Administration of selective endothelin receptor type A antagonist Ro 61- 1790 does not improve outcome in focal cerebral ischemia in cat

Journal of Cerebral Blood Flow and Metabolism

Volumn 20, Issue 3, 2000, Pages 499-504

  Bhardwaj, Anish ^a,b   Wu, Ying ^a   Hum, Patricia D ^a   Kirsch, Jeffrey R ^a   Traystman, Richard J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

Endothelin; Endothelin receptor type A antagonist; Focal ischemia; Middle cerebral artery occlusion; Neuroprotection

Indexed keywords

5 METHYLPYRIDINE 2 SULFONIC ACID 6 (2 HYDROXYETHOXY) 5 (2 METHOXYPHENOXY) 2 (2 1H TETRAZOL 5 YLPYRIDIN 4 YL)PYRIMIDIN 4 YLAMIDE SODIUM; CLAZOSENTAN; ENDOTHELIN A RECEPTOR ANTAGONIST; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; BRAIN PROTECTION; CAT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG SELECTIVITY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MORTALITY; NONHUMAN; PIA ARTERY; PRIORITY JOURNAL; STROKE;

EID: 0034066699     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200003000-00008     Document Type: Article

References (10)

1. Armstead WM, Mirro R, Leffler CW, Busija DW (1989) Influence of endothelin on piglet cerebral microcirculation. Am J Physiol 257:H707-H710
2. Barone FC, Globus MY-T, Price WJ, White RF, Storer BL, Feuerstein GZ, et al. (1994) Endothelin levels increase in rat focal and global ischemia. J Cereb Blood Flow Metab 14:337-342
3. Baskin DS, Widmayer MA, Browning JL, Heizer ML, Schmidt WK (1994) Evaluation of delayed treatment of focal cerebral ischemia with three selective κ-opioid agonists agonists in cats. Stroke 25: 2047-2054
4. Bederson JB, Pitts LH, Germano SM, Nishimura MC, Davis RL, Bartkowski HM (1986) Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17:1304-1308
5. Berrino L, D'Amico M, Pizziruso A, Vitagliano S, Rossi F (1994) Excitatory amino acids modulate the cardiovascular effects of endothelin-1 in the periaqueductal gray area. Br J Pharmacol 111:173P
6. Takeshima R, Kirsch JR, Koehler RC, Gomoll AW, Traystman RJ (1992) Monoclonal leukocyte antibody (MoAb 60.3) does not decrease injury following transient focal cerebral ischemia in cats. Stroke 23:247-252
7. Tatlisumak T, Carano RA, Takano K, Opgenorth TJ, Sotak CH, Fisher M (1998) A novel endothelin antagonist, A-127722, attenuates ischemic lesion size in rats with temporary middle cerebral artery occlusion: a diffusion and perfusion MRI study. Stroke 29:850-857
8. Willette RN, Sauermelch C, Ezekiel M, Fuerstein G, Ohlstein EH (1990) Effect of endothelin on conical microvascular perfusion in rats. Stroke 21:451-458
9. Yanasgisawa M, Kurihara H, Kimura S, Tomobe Y, Kobayashi M, Mitsui Y, et al. (1988) A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332:411-415
10. Ziv I, Fleminger G, Djaldetti R, Achiron A, Melamed E, Sokolovsky M (1992) Increased plasma endothelin-1 in acute ischemic stroke. Stroke 23:1014-1016