P450 interaction with farnesyl-protein transferase inhibitors metabolic stability, inhibitory potency, and P450 binding spectra in human liver microsomes

Biochemical Pharmacology

Volumn 62, Issue 6, 2001, Pages 773-776

  Chiba, Masato ^a,b   Tang, Cuyue ^a   Neway, William E ^a   Williams, Theresa M ^a   Jane Desolms, S ^a   Dinsmore, Christopher J ^a   Wai, John S ^a   Lin, Jiunn H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b BANYU PHARMACEUTICAL CO LTD   (Japan)

Author keywords

CYP3A4; Farnesyl protein transferase inhibitor; Metabolic inhibition; P450 binding spectra; Type I binding; Type II binding

Indexed keywords

2 METHYLIMIDAZOLE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; ENZYME ANTIBODY; HEME; IMIDAZOLE DERIVATIVE; METHYL GROUP; MONOCLONAL ANTIBODY; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG METABOLISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; IC 50; IMMUNOCHEMISTRY; LIVER MICROSOME; METABOLIC CLEARANCE RATE; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; SPECTRUM ANALYSIS;

EID: 0035885248     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(01)00724-9     Document Type: Article

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