Retraction: Regulation of Proapoptotic Mammalian ste20–Like Kinase MST2 by the IGF1-Akt Pathway (PLoS ONE (2010) 5:3 (e961) DOI: 10.1371/journal.pone.0009616);Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway

PLoS ONE

Volumn 5, Issue 3, 2010, Pages

  Kim, Donghwa ^a   Shu, Shaokun ^a   Coppola, Marc D ^a   Kaneko, Satoshi ^a,b   Yuan, Zeng Qiang ^a,c   Cheng, Jin Q ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c INSTITUTE OF BIOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MITOGEN ACTIVATED PROTEIN KINASE; MST2 PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SOMATOMEDIN; SOMATOMEDIN 1; THREONINE; UNCLASSIFIED DRUG; CASPASE 3; CASPASE 7; PROTEIN SERINE THREONINE KINASE; SOMATOMEDIN C; STK3 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; APOPTOSIS; ARTICLE; AUTOPHOSPHORYLATION; BREAST TUMOR; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; GENE CONTROL; GROWTH DISORDER; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; PROTEIN CLEAVAGE; PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ACTIVE TRANSPORT; ANIMAL; CELL LINE; CELL STRAIN COS1; CERCOPITHECUS; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PHOSPHORYLATION;

MAMMALIA;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BREAST NEOPLASMS; CASPASE 3; CASPASE 7; CELL LINE; CERCOPITHECUS AETHIOPS; COS CELLS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INSULIN-LIKE GROWTH FACTOR I; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 77949718255     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0289329     Document Type: Erratum

References (42)

1. Creasy CL, Chernoff J (1995) Cloning and characterization of a human protein kinase with homology to Ste20. J Biol Chem 270: 21695-21700.
2. Vaux DL, Korsmeyer SJ (1999) Cell death in development. Cell 96: 245-254.
3. Kyriakis JM (1999) Signaling by the germinal center kinase family of protein kinases. J Biol Chem 274: 5259-5262.
4. Taylor LK, Wang HC, Erikson RL (1996) Newly identified stress-responsive protein kinases, Krs-1 and Krs-2. Proc Natl Acad Sci U S A 93: 10099-10104.
5. Graves JD, Gotoh Y, Draves KE, Ambrose D, Han DK, et al. (1998) Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1. Embo J 17: 2224-2234.
6. Lee KK, Murakawa M, Nishida E, Tsubuki S, Kawashima S, et al. (1998) Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis. Oncogene 16: 3029-3037.
7. Cheung WL, Ajiro K, Samejima K, Kloc M, Cheung P, et al. (2003) Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase. Cell 113: 507-517.
8. O'Neill E, Rushworth L, Baccarini M, Kolch W (2004) Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1. Science 306: 2267-2270.
9. O'Neill E, Kolch W (2005) Taming the Hippo: Raf-1 controls apoptosis by suppressing MST2/Hippo. Cell Cycle 4: 365-367.
10. Khokhlatchev A, Rabizadeh S, Xavier R, Nedwidek M, Chen T, et al. (2002) Identification of a novel Ras-regulated proapoptotic pathway. Curr Biol 12: 253-265.
11. Praskova M, Khoklatchev A, Ortiz-Vega S, Avruch J (2004) Regulation of the MST1 kinase by autophosphorylation, by the growth inhibitory proteins, RASSF1 and NORE1, and by Ras. Biochem J 381: 453-462.
12. Oh HJ, Lee KK, Song SJ, Jin MS, Song MS, et al. (2006) Role of the tumor suppressor RASSF1A in Mst1-mediated apoptosis. Cancer Res 66: 2562-2569.
13. Matallanas D, Romano D, Yee K, Meissl K, Kucerova L, et al. (2007) RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. Mol Cell 27: 962-975.
14. Vichalkovski A, Gresko E, Cornils H, Hergovich A, Schmitz D, et al. (2008) NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis. Curr Biol 18: 1889-1895.
15. Zhou D, Medoff BD, Chen L, Li L, Zhang XF, et al. (2008) The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells. Proc Natl Acad Sci U S A 105: 20321-20326.
16. Guo C, Tommasi S, Liu L, Yee JK, Dammann R, et al. (2007) RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network. Curr Biol 17: 700-705.
17. Ikeda M, Kawata A, Nishikawa M, Tateishi Y, Yamaguchi M, et al. (2009) Hippo pathway-dependent and -independent roles of RASSF6. Sci Signal 2: ra59.
18. Harvey KF, Pfleger CM, Hariharan IK (2003) The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell 114: 457-467.
19. Wu S, Huang J, Dong J, Pan D (2003) hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell 114: 445-456.
20. Huang J, Wu S, Barrera J, Matthews K, Pan D (2005) The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 122: 421-434.
21. Dong J, Feldmann G, Huang J, Wu S, Zhang N, et al. (2007) Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130: 1120-1133.
22. Zhao B, Wei X, Li W, Udan RS, Yang Q, et al. (2007) Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev 21: 2747-2761.
23. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, et al. (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318-1321.
24. Dan HC, Sun M, Kaneko S, Feldman RI, Nicosia SV, et al. (2004) Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem 279: 5405-5412.
25. Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13: 2905-2927.
26. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
27. Greer EL, Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24: 7410-7425.
28. Kim AH, Khursigara G, Sun X, Franke TF, Chao MV (2001) Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 21: 893-901.
29. Goswami A, Burikhanov R, de Thonel A, Fujita N, Goswami M, et al. (2005) Binding and phosphorylation of par-4 by akt is essential for cancer cell survival. Mol Cell 20: 33-44.
30. Gardai SJ, Hildeman DA, Frankel SK, Whitlock BB, Frasch SC, et al. (2004) Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biol Chem 279: 21085-21095.
31. Xin M, Deng X (2005) Nicotine inactivation of the proapoptotic function of Bax through phosphorylation. J Biol Chem 280: 10781-10789.
32. Yang L, Sun M, Sun XM, Cheng GZ, Nicosia SV, et al. (2007) Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212. J Biol Chem 282: 10981-10987.
33. Creasy CL, Chernoff J (1995) Cloning and characterization of a member of the MST subfamily of Ste20-like kinases. Gene 167: 303-306.
34. Sun M, Wang G, Paciga JE, Feldman RI, Yuan ZQ, et al. (2001) AKT1/ PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells. Am J Pathol 159: 431-437.
35. Yang L, Dan HC, Sun M, Liu Q, Sun XM, et al. (2004) Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res 64: 4394-4399.
36. Praskova M, Xia F, Avruch J (2008) MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation. Curr Biol 18: 311-321.
37. Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G (2003) Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol 5: 914-920.
38. Saucedo LJ, Edgar BA (2007) Filling out the Hippo pathway. Nat Rev Mol Cell Biol 8: 613-621.
39. Verdu J, Buratovich MA, Wilder EL, Birnbaum MJ (1999) Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat Cell Biol 1: 500-506.
40. Miron M, Lasko P, Sonenberg N (2003) Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Mol Cell Biol 23: 9117-9126.
41. Jang SW, Yang SJ, Srinivasan S, Ye K (2007) Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation. J Biol Chem 282: 30836-30844.
42. Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, et al. (2007) The proapoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1. EMBO J 26: 4523-4534.