Osteoarthritis associated with estrogen deficiency

Arthritis Research and Therapy

Volumn 11, Issue 5, 2009, Pages

  Roman Blas, Jorge A ^a,b   Castañeda, Santos ^a   Largo, Raquel ^a   Herrero Beaumont, Gabriel ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALENDRONIC ACID; ARZOXIFENE; BAZEDOXIFENE; CENTCHROMAN; CLOMIFENE; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FULVESTRANT; HMR 3339; LASOFOXIFENE; NNC 45 0320; NNC 45 0781; NNC 45 1506; OSPEMIFENE; PIPENDOXIFENE; PRINABEREL; RALOXIFENE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; STEROID; TAMOXIFEN; TOREMIFENE; UNCLASSIFIED DRUG; WAY 169916; WAY 204688;

BREAST CANCER; CANCER PREVENTION; CHRONIC ARTHRITIS; DISEASE ASSOCIATION; DISEASE COURSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; ENDOMETRIOSIS; ESTROGEN ACTIVITY; ESTROGEN DEFICIENCY; ESTROGEN RESPONSIVE ELEMENT; ESTROGEN THERAPY; GENETIC ASSOCIATION; HIP OSTEOARTHRITIS; HORMONAL REGULATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; KNEE OSTEOARTHRITIS; NONHUMAN; OSTEOARTHRITIS; OSTEOPOROSIS; PATHOGENESIS; POSTMENOPAUSE OSTEOPOROSIS; REVIEW; RISK REDUCTION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TARGET ORGAN; TISSUE METABOLISM; UTERUS CANCER; VAGINA ATROPHY; ANIMAL; FEMALE; JOINT; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; POSTMENOPAUSE;

ANIMALS; ESTROGENS; FEMALE; HUMANS; JOINTS; OSTEOARTHRITIS; OSTEOPOROSIS; POSTMENOPAUSE;

EID: 75649095702     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar2791     Document Type: Review

References (123)

1. Brandt KD, Radin EL, Dieppe PA, Putte L. Yet more evidence that osteoarthritis is not a cartilage disease. Ann Rheum Dis 2006, 65:1261-1264. 16973787, 10.1136/ard.2006.058347.
2. Sellam J, Herrero-Beaumont G, Berenbaum F. Osteoarthritis: pathogenesis, clinical aspects and diagnosis. EULAR Compendium on Rheumatic Diseases 2009, 444-463. London, UK: BMJ Publishing Group Ltd, Hans Bijlsma.
3. Brandt KD, Dieppe P, Radin EL. Etiopathogenesis of osteoarthritis. Rheum Dis Clin North Am 2008, 34:531-559. 18687271, 10.1016/j.rdc.2008.05.011.
4. Herrero-Beaumont G, Roman-Blas JA, Castañeda S, Jimenez SA. Primary osteoarthritis: three subsets with etiological, clinical and therapeutic characteristics. Semin Arthritis Rheum 2009,
5. Gokhale JA, Frenkel SR, Dicesare PE. Estrogen and osteoarthritis. Am J Orthop 2004, 33:71-80.
6. Tankó LB, Søndergaard BC, Oestergaard S, Karsdal MA, Christiansen C. An update review of cellular mechanisms conferring the indirect and direct effects of estrogen on articular cartilage. Climacteric 2008, 11:4-16. 18202960, 10.1080/13697130701857639.
7. Sniekers YH, Weinans H, Bierma-Zeinstra SM, van Leeuwen JP, van Osch GJ. Animal models for osteoarthritis: the effect of ovariectomy and estrogen treatment - a systematic approach. Osteoarthritis Cartilage 2008, 16:533-541. 18280756, 10.1016/j.joca.2008.01.002.
8. Srikanth VK, Fryer JL, Zhai G, Winzenberg TM, Hosmer D, Jones G. A meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis. Osteoarthritis Cartilage 2005, 13:769-781. 15978850, 10.1016/j.joca.2005.04.014.
9. Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, Heyse SP, Hirsch R, Hochberg MC, Hunder GG, Liang MH, Pillemer SR, Steen VD, Wolfe F. Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 1998, 41:778-799. 9588729, 10.1002/1529-0131(199805)41:5<778::AID-ART4>3.0.CO;2-V.
10. Ushiyama T, Ueyama H, Inoue K, Ohkubo I, Hukuda S. Expression of genes for estrogen receptors alpha and beta in human articular chondrocytes. Osteoarthritis Cartilage 1999, 7:560-566. 10558854, 10.1053/joca.1999.0260.
11. Braidman IP, Hainey L, Batra G, Selby PL, Saunders PT, Hoyland JA. Localization of estrogen receptor beta protein expression in adult human bone. J Bone Miner Res 2001, 16:214-220. 11204421, 10.1359/jbmr.2001.16.2.214.
12. Dietrich W, Haitel A, Holzer G, Huber JC, Kolbus A, Tschugguel W. Estrogen receptor-beta is the predominant estrogen receptor subtype in normal human synovia. J Soc Gynecol Investig 2006, 13:512-517.
13. Sciore P, Frank CB, Hart DA. Identification of sex hormone receptors in human and rabbit ligaments of the knee by reverse transcription polymerase chain reaction: evidence that receptors are present in tissue from both male and female subjects. J Orthop Res 1998, 16:604-610. 9820285, 10.1002/jor.1100160513.
14. Kahlert S, Grohé C, Karas RH, Löbbert K, Neyses L, Vetter H. Effects of estrogen on skeletal myoblast growth. Biochem Biophys Res Commun 1997, 232:373-378. 9125184, 10.1006/bbrc.1997.6223.
15. Maneix L, Beauchef G, Servent A, Wegrowski Y, Maquart FX, Boujrad N, Flouriot G, Pujol JP, Boumediene K, Galéra P, Moslemi S. 17Beta-oestradiol up-regulates the expression of a functional UDP-glucose dehydrogenase in articular chondrocytes: comparison with effects of cytokines and growth factors. Rheumatology 2008, 47:281-288. 18238796, 10.1093/rheumatology/kem323.
16. Oestergaard S, Sondergaard BC, Hoegh-Andersen P, Henriksen K, Qvist P, Christiansen C, Tankó LB, Karsdal MA. Effects of ovariectomy and estrogen therapy on type II collagen degradation and structural integrity of articular cartilage in rats: implications of the time of initiation. Arthritis Rheum 2006, 54:2441-2451. 16871544, 10.1002/art.22009.
17. Morisset S, Patry C, Lora M, de Brum-Fernandes AJ. Regulation of cyclooxygenase-2 expression in bovine chondrocytes in culture by interleukin 1β, tumor necrosis factor-α, glucocorticoids, and 17β-estradiol. J Rheumatol 1998, 25:1146-1153.
18. Claassen H, Schünke M, Kurz B. Estradiol protects cultured articular chondrocytes from oxygen-radical-induced damage. Cell Tissue Res 2005, 319:439-445. 15668798, 10.1007/s00441-004-1029-9.
19. Scranton PE, McMaster JH, Diamond PE. Hormone suppression of DNA synthesis in cultured Hormone suppression of DNA synthesis in cultured chondrocyte and osteosarcoma cell line. Clin Orthop Relat Res 1975, 112:340-348. 1059508, 10.1097/00003086-197510000-00036.
20. Mackintosh D, Mason RM. Pharmacological actions of 17 beta-oestradiol on articular cartilage chondrocytes and chondrosarcoma chondrocytes in the absence of oestrogen receptors. Biochim Biophys Acta 1988, 964:295-302.
21. Talwar RM, Wong BS, Svoboda K, Harper RP. Effects of estrogen on chondrocyte proliferation and collagen synthesis in skeletally mature articular cartilage. J Oral Maxillofac Surg 2006, 64:600-609. 16546639, 10.1016/j.joms.2005.12.006.
22. Blanchard O, Tsagris L, Rappaport R, Duval-Beaupere G, Corvol M. Age-dependent responsiveness of rabbit and human cartilage cells to sex steroids in vitro. J Steroid Biochem Mol Biol 1991, 40:711-716. 1958568, 10.1016/0960-0760(91)90295-G.
23. Dayani N, Corvol MT, Robel P, Eychenne B, Moncharmont B, Tsagris L, Rappaport R. Estrogen receptors in cultured rabbit articular chondrocytes: influence of age. J Steroid Biochem 1988, 31:351-356. 3419165, 10.1016/0022-4731(88)90361-5.
24. Høegh-Andersen P, Tankó LB, Andersen TL, Lundberg CV, Mo JA, Heegaard AM, Delaissé JM, Christgau S. Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application. Arthritis Res Ther 2004, 6:R169-180. 15059281, 10.1186/ar1152, 400436.
25. Ham KD, Loeser RF, Lindgren BR, Carlson CS. Effects of long-term estrogen replacement therapy on osteoarthritis severity in cynomolgus monkeys. Arthritis Rheum 2002, 46:1956-1964. 12124881, 10.1002/art.10406.
26. Ma HL, Blanchet TJ, Peluso D, Hopkins B, Morris EA, Glasson SS. Osteoarthritis severity is sex dependent in a surgical mouse model. Osteoarthritis Cartilage 2007, 15:695-700. 17207643, 10.1016/j.joca.2006.11.005.
27. Ham KD, Carlson CS. Effects of estrogen replacement therapy on bone turnover in subchondral bone and epiphyseal metaphyseal cancellous bone of ovariectomized cynomolgus monkeys. J Bone Miner Res 2004, 19:823-829. 15068506, 10.1359/JBMR.040309.
28. Olson EJ, Lindgren BR, Carlson CS. Effects of long-term estrogen replacement therapy on the prevalence and area of periarticular tibial osteophytes in surgically postmenopausal cynomolgus monkeys. Bone 2007, 41:282-289. 17540630, 10.1016/j.bone.2007.04.175, 1993811.
29. Quasnichka HL, Anderson-MacKenzie JM, Bailey AJ. Subchondral bone and ligament changes precede cartilage degradation in guinea pig osteoarthritis. Biorheology 2006, 43:389-397.
30. Castañeda S, Largo R, Calvo E, Rodríguez-Salvanés F, Marcos ME, Díaz-Curiel M, Herrero-Beaumont G. Bone mineral measurements of subchondral and trabecular bone in healthy and osteoporotic rabbits. Skeletal Radiol 2006, 35:34-41. 16247642, 10.1007/s00256-005-0022-z.
31. Calvo E, Castañeda S, Largo R, Fernández-Valle ME, Rodríguez-Salvanés F, Herrero-Beaumont G. Osteoporosis increases the severity of cartilage damage in an experimental model of osteoarthritis in rabbits. Osteoarthritis Cartilage 2007, 15:69-77. 16861013, 10.1016/j.joca.2006.06.006.
32. Gilsanz V, Roe TF, Gibbens DT, Schulz EE, Carlson ME, Gonzalez O, Boechat MI. Effect of sex steroids on peak bone density of growing rabbits. Am J Physiol Endocrinol Metab 1988, 255:E416-421.
33. Castañeda S, Calvo E, Largo R, González-González R, de la Piedra C, Díaz-Curiel M, Herrero-Beaumont G. Characterization of a new experimental model of osteoporosis in rabbits. J Bone Miner Metab 2008, 26:53-59. 18095064, 10.1007/s00774-007-0797-1.
34. Strickland SM, Belknap TW, Turner SA, Wright TM, Hannafin JA. Lack of hormonal influences on mechanical properties of sheep knee ligaments. Am J Sports Med 2003, 31:210-215.
35. Komulainen J, Koskinen SO, Kalliokoski R, Takala TE, Vihko V. Gender differences in skeletal muscle fibre damage after eccentrically biased downhill running in rats. Acta Physiol Scand 1999, 165:57-63. 10072098, 10.1046/j.1365-201x.1999.00481.x.
36. Bergink AP, van Meurs JB, Loughlin J, Arp PP, Fang Y, Hofman A, van Leeuwen JP, van Duijn CM, Uitterlinden AG, Pols HA. Estrogen receptor alpha gene haplotype is associated with radiographic osteoarthritis of the knee in elderly men and women. Arthritis Rheum 2003, 48:1913-1922. 12847685, 10.1002/art.11046.
37. Valdes AM, Van Oene M, Hart DJ, Surdulescu GL, Loughlin J, Doherty M, Spector TD. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum 2006, 54:533-539. 16453284, 10.1002/art.21621.
38. Jin SY, Hong SJ, Yang HI, Park SD, Yoo MC, Lee HJ, Hong MS, Park HJ, Yoon SH, Kim BS, Yim SV, Park HK, Chung JH. Estrogen receptor-alpha gene haplotype is associated with primary knee osteoarthritis in Korean population. Arthritis Res Ther 2004, 6:R415-421. 15380041, 10.1186/ar1207, 546279.
39. Loughlin J, Sinsheimer JS, Mustafa Z, Carr AJ, Clipsham K, Bloomfield VA, Chitnavis J, Bailey A, Sykes B, Chapman K. Association analysis of the vitamin D receptor gene, the type I collagen gene COL1A1, and the estrogen receptor gene in idiopathic osteoarthritis. J Rheumatol 2000, 27:779-784.
40. Lian K, Lui L, Zmuda JM, Nevitt MC, Hochberg MC, Lee JM, Li J, Lane NE. Estrogen receptor alpha genotype is associated with a reduced prevalence of radiographic hip osteoarthritis in elderly Caucasian women. Osteoarthritis Cartilage 2007, 15:972-978. 17419075, 10.1016/j.joca.2007.02.020, 2204046.
41. Felson DT, Zhang Y, Hannan MT, Naimark A, Weissman BN, Aliabadi P, Levy D. The incidence and natural history of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum 1995, 38:1500-1505. 7575700, 10.1002/art.1780381017.
42. Wood P. Age and the rheumatic diseases. Population Studies of the Rheumatic Diseases 1982, 4:26-37. Amsterdam: Excerpta Medica, Bennett PH, Wood PH.
43. Nadkar MY, Samant RS, Vaidya SS, Borges NE. Relationship between osteoarthritis of knee and menopause. J Assoc Phys India 1999, 47:1161-1163.
44. Kellgren JH, Moore R. Generalized osteoarthritis and Heberdens nodes. BMJ 1952, 1:181-187. 14896078, 10.1136/bmj.1.4751.181, 2022370.
45. Felson DT, Nevitt MC. The effects of estrogen on osteoarthritis. Curr Opin Rheumatol 1998, 10:269-272. 9608332, 10.1097/00002281-199805000-00019.
46. Punzi L, Ramonda R, Sfriso P. Erosive osteoarthritis. Best Pract Res Clin Rheumatol 2004, 18:739-758. 15454130, 10.1016/j.berh.2004.05.010.
47. Sowers MR, McConnell D, Jannausch M, Buyuktur AG, Hochberg M, Jamadar DA. Estradiol and its metabolites and their association with knee osteoarthritis. Arthritis Rheum 2006, 54:2481-2487. 16871545, 10.1002/art.22005.
48. Sipilä S. Body composition and muscle performance during menopause and hormone replacement therapy. J Endocrinol Invest 2003, 26:893-901.
49. Slemenda C, Heilman DK, Brandt KD, Katz BP, Mazzuca SA, Braunstein EM, Byrd D. Reduced quadriceps strength relative to body weight: a risk factor for knee osteoarthritis in women?. Arthritis Rheum 1998, 41:1951-1959. 9811049, 10.1002/1529-0131(199811)41:11<1951::AID-ART9>3.0.CO;2-9.
50. Sipilä S, Poutamo J. Muscle performance, sex hormones and training in peri-menopausal and post-menopausal women. Scand J Med Sci Sports 2003, 13:19-25. 12535313, 10.1034/j.1600-0838.2003.20210.x.
51. Sharma L, Lou C, Felson DT, Dunlop DD, Kirwan-Mellis G, Hayes KW, Weinrach D, Buchanan TS. Laxity in healthy and osteoarthritic knees. Arthritis Rheum 1999, 42:861-870. 10323441, 10.1002/1529-0131(199905)42:5<861::AID-ANR4>3.0.CO;2-N.
52. Karsdal MA, Leeming DJ, Dam EB, Henriksen K, Alexandersen P, Pastoureau P, Altman RD, Christiansen C. Should subchondral bone turnover be targeted when treating osteoarthritis?. Osteoarthritis Cartilage 2008, 16:638-646. 18362080, 10.1016/j.joca.2008.01.014.
53. Hopwood B, Tsykin A, Findlay DM, Fazzalari NL. Microarray gene expression profiling of osteoarthritic bone suggests altered bone remodelling, WNT and transforming growth factor-beta/bone morphogenic protein signalling. Arthritis Res Ther 2007, 9:R100. 17900349, 10.1186/ar2301, 2212557.
54. Sanchez C, Deberg MA, Piccardi N, Msika P, Reginster JY, Henrotin YE. Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked by inter-leukin-6, -1beta and oncostatin M pre-treated non-sclerotic osteoblasts. Osteoarthritis Cartilage 2005, 13:979-987. 16243232, 10.1016/j.joca.2005.03.008.
55. Stewart A, Black A. Bone mineral density in osteoarthritis. Curr Opin Rheumatol 2000, 12:464-467. 10990188, 10.1097/00002281-200009000-00021.
56. Dequeker J, Aerssens J, Luyten FP. Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship. Aging Clin Exp Res 2003, 15:426-439.
57. Ng MC, Revell PA, Beer M, Boucher BJ, Cohen RD, Currey LF. Incidence of metabolic bone disease in rheumatoid arthritis and osteoarthritis. Ann Rheum Dis 1984, 43:370-377. 6742898, 10.1136/ard.43.3.370, 1001347.
58. Perilli E, Baleani M, Ohman C, Baruffaldi F, Viceconti M. Structural parameters and mechanical strength of cancellous bone in the femoral head in osteoarthritis do not depend on age. Bone 2007, 41:760-768. 17707709, 10.1016/j.bone.2007.07.014.
59. Bruyere O, Dardenne C, Lejeune E, Zegels B, Pahaut A, Richy F, Seidel L, Ethgen O, Henrotin Y, Reginster JY. Subchondral tibial bone mineral density predicts future joint space narrowing at the medial femorotibial compartment in patients with knee osteoarthritis. Bone 2003, 32:541-545. 12753870, 10.1016/S8756-3282(03)00059-0.
60. Karvonen RL, Miller PR, Nelson DA, Granda JL, Fernandez-Madrid F. Periarticular osteoporosis in osteoarthritis of the knee. J Rheumatol 1998, 25:2187-2194.
61. Klinge CM. Estrogen receptor interaction with estrogen response elements. Nucleic Acids Res 2001, 29:2905-2919. 11452016, 10.1093/nar/29.14.2905, 55815.
62. Gruber CJ, Gruber DM, Gruber IM, Wieser F, Huber JC. Anatomy of the estrogen response element. Trends Endocrinol Metab 2004, 15:73-78. 15036253, 10.1016/j.tem.2004.01.008.
63. Ellmann S, Sticht H, Thiel F, Beckmann MW, Strick R, Strissel PL. Estrogen and progesterone receptors: from molecular structures to clinical targets. Cell Mol Life Sci 2009, 66:2405-2426. 19333551, 10.1007/s00018-009-0017-3.
64. Cheskis BJ, Greger JG, Nagpal S, Freedman LP. Signaling by estrogens. J Cell Physiol 2007, 213:610-617. 17886255, 10.1002/jcp.21253.
65. Weihua Z, Andersson S, Cheng G, Simpson ER, Warner M, Gustafsson JA. Update on estrogen signaling. FEBS Lett 2003, 546:17-24. 12829231, 10.1016/S0014-5793(03)00436-8.
66. Matthews J, Gustafsson JA. Estrogen signaling: a subtle balance between ER alpha and ER beta. Mol Interv 2003, 3:281-292. 14993442, 10.1124/mi.3.5.281.
67. Hirata S, Shoda T, Kato J, Hoshi K. Isoform/variant mRNAs for sex steroid hormone receptors in humans. Trends Endocrinol Metab 2003, 14:124-129. 12670738, 10.1016/S1043-2760(03)00028-6.
68. Bord S, Horner A, Beavan S, Compston J. Estrogen receptors alpha and beta are differentially expressed in developing human bone. J Clin Endocrinol Metab 2001, 86:2309-2314. 11344243, 10.1210/jc.86.5.2309.
69. Onoe Y, Miyaura C, Ohta H, Nozawa S, Suda T. Expression of estrogen receptor beta in rat bone. Endocrinology 1997, 138:4509-4512. 9322974, 10.1210/en.138.10.4509.
70. Oreffo RO, Kusec V, Virdi AS, Flanagan AM, Grano M, Zambonin-Zallone A, Triffitt JT. Expression of estrogen receptor-alpha in cells of the osteoclastic lineage. Histochem Cell Biol 1999, 111:125-133. 10090573, 10.1007/s004180050342.
71. Faryniarz DA, Bhargava M, Lajam C, Attia ET, Hannafin JA. Quantitation of estrogen receptors and relaxin binding in human anterior cruciate ligament fibroblasts. In Vitro Cell Dev Biol Anim 2006, 42:176-181. 16948498, 10.1290/0512089.1.
72. Wiik A, Glenmark B, Ekman M, Esbjörnsson-Liljedahl M, Johansson O, Bodin K. Oestrogen receptor beta is expressed in adult human skeletal muscle both at the mRNA and protein level. Acta Physiol Scand 2003, 179:381-387. 14656376, 10.1046/j.0001-6772.2003.01186.x.
73. Wiik A, Gustafsson T, Esbjörnsson M, Johansson O, Ekman M, Sundberg CJ, Jansson E. Expression of oestrogen receptor alpha and beta is higher in skeletal muscle of highly endurance-trained than of moderately active men. Acta Physiol Scand 2005, 184:105-112. 15916670, 10.1111/j.1365-201X.2005.01433.x.
74. Sims NA, Dupont S, Krust A, Clement-Lacroix P, Minet D, Resche-Rigon M, Gaillard-Kelly M, Baron R. Deletion of estrogen receptors reveals a regulatory role for estrogen receptors-beta in bone remodeling in females but not in males. Bone 2002, 30:18-25. 11792560, 10.1016/S8756-3282(01)00643-3.
75. Sniekers YH, van Osch GJ, Ederveen AG, Inzunza J, Gustafsson JA, van Leeuwen JP, Weinans H. Development of osteoarthritic features in estrogen receptor knockout mice. Osteoarthritis Cartilage 2009,
76. Brown M, Ning J, Ferreira JA, Bogener JL, Lubahn DB. Estrogen receptor-{alpha} and -{beta} and aromatase knockout effects on lower limb muscle mass and contractile function in female mice. Am J Physiol Endocrinol Metab 2009, 296:E854-861. 19176355, 10.1152/ajpendo.90696.2008.
77. Warden SJ, Saxon LK, Castillo AB, Turner CH. Knee ligament mechanical properties are not influenced by estrogen or its receptors. Am J Physiol Endocrinol Metab 2006, 290:E1034-1040. 16317027, 10.1152/ajpendo.00367.2005.
78. Safe S, Kim K. Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. J Mol Endocrinol 2008, 41:263-275. 18772268, 10.1677/JME-08-0103.
79. Lonard DM, O'malley BW. Nuclear receptor coregulators: judges, juries, and executioners of cellular regulation. Mol Cell 2007, 27:691-700. 17803935, 10.1016/j.molcel.2007.08.012.
80. Richette P, Dumontier MF, Tahiri K, Widerak M, Torre A, Benallaoua M, Rannou F, Corvol MT, Savouret JF. Oestrogens inhibit interleukin 1beta-mediated nitric oxide synthase expression in articular chondrocytes through nuclear factor-kappa B impairment. Ann Rheum Dis 2007, 66:345-350. Erratum in: Ann Rheum Dis 2007, 66:708, 17068060, 10.1136/ard.2006.059550.
81. Lu T, Achari Y, Rattner JB, Hart DA. Evidence that estrogen receptor beta enhances MMP-13 promoter activity in HIG-82 cells and that this enhancement can be influenced by ligands and involves specific promoter sites. Biochem Cell Biol 2007, 85:326-336. 17612627, 10.1139/O07-016.
82. Syed FA, Mödder UI, Fraser DG, Spelsberg TC, Rosen CJ, Krust A, Chambon P, Jameson JL, Khosla S. Skeletal effects of estrogen are mediated by opposing actions of classical and non-classical estrogen receptor pathways. J Bone Miner Res 2005, 20:1992-2001. 16234973, 10.1359/JBMR.050713, 1352155.
83. Levin ER. Cellular functions of plasma membrane estrogen receptors. Steroids 2002, 67:471-475. 11960623, 10.1016/S0039-128X(01)00179-9.
84. Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 2005, 307:1625-1630. 15705806, 10.1126/science.1106943.
85. Wong CW, McNally C, Nickbarg E, Komm BS, Cheskis BJ. Estrogen receptor interacting protein that modulates its nongenomic activity-crosstalk with Src/Erk phosphorylation cascade. Proc Natl Acad Sci USA 2002, 99:14783-14788. 12415108, 10.1073/pnas.192569699, 137496.
86. Kinney RC, Schwartz Z, Week K, Lotz MK, Boyan BD. Human articular chondrocytes exhibit sexual dimorphism in their responses to 17b-estradiol. Osteoarthritis Cartilage 2005, 13:330-337. 15780646, 10.1016/j.joca.2004.12.003.
87. Boyan BD, Schwartz Z. Rapid vitamin D-dependent PKC signaling shares features with estrogen-dependent PKC signaling in cartilage and bone. Steroids 2004, 69:591-597. 15288775, 10.1016/j.steroids.2004.05.008.
88. McMillan J, Fatehi-Sedeh S, Sylvia VL, Bingham V, Zhong M, Boyan BD, Schwartz Z. Sex-specific regulation of growth plate chondrocytes by estrogen is via multiple MAP kinase signaling pathways. Biochem Biophys Acta 2006, 1763:381-392. 16713447, 10.1016/j.bbamcr.2006.02.010.
89. Eckstein Ekstein J, Nasatzky E, Boyan BD, Ornoy A, Schwartz Z. Growth-plate chondrocytes respond to 17beta-estradiol with sex-specific increases in IP3 and intracellular calcium ion signalling via a capacitative entry mechanism. Steroids 2005, 70:775-786. 16005036, 10.1016/j.steroids.2005.04.007.
90. Chen JR, Plotkin LI, Aguirre JI, Han L, Jilka RL, Kousteni S, Bellido T, Manolagas SC. Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens. J Biol Chem 2005, 280:4632-4638. 15557324, 10.1074/jbc.M411530200.
91. Boland R, Vasconsuelo A, Milanesi L, Ronda AC, de Boland AR. 17beta-Estradiol signaling in skeletal muscle cells and its relationship to apoptosis. Steroids 2008, 73:859-863. 18272190, 10.1016/j.steroids.2007.12.027.
92. Almeida M, Han L, O'brien CA, Kousteni S, Manolagas SC. Classical genotropic versus kinase-initiated regulation of gene transcription by the estrogen receptor alpha. Endocrinology 2006, 147:1986-1996. 16384865, 10.1210/en.2005-1314.
93. Osborne CK, Shou J, Massarweh S, Schiff R. Crosstalk between estrogen receptor and growth factor receptor pathways as a cause for endocrine therapy resistance in breast cancer. Clin Cancer Res 2005, 11:865s-870s.
94. Fagan DH, Yee D. Crosstalk between IGF1R and estrogen receptor signaling in breast cancer. J Mammary Gland Biol Neoplasia 2008, 13:423-429. 19003523, 10.1007/s10911-008-9098-0.
95. Hawse JR, Subramaniam M, Ingle JN, Oursler MJ, Rajamannan NM, Spelsberg TC. Estrogen-TGFbeta cross-talk in bone and other cell types: role of TIEG, Runx2, and other transcription factors. J Cell Biochem 2008, 103:383-392. 17541956, 10.1002/jcb.21425.
96. Heino TJ, Hentunen TA, Väänänen HK. Osteocytes inhibit osteoclastic bone resorption through transforming growth factor-beta: enhancement by estrogen. J Cell Biochem 2002, 85:185-197. 11891862, 10.1002/jcb.10109.
97. Kouzmenko AP, Takeyama K, Ito S, Furutani T, Sawatsubashi S, Maki A, Suzuki E, Kawasaki Y, Akiyama T, Tabata T, Kato S. Wnt/beta-catenin and estrogen signaling converge in vivo. J Biol Chem 2004, 279:40255-40258. 15304487, 10.1074/jbc.C400331200.
98. Armstrong VJ, Muzylak M, Sunters A, Zaman G, Saxon LK, Price JS, Lanyon LE. Wnt/beta-catenin signaling is a component of osteoblastic bone cell early responses to load-bearing and requires estrogen receptor alpha. J Biol Chem 2007, 282:20715-20727. 17491024, 10.1074/jbc.M703224200.
99. Richmond RS, Carlson CS, Register TC, Shanker G, Loeser RF. Functional estrogen receptors in adult articular cartilage. Estrogen replacement therapy increases chondrocyte synthesis of proteoglycans and insulin-like growth factor binding protein 2. Arthritis Rheum 2000, 43:2081-2090. 11014360, 10.1002/1529-0131(200009)43:9<2081::AID-ANR20>3.0.CO;2-I.
100. Blaney Davidson EN, Kraan PM, Berg WB. TGF-beta and osteoarthritis. Osteoarthritis Cartilage 2007, 15:597-604. 17391995, 10.1016/j.joca.2007.02.005.
101. Johnson ML, Kamel MA. The Wnt signaling pathway and bone metabolism. Curr Opin Rheumatol 2007, 19:376-382. 17551370, 10.1097/BOR.0b013e32816e06f9.
102. Corr M. Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis. Nat Clin Pract Rheumatol 2008, 4:550-556. 18820702, 10.1038/ncprheum0904.
103. Tsai CL, Liu TK. Estradiol-induced knee osteoarthrosis in ovariectomized rabbits. Clin Orthop Relat Res 1993, 291:295-302.
104. Ng MC, Harper RP, Le CT, Wong BS. Effects of estrogen on the condylar cartilage of the rat mandible in organ culture. J Oral Maxillofac Surg 1999, 57:818-823. 10416629, 10.1016/S0278-2391(99)90823-6.
105. Rosner IA, Boja BA, Goldberg VM, Moskowitz RW. Tamoxifen therapy in experimental osteoarthritis. Curr Ther Res 1983, 34:409-414.
106. Tsai CL, Liu TK. Inhibition of estradiol-induced early osteoarthritic changes by tamoxifen. Life Sci 1992, 50:1943-1951. 1593922, 10.1016/0024-3205(92)90523-R.
107. Christgau S, Tankó LB, Cloos PA, Mouritzen U, Christiansen C, Delaissé JM, Høegh-Andersen P. Suppression of elevated cartilage turnover in postmenopausal women and in ovariectomized rats by estrogen and a selective estrogen-receptor modulator (SERM). Menopause 2004, 11:508-518. 15356403, 10.1097/01.WCB.0000121484.18437.98.
108. Olson EJ, Lindgren BR, Carlson CS. Effects of long-term estrogen replacement therapy on bone turnover in periarticular tibial osteophytes in surgically postmenopausal cynomolgus monkeys. Bone 2008, 42:907-913. 18291743, 10.1016/j.bone.2007.12.007, 2435307.
109. Fernihough JK, Richmond RS, Carlson CS, Cherpes T, Holly JM, Loeser RF. Estrogen replacement therapy modulation of the insulin-like growth factor system in monkey knee joints. Arthritis Rheum 1999, 42:2103-2111. 10524681, 10.1002/1529-0131(199910)42:10<2103::AID-ANR10>3.0.CO;2-S.
110. Moran AL, Nelson SA, Landisch RM, Warren GL, Lowe DA. Estradiol replacement reverses ovariectomy-induced muscle contractile and myosin dysfunction in mature female mice. J Appl Physiol 2007, 102:1387-1393. 17218423, 10.1152/japplphysiol.01305.2006.
111. Nevitt MC, Cummings SR, Lane NE, Hochberg MC, Scott JC, Pressman AR, Genant HK, Cauley JA. Association of estrogen replacement therapy with the risk of osteoarthritis of the hip in elderly white women. Study of Osteoporotic Fractures Research Group. Arch Intern Med 1996, 156:2073-2080. 8862099, 10.1001/archinte.156.18.2073.
112. Spector TD, Nandra D, Hart DJ, Doyle DV. Is hormone replacement therapy protective for hand and knee osteoarthritis in women? The Chingford Study. Ann Rheum Dis 1997, 56:432-444. 9486006, 10.1136/ard.56.7.432, 1752418.
113. Hart DJ, Doyle DV, Spector TD. Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: the Chingford Study. Arthritis Rheum 1999, 42:17-24. 9920009, 10.1002/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-E.
114. Hannan MT, Felson DT, Anderson JJ, Naimark A, Kannel WB. Estrogen use and radiographic osteoarthritis of the knee in women: the Framingham Osteoarthritis Study. Arthritis Rheum 1990, 33:525-532. 2328031, 10.1002/art.1780330410.
115. Zhang Y, McAlindon TE, Hannan MT, Chaisson CE, Klein R, Wilson PW, Felson DT. Estrogen replacement therapy and worsening of radiographic knee osteoarthritis: the Framingham Study. Arthritis Rheum 1998, 41:1867-1873. 9778229, 10.1002/1529-0131(199810)41:10<1867::AID-ART20>3.0.CO;2-W.
116. de Klerk BM, Schiphof D, Groeneveld FP, Koes BW, van Osch GJ, van Meurs JB, Bierma-Zeinstra SM. Limited evidence for a protective effect of unopposed oestrogen therapy for osteoarthritis of the hip: a systematic review. Rheumatology 2009, 48:104-12. 19000994, 10.1093/rheumatology/ken390.
117. Cirillo DJ, Wallace RB, Wu L, Yood RA. Effect of hormone therapy on risk of hip and knee joint replacement in the Women's Health Initiative. Arthritis Rheum 2006, 54:3194-3204. 17009251, 10.1002/art.22138.
118. Carbone LD, Nevitt MC, Wildy K, Barrow KD, Harris F, Felson D, Peterfy C, Visser M, Harris TB, Wang BW, Kritchevsky SB, . Health, Aging and Body Composition Study The relationship of antiresorptive drug use to structural findings and symptoms of knee osteoarthritis. Arthritis Rheum 2004, 50:3516-3525. 15529367, 10.1002/art.20627, Health, Aging and Body Composition Study.
119. Taaffe DR, Sipilä S, Cheng S, Puolakka J, Toivanen J, Suominen H. The effect of hormone replacement therapy and/or exercise on skeletal muscle attenuation in postmenopausal women: a yearlong intervention. Clin Physiol Funct Imaging 2005, 25:297-304. 16117734, 10.1111/j.1475-097X.2005.00628.x.
120. Harnish DC. Estrogen receptor ligands in the control of pathogenic inflammation. Curr Opin Investig Drugs 2006, 7:997-1001.
121. Shelly W, Draper MW, Krishnan V, Wong M, Jaffe RB. Selective estrogen receptor modulators: an update on recent clinical findings. Obstet Gynecol Surv 2008, 63:163-181.
122. Harris HA, Albert LM, Leathurby Y, Malamas MS, Mewshaw RE, Miller CP, Kharode YP, Marzolf J, Komm BS, Winneker RC, Frail DE, Henderson RA, Zhu Y, Keith JC. Evaluation of an estrogen receptor-β agonist in animal models of human disease. Endocrinology 2003, 144:4241-4249. 14500559, 10.1210/en.2003-0550.
123. Keith JC, Albert LM, Leathurby Y, Follettie M, Wang L, Borges-Marcucci L, Chadwick CC, Steffan RJ, Harnish DC. The utility of pathway selective estrogen receptor ligands that inhibit nuclear factor-kappa B transcriptional activity in models of rheumatoid arthritis. Arthritis Res Ther 2005, 7:R427-438. 15899029, 10.1186/ar1692, 1174937.