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Volumn 64, Issue 7, 2012, Pages 960-967

Mechanical and biologic link between cartilage and subchondral bone in osteoarthritis

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FACTOR;

EID: 84863451354     PISSN: 2151464X     EISSN: 21514658     Source Type: Journal    
DOI: 10.1002/acr.21640     Document Type: Review
Times cited : (32)

References (97)
  • 1
    • 84862833458 scopus 로고    scopus 로고
    • Methodologic challenges in studying risk factors for progression of knee osteoarthritis
    • Hoboken
    • Zhang Y, Niu J, Felson DT, Choi HK, Nevitt M, Neogi T. Methodologic challenges in studying risk factors for progression of knee osteoarthritis. Arthritis Care Res (Hoboken) 2010; 62:1527-32.
    • (2010) Arthritis Care Res , vol.62 , pp. 1527-1532
    • Zhang, Y.1    Niu, J.2    Felson, D.T.3    Choi, H.K.4    Nevitt, M.5    Neogi, T.6
  • 2
    • 77950439220 scopus 로고    scopus 로고
    • Obesity, physically demanding work and traumatic knee injury are major risk factors for knee osteoarthritis: A population-based study with a follow-up of 22 years
    • Oxford
    • Toivanen AT, Heliovaara M, Impivaara O, Arokoski JP, Knekt P, Lauren H, et al. Obesity, physically demanding work and traumatic knee injury are major risk factors for knee osteoarthritis: a population-based study with a follow-up of 22 years. Rheumatology (Oxford) 2010;49:308-14.
    • (2010) Rheumatology , vol.49 , pp. 308-314
    • Toivanen, A.T.1    Heliovaara, M.2    Impivaara, O.3    Arokoski, J.P.4    Knekt, P.5    Lauren, H.6
  • 3
    • 80051742498 scopus 로고    scopus 로고
    • What if we prevent obesity? Risk reduction in knee osteoarthritis estimated through a meta-analysis of observational studies
    • Hoboken
    • Muthuri SG, Hui M, Doherty M, Zhang W. What if we prevent obesity? Risk reduction in knee osteoarthritis estimated through a meta-analysis of observational studies. Arthritis Care Res (Hoboken) 2011;63:982-90.
    • (2011) Arthritis Care Res , vol.63 , pp. 982-990
    • Muthuri, S.G.1    Hui, M.2    Doherty, M.3    Zhang, W.4
  • 4
    • 79952815200 scopus 로고    scopus 로고
    • Osteoarthritis year 2010 in review: Genetics
    • Loughlin J. Osteoarthritis year 2010 in review: genetics. Osteoarthritis Cartilage 2011;19:342-5.
    • (2011) Osteoarthritis Cartilage , vol.19 , pp. 342-345
    • Loughlin, J.1
  • 5
    • 75649122624 scopus 로고    scopus 로고
    • Biomarkers: In combination they may do better
    • Williams FM. Biomarkers: in combination they may do better. Arthritis Res Ther 2009;11:130.
    • (2009) Arthritis Res Ther , vol.11 , pp. 130
    • Williams, F.M.1
  • 7
    • 0242552331 scopus 로고    scopus 로고
    • Mono-Iodoacetate-Induced Histologic Changes in Subchondral Bone and Articular Cartilage of Rat Femorotibial Joints: An Animal Model of Osteoarthritis
    • Guzman RE, Evans MG, Bove S, Morenko B, Kilgore K. Monoiodoacetate- induced histologic changes in subchondral bone and articular cartilage of rat femorotibial joints: an animal model of osteoarthritis. Toxicol Pathol 2003;31:619-24. (Pubitemid 37433471)
    • (2003) Toxicologic Pathology , vol.31 , Issue.6 , pp. 619-624
    • Guzman, R.E.1    Evans, M.G.2    Bove, S.3    Morenko, B.4    Kilgore, K.5
  • 10
    • 73249137617 scopus 로고    scopus 로고
    • Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
    • Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, et al. Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development. Arthritis Rheum 2009;60:3723-33.
    • (2009) Arthritis Rheum , vol.60 , pp. 3723-3733
    • Little, C.B.1    Barai, A.2    Burkhardt, D.3    Smith, S.M.4    Fosang, A.J.5    Werb, Z.6
  • 14
    • 79952048883 scopus 로고    scopus 로고
    • Femorotibial subchondral bone area and regional cartilage thickness: A cross-sectional description in healthy reference cases and various radiographic stages of osteoarthritis in 1,003 knees from the Osteoarthritis Initiative
    • for the Osteoarthritis Initiative Investigators. Hoboken
    • Frobell RB, Nevitt MC, Hudelmaier M, Wirth W, Wyman BT, Benichou O, et al, for the Osteoarthritis Initiative Investigators. Femorotibial subchondral bone area and regional cartilage thickness: a cross-sectional description in healthy reference cases and various radiographic stages of osteoarthritis in 1,003 knees from the Osteoarthritis Initiative. Arthritis Care Res (Hoboken) 2010;62:1612-23.
    • (2010) Arthritis Care Res , vol.62 , pp. 1612-1623
    • Frobell, R.B.1    Nevitt, M.C.2    Hudelmaier, M.3    Wirth, W.4    Wyman, B.T.5    Benichou, O.6
  • 15
    • 77951613943 scopus 로고    scopus 로고
    • Subchondral bone attrition may be a reflection of compartment-specific mechanical load: The MOST Study
    • Neogi T, Nevitt M, Niu J, Sharma L, Roemer F, Guermazi A, et al. Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study. Ann Rheum Dis 2010;69:841-4.
    • (2010) Ann Rheum Dis , vol.69 , pp. 841-844
    • Neogi, T.1    Nevitt, M.2    Niu, J.3    Sharma, L.4    Roemer, F.5    Guermazi, A.6
  • 18
    • 0029787133 scopus 로고    scopus 로고
    • Osteoarthritis in cynomolgus macaques III: Effects of age, gender, and subchondral bone thickness on the severity of disease
    • Carlson CS, Loeser RF, Purser CB, Gardin JF, Jerome CP. Osteoarthritis in cynomolgus macaques. III. Effects of age, gender, and subchondral bone thickness on the severity of disease. J Bone Miner Res 1996;11:1209-17. (Pubitemid 26282520)
    • (1996) Journal of Bone and Mineral Research , vol.11 , Issue.9 , pp. 1209-1217
    • Carlson, C.S.1    Loeser, R.F.2    Purser, C.B.3    Gardin, J.F.4    Jerome, C.P.5
  • 19
    • 1042278738 scopus 로고    scopus 로고
    • Is Osteoarthritis a Systemic Disorder of Bone?
    • DOI 10.1002/art.20136
    • Rogers J, Shepstone L, Dieppe P. Is osteoarthritis a systemic disorder of bone? Arthritis Rheum 2004;50:452-7. (Pubitemid 38198829)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.2 , pp. 452-457
    • Rogers, J.1    Shepstone, L.2    Dieppe, P.3
  • 20
    • 77950659332 scopus 로고    scopus 로고
    • Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
    • Goldring MB, Goldring SR. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci 2010;1192:230-7.
    • (2010) Ann N Y Acad Sci , vol.1192 , pp. 230-237
    • Goldring, M.B.1    Goldring, S.R.2
  • 21
    • 77955080402 scopus 로고    scopus 로고
    • Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis
    • Bellido M, Lugo L, Roman-Blas JA, Castaneda S, Caeiro JR, Dapia S, et al. Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis. Arthritis Res Ther 2010;12:R152.
    • (2010) Arthritis Res Ther , vol.12
    • Bellido, M.1    Lugo, L.2    Roman-Blas, J.A.3    Castaneda, S.4    Caeiro, J.R.5    Dapia, S.6
  • 22
    • 70349213369 scopus 로고    scopus 로고
    • In situ measurement of transport between subchondral bone and articular cartilage
    • Pan J, Zhou X, Li W, Novotny JE, Doty SB, Wang L. In situ measurement of transport between subchondral bone and articular cartilage. J Orthop Res 2009;27:1347-52.
    • (2009) J Orthop Res , vol.27 , pp. 1347-1352
    • Pan, J.1    Zhou, X.2    Li, W.3    Novotny, J.E.4    Doty, S.B.5    Wang, L.6
  • 23
    • 33747394448 scopus 로고    scopus 로고
    • The normal human chondro-osseous junctional region: Evidence for contact of uncalcified cartilage with subchondral bone and marrow spaces
    • Lyons TJ, McClure SF, Stoddart RW, McClure J. The normal human chondro-osseous junctional region: evidence for contact of uncalcified cartilage with subchondral bone and marrow spaces. BMC Musculoskelet Disord 2006;7:52.
    • (2006) BMC Musculoskelet Disord , vol.7 , pp. 52
    • Lyons, T.J.1    McClure, S.F.2    Stoddart, R.W.3    McClure, J.4
  • 24
    • 65649151955 scopus 로고    scopus 로고
    • Chondrocyte survival in articular cartilage: The influence of subchondral bone in a bovine model
    • Amin AK, Huntley JS, Simpson AH, Hall AC. Chondrocyte survival in articular cartilage: the influence of subchondral bone in a bovine model. J Bone Joint Surg Br 2009;91:691-9.
    • (2009) J Bone Joint Surg Br , vol.91 , pp. 691-699
    • Amin, A.K.1    Huntley, J.S.2    Simpson, A.H.3    Hall, A.C.4
  • 25
    • 44449159269 scopus 로고    scopus 로고
    • Solute transport in the deep and calcified zones of articular cartilage
    • DOI 10.1016/j.joca.2007.10.001, PII S1063458407003160
    • Arkill KP, Winlove CP. Solute transport in the deep and calcified zones of articular cartilage. Osteoarthritis Cartilage 2008;16:708-14. (Pubitemid 351753712)
    • (2008) Osteoarthritis and Cartilage , vol.16 , Issue.6 , pp. 708-714
    • Arkill, K.P.1    Winlove, C.P.2
  • 26
    • 78650970042 scopus 로고    scopus 로고
    • Subchondral bone loss following orthodontically induced cartilage degradation in the mandibular condyles of rats
    • Jiao K, Niu LN, Wang MQ, Dai J, Yu SB, Liu XD, et al. Subchondral bone loss following orthodontically induced cartilage degradation in the mandibular condyles of rats. Bone 2011;48:362-71.
    • (2011) Bone , vol.48 , pp. 362-371
    • Jiao, K.1    Niu, L.N.2    Wang, M.Q.3    Dai, J.4    Yu, S.B.5    Liu, X.D.6
  • 27
    • 27544459954 scopus 로고    scopus 로고
    • Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes
    • DOI 10.1016/j.joca.2005.07.012, PII S1063458405001962
    • Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JY, Henrotin YE. Subchondral bone osteoblasts induce phenotypic changes in human osteoarthritic chondrocytes. Osteoarthritis Cartilage 2005;13:988-97. (Pubitemid 41536131)
    • (2005) Osteoarthritis and Cartilage , vol.13 , Issue.11 , pp. 988-997
    • Sanchez, C.1    Deberg, M.A.2    Piccardi, N.3    Msika, P.4    Reginster, J.-Y.L.5    Henrotin, Y.E.6
  • 28
    • 27544466756 scopus 로고    scopus 로고
    • Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by interleukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts
    • DOI 10.1016/j.joca.2005.03.008, PII S1063458405000944
    • Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JY, Henrotin YE. Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes: this effect is mimicked by interleukin-6, -1β and oncostatin M pre-treated non-sclerotic osteoblasts. Osteoarthritis Cartilage 2005;13:979-87. (Pubitemid 41536130)
    • (2005) Osteoarthritis and Cartilage , vol.13 , Issue.11 , pp. 979-987
    • Sanchez, C.1    Deberg, M.A.2    Piccardi, N.3    Msika, P.4    Reginster, J.-Y.L.5    Henrotin, Y.E.6
  • 29
    • 77951662820 scopus 로고    scopus 로고
    • Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a coculture system
    • Lin YY, Tanaka N, Ohkuma S, Iwabuchi Y, Tanne Y, Kamiya T, et al. Applying an excessive mechanical stress alters the effect of subchondral osteoblasts on chondrocytes in a coculture system. Eur J Oral Sci 2010;118:151-8.
    • (2010) Eur J Oral Sci , vol.118 , pp. 151-158
    • Lin, Y.Y.1    Tanaka, N.2    Ohkuma, S.3    Iwabuchi, Y.4    Tanne, Y.5    Kamiya, T.6
  • 30
    • 4644338099 scopus 로고    scopus 로고
    • Neuromuscular aspects of osteoarthritis: A perspective
    • discussion 58-63; 100-4; 277-109
    • Brandt KD. Neuromuscular aspects of osteoarthritis: a perspective. Novartis Found Symp 2004;260:49-58; discussion 58-63; 100-4; 277-109.
    • (2004) Novartis Found Symp , vol.260 , pp. 49-58
    • Brandt, K.D.1
  • 31
    • 78650846194 scopus 로고    scopus 로고
    • Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis
    • Zhu F, Wang P, Lee NH, Goldring MB, Konstantopoulos K. Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis. PLoS One 2011;5:e15174.
    • (2011) PLoS One , vol.5
    • Zhu, F.1    Wang, P.2    Lee, N.H.3    Goldring, M.B.4    Konstantopoulos, K.5
  • 32
    • 81155151366 scopus 로고    scopus 로고
    • Analysis of bone architecture sensitivity for changes in mechanical loading, cellular activity, mechanotransduction, and tissue properties
    • Cox LG, van Rietbergen B, van Donkelaar CC, Ito K. Analysis of bone architecture sensitivity for changes in mechanical loading, cellular activity, mechanotransduction, and tissue properties. Biomech Model Mechanobiol 2011;10:701-12.
    • (2011) Biomech Model Mechanobiol , vol.10 , pp. 701-712
    • Cox, L.G.1    Van Rietbergen, B.2    Van Donkelaar, C.C.3    Ito, K.4
  • 33
    • 43249084135 scopus 로고    scopus 로고
    • Temporal effects of impact on articular cartilage cell death, gene expression, matrix biochemistry, and biomechanics
    • Natoli RM, Scott CC, Athanasiou KA. Temporal effects of impact on articular cartilage cell death, gene expression, matrix biochemistry, and biomechanics. Ann Biomed Eng 2008; 36:780-92.
    • (2008) Ann Biomed Eng , vol.36 , pp. 780-792
    • Natoli, R.M.1    Scott, C.C.2    Athanasiou, K.A.3
  • 34
    • 42049100497 scopus 로고    scopus 로고
    • Effect of intermittent shear stress on mechanotransductive signaling and osteoblastic differentiation of bone marrow stromal cells
    • DOI 10.1089/tea.2007.0068
    • Kreke MR, Sharp LA, Lee YW, Goldstein AS. Effect of intermittent shear stress on mechanotransductive signaling and osteoblastic differentiation of bone marrow stromal cells. Tissue Eng Part A 2008;14:529-37. (Pubitemid 351520460)
    • (2008) Tissue Engineering - Part A. , vol.14 , Issue.4 , pp. 529-537
    • Kreke, M.R.1    Sharp, L.A.2    Woo, L.Y.3    Goldstein, A.S.4
  • 35
    • 43649089910 scopus 로고    scopus 로고
    • In vivo intervertebral disc remodeling: Kinetics of mRNA expression in response to a single loading event
    • MacLean JJ, Roughley PJ, Monsey RD, Alini M, Iatridis JC. In vivo intervertebral disc remodeling: kinetics of mRNA expression in response to a single loading event. J Orthop Res 2008;26:579-88.
    • (2008) J Orthop Res , vol.26 , pp. 579-588
    • MacLean, J.J.1    Roughley, P.J.2    Monsey, R.D.3    Alini, M.4    Iatridis, J.C.5
  • 36
    • 56349134411 scopus 로고    scopus 로고
    • Mechanical stimulation induces preprotachykinin gene expression in osteoarthritic chondrocytes which is correlated with modulation of the transcription factor neuron restrictive silence factor
    • Howard MR, Millward-Sadler SJ, Vasilliou AS, Salter DM, Quinn JP. Mechanical stimulation induces preprotachykinin gene expression in osteoarthritic chondrocytes which is correlated with modulation of the transcription factor neuron restrictive silence factor. Neuropeptides 2008;42:681-6.
    • (2008) Neuropeptides , vol.42 , pp. 681-686
    • Howard, M.R.1    Millward-Sadler, S.J.2    Vasilliou, A.S.3    Salter, D.M.4    Quinn, J.P.5
  • 37
    • 79960978993 scopus 로고    scopus 로고
    • The expressions of the SOX trio, PTHrP (parathyroid hormone-related peptide)/IHH (Indian hedgehog protein) in surgically induced osteoarthritis of the rat
    • Kim SY, Im GI. The expressions of the SOX trio, PTHrP (parathyroid hormone-related peptide)/IHH (Indian hedgehog protein) in surgically induced osteoarthritis of the rat. Cell Biol Int 2011;35:529-35.
    • (2011) Cell Biol Int , vol.35 , pp. 529-535
    • Kim, S.Y.1    Im, G.I.2
  • 38
    • 0033711025 scopus 로고    scopus 로고
    • Mechanotransduction via integrins and interleukin-4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes
    • Millward-Sadler SJ, Wright MO, Davies LW, Nuki G, Salter DM. Mechanotransduction via integrins and interleukin-4 results in altered aggrecan and matrix metalloproteinase 3 gene expression in normal, but not osteoarthritic, human articular chondrocytes. Arthritis Rheum 2000;43:2091-9.
    • (2000) Arthritis Rheum , vol.43 , pp. 2091-2099
    • Millward-Sadler, S.J.1    Wright, M.O.2    Davies, L.W.3    Nuki, G.4    Salter, D.M.5
  • 39
    • 79959867275 scopus 로고    scopus 로고
    • Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage
    • Takada K, Hirose J, Senba K, Yamabe S, Oike Y, Gotoh T, et al. Enhanced apoptotic and reduced protective response in chondrocytes following endoplasmic reticulum stress in osteoarthritic cartilage. Int J Exp Pathol 2011;92:232-42.
    • (2011) Int J Exp Pathol , vol.92 , pp. 232-242
    • Takada, K.1    Hirose, J.2    Senba, K.3    Yamabe, S.4    Oike, Y.5    Gotoh, T.6
  • 40
    • 52449116964 scopus 로고    scopus 로고
    • Mechanical regulation of proteoglycan synthesis in normal and osteoarthritic human articular chondrocytes: Roles for α5 and αVβ5 integrins
    • Holledge MM, Millward-Sadler SJ, Nuki G, Salter DM. Mechanical regulation of proteoglycan synthesis in normal and osteoarthritic human articular chondrocytes: roles for α5 and αVβ5 integrins. Biorheology 2008;45:275-88.
    • (2008) Biorheology , vol.45 , pp. 275-288
    • Holledge, M.M.1    Millward-Sadler, S.J.2    Nuki, G.3    Salter, D.M.4
  • 41
    • 74149085207 scopus 로고    scopus 로고
    • Av and β1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways
    • Chai DH, Arner EC, Griggs DW, Grodzinsky AJ. Av and β1 integrins regulate dynamic compression-induced proteoglycan synthesis in 3D gel culture by distinct complementary pathways. Osteoarthritis Cartilage 2010;18:249-56.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 249-256
    • Chai, D.H.1    Arner, E.C.2    Griggs, D.W.3    Grodzinsky, A.J.4
  • 42
    • 58549119194 scopus 로고    scopus 로고
    • Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology
    • Blain EJ. Involvement of the cytoskeletal elements in articular cartilage homeostasis and pathology. Int J Exp Pathol 2009; 90:1-15.
    • (2009) Int J Exp Pathol , vol.90 , pp. 1-15
    • Blain, E.J.1
  • 43
    • 0036282863 scopus 로고    scopus 로고
    • Differential responses of chondrocytes from normal and osteoarthritic human articular cartilage to mechanical stimulation
    • Salter DM, Millward-Sadler SJ, Nuki G, Wright MO. Differential responses of chondrocytes from normal and osteoarthritic human articular cartilage to mechanical stimulation. Biorheology 2002;39:97-108. (Pubitemid 34626053)
    • (2002) Biorheology , vol.39 , Issue.1-2 , pp. 97-108
    • Salter, D.M.1    Millward-Sadler, S.J.2    Nuki, G.3    Wright, M.O.4
  • 44
    • 61549087822 scopus 로고    scopus 로고
    • Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts
    • Sanchez C, Gabay O, Salvat C, Henrotin YE, Berenbaum F. Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts. Osteoarthritis Cartilage 2009;17:473-81.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 473-481
    • Sanchez, C.1    Gabay, O.2    Salvat, C.3    Henrotin, Y.E.4    Berenbaum, F.5
  • 45
    • 79952318924 scopus 로고    scopus 로고
    • Molecular regulation of articular chondrocyte function and its significance in osteoarthritis
    • Schroeppel JP, Crist JD, Anderson HC, Wang J. Molecular regulation of articular chondrocyte function and its significance in osteoarthritis. Histol Histopathol 2011;26:377-94.
    • (2011) Histol Histopathol , vol.26 , pp. 377-394
    • Schroeppel, J.P.1    Crist, J.D.2    Anderson, H.C.3    Wang, J.4
  • 46
    • 74249102515 scopus 로고    scopus 로고
    • Progress of research in osteoarthritis: Metalloproteinases in osteoarthritis
    • Okada A, Okada Y. Progress of research in osteoarthritis: metalloproteinases in osteoarthritis. Clin Calcium 2009;19: 1593-601.
    • (2009) Clin Calcium , vol.19 , pp. 1593-1601
    • Okada, A.1    Okada, Y.2
  • 47
    • 77149180092 scopus 로고    scopus 로고
    • Anticytokine therapy for osteoarthritis: Evidence to date
    • Malemud CJ. Anticytokine therapy for osteoarthritis: evidence to date. Drugs Aging 2010;27:95-115.
    • (2010) Drugs Aging , vol.27 , pp. 95-115
    • Malemud, C.J.1
  • 48
    • 33751174529 scopus 로고    scopus 로고
    • The effects of TGF-beta1 and IGF-I on the biomechanics and cytoskeleton of single chondrocytes
    • DOI 10.1016/j.joca.2006.05.013, PII S1063458406001622
    • Leipzig ND, Eleswarapu SV, Athanasiou KA. The effects of TGF-β1 and IGF-I on the biomechanics and cytoskeleton of single chondrocytes. Osteoarthritis Cartilage 2006;14:1227-36. (Pubitemid 44774439)
    • (2006) Osteoarthritis and Cartilage , vol.14 , Issue.12 , pp. 1227-1236
    • Leipzig, N.D.1    Eleswarapu, S.V.2    Athanasiou, K.A.3
  • 50
    • 0036084062 scopus 로고    scopus 로고
    • 2 by isolated human subchondral osteoblasts identity two subgroups of osteoarthritic patients
    • DOI 10.1053/joca.2002.0528
    • Massicotte F, Lajeunesse D, Benderdour M, Pelletier JP, Hilal G, Duval N, et al. Can altered production of interleukin-1β, interleukin-6, transforming growth factor-β and prostaglandin E by isolated human subchondral osteoblasts identify two subgroups of osteoarthritic patients. Osteoarthritis Cartilage 2002;10:491-500. (Pubitemid 34679302)
    • (2002) Osteoarthritis and Cartilage , vol.10 , Issue.6 , pp. 491-500
    • Massicotte, F.1    Lajeunesse, D.2    Benderdour, M.3    Pelletier, J.-P.4    Hilal, G.5    Duval, N.6    Martel-Pelletier, J.7
  • 51
    • 32844456504 scopus 로고    scopus 로고
    • Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts
    • DOI 10.1016/j.bone.2005.09.007, PII S8756328205003881
    • Massicotte F, Fernandes JC, Martel-Pelletier J, Pelletier JP, Lajeunesse D. Modulation of insulin-like growth factor 1 levels in human osteoarthritic subchondral bone osteoblasts. Bone 2006;38:333-41. (Pubitemid 43255427)
    • (2006) Bone , vol.38 , Issue.3 , pp. 333-341
    • Massicotte, F.1    Fernandes, J.C.2    Martel-Pelletier, J.3    Pelletier, J.-P.4    Lajeunesse, D.5
  • 52
    • 43349095508 scopus 로고    scopus 로고
    • The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells
    • Kwan Tat S, Pelletier JP, Lajeunesse D, Fahmi H, Lavigne M, Martel-Pelletier J. The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells. Clin Exp Rheumatol 2008;26:295-304. (Pubitemid 351659137)
    • (2008) Clinical and Experimental Rheumatology , vol.26 , Issue.2 , pp. 295-304
    • Kwan, T.S.1    Pelletier, J.-P.2    Lajeunesse, D.3    Fahmi, H.4    Lavigne, M.5    Martel-Pelletier, J.6
  • 53
    • 65949100790 scopus 로고    scopus 로고
    • New perspective in osteoarthritis: The OPG and RANKL system as a potential therapeutic target?
    • Tat SK, Pelletier JP, Velasco CR, Padrines M, Martel-Pelletier J. New perspective in osteoarthritis: the OPG and RANKL system as a potential therapeutic target? Keio J Med 2009;58: 29-40.
    • (2009) Keio J Med , vol.58 , pp. 29-40
    • Tat, S.K.1    Pelletier, J.P.2    Velasco, C.R.3    Padrines, M.4    Martel-Pelletier, J.5
  • 54
    • 52449134369 scopus 로고    scopus 로고
    • Tensile and compressive properties of healthy and osteoarthritic human articular cartilage
    • Boschetti F, Peretti GM. Tensile and compressive properties of healthy and osteoarthritic human articular cartilage. Biorheology 2008;45:337-44.
    • (2008) Biorheology , vol.45 , pp. 337-344
    • Boschetti, F.1    Peretti, G.M.2
  • 55
    • 33750628318 scopus 로고    scopus 로고
    • Regulation of chondrocyte differentiation level via co-culture with osteoblasts
    • DOI 10.1089/ten.2006.12.2425
    • Nakaoka R, Hsiong SX, Mooney DJ. Regulation of chondrocyte differentiation level via co-culture with osteoblasts. Tissue Eng 2006;12:2425-33. (Pubitemid 46141266)
    • (2006) Tissue Engineering , vol.12 , Issue.9 , pp. 2425-2433
    • Nakaoka, R.1    Hsiong, S.X.2    Mooney, D.J.3
  • 56
    • 77957253816 scopus 로고    scopus 로고
    • Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis
    • Sniekers YH, Weinans H, van Osch GJ, van Leeuwen JP. Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis. Arthritis Res Ther 2010;12:R182.
    • (2010) Arthritis Res Ther , vol.12
    • Sniekers, Y.H.1    Weinans, H.2    Van Osch, G.J.3    Van Leeuwen, J.P.4
  • 58
    • 77955482258 scopus 로고    scopus 로고
    • Epidemiology of osteoarthritis
    • Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med 2010;26:355-69.
    • (2010) Clin Geriatr Med , vol.26 , pp. 355-369
    • Zhang, Y.1    Jordan, J.M.2
  • 59
    • 26944446898 scopus 로고    scopus 로고
    • Immunolocalization of receptor activator of nuclear facotr-κB ligand (RANKL) and osteoprotegrin (OPG) in Meckel's cartilage compared with developing endochondral bones in mice
    • DOI 10.1111/j.1469-7580.2005.00466.x
    • Sakakura Y, Tsuruga E, Irie K, Hosokawa Y, Nakamura H, Yajima T. Immunolocalization of receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) in Meckel's cartilage compared with developing endochondral bones in mice. J Anat 2005;207:325-37. (Pubitemid 41479537)
    • (2005) Journal of Anatomy , vol.207 , Issue.4 , pp. 325-337
    • Sakakura, Y.1    Tsuruga, E.2    Irie, K.3    Hosokawa, Y.4    Nakamura, H.5    Yajima, T.6
  • 61
    • 84857055640 scopus 로고    scopus 로고
    • The expression of RANKL and OPG in the various grades of osteoarthritic cartilage
    • Upton AR, Holding CA, Dharmapatni AA, Haynes DR. The expression of RANKL and OPG in the various grades of osteoarthritic cartilage. Rheumatol Int 2012;32:535-40.
    • (2012) Rheumatol Int , vol.32 , pp. 535-540
    • Upton, A.R.1    Holding, C.A.2    Dharmapatni, A.A.3    Haynes, D.R.4
  • 62
    • 36949023800 scopus 로고    scopus 로고
    • Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling
    • Hopwood B, Tsykin A, Findlay DM, Fazzalari NL. Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-β/bone morphogenic protein signalling. Arthritis Res Ther 2007;9:R100.
    • (2007) Arthritis Res Ther , vol.9
    • Hopwood, B.1    Tsykin, A.2    Findlay, D.M.3    Fazzalari, N.L.4
  • 63
    • 72949087782 scopus 로고    scopus 로고
    • Asporin and transforming growth factor-β gene expression in osteoblasts from subchondral bone and osteophytes in osteoarthritis
    • Sakao K, Takahashi KA, Arai Y, Saito M, Honjyo K, Hiraoka N, et al. Asporin and transforming growth factor-β gene expression in osteoblasts from subchondral bone and osteophytes in osteoarthritis. J Orthop Sci 2009;14:738-47.
    • (2009) J Orthop Sci , vol.14 , pp. 738-747
    • Sakao, K.1    Takahashi, K.A.2    Arai, Y.3    Saito, M.4    Honjyo, K.5    Hiraoka, N.6
  • 64
    • 70449640613 scopus 로고    scopus 로고
    • TGF-β signaling in chondrocyte terminal differentiation and osteoarthritis: Modulation and integration of signaling pathways through receptor-Smads
    • Van der Kraan PM, Blaney Davidson EN, Blom A, van den Berg WB. TGF-β signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads. Osteoarthritis Cartilage 2009;17:1539-45.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 1539-1545
    • Van Der Kraan, P.M.1    Blaney Davidson, E.N.2    Blom, A.3    Van Den Berg, W.B.4
  • 65
    • 77951725798 scopus 로고    scopus 로고
    • Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees
    • Weng LH, Wang CJ, Ko JY, Sun YC, Wang FS. Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees. Arthritis Rheum 2010;62:1393-402.
    • (2010) Arthritis Rheum , vol.62 , pp. 1393-1402
    • Weng, L.H.1    Wang, C.J.2    Ko, J.Y.3    Sun, Y.C.4    Wang, F.S.5
  • 66
    • 77951073232 scopus 로고    scopus 로고
    • To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy
    • Blom AB, van Lent PL, van der Kraan PM, van den Berg WB. To seek shelter from the WNT in osteoarthritis? WNT-signaling as a target for osteoarthritis therapy. Curr Drug Targets 2010;11:620-9.
    • (2010) Curr Drug Targets , vol.11 , pp. 620-629
    • Blom, A.B.1    Van Lent, P.L.2    Van Der Kraan, P.M.3    Van Den Berg, W.B.4
  • 67
    • 59649095502 scopus 로고    scopus 로고
    • Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1
    • Blom AB, Brockbank SM, van Lent PL, van Beuningen HM, Geurts J, Takahashi N, et al. Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1. Arthritis Rheum 2009;60:501-12.
    • (2009) Arthritis Rheum , vol.60 , pp. 501-512
    • Blom, A.B.1    Brockbank, S.M.2    Van Lent, P.L.3    Van Beuningen, H.M.4    Geurts, J.5    Takahashi, N.6
  • 68
    • 73949159516 scopus 로고    scopus 로고
    • Low-density lipoprotein receptor-related protein 5 (LRP5) expression in human osteoarthritic chondrocytes
    • Papathanasiou I, Malizos KN, Tsezou A. Low-density lipoprotein receptor-related protein 5 (LRP5) expression in human osteoarthritic chondrocytes. J Orthop Res 2010;28:348-53.
    • (2010) J Orthop Res , vol.28 , pp. 348-353
    • Papathanasiou, I.1    Malizos, K.N.2    Tsezou, A.3
  • 69
    • 77956870193 scopus 로고    scopus 로고
    • Critical molecular regulators, histomorphometric indices and their correlations in the trabecular bone in primary hip osteoarthritis
    • Kumarasinghe DD, Perilli E, Tsangari H, Truong L, Kuliwaba JS, Hopwood B, et al. Critical molecular regulators, histomorphometric indices and their correlations in the trabecular bone in primary hip osteoarthritis. Osteoarthritis Cartilage 2010;18:1337-44.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 1337-1344
    • Kumarasinghe, D.D.1    Perilli, E.2    Tsangari, H.3    Truong, L.4    Kuliwaba, J.S.5    Hopwood, B.6
  • 70
    • 77951733792 scopus 로고    scopus 로고
    • ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts
    • Prasadam I, van Gennip S, Friis T, Shi W, Crawford R, Xiao Y. ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts. Arthritis Rheum 2010;62: 1349-60.
    • (2010) Arthritis Rheum , vol.62 , pp. 1349-1360
    • Prasadam, I.1    Van Gennip, S.2    Friis, T.3    Shi, W.4    Crawford, R.5    Xiao, Y.6
  • 71
    • 72049114993 scopus 로고    scopus 로고
    • Osteoarthritic cartilage chondrocytes alter subchondral bone osteoblast differentiation via MAPK signalling pathway involving ERK1/2
    • Prasadam I, Friis T, Shi W, van Gennip S, Crawford R, Xiao Y. Osteoarthritic cartilage chondrocytes alter subchondral bone osteoblast differentiation via MAPK signalling pathway involving ERK1/2. Bone 2010;46:226-35.
    • (2010) Bone , vol.46 , pp. 226-235
    • Prasadam, I.1    Friis, T.2    Shi, W.3    Van Gennip, S.4    Crawford, R.5    Xiao, Y.6
  • 73
    • 37749024290 scopus 로고    scopus 로고
    • The additive effect of individual genes in predicting risk of knee osteoarthritis
    • Valdes AM, Doherty M, Spector TD. The additive effect of individual genes in predicting risk of knee osteoarthritis. Ann Rheum Dis 2008;67:124-7.
    • (2008) Ann Rheum Dis , vol.67 , pp. 124-127
    • Valdes, A.M.1    Doherty, M.2    Spector, T.D.3
  • 74
    • 44449153906 scopus 로고    scopus 로고
    • Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis
    • Valdes AM, Loughlin J, Timms KM, van Meurs JJ, Southam L, Wilson SG, et al. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Am J Hum Genet 2008;82:1231-40.
    • (2008) Am J Hum Genet , vol.82 , pp. 1231-1240
    • Valdes, A.M.1    Loughlin, J.2    Timms, K.M.3    Van Meurs, J.J.4    Southam, L.5    Wilson, S.G.6
  • 77
    • 65249106542 scopus 로고    scopus 로고
    • Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage
    • Da Silva MA, Yamada N, Clarke NM, Roach HI. Cellular and epigenetic features of a young healthy and a young osteoarthritic cartilage compared with aged control and OA cartilage. J Orthop Res 2009;27:593-601.
    • (2009) J Orthop Res , vol.27 , pp. 593-601
    • Da Silva, M.A.1    Yamada, N.2    Clarke, N.M.3    Roach, H.I.4
  • 78
    • 61449135868 scopus 로고    scopus 로고
    • Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA demethylation
    • Cheung KS, Hashimoto K, Yamada N, Roach HI. Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA demethylation. Rheumatol Int 2009;29:525-34.
    • (2009) Rheumatol Int , vol.29 , pp. 525-534
    • Cheung, K.S.1    Hashimoto, K.2    Yamada, N.3    Roach, H.I.4
  • 79
    • 79951580355 scopus 로고    scopus 로고
    • The epigenetic effect of glucosamine and a nuclear factor-κB (NF-κB) inhibitor on primary human chondrocytes: Implications for osteoarthritis
    • Imagawa K, de Andres MC, Hashimoto K, Pitt D, Itoi E, Goldring MB, et al. The epigenetic effect of glucosamine and a nuclear factor-κB (NF-κB) inhibitor on primary human chondrocytes: implications for osteoarthritis. Biochem Biophys Res Commun 2011;405:362-7.
    • (2011) Biochem Biophys Res Commun , vol.405 , pp. 362-367
    • Imagawa, K.1    De Andres, M.C.2    Hashimoto, K.3    Pitt, D.4    Itoi, E.5    Goldring, M.B.6
  • 81
    • 79551658047 scopus 로고    scopus 로고
    • Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage
    • Rosenthal AK, Gohr CM, Ninomiya J, Wakim BT. Proteomic analysis of articular cartilage vesicles from normal and osteoarthritic cartilage. Arthritis Rheum 2011;63:401-11.
    • (2011) Arthritis Rheum , vol.63 , pp. 401-411
    • Rosenthal, A.K.1    Gohr, C.M.2    Ninomiya, J.3    Wakim, B.T.4
  • 82
    • 57049092882 scopus 로고    scopus 로고
    • The contribution of genes to osteoarthritis
    • Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Med Clin North Am 2009;93:45-66.
    • (2009) Med Clin North Am , vol.93 , pp. 45-66
    • Valdes, A.M.1    Spector, T.D.2
  • 83
    • 36549024994 scopus 로고    scopus 로고
    • Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: Possible molecular target for osteoarthritis therapeutic intervention
    • DOI 10.1136/ard.2007.069377
    • Iliopoulos D, Malizos KN, Tsezou A. Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Ann Rheum Dis 2007;66:1616-21. (Pubitemid 350205450)
    • (2007) Annals of the Rheumatic Diseases , vol.66 , Issue.12 , pp. 1616-1621
    • Iliopoulos, D.1    Malizos, K.N.2    Tsezou, A.3
  • 84
    • 33846393572 scopus 로고    scopus 로고
    • DNA methylation in osteoarthritic chondrocytes: A new molecular target
    • DOI 10.1016/j.joca.2006.07.002, PII S1063458406002159
    • Roach HI, Aigner T. DNA methylation in osteoarthritic chondrocytes: a new molecular target. Osteoarthritis Cartilage 2007;15:128-37. (Pubitemid 46132098)
    • (2007) Osteoarthritis and Cartilage , vol.15 , Issue.2 , pp. 128-137
    • Roach, H.I.1    Aigner, T.2
  • 85
    • 77951026170 scopus 로고    scopus 로고
    • Targets to tackle: The pathophysiology of the disease
    • Schmitz N, Kraus VB, Aigner T. Targets to tackle: the pathophysiology of the disease. Curr Drug Targets 2010;11:521-7.
    • (2010) Curr Drug Targets , vol.11 , pp. 521-527
    • Schmitz, N.1    Kraus, V.B.2    Aigner, T.3
  • 89
    • 61449263607 scopus 로고    scopus 로고
    • Change in cartilage morphometry: A sample of the progression cohort of the Osteoarthritis Initiative
    • Hunter DJ, Niu J, Zhang Y, Totterman S, Tamez J, Dabrowski C, et al. Change in cartilage morphometry: a sample of the progression cohort of the Osteoarthritis Initiative. Ann Rheum Dis 2009;68:349-56.
    • (2009) Ann Rheum Dis , vol.68 , pp. 349-356
    • Hunter, D.J.1    Niu, J.2    Zhang, Y.3    Totterman, S.4    Tamez, J.5    Dabrowski, C.6
  • 90
    • 77957278374 scopus 로고    scopus 로고
    • Relationship of serum markers of cartilage metabolism to imaging and clinical outcome measures of knee joint structure
    • Berry PA, Maciewicz RA, Wluka AE, Downey-Jones MD, Forbes A, Hellawell CJ, et al. Relationship of serum markers of cartilage metabolism to imaging and clinical outcome measures of knee joint structure. Ann Rheum Dis 2010;69:1816-22.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1816-1822
    • Berry, P.A.1    Maciewicz, R.A.2    Wluka, A.E.3    Downey-Jones, M.D.4    Forbes, A.5    Hellawell, C.J.6
  • 91
    • 33747793076 scopus 로고    scopus 로고
    • Ultra-High-Field MRI of Knee Joint at 7.0T: Preliminary Experience
    • DOI 10.1016/j.acra.2006.06.007, PII S1076633206003229
    • Pakin SK, Cavalcanti C, La Rocca R, Schweitzer ME, Regatte RR. Ultra-high-field MRI of knee joint at 7.0T: preliminary experience. Acad Radiol 2006;13:1135-42. (Pubitemid 44279452)
    • (2006) Academic Radiology , vol.13 , Issue.9 , pp. 1135-1142
    • Pakin, S.K.1    Cavalcanti, C.2    La, R.R.3    Schweitzer, M.E.4    Regatte, R.R.5
  • 92
    • 70349378297 scopus 로고    scopus 로고
    • Primary osteoarthritis no longer primary: Three subsets with distinct etiological, clinical, and therapeutic characteristics
    • Herrero-Beaumont G, Roman-Blas JA, Castaneda S, Jimenez SA. Primary osteoarthritis no longer primary: three subsets with distinct etiological, clinical, and therapeutic characteristics. Semin Arthritis Rheum 2009;39:71-80.
    • (2009) Semin Arthritis Rheum , vol.39 , pp. 71-80
    • Herrero-Beaumont, G.1    Roman-Blas, J.A.2    Castaneda, S.3    Jimenez, S.A.4
  • 93
    • 70349677318 scopus 로고    scopus 로고
    • A prospective, randomized clinical study of osteochondral autologous transplantation versus microfracture for the treatment of osteochondritis dissecans in the knee joint in children
    • Gudas R, Simonaityte R, Cekanauskas E, Tamosiunas R. A prospective, randomized clinical study of osteochondral autologous transplantation versus microfracture for the treatment of osteochondritis dissecans in the knee joint in children. J Pediatr Orthop 2009;29:741-8.
    • (2009) J Pediatr Orthop , vol.29 , pp. 741-748
    • Gudas, R.1    Simonaityte, R.2    Cekanauskas, E.3    Tamosiunas, R.4
  • 94
    • 77957891711 scopus 로고    scopus 로고
    • Osteochondral autologous transplantation was more effective than microfracture for osteochondritis dissecans in children younger than eighteen years
    • Chambers HG. Osteochondral autologous transplantation was more effective than microfracture for osteochondritis dissecans in children younger than eighteen years. J Bone Joint Surg Am 2010;92:1998.
    • (2010) J Bone Joint Surg Am , vol.92 , pp. 1998
    • Chambers, H.G.1
  • 95
    • 77952390429 scopus 로고    scopus 로고
    • Osteochondral autograft transplantation for osteochondritis dissecans of the knee: Preliminary results of a prospective case series
    • Smolders JM, Kock NB, Koeter S, van Susante JL. Osteochondral autograft transplantation for osteochondritis dissecans of the knee: preliminary results of a prospective case series. Acta Orthop Belg 2010;76:208-18.
    • (2010) Acta Orthop Belg , vol.76 , pp. 208-218
    • Smolders, J.M.1    Kock, N.B.2    Koeter, S.3    Van Susante, J.L.4
  • 96
    • 77955812504 scopus 로고    scopus 로고
    • Is osteoarthritis a disease involving only cartilage or other articular tissues?
    • Martel-Pelletier J, Pelletier JP. Is osteoarthritis a disease involving only cartilage or other articular tissues? Eklem Hastalik Cerrahis 2010;21:2-14.
    • (2010) Eklem Hastalik Cerrahis , vol.21 , pp. 2-14
    • Martel-Pelletier, J.1    Pelletier, J.P.2
  • 97
    • 74549210046 scopus 로고    scopus 로고
    • The role of biomechanics in the initiation and progression of OA of the knee
    • Englund M. The role of biomechanics in the initiation and progression of OA of the knee. Best Pract Res Clin Rheumatol 2010;24:39-46.
    • (2010) Best Pract Res Clin Rheumatol , vol.24 , pp. 39-46
    • Englund, M.1


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