Mechanical stimulation induces preprotachykinin gene expression in osteoarthritic chondrocytes which is correlated with modulation of the transcription factor neuron restrictive silence factor

Neuropeptides

Volumn 42, Issue 5-6, 2008, Pages 681-686

  Howard, M R ^a   Millward Sadler, S J ^b   Vasilliou, A S ^a   Salter, D M ^c   Quinn, J P ^a  

^a School of Biological Sciences Derby Building   (United Kingdom)

^b School of Clinical   (United Kingdom)

^c Queens Medical Research Institute   (United Kingdom)

Author keywords

Cartilage mechanobiology; Chondrocyte; Gene; Osteoarthritis; Transcription factor

Indexed keywords

NEURON RESTRICTIVE SILENCER FACTOR; PREPROTACHYKININ; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; MECHANICAL STIMULATION; OSTEOARTHRITIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE CULTURE; UPREGULATION;

AGED; AGED, 80 AND OVER; CELLS, CULTURED; CHONDROCYTES; GENE EXPRESSION REGULATION; HUMANS; MECHANOTRANSDUCTION, CELLULAR; OSTEOARTHRITIS, KNEE; PROTEIN PRECURSORS; REPRESSOR PROTEINS; STRESS, MECHANICAL; TACHYKININS;

EID: 56349134411     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.npep.2008.09.004     Document Type: Article

References (22)

1. Belyaev N.D., Wood I.C., Bruce A.W., Street M., Trinh J.B., and Buckley N.J. Distinct RE-1 silencing transcription factor-containing complexes interact with different target genes. J. Biol. Chem. 279 1 (2004) 556-561
2. Brecha N.C., Sternini C., Anderson K., and Krause J.E. Expression and cellular localization of substance P/neurokinin A and neurokinin B mRNAs in the rat retina. Vis. Neurosci. 3 6 (1989) 527-535
3. Collins D.H., and McElligott T.F. Sulphate uptake by chondrocytes in relation to histological changes in osteoarthritic human articular cartilage. Ann. Rheum. Dis. 19 (1960) 318-330
4. Coulson J.M., Fiskerstrand C.E., Woll P.J., and Quinn J.P. Arginine vasopressin promoter regulation is mediated by a neuron- restrictive silencer element in small cell lung cancer [In Process Citation]. Cancer Res. 59 20 (1999) 5123-5127
5. Coulson J.M., Edgson J.L., Woll P.J., and Quinn J.P. A splice variant of the neuron-restrictive silencer factor repressor is expressed in small cell lung cancer: a potential role in derepression of neuroendocrine genes and a useful clinical marker. Cancer Res. 60 7 (2000) 1840-1844
6. Coulson J.M., Ahmed S.I., Quinn J.P., and Woll P.J. Detection of small cell lung cancer by RT-PCR for neuropeptides, neuropeptide receptors, or a splice variant of the neuron restrictive silencer factor. Methods Mol. Med. 75 (2003) 335-352
7. Fan Z., Bau B., Yang H., Soeder S., and Aigner T. Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta. Arthritis Rheum. 52 1 (2005) 136-143
8. Freidin M., and Kessler J.A. Cytokine regulation of substance P expression in sympathetic neurons. Proc. Natl. Acad. Sci. USA 88 8 (1991) 3200-3203
9. Greco S.J., Smirnov S.V., Murthy R.G., and Rameshwar P. Synergy between the RE-1 silencer of transcription and NFkappaB in the repression of the neurotransmitter gene TAC1 in human mesenchymal stem cells. J. Biol. Chem. 282 41 (2007) 30039-30050
10. Mendelson S.C., and Quinn J.P. Characterisation of potential regulatory elements within the rat preprotachykinin-A promoter. Neurosci. lett. 184 (1995) 125-128
11. Millward-Sadler S.J., Wright M.O., Davies L.W., Nuki G., and Salter D.M. Cyclical mechanotransduction regulates aggrecan and matrix metalloproteinase 3 mRNA levels in normal but not osteoarthritic human articular chondrocytes. Arthritis Rheum. 43 (2000) 2091-2099
12. Millward-Sadler S.J., Wright M.O., Lee H.-S., Caldwell H., Nuki G., and Salter D.M. Chondrocytes derived from osteoarthritic cartilage show an altered electrophysiological response to mechanical stimulation. OA Cart. 8 (2000) 272-278
13. Millward-Sadler S.J., Mackenzie A., Wright M.O., Lee H.-S., Elliot K., Gerrard L., Fiskerstrand C.E., Salter D.M., and Quinn J.P. Tachykinin expression in cartilage and function in human articular chondrocyte mechanotransduction. Arthritis Rheum. 48 (2003) 146-156
14. Palm K., Metsis M., and Timmusk T. Neuron-specific splicing of zinc finger transcription factor REST/NRSF/XBR is frequent in neuroblastomas and conserved in human, mouse and rat. Brain Res. Mol. Brain Res. 72 1 (1999) 30-39
15. Quinn J.P., Bubb V.J., Marshall-Jones Z.V., and Coulson J.M. Neuron restrictive silencer factor as a modulator of neuropeptide gene expression. Regul. Pept. 108 2-3 (2002) 135-141
16. Rameshwar P., and Gascon P. Substance P (SP) mediates production of stem cell factor and interleukin-1 in bone marrow stroma: potential autoregulatory role for these cytokines in SP receptor expression and induction. Blood 86 2 (1995) 482-490
17. Salter D.M., Millward-Sadler S.J., Nuki G., and Wright M.O. Differential responses of chondrocytes from normal and osteoarthritic human articular cartilage to mechanical stimulation. Biorheology 39 (2002) 97-108
18. Salter D.M., Wright M.O., and Millward-Sadler S.J. NMDA receptor expression and roles in human articular chondrocyte mechanotransduction. Biorheology 41 (2004) 273-281
19. Schoenherr C.J., and Anderson D.J. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron specific genes. Science 267 (1995) 1360-1363
20. Shih C., and Bernard G.W. Neurogenic substance P stimulates osteogenesis in vitro. Peptides 18 (1997) 323-326
21. Spencer E.M., Chandler K.E., Haddley K., Howard M.R., Hughes D., Belyaev N.D., et al. Regulation and role of REST and REST4 variants in modulation of gene expression in in vivo and in vitro in epilepsy models. Neurobiol. Dis. 24 1 (2006) 41-52
22. Wright M.O., Jobanputra P., Bavington C., Salter D.M., and Nuki G. The effects of intermittent pressurisation on the electrophysiology of cultured human articular chondrocytes: evidence for the presence of stretch-activated membrane ion channels. Clin. Sci. 90 (1996) 61-71