Understanding the impact of the P-loop conformation on kinase selectivity

Journal of Chemical Information and Modeling

Volumn 51, Issue 6, 2011, Pages 1199-1204

  Guimarães, Cristiano R W ^a   Rai, Brajesh K ^a   Munchhof, Michael J ^a   Liu, Shenping ^a   Wang, Jian ^a   Bhattacharya, Samit K ^a   Buckbinder, Leonard ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES;

COMPUTATIONAL ANALYSIS; FOLDED CONFORMATION; LOOP CONFORMATION;

CRYSTAL STRUCTURE;

MAPK4 PROTEIN, RAT; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYME SPECIFICITY; LETTER; METABOLISM; PROTEIN CONFORMATION; PROTEIN DATABASE; PROTEIN FOLDING;

DATABASES, PROTEIN; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN KINASE INHIBITORS; SUBSTRATE SPECIFICITY;

EID: 79959758717     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci200153c     Document Type: Article

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