; DIMETHYL[5 (1,3,5 TRIMETHYL 1H PYRAZOL 4 YL) 1,2,3,4 TETRAHYDRONAPHTHALEN 2 YL]AMINE; E 57431; SEROTONIN 7 RECEPTOR; SEROTONIN AGONIST; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG EFFICACY; DRUG TARGETING; EVOKED RESPONSE; EXPERIMENTAL MOUSE; GABAERGIC SYSTEM; HEAT SENSITIVITY; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; INTERNEURON; MOUSE; NERVE INJURY; NERVE STIMULATION; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; SHAM PROCEDURE; SPINAL CORD DORSAL HORN;

ANALGESIA; ANIMALS; DISEASE MODELS, ANIMAL; HYPERALGESIA; MALE; MICE; PAIN MEASUREMENT; PAIN THRESHOLD; PERIPHERAL NERVOUS SYSTEM DISEASES; PYRAZOLES; RECEPTORS, SEROTONIN; SEROTONIN RECEPTOR AGONISTS; TETRAHYDRONAPHTHALENES; TREATMENT OUTCOME;

EID: 77952321659     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2010.03.007     Document Type: Article

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