Structures of Helicobacter pylori shikimate kinase reveal a selective inhibitor-induced-fit mechanism

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Cheng, Wen Chi ^a   Chen, Yen Fu ^b   Wang, Hung Jung ^a   Hsu, Kai Cheng ^b   Lin, Shuang Chih ^a   Chen, Tzu Jung ^a   Yang, Jinn Moon ^b   Wang, Wen Ching ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

SHIKIMIC ACID; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; ENZYME INHIBITOR; PHOSPHOTRANSFERASE; RECOMBINANT PROTEIN; SHIKIMATE KINASE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; HELICOBACTER PYLORI; ISOTHERMAL TITRATION CALORIMETRY; MICHAELIS MENTEN KINETICS; MOLECULAR DOCKING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; WILD TYPE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BACTERIAL GENE; CALORIMETRY; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DEVELOPMENT; DRUG EFFECT; ENZYME ACTIVE SITE; ENZYMOLOGY; GENETICS; HUMAN; KINETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SEQUENCE HOMOLOGY; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

FUNGI; HELICOBACTER PYLORI; MAMMALIA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; CALORIMETRY; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; ENZYME INHIBITORS; GENES, BACTERIAL; HELICOBACTER PYLORI; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SHIKIMIC ACID; STATIC ELECTRICITY;

EID: 84863378835     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033481     Document Type: Article

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