A mechanism for synergy with combined mTOR and Pi3 kinase inhibitors

PLoS ONE

Volumn 6, Issue 10, 2011, Pages

  Yang, Shujie ^a,b   Xiao, Xue ^a,b   Meng, Xiangbing ^a,b   Leslie, Kimberly K ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; 2 (2 DIFLUOROMETHYLBENZIMIDAZOL 1 YL) 4,6 DIMORPHOLINO 1,3,5 TRIAZINE; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P27; S6 KINASE; TEMSIROLIMUS; DRUG DERIVATIVE; IMIDAZOLE DERIVATIVE; MTOR PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PTEN PROTEIN, HUMAN; QUINOLINE DERIVATIVE; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE; TRIAZINE DERIVATIVE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CANCER INHIBITION; CANCER RESISTANCE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CELL POPULATION; CELL VIABILITY; COMPARATIVE EFFECTIVENESS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG RESPONSE; DRUG SENSITIVITY; ENDOMETRIUM CANCER; ENZYME INACTIVATION; IN VITRO STUDY; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION; CELL CYCLE; CELL DIVISION; DRUG ANTAGONISM; HUMAN; METABOLISM; PHOSPHORYLATION; TUMOR CELL LINE; WESTERN BLOTTING;

MAMMALIA;

BLOTTING, WESTERN; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; DRUG SYNERGISM; HUMANS; IMIDAZOLES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; QUINOLINES; SIROLIMUS; TOR SERINE-THREONINE KINASES; TRIAZINES;

EID: 80054785459     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0026343     Document Type: Article

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