메뉴 건너뛰기




Volumn 58, Issue 112, 2011, Pages 2106-2111

Curcumin attenuates insulin resistance in hepatocytes by inducing Nrf2 nuclear translocation

Author keywords

Curcumin; Hepato protection; Insulin resistance; NF E2 related factor 2; Oxidative stress

Indexed keywords

ASPARTATE AMINOTRANSFERASE; CURCUMIN; GLUCOSE OXIDASE; GLUTATHIONE; LACTATE DEHYDROGENASE; LIVER ENZYME; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NRF2; WORTMANNIN;

EID: 84863260532     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: 10.5754/hge11219     Document Type: Article
Times cited : (36)

References (38)
  • 1
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • DOI 10.1016/j.cell.2004.12.041
    • Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M: Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120:649-661. (Pubitemid 40343077)
    • (2005) Cell , vol.120 , Issue.5 , pp. 649-661
    • Kamata, H.1    Honda, S.-I.2    Maeda, S.3    Chang, L.4    Hirata, H.5    Karin, M.6
  • 2
    • 0036163870 scopus 로고    scopus 로고
    • Hepatitis C virus proteins: Direct link to hepatic oxidative stress, steatosis, carcinogenesis and more
    • Lai MM: Hepatitis C virus proteins: direct link to hepatic oxidative stress, steatosis, carcinogenesis and more. Gastroenterology 2002; 122:568-571.
    • (2002) Gastroenterology , vol.122 , pp. 568-571
    • Lai, M.M.1
  • 3
    • 58349104620 scopus 로고    scopus 로고
    • Comparative redox status in alcoholic liver disease and nonalcoholic fatty liver disease
    • DOI 10.1007/s12072-008-9060-7
    • Bhardwaj P, Madan K, Thareja S, Joshi YK, Saraya A: Comparative redox status in alcoholic liver disease and nonalcoholic fatty liver disease. Hepatol Int 2008; 2: 202-208. (Pubitemid 351650149)
    • (2008) Hepatology International , vol.2 , Issue.2 , pp. 202-208
    • Bhardwaj, P.1    Madan, K.2    Thareja, S.3    Joshi, Y.K.4    Saraya, A.5
  • 6
    • 4844225631 scopus 로고    scopus 로고
    • Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice
    • DOI 10.1152/physiolgenomics.00209.2003
    • Li J, Stein TD, Johnson JA: Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice. Physiol Genomics 2004; 18:261-272. (Pubitemid 39319509)
    • (2004) Physiological Genomics , vol.18 , pp. 261-272
    • Li, J.1    Stein, T.D.2    Johnson, J.A.3
  • 7
    • 1942520367 scopus 로고    scopus 로고
    • Nrf2 signaling in coordinated activation of antioxidant gene expression
    • Jaiswal AK: Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med 2004; 36:1199-1207.
    • (2004) Free Radic Biol Med , vol.36 , pp. 1199-1207
    • Jaiswal, A.K.1
  • 8
    • 0035153227 scopus 로고    scopus 로고
    • High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes
    • DOI 10.1093/toxsci/59.1.169
    • Enomoto A, Itoh K, Nagayoshi E, Haruta J, Kimura T, O'Connor T, Harada T, Yamamoto M: High sensitivity of Nrf2 knockout mice to acetaminophen hepatotoxicity associated with decreased expression of ARE-regulated drug metabolizing enzymes and antioxidant genes. Toxicol Sci 2001; 59:169-177. (Pubitemid 32117993)
    • (2001) Toxicological Sciences , vol.59 , Issue.1 , pp. 169-177
    • Enomoto, A.1    Itoh, K.2    Nagayoshi, E.3    Haruta, J.4    Kimura, T.5    O'Connor, T.6    Harada, T.7    Yamamoto, M.8
  • 10
    • 33749239623 scopus 로고    scopus 로고
    • The metabolic syndrome: Role of skeletal muscle metabolism
    • DOI 10.1080/07853890600888413, PII P89Q634296410732
    • Stump CS, Henriksen EJ, Wei Y, Sowers JR: The metabolic syndrome: role of skeletal muscle metabolism. Ann Med 2006; 38:389-402. (Pubitemid 44484877)
    • (2006) Annals of Medicine , vol.38 , Issue.6 , pp. 389-402
    • Stump, C.S.1    Henriksen, E.J.2    Wei, Y.3    Sowers, J.R.4
  • 11
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • Houstis N, Rosen ED, Lander ES: Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006; 440:944-948.
    • (2006) Nature , vol.440 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 14
    • 38349011007 scopus 로고    scopus 로고
    • Curcumin: Preventive and therapeutic properties in laboratory studies and clinical trials
    • Strimpakos AS, Sharma RA: Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal 2008; 10:511-545.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 511-545
    • Strimpakos, A.S.1    Sharma, R.A.2
  • 18
    • 0345074085 scopus 로고    scopus 로고
    • Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: Possible role in protection against chemical carcinogenesis and toxicity
    • DOI 10.1034/j.1600-0773.2003.920106.x
    • Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S: Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol 2003; 92:33-38. (Pubitemid 36238075)
    • (2003) Pharmacology and Toxicology , vol.92 , Issue.1 , pp. 33-38
    • Iqbal, M.1    Sharma, S.D.2    Okazaki, Y.3    Fujisawa, M.4    Okada, S.5
  • 19
    • 0037569694 scopus 로고    scopus 로고
    • Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
    • DOI 10.1042/BJ20021619
    • Balogun E, Hoque M, Gong P, Killeen E, Green CJ, Foresti R, Alam J, Motterlini R: Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element Biochem J 2003; 371:887-895. (Pubitemid 36578887)
    • (2003) Biochemical Journal , vol.371 , Issue.3 , pp. 887-895
    • Balogun, E.1    Hoque, M.2    Gong, P.3    Killeen, E.4    Green, C.J.5    Foresti, R.6    Alam, J.7    Motterlini, R.8
  • 20
    • 39149106003 scopus 로고    scopus 로고
    • Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1
    • DOI 10.1016/j.fct.2007.09.095, PII S0278691507004292
    • Farombi EO, Shrotriya S, Na HK, Kim SH, Surh YJ: Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem Toxicol 2008; 46:1279-1287. (Pubitemid 351258204)
    • (2008) Food and Chemical Toxicology , vol.46 , Issue.4 , pp. 1279-1287
    • Farombi, E.O.1    Shrotriya, S.2    Na, H.-K.3    Kim, S.-H.4    Surh, Y.-J.5
  • 21
    • 32344432720 scopus 로고    scopus 로고
    • Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes
    • DOI 10.1016/j.bbrc.2006.01.065, PII S0006291X0600146X
    • Rushworth SA, Ogborne RM, Charalambos CA, O'Connell MA: Role of protein kinase C delta in curcumin-induced antioxidant response element-mediated gene expression in human monocytes. Biochem Biophys Res Commun 2006; 341:1007-1016. (Pubitemid 43221766)
    • (2006) Biochemical and Biophysical Research Communications , vol.341 , Issue.4 , pp. 1007-1016
    • Rushworth, S.A.1    Ogborne, R.M.2    Charalambos, C.A.3    O'Connell, M.A.4
  • 23
    • 34548429119 scopus 로고    scopus 로고
    • Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells
    • DOI 10.1152/ajpendo.00111.2007
    • Pugazhenthi S, Akhov L, Selvaraj G, Wang M, Alam J: Regulation of heme oxygenase-1 expression by demethoxy curcuminoids through Nrf2 by a PI3-kinase/Akt-mediated pathway in mouse beta-cells. Am J Physiol Endocrinol Metab 2007; 293:E645-655. (Pubitemid 47358975)
    • (2007) American Journal of Physiology - Endocrinology and Metabolism , vol.293 , Issue.3
    • Pugazhenthi, S.1    Akhov, L.2    Selvaraj, G.3    Wang, M.4    Alam, J.5
  • 24
    • 33645799492 scopus 로고    scopus 로고
    • Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: Role of IKK, JNK, and ROS pathways
    • Schwabe RF, Brenner DA: Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 2006; 290:G583-589.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Schwabe, R.F.1    Brenner, D.A.2
  • 25
    • 34347392509 scopus 로고    scopus 로고
    • Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways
    • DOI 10.1016/j.jhep.2007.02.008, PII S0168827807001225
    • Yao P, Nussler A, LIu L, Hao L, Song F, Schirmeier A, Nussler N: Quercetin protects human hepatocytes from ethanol-derived oxidative stress by inducing heme oxygenase-1 via the MAPK/Nrf2 pathways. J Hepatol 2007; 47:253-261. (Pubitemid 47023137)
    • (2007) Journal of Hepatology , vol.47 , Issue.2 , pp. 253-261
    • Yao, P.1    Nussler, A.2    Liu, L.3    Hao, L.4    Song, F.5    Schirmeier, A.6    Nussler, N.7
  • 26
    • 0036840585 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress
    • DOI 10.1124/mol.62.5.1001
    • Kang KW, Lee SJ, Park JW, Kim SG: Phosphatidylinositol 3-kinase regulates nuclear translocation of NF-E2-related factor 2 through actin rearrangement in response to oxidative stress. Mol Pharmacol 2002; 62:1001-1010. (Pubitemid 35222491)
    • (2002) Molecular Pharmacology , vol.62 , Issue.5 , pp. 1001-1010
    • Kang, K.W.1    Lee, S.J.2    Park, J.W.3    Kim, S.G.4
  • 27
    • 33244481462 scopus 로고    scopus 로고
    • Ser/Thr phosphorylation of IRS proteins: A molecular basis for insulin resistance
    • Zick Y: Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance. Sci STKE 2005; 2005:pe4.
    • (2005) Sci STKE , vol.2005
    • Zick, Y.1
  • 28
    • 33845542745 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
    • Morino K, Petersen KF, Shulman GI: Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction. Diabetes 2006; 55 Suppl 2:S9-15.
    • (2006) Diabetes , vol.55 , Issue.SUPPL. 2
    • Morino, K.1    Petersen, K.F.2    Shulman, G.I.3
  • 30
    • 10044265209 scopus 로고    scopus 로고
    • JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species
    • DOI 10.1101/gad.1223004
    • Ventura JJ, Cogswell P, Flavell RA, Baldwin AS Jr, Davis RJ: JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species. Genes Dev 2004; 18:2905-2915. (Pubitemid 39602309)
    • (2004) Genes and Development , vol.18 , Issue.23 , pp. 2905-2915
    • Ventura, J.-J.1    Cogswell, P.2    Flavell, R.A.3    Baldwin Jr., A.S.4    Davis, R.J.5
  • 31
    • 0037059330 scopus 로고    scopus 로고
    • 307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • DOI 10.1074/jbc.M101521200
    • Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF: Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 2002; 277:1531-1537. (Pubitemid 34968910)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.2 , pp. 1531-1537
    • Aguirre, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 33
    • 65649110522 scopus 로고    scopus 로고
    • Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes
    • Ndisang JF, Jadhav A: Heme oxygenase system enhances insulin sensitivity and glucose metabolism in streptozotocin-induced diabetes. Am J Physiol Endocrinol Metab 2009; 296:E829-841.
    • (2009) Am J Physiol Endocrinol Metab , vol.296
    • Ndisang, J.F.1    Jadhav, A.2
  • 34
    • 0036319473 scopus 로고    scopus 로고
    • Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice
    • DOI 10.1046/j.1471-4159.2002.00913.x
    • Johnson DA, Andrews GK, Xu W, Johnson JA: Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice. J Neurochem 2002; 81:1233-1241. (Pubitemid 34809257)
    • (2002) Journal of Neurochemistry , vol.81 , Issue.6 , pp. 1233-1241
    • Johnson, D.A.1    Andrews, G.K.2    Xu, W.3    Johnson, J.A.4
  • 35
    • 0036007614 scopus 로고    scopus 로고
    • Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats
    • DOI 10.1023/A:1013106527829
    • Arun N, Nalini N: Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum Nutr 2002; 57:41-52. (Pubitemid 34128408)
    • (2002) Plant Foods for Human Nutrition , vol.57 , Issue.1 , pp. 41-52
    • Arun, N.1    Nalini, N.2
  • 36
    • 54949119528 scopus 로고    scopus 로고
    • Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice
    • Seo KI, Choi MS, Jung UJ, Kim HJ, Yeo J, Jeon SM, Lee MK: Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol Nutr Food Res 2008; 52:995-1004.
    • (2008) Mol Nutr Food Res , vol.52 , pp. 995-1004
    • Seo, K.I.1    Choi, M.S.2    Jung, U.J.3    Kim, H.J.4    Yeo, J.5    Jeon, S.M.6    Lee, M.K.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.