Endothelin receptor antagonist increases cerebral perfusion and reduces ischaemic damage in feline focal cerebral ischaemia

Journal of Cerebral Blood Flow and Metabolism

Volumn 16, Issue 5, 1996, Pages 950-958

  Patel, Toshal R ^a   Galbraith, Samuel ^a   Graham, David I ^b   Hallak, Hussein ^c   Doherty, Annette M ^c   McCulloch, James ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b SOUTHERN GENERAL HOSPITAL   (United Kingdom)

^c PFIZER INC   (United States)

Author keywords

Cerebral blood flow; Endothelin; Endothelin ET(A) antagonist; Focal cerebral ischaemia; PD156707; Quantitative histopathology

Indexed keywords

4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID; ENDOTHELIN 1; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTERY RESISTANCE; ARTICLE; BRAIN ISCHEMIA; BRAIN PERFUSION; CAT; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; FEMALE; INTRAVENOUS DRUG ADMINISTRATION; LASER DOPPLER FLOWMETRY; MIDDLE CEREBRAL ARTERY; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; VASOCONSTRICTION;

EID: 0029745602     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-199609000-00019     Document Type: Article

References (20)

1. Baez S (1966) Recording of microvascular dimensions with an image splitter television microscope. J Appl Physiol 21:299-301
2. Barone FC, Globus MY-T, Price WJ, White RF, Storer BL, Feuerstein GZ, Busto R, Ohlstein EH (1994) Endothelin levels increase in rat focal and global ischaemia. J Ccreb Blood Flow Metab 14:337-342
3. Berrino L, D'Amico M, Pizziruso A, Vitagliano S, Rossi F (1994) Excitatory amino acids modulate the cardiovascular effects of endothelin-1 in the periaqueductal gray area. Br J Pharmacol 111:173P
4. Brandt L, Ljunggren B, Persson K-E, Edvinsson L, MacKenzie E, Tamura A, Teasdale G (1983) Effect of topical application of a calcium antagonist (nifedipine) on feline cortical pial microvasculature under normal conditions and in focal ischaemia. J Cercb Blood Flow Metab 3:44-50.
5. Bullock R, Graham DI, Swanson S, McCulloch J (1994) Neuroprotective effect of the AMPA receptor antagonist LY-293558 in focal cerebral ischaemia in the cat. J Cereb Blood Flow Metab 14:466-471
6. Chen M, Bullock R, Graham DI, Frey P, Lowe D, McCulloch J (1991) Evaluation of a competitive NMDA antagonist (D-CPPene) in feline focal cerebral ischaemia. Ann Neural 30:62-70
7. Clozel M, Breu V, Gray GA, Kalina B, Loffler B-M, Burri K, Cassai J-M, Hirth G, Muller M, Neidhart W, Ramuz H (1994) Pharmacological characterisation of Bosentan, a new potent orally active non-peptide endothelin receptor antagonist. J Pharmacol Exp Ther 270:228-235
8. Date H, Hossmann KA (1984) Effect of vasodilating drugs on intracortical and extracortical vascular resistance following middle cerebral artery occlusion in cats. Ann Neurol 16:330-336
9. A) receptor selective antagonists. J Med Chem 38:1259-1263
10. Edvinsson L, MacKenzie ET, McCulloch J (1993) Cerebral Blood Flow and Metabolism, New York, Raven Press
11. Ehrenreich H, Kehrl J, Anderson R, Rieckmann P, Vitkovic L, Coligan J, Fauci A (1991) A vasoactive peptide, endothelin-3 is produced by and specifically binds to primary astrocytes. Brain Res 538:54-58
12. Elton TS, Oparil S, Taylor GR, Hicks PH, Yang R-h, Jin H, Chen YF (1992) Normabaric hypoxia stimulates endothelin-1 gene expression in the rat. Am J Physiol 263:R1260-R1264
13. Feger GI, Schilling L, Ehrenreich H, Wahl M (1994) Endothelin-induced contraction and relaxation of isolated rat basilar artery: effect of BQ-123. J Cereb Blood Flow Metab 14:845-852
14. A) antagonist is neuroprotective in gerbil transient forebrain ischaemia. Stroke 25:264
15. Fisher M, Grotta J (1993) New uses for calcium channel blockers-therapeutic implications. Drugs 46:961-975
16. Foley PL, Caner HH, Kassell NF, Lee K-S (1994) Reversal of subarachnoid hemorrhage-induced vasoconstriction with an endothelin receptor antagonist. Neurosurgery 34:108-113
17. Fuxe K, Kurosawa N, Cintra A, Hallstrom A, Goiny M, Rosen L, Agnati LF, Ungerstedt U (1992) Involvement of local ischaemia in endothelin-1 induced lesions of the neostriatum of the anaesthetised rat. Exp Brain Res 88:131-139
18. Gill R (1994) The pharmacology of alpha-amino-3-hydroxy-5-methyl-isoxazole proprionate (AMPA)/kainate antagonists and their role in cerebral ischaemia. Cerebrovasc Brain Metab Rev 6:225-256
19. Gross PM, Beninger RJ, Shaver SW, Wainman DS, Espinosa FJ, Weaver DF (1993) Metabolic and neuroanatomical correlates of barrel-rolling and oculoclonic convulsions induced by intraventricular endothelin-1: a novel peptidergic signalling mechanism in visuovestibular and oculomotor regulation? Exp Brain Res 95:397-408
20. Hatashita S, Hoff JT (1986) Cortical tissue pressure gradients in early ischaemic brain oedema. J Cereb Blood Flow Metab 6:1-7