메뉴 건너뛰기




Volumn 189, Issue 2, 2012, Pages 1081-1093

IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and b cell-intrinsic mechanisms

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; INTERLEUKIN 21; INTERLEUKIN 21 RECEPTOR;

EID: 84863617821     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1200318     Document Type: Article
Times cited : (32)

References (54)
  • 2
    • 0036852893 scopus 로고    scopus 로고
    • Interleukin-21 and the IL-21 receptor: Novel effectors of NK and T cell responses
    • Parrish-Novak, J., D. C. Foster, R. D. Holly, and C. H. Clegg. 2002. Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses. J. Leukoc. Biol. 72: 856-863. (Pubitemid 35365159)
    • (2002) Journal of Leukocyte Biology , vol.72 , Issue.5 , pp. 856-863
    • Parrish-Novak, J.1    Foster, D.C.2    Holly, R.D.3    Clegg, C.H.4
  • 5
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang, A., H. M. McGuire, D. Yu, J. Sprent, C. R. Mackay, and C. King. 2008. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29: 127-137.
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1    McGuire, H.M.2    Yu, D.3    Sprent, J.4    Mackay, C.R.5    King, C.6
  • 10
    • 33749531054 scopus 로고    scopus 로고
    • Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21
    • Good, K. L., V. L. Bryant, and S. G. Tangye. 2006. Kinetics of human B cell behavior and amplification of proliferative responses following stimulation with IL-21. J. Immunol. 177: 5236-5247. (Pubitemid 44527596)
    • (2006) Journal of Immunology , vol.177 , Issue.8 , pp. 5236-5247
    • Good, K.L.1    Bryant, V.L.2    Tangye, S.G.3
  • 15
    • 33749552196 scopus 로고    scopus 로고
    • Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis
    • DOI 10.1111/j.1365-3083.2006.01795.x
    • Li, J., W. Shen, K. Kong, and Z. Liu. 2006. Interleukin-21 induces T-cell activation and proinflammatory cytokine secretion in rheumatoid arthritis. Scand. J. Immunol. 64: 515-522. (Pubitemid 44536336)
    • (2006) Scandinavian Journal of Immunology , vol.64 , Issue.5 , pp. 515-522
    • Li, J.1    Shen, W.2    Kong, K.3    Liu, Z.4
  • 16
    • 84863634084 scopus 로고    scopus 로고
    • Elevated IL-21 expression in serum and peripheral blood mononuclear cells from lupus patients
    • Nguyen, V., B. Siaton, S. Shorter, and V. Rus. 2008. Elevated IL-21 expression in serum and peripheral blood mononuclear cells from lupus patients. Arthritis Rheum. 58: S816.
    • (2008) Arthritis Rheum. , vol.58
    • Nguyen, V.1    Siaton, B.2    Shorter, S.3    Rus, V.4
  • 17
    • 63749101171 scopus 로고    scopus 로고
    • Changes of serum BAFF and IL-21 levels in patients with systemic lupus erythematosus and their clinical significance
    • Wang, X. F., S. L. Yuan, L. Jiang, X. L. Zhang, S. F. Li, Y. Guo, C. L. Wu, and J. J. Chen. 2007. [Changes of serum BAFF and IL-21 levels in patients with systemic lupus erythematosus and their clinical significance]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23: 1041-1042.
    • (2007) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi , vol.23 , pp. 1041-1042
    • Wang, X.F.1    Yuan, S.L.2    Jiang, L.3    Zhang, X.L.4    Li, S.F.5    Guo, Y.6    Wu, C.L.7    Chen, J.J.8
  • 22
    • 33947215987 scopus 로고    scopus 로고
    • IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression
    • Herber, D., T. P. Brown, S. Liang, D. A. Young, M. Collins, and K. Dunussi-Joannopoulos. 2007. IL-21 has a pathogenic role in a lupus-prone mouse model and its blockade with IL-21R.Fc reduces disease progression. J. Immunol. 178: 3822-3830. (Pubitemid 46417651)
    • (2007) Journal of Immunology , vol.178 , Issue.6 , pp. 3822-3830
    • Herber, D.1    Brown, T.P.2    Liang, S.3    Young, D.A.4    Collins, M.5    Dunussi-Joannopoulos, K.6
  • 23
    • 35748930247 scopus 로고    scopus 로고
    • Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus
    • DOI 10.1196/annals.1423.063, Autoimmunity, Part B Novel Applications of Basic Research
    • Bubier, J. A., S. M. Bennett, T. J. Sproule, B. L. Lyons, S. Olland, D. A. Young, and D. C. Roopenian. 2007. Treatment of BXSB-Yaa mice with IL-21R-Fc fusion protein minimally attenuates systemic lupus erythematosus. Ann. N. Y. Acad. Sci. 1110: 590-601. (Pubitemid 350043049)
    • (2007) Annals of the New York Academy of Sciences , vol.1110 , pp. 590-601
    • Bubier, J.A.1    Bennett, S.M.2    Sproule, T.J.3    Lyons, B.L.4    Olland, S.5    Young, D.A.6    Roopenian, D.C.7
  • 25
    • 77952973583 scopus 로고    scopus 로고
    • Advances in lupus stemming from the parent-into-F1 model
    • Via, C. S. 2010. Advances in lupus stemming from the parent-into-F1 model. Trends Immunol. 31: 236-245.
    • (2010) Trends Immunol. , vol.31 , pp. 236-245
    • Via, C.S.1
  • 28
    • 77953020478 scopus 로고    scopus 로고
    • Donor CD8 T cell activation is critical for greater renal disease severity in female chronic graft-vs.-host mice and is associated with increased splenic ICOS(hi) host CD4 T cells and IL-21 expression
    • Foster, A. D., M. Haas, I. Puliaeva, K. Soloviova, R. Puliaev, and C. S. Via. 2010. Donor CD8 T cell activation is critical for greater renal disease severity in female chronic graft-vs.-host mice and is associated with increased splenic ICOS(hi) host CD4 T cells and IL-21 expression. Clin. Immunol. 136: 61-73.
    • (2010) Clin. Immunol. , vol.136 , pp. 61-73
    • Foster, A.D.1    Haas, M.2    Puliaeva, I.3    Soloviova, K.4    Puliaev, R.5    Via, C.S.6
  • 29
    • 67349262037 scopus 로고    scopus 로고
    • TRAIL, DR4 and DR5 are upregulated in kidneys from patients with lupus nephritis and exert proliferative and proinflammatory effects
    • Nguyen, V., C. Cudrici, V. Zernetkina, F. Niculescu, H. Rus, C. Drachenberg, and V. Rus. 2009. TRAIL, DR4 and DR5 are upregulated in kidneys from patients with lupus nephritis and exert proliferative and proinflammatory effects. Clin. Immunol. 132: 32-42.
    • (2009) Clin. Immunol. , vol.132 , pp. 32-42
    • Nguyen, V.1    Cudrici, C.2    Zernetkina, V.3    Niculescu, F.4    Rus, H.5    Drachenberg, C.6    Rus, V.7
  • 30
    • 0037389562 scopus 로고    scopus 로고
    • Enhanced susceptibility to end-organ disease in the lupus-facilitating NZW mouse strain
    • DOI 10.1002/art.10887
    • Xie, C., X. J. Zhou, X. Liu, and C. Mohan. 2003. Enhanced susceptibility to end-organ disease in the lupus-facilitating NZW mouse strain. Arthritis Rheum. 48: 1080-1092. (Pubitemid 36418251)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.4 , pp. 1080-1092
    • Xie, C.1    Zhou, X.J.2    Liu, X.3    Mohan, C.4
  • 32
    • 0029153107 scopus 로고
    • Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells
    • Rus, V., A. Svetic, P. Nguyen, W. C. Gause, and C. S. Via. 1995. Kinetics of Th1 and Th2 cytokine production during the early course of acute and chronic murine graft-versus-host disease. Regulatory role of donor CD8+ T cells. J. Immunol. 155: 2396-2406.
    • (1995) J. Immunol. , vol.155 , pp. 2396-2406
    • Rus, V.1    Svetic, A.2    Nguyen, P.3    Gause, W.C.4    Via, C.S.5
  • 33
    • 62849090439 scopus 로고    scopus 로고
    • Cytokine-secreting follicular T cells shape the antibody repertoire
    • Reinhardt, R. L., H. E. Liang, and R. M. Locksley. 2009. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat. Immunol. 10: 385-393.
    • (2009) Nat. Immunol. , vol.10 , pp. 385-393
    • Reinhardt, R.L.1    Liang, H.E.2    Locksley, R.M.3
  • 34
    • 79952675131 scopus 로고    scopus 로고
    • Follicular helper CD4 T cells (TFH)
    • Crotty, S. 2011. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29: 621-663.
    • (2011) Annu. Rev. Immunol. , vol.29 , pp. 621-663
    • Crotty, S.1
  • 35
    • 0025138736 scopus 로고
    • Autoantibodies in chronic graft versus host result from cognate T-B interactions
    • Morris, S. C., R. L. Cheek, P. L. Cohen, and R. A. Eisenberg. 1990. Autoantibodies in chronic graft versus host result from cognate T-B interactions. J. Exp. Med. 171: 503-517. (Pubitemid 20059044)
    • (1990) Journal of Experimental Medicine , vol.171 , Issue.2 , pp. 503-517
    • Morris, S.C.1    Cheek, R.L.2    Cohen, P.L.3    Eisenberg, R.A.4
  • 39
    • 62449202866 scopus 로고    scopus 로고
    • Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches
    • Tsuji, M., N. Komatsu, S. Kawamoto, K. Suzuki, O. Kanagawa, T. Honjo, S. Hori, and S. Fagarasan. 2009. Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science 323: 1488-1492.
    • (2009) Science , vol.323 , pp. 1488-1492
    • Tsuji, M.1    Komatsu, N.2    Kawamoto, S.3    Suzuki, K.4    Kanagawa, O.5    Honjo, T.6    Hori, S.7    Fagarasan, S.8
  • 40
    • 10944228245 scopus 로고    scopus 로고
    • + T cells
    • DOI 10.1002/eji.200425478
    • Ebert, L. M., M. P. Horn, A. B. Lang, and B. Moser. 2004. B cells alter the phenotype and function of follicular-homing CXCR5+ T cells. Eur. J. Immunol. 34: 3562-3571. (Pubitemid 40012174)
    • (2004) European Journal of Immunology , vol.34 , Issue.12 , pp. 3562-3571
    • Ebert, L.M.1    Horn, M.P.2    Lang, A.B.3    Moser, B.4
  • 45
    • 1242267910 scopus 로고    scopus 로고
    • + Regulatory T Cells Generated Ex Vivo with IL-2 and TGF-beta Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome
    • Zheng, S. G., J. H. Wang, M. N. Koss, F. Quismorio, Jr., J. D. Gray, and D. A. Horwitz. 2004. CD4+ and CD8+ regulatory T cells generated ex vivo with IL-2 and TGF-beta suppress a stimulatory graft-versus-host disease with a lupus-like syndrome. J. Immunol. 172: 1531-1539. (Pubitemid 38116797)
    • (2004) Journal of Immunology , vol.172 , Issue.3 , pp. 1531-1539
    • Zheng, S.G.1    Wang, J.H.2    Koss, M.N.3    Quismorio Jr., F.4    Gray, J.D.5    Horwitz, D.A.6
  • 46
    • 33846900430 scopus 로고    scopus 로고
    • high T regulatory cell function in patients with active systemic lupus erythematosus
    • Valencia, X., C. Yarboro, G. Illei, and P. E. Lipsky. 2007. Deficient CD4+ CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J. Immunol. 178: 2579-2588. (Pubitemid 46233461)
    • (2007) Journal of Immunology , vol.178 , Issue.4 , pp. 2579-2588
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 47
    • 38349178776 scopus 로고    scopus 로고
    • Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    • Hsu, H. C., P. Yang, J. Wang, Q. Wu, R. Myers, J. Chen, J. Yi, T. Guentert, A. Tousson, A. L. Stanus, et al. 2008. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat. Immunol. 9: 166-175.
    • (2008) Nat. Immunol. , vol.9 , pp. 166-175
    • Hsu, H.C.1    Yang, P.2    Wang, J.3    Wu, Q.4    Myers, R.5    Chen, J.6    Yi, J.7    Guentert, T.8    Tousson, A.9    Stanus, A.L.10
  • 48
    • 55249119291 scopus 로고    scopus 로고
    • IL-17 and the Th17 lineage in systemic lupus erythematosus
    • Garrett-Sinha, L. A., S. John, and S. L. Gaffen. 2008. IL-17 and the Th17 lineage in systemic lupus erythematosus. Curr. Opin. Rheumatol. 20: 519-525.
    • (2008) Curr. Opin. Rheumatol. , vol.20 , pp. 519-525
    • Garrett-Sinha, L.A.1    John, S.2    Gaffen, S.L.3
  • 50
    • 46749156754 scopus 로고    scopus 로고
    • Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
    • Coquet, J. M., S. Chakravarti, M. J. Smyth, and D. I. Godfrey. 2008. Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis. J. Immunol. 180: 7097-7101.
    • (2008) J. Immunol. , vol.180 , pp. 7097-7101
    • Coquet, J.M.1    Chakravarti, S.2    Smyth, M.J.3    Godfrey, D.I.4
  • 51
    • 46749133961 scopus 로고    scopus 로고
    • IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo
    • Sonderegger, I., J. Kisielow, R. Meier, C. King, and M. Kopf. 2008. IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo. Eur. J. Immunol. 38: 1833-1838.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1833-1838
    • Sonderegger, I.1    Kisielow, J.2    Meier, R.3    King, C.4    Kopf, M.5
  • 52
  • 53
    • 52049095927 scopus 로고    scopus 로고
    • The modulatory capacity of interleukin-21 in the pathogenesis of autoimmune disease
    • Vogelzang, A., and C. King. 2008. The modulatory capacity of interleukin-21 in the pathogenesis of autoimmune disease. Front. Biosci. 13: 5304-5315.
    • (2008) Front. Biosci. , vol.13 , pp. 5304-5315
    • Vogelzang, A.1    King, C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.