Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1

Journal of Biological Chemistry

Volumn 287, Issue 28, 2012, Pages 23698-23709

  Collak, Filiz Kisaayak ^a,b   Yagiz, Kader ^a,b   Luthringer, Daniel J ^c   Erkaya, Bahriye ^a,b   Cinar, Bekir ^a,b  

^a Samuel Oschin Comprehensive Cancer Institute   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTORS; ANTI-TUMOR ACTIVITIES; CANCER CELL GROWTH; CANCER CELLS; CELL RESISTANCE; IMMUNOHISTOCHEMISTRY; LY294002; MAMMALIAN TARGET; MAMMALIAN TARGET OF RAPAMYCIN (MTOR); NUCLEAR LOCALIZATION; PROSTATE CANCER CELLS; PROSTATE CANCERS; PROSTATE TUMOR; SMALL MOLECULE INHIBITOR; UP-REGULATION;

AMINO ACIDS; CELL DEATH; DISEASES; ENZYMES; GENE EXPRESSION; MAMMALS; MUTAGENESIS; PHOSPHORYLATION;

ANTIBIOTICS;

ANDROGEN RECEPTOR; MAMMALIAN STERILE 20 LIKE KINASE 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; PROTEIN KINASE B; THREONINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CASTRATION RESISTANT PROSTATE CANCER; CELL GROWTH; CELL NUCLEUS; CELL STRAIN LNCAP; CELL SURVIVAL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; REGULATORY MECHANISM; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL NUCLEUS; CHROMONES; HEK293 CELLS; HELA CELLS; HUMANS; MALE; MICE; MICE, NUDE; MORPHOLINES; NEOPLASMS, EXPERIMENTAL; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRIMIDINES; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SIROLIMUS; THREONINE; TOR SERINE-THREONINE KINASES; TRANSPLANTATION, HETEROLOGOUS; TUMOR BURDEN;

MAMMALIA;

EID: 84863618427     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.358713     Document Type: Article

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