A novel podophyllotoxin derivative (YB-1EPN) induces apoptosis and down-regulates express of P-glycoprotein in multidrug resistance cell line KBV200

European Journal of Pharmacology

Volumn 627, Issue 1-3, 2010, Pages 69-74

  Chen, Hong ^a,b   Bi, Wenchao ^a,d   Cao, Bo ^a   Yang, Zaixin ^a,b   Chen, Shiwei ^a   Shang, Hai ^c   Yu, Pengfei ^c   Yang, Jie ^d  

^a MEDICAL COLLEGE OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

^b Tianjin Key Laboratory for Biomarkers of Occupational and Environmental Hazard   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^d Shan Dong Municipal Corps Hospital of Chinese People's Armed Police Force   (China)

Author keywords

MDR; P glycoprotein; Podophyllotoxin derivative; YB 1EPN

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ETOPOSIDE; GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; PODOPHYLLOTOXIN DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; UNCLASSIFIED DRUG; YB 1EPN;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL LINE; CHROMATIN CONDENSATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; GENE EXPRESSION; GROWTH CURVE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRUCTURE ANALYSIS; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; DOWN-REGULATION; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; P-GLYCOPROTEIN; PODOPHYLLOTOXIN; RNA, MESSENGER;

EID: 73449084766     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.10.056     Document Type: Article

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