Discovery of Helicobacter pylori shikimate kinase inhibitors: Bioassay and molecular modeling

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 2, 2007, Pages 656-662

  Han, Cong ^a   Zhang, Jian ^a   Chen, Lili ^a   Chen, Kaixian ^a   Shen, Xu ^a,b   Jiang, Hualiang ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Enzyme inhibitor; Helicobacter pylori; Molecular modeling; Shikimate kinase; Surface plasmon resonance

Indexed keywords

3 METHOXY 4 [[2 [[2 METHOXY 4 [(4 OXO 2 THIOXO 1,3 THIAZOLIDIN 5 YLIDENE)METHYL]PHENOXY]METHYL]BENZYL]OXY]BENZALDEHYDE; 5 BROMO 2 [5 [[1 (3,4 DICHLOROPHENYL) 3,5 DIOXO 4 PYRAZOLIDINYLIDENE] METHYL] 2 FURYL]BENZOIC ACID; ADENOSINE TRIPHOSPHATE MAGNESIUM; PHOSPHOTRANSFERASE INHIBITOR; SHIKIMATE KINASE INHIBITOR;

ANTIBACTERIAL ACTIVITY; ARTICLE; COMPETITIVE INHIBITION; DISSOCIATION CONSTANT; DRUG DETERMINATION; DRUG PROTEIN BINDING; ELECTRON SPIN RESONANCE; ENZYME INHIBITION; HELICOBACTER PYLORI; IC 50; MOLECULAR INTERACTION; MOLECULAR MODEL; NUCLEOTIDE SEQUENCE;

ALGORITHMS; BIOLOGICAL ASSAY; CLONING, MOLECULAR; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HELICOBACTER PYLORI; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE;

HELICOBACTER PYLORI;

EID: 33845398326     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.10.058     Document Type: Article

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