Novel biotransformation process of podophyllotoxin to 4β-sulfur- substituted podophyllum derivates with anti-tumor activity by penicillium purpurogenum Y.J. Tang

Current Medicinal Chemistry

Volumn 19, Issue 6, 2012, Pages 927-936

  Bai, J K ^a   Zhao, W ^a,b   Li, H M ^a   Tang, Y J ^a,b  

^a HUBEI UNIVERSITY OF TECHNOLOGY   (China)

^b SHANGHAI ADVANCED RESEARCH INSTITUTE   (China)

Author keywords

4 (1,2,4 triazole 3 yl) sulfanyl 4 deoxy podophyllotoxin; 4 (1,2,4 triazole 3 yl)sulfanyl 4 deoxy 4' demethylepipodophyllotoxin; 4 (1,3,4 thiadiazole 2 yl)sulfanyl 4 deoxy podophyllotoxin; 4 (1,3,4 thiadiazole 2 yl)sulfanyl 4 deoxy 4' demethylepipodophyllotoxin; 4 sulfur substituted; 4' demethylepipodophyllotoxin; Biological activity; Biotransformation; Drug design; Penicillium purpurogenum Y.J. Tang; Podophyllotoxin; Structure function relationship

Indexed keywords

4BETA (1,2,4 TRIAZOLE 3 YL)SULFANYL 4 DEOXY 4' DEMETHYLEPIPODOPHYLLOTOXIN; 4BETA (1,2,4 TRIAZOLE 3 YL)SULFANYL 4 DEOXY PODOPHYLLOTOXIN; 4BETA (1,3,4 THIADIAZOLE 2 YL)SULFANYL 4 DEOXY 4' DEMETHYLEPIPODOPHYLLOTOXIN; 4BETA (1,3,4 THIADIAZOLE 2 YL)SULFANYL 4 DEOXY PODOPHYLLOTOXIN; ANTINEOPLASTIC AGENT; ETOPOSIDE; PODOPHYLLOTOXIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DIPHYLLEIA SINENSIS; DRUG ISOLATION; DRUG TRANSFORMATION; HUMAN; HUMAN CELL; MEDICINAL PLANT; PENICILLIUM PURPUROGENUM;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BIOTRANSFORMATION; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; MOLECULAR SEQUENCE DATA; PENICILLIUM; PHYLOGENY; PODOPHYLLOTOXIN; RNA, FUNGAL; RNA, RIBOSOMAL, 18S;

EID: 84863292054     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986712799034914     Document Type: Article

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