EndothelinA receptor antagonist BSF-208075 causes immune modulation and neuroprotection after stroke in gerbils

Brain Research

Volumn 1157, Issue 1, 2007, Pages 138-145

  Hauck, Erik F ^a,b   Hoffmann, Julie F ^b   Heimann, Axel ^b   Kempski, Oliver ^b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Endothelin; Intravital microscopy; Leukocyte activation; Postischemic inflammation

Indexed keywords

AMBRISENTAN; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN; ENDOTHELIN A RECEPTOR; IMMUNOLOGIC FACTOR; NEUROPROTECTIVE AGENT; PHENYLPROPIONIC ACID DERIVATIVE; PYRIDAZINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM CELL; GERBIL; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; MALE; MICROSCOPY; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SHAM FEEDING; STROKE; THERAPY EFFECT; TREATMENT OUTCOME; TREATMENT RESPONSE; ANIMAL; BRAIN; BRAIN CIRCULATION; CEREBROVASCULAR ACCIDENT; DRUG ANTAGONISM; DRUG EFFECT; ENCEPHALITIS; IMMUNOLOGY; LEUKOCYTE; METABOLISM; NERVE DEGENERATION; NEUTROPHIL CHEMOTAXIS; PATHOPHYSIOLOGY; PHYSIOLOGY; REPERFUSION INJURY;

ANIMALIA; GERBILLINAE;

ANIMALS; BRAIN; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CEREBROVASCULAR CIRCULATION; CHEMOTAXIS, LEUKOCYTE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENCEPHALITIS; ENDOTHELINS; GERBILLINAE; IMMUNOLOGIC FACTORS; LEUKOCYTES; MALE; NERVE DEGENERATION; NEUROPROTECTIVE AGENTS; PHENYLPROPIONATES; PYRIDAZINES; RECEPTOR, ENDOTHELIN A; REPERFUSION INJURY; TREATMENT OUTCOME;

EID: 34250614748     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.04.047     Document Type: Article

References (53)

1. Baggiolini M., Dewald B., and Moser B. Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv. Immunol. 55 (1994) 97-179
2. Barone F.C., and Feuerstein G.Z. Inflammatory mediators and stroke: new opportunities for novel therapeutics. J. Cereb. Blood Flow Metab. 9 (1999) 819-834
3. Barone F.C., Schmidt D.B., Hillegass L.M., Price W.J., White R.F., Feuerstein G.Z., Clark R.K., Lee E.V., Griswold D.E., and Sarau H.M. Reperfusion increases neutrophils and leukotriene B4 receptor binding in rat focal ischemia. Stroke 23 9 (1992) 1337-1347 (Sep)
4. Barone F.C., Globus M.Y.T., Price W.J., White R.F., Storer B.L., Feuerstein G.Z., Busto R., and Ohlstein E.H. Endothelin levels increase in rat focal and global ischemia. J. Cereb. Blood Flow Metab. 14 (1994) 337-342
5. Barone F.C., Hillegass L.M., Tzimas M.N., Schmidt D.B., Foley J.J., White R.F., Price W.J., Feuerstein G.Z., Clark R.K., and Griswold D.E. Time-related changes in myeloperoxidase activity and leukotriene B4 receptor binding reflect leukocyte influx in cerebral focal stroke. Mol. Chem. Neuropathol. 24 1 (1995) 13-30 (Jan)
6. Becker K.J., McCarron R.M., Ruetzler C., Laban O., Sternberg E., Flanders K.C., and Hallenbeck J.M. Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia. Proc. Natl. Acad. Sci. U. S. A. 94 20 (1997) 10873-10878 (Sep 30)
7. Bednar M.M., Raymond S., McAuliffe T., Lodge P.A., and Gross C.E. The role of neutrophils and platelets in a rabbit model of thromboembolic stroke. Stroke 22 1 (1991) 44-50 (Jan)
8. Billman G.E. Ambrisentan (myogen). Curr. Opin. Investig. Drugs 3 10 (2002) 1483-1486 (Oct)
9. Bonnekoh P., Barbier A., Oschlies U., and Hossmann K.A. Selective vulnerability in the gerbil hippocampus: morphological changes after 5-min ischemia and long survival times. Acta Neuropathol. (Berl) 80 1 (1990) 18-25
10. Bramlett H.M., and Dietrich W.D. Pathophysiology of cerebral ischemia and brain trauma: similarities and differences. J. Cereb. Blood Flow Metab. 24 2 (2004) 133-150 (Feb)
11. Chen P., Shibata M., Zidovetzki R., Fisher M., Zlokovic B.V., and Hofman F.M. Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brain-derived endothelial cell cultures. J. Neuroimmunol. 116 1 (2001) 62-73 (May 1)
12. Clark W.M. Cytokines and reperfusion injury. Neurology 49 suppl 4 (1997) S10-S14
13. Connolly Jr. E.S., Winfree C.J., Prestigiacomo C.J., Kim S.C., Choudhri T.F., Hoh B.L., Naka Y., Solomon R.A., and Pinsky D.J. Exacerbation of cerebral injury in mice that express the P-selectin gene: identification of P-selectin blockade as a new target for the treatment of stroke. Circ. Res. 81 (1997) 304-310
14. Dawson D.A., Sugano H., McCarron R.M., Hallenbeck J.M., and Spatz M. Endothelin receptor antagonist preserves microvascular perfusion and reduces ischemic brain damage following permanent focal ischemia. Neurochem. Res. 24 12 (1999) 1499-1505 (Dec)
15. Dutka A.J., Kochanek P.M., and Hallenbeck J.M. Influence of granulocytopenia on canine cerebral ischemia induced by air embolism. Stroke 20 (1989) 390-395
16. Fernandez-Patron C., Zouki C., Whittal R., Chan J.S., Davidge S.T., and Filep J.G. Matrix metalloproteinases regulate neutrophil-endothelial cell adhesion through generation of endothelin-1[1-32]. FASEB J. 15 12 (2001) 2230-2240 (Oct)
17. Feuerstein G., Gu J.L., Ohlstein E.H., Barone F.C., and Yue T.L. Peptidic endothelin-1 receptor antagonist, BQ-123, and neuroprotection. Peptides 15 3 (1994) 467-469
18. Fuxe K., Kurosawa N., Cintra A., Hallstrom A., Goiny M., Rosen L., Agnati L.F., and Ungerstedt U. Involvement of local ischemia in endothelin-1 induced lesions of the neostriatum of the anaesthetized rat. Exp. Brain Res. 88 1 (1992) 131-139
19. Garcia J.H., and Kamijyo Y. Cerebral infarction. Evolution of histopathological changes after occlusion of a middle cerebral artery in primates. J. Neuropathol. Exp. Neurol. 33 3 (1974) 408-421 (Jul)
20. Hallenbeck J.M., Dutka A.J., Tanishima T., Kochanek P.M., Kumaroo K.K., Thompson C.B., Obrenovitch T.P., and Contreras T.J. Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. Stroke 17 (1986) 246-253
21. Hauck E.F., Apostel S., Hoffmann J.F., Heimann A., and Kempski O. Capillary flow and diameter changes during reperfusion after global cerebral ischemia studied by intravital video microscopy. J. Cereb. Blood Flow Metab. 24 4 (2004) 383-391 (Apr)
22. Hofman F.M., Chen P., Jeyaseelan R., Incardona F., Fisher M., and Zidovetzki R. Endothelin-1 induces production of the neutrophil chemotactic factor interleukin-8 by human brain-derived endothelial cells. Blood 92 9 (1998) 3064-3072 (Nov 1)
23. Imdahl A., and Hossmann K.A. Morphometric evaluation of post-ischemic capillary perfusion in selectively vulnerable areas of gerbil brain. Acta Neuropathol. (Berl) 69 3-4 (1986) 267-271
24. Jean W.C., Spellman S.R., Nussbaum E.S., and Low W.C. Reperfusion injury after focal cerebral ischemia: the role of inflammation and the therapeutic horizon. Neurosurgery 43 (1998) 1382-1396
25. Kochanek P.M., and Hallenbeck J.M. Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke. Stroke 23 (1992) 1367-1379
26. Kuroda S., and Siesjo B.K. Reperfusion damage following focal ischemia: pathophysiology and therapeutic windows. Clin. Neurosci. 4 (1997) 199-212
27. Kurzelewski M., Czarnowska E., and Beresewicz A. Endothelin in the mechanism of endothelial injury and neutrophil adhesion in the post-ischemic guinea-pig heart. Eur. J. Pharmacol. 434 1-2 (2002) 95-107 (Jan 2)
28. Lehmberg J., Putz C., Furst M., Beck J., Baethmann A., and Uhl E. Impact of the endothelin-A receptor antagonist BQ 610 on microcirculation in global cerebral ischemia and reperfusion. Brain Res. 961 2 (2003) 277-286 (Jan 31)
29. Matsumoto H., Suzuki N., Onda H., and Fujino M. Abundance of endothelin-3 in rat intestine, pituitary gland and brain. Biochem. Biophys. Res. Commun. 164 1 (1989) 74-80 (Oct 16)
30. Matsuo Y., Onodera H., Shiga Y., Nakamura M., Ninomiya M., Kihara T., and Kogure K. Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat: effects of neutrophil depletion. Stroke 25 (1994) 1469-1475
31. McCarron R.M., Wang L., Stanimirovic D.B., and Spatz M. Endothelin induction of adhesion molecule expression on human brain microvascular endothelial cells. Neurosci. Lett. 156 1-2 (1993) 31-34 (Jun 25)
32. Mori E., del Zoppo G.J., Chambers J.D., Copeland B.R., and Arfors K.E. Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons. Stroke 23 (1992) 712-718
33. Motte S., McEntee K., and Naeije R. Endothelin receptor antagonists. Pharmacol. Ther. 110 3 (2006) 386-414 (Jun, Electronic publication 2005 Oct 10. Review)
34. Nikolov R., Rami A., and Krieglstein J. Endothelin-1 exacerbates focal cerebral ischemia without exerting neurotoxic action in vitro. Eur. J. Pharmacol. 248 2 (1993) 205-208 (Aug 2)
35. Oktar B.K., Gulpinar M.A., Bozkurt A., Ghandour S., Cetinel S., Moini H., Yegen B.C., Bilsel S., Granger D.N., and Kurtel H. Endothelin receptor blockers reduce I/R-induced intestinal mucosal injury: role of blood flow. Am. J. Physiol. Gasterointest. Liver Physiol. 282 4 (2002) G647-G655 (Apr)
36. Palazzo A.J., Jones S.P., Girod W.G., Anderson D.C., Granger D.N., and Lefer D.J. Myocardial ischemia-reperfusion injury in CD18- and ICAM-1-deficient mice. Am. J. Physiol. 275 6 Pt 2 (1998) H2300-H2307 (Dec)
37. Palazzo A.J., Jones S.P., Anderson D.C., Granger D.N., and Lefer D.J. Coronary endothelial P-selectin in the pathogenesis of myocardial ischemia-reperfusion injury. Am. J. Physiol. 275 (1998) H1865-H1872
38. Patel T.R., and McCulloch J. Failure of an endothelin antagonist to modify hypoperfusion after transient global ischaemia in the rat. J. Cereb. Blood Flow Metab. 16 3 (1996) 490-499 (May)
39. Pozzilli C., Lenzi G.L., Argentino C., Carolei A., Rasura M., Signore A., Bozzao L., and Pozzilli P. Imaging of leukocytic infiltration in human cerebral infarcts. Stroke 16 2 (1985) 251-255 (Mar-Apr)
40. Proescholdt M., Heimann A., and Kempski O. Neuroprotection of S(+) ketamine isomer in global forebrain ischemia. Brain Res. 904 2 (2001) 245-251 (Jun 22)
41. Ruehl M.L., Orozco J.A., Stoker M.B., McDonagh P.F., Coull B.M., and Ritter L.S. Protective effects of inhibiting both blood and vascular selectins after stroke and reperfusion. Neurol. Res. 24 3 (2002) 226-232 (Apr)
42. Russell J., Cooper D., Tailor A., Stokes K.Y., and Granger D.N. Low venular shear rates promote leukocyte-dependent recruitment of adherent platelets. Am. J. Physiol. Gasterointest. Liver Physiol. 284 1 (2003) G123-G129 (Jan)
43. Shiga Y., Onodera H., Matsuo Y., and Kogure K. Cyclosporin A protects against ischemia-reperfusion injury in the brain. Brain Res. 595 1 (1992) 145-148 (Nov 6)
44. Shinmi O., Kimura S., Sawamura T., Sugita Y., Yoshizawa T., Uchiyama Y., Yanagisawa M., Goto K., Masaki T., and Kanazawa I. Endothelin-3 is a novel neuropeptide: isolation and sequence determination of endothelin-1 and endothelin-3 in porcine brain. Biochem. Biophys. Res. Commun. 164 1 (1989) 587-593 (Oct 16)
45. Spatz M., Yasuma Y., Strasser A., and McCarron R.M. Cerebral postischemic hypoperfusion is mediated by ETA receptors. Brain Res. 726 1-2 (1996) 242-246 (Jul 8)
46. Stummer W., Weber K., Tranmer B., Baethmann A., and Kempski O. Reduced mortality and brain damage after locomotor activity in gerbil forebrain ischemia. Stroke 9 (1994) 1861-1868
47. Takeda H., Spatz M., Ruetzler C., McCarron R., Becker K., and Hallenbeck J. Induction of mucosal tolerance to E-selectin prevents ischemic and hemorrhagic stroke in spontaneously hypertensive genetically stroke-prone rats. Stroke 33 9 (2002) 2156-2163 (Sep)
48. Uhl E., Beck J., Stummer W., Lehmberg J., and Baethmann A. Leukocyte-endothelium interactions in pial venules during the early and late reperfusion period after global cerebral ischemia in gerbils. J. Cereb. Blood Flow Metab. 20 (2000) 979-987
49. Yanagisawa M., Kurihara H., Kimura S., Tomobe Y., Kobayashi M., Mitsui Y., Yazaki Y., Goto K., and Masaki T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332 6163 (1988) 411-415 (Mar 31)
50. Zhang R.L., Chopp M., Chen H., and Garcia J.H. Temporal profile of ischemic tissue damage, neutrophil response, and vascular plugging following permanent and transient (2H) middle cerebral artery occlusion in the rat. J Neurol Sci. 125 1 (1994) 3-10 (Aug, Erratum in: J Neurol Sci 1994 Oct;126(1):96)
51. Zhang Z.G., Chopp M., Tang W.X., Jiang N., and Zhang R.L. Postischemic treatment (2-4 h) with anti-CD11b and anti-CD18 monoclonal antibodies are neuroprotective after transient (2 h) focal cerebral ischemia in the rat. Brain Res. 698 (1995) 79-85
52. Zhao G., and Flavin M.P. Differential sensitivity of rat hippocampal and cortical astrocytes to oxygen-glucose deprivation injury. Neurosci. Lett. 285 3 (2000) 177-180 (May 19)
53. Zouki C., Baron C., Fournier A., and Filep J.G. Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ET(A) receptors and platelet-activating factor. Br. J. Pharmacol. 127 4 (1999) 969-979 (Jun)