Synergistic effect of an endothelin type A receptor antagonist, S-0139, with rtPA on the neuroprotection after embolic stroke

Stroke

Volumn 39, Issue 10, 2008, Pages 2830-2836

  Zhang, Rui Lan ^a   Zhang, Chunling ^a   Zhang, Li ^a   Roberts, Cindi ^a   Lu, Mei ^a   Kapke, Alissa ^a   Cui, Yisheng ^a   Ninomiya, Mitsuyoshi ^b   Nagafuji, Toshiaki ^b   Albala, Bruce ^b   Zhang, Zheng Gang ^a   Chopp, Michael ^a,c  

^a HENRY FORD HOSPITAL   (United States)

^b SHIONOGI AND CO LTD   (Japan)

^c OAKLAND UNIVERSITY   (United States)

Author keywords

Antagonist; Embolic; Integrity; Patency; Rat; Stroke

Indexed keywords

27 O [3 [2 (3 CARBOXYACRYLOYLAMINO) 5 HYDROXYPHENYL]ACRYLOYLOXY]MYRICERONE; ALTEPLASE; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; INTERCELLULAR ADHESION MOLECULE 1; LAMININ; OCCLUDIN; PROTEIN ZO1; PROTEINASE ACTIVATED RECEPTOR 1; SODIUM CHLORIDE; CAFFEIC ACID DERIVATIVE; COLLAGEN TYPE 4; DRUG DERIVATIVE; ENDOTHELIN RECEPTOR; FIBRINOLYTIC AGENT; NEUROPROTECTIVE AGENT; OLEANOLIC ACID; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; BRAIN HEMORRHAGE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; IMMUNOHISTOCHEMISTRY; MALE; MICROVASCULATURE; MIDDLE CEREBRAL ARTERY OCCLUSION; MONOTHERAPY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; STROKE; THROMBOCYTE; THROMBOSIS; ANIMAL; BIOSYNTHESIS; BRAIN; CEREBRAL ARTERY DISEASE; CONVALESCENCE; DRUG ANTAGONISM; DRUG POTENTIATION; PATHOLOGY; TIGHT JUNCTION; WISTAR RAT;

ANIMALS; BLOOD PLATELETS; BLOOD-BRAIN BARRIER; BRAIN; CAFFEIC ACIDS; COLLAGEN TYPE IV; DRUG SYNERGISM; FIBRINOLYTIC AGENTS; IMMUNOHISTOCHEMISTRY; INFARCTION, MIDDLE CEREBRAL ARTERY; INTERCELLULAR ADHESION MOLECULE-1; MALE; NEUROPROTECTIVE AGENTS; OLEANOLIC ACID; RATS; RATS, WISTAR; RECEPTOR, PAR-1; RECEPTORS, ENDOTHELIN; RECOVERY OF FUNCTION; TIGHT JUNCTIONS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 54049120640     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/STROKEAHA.108.515684     Document Type: Article

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