Biophysical and mechanistic insights into novel allosteric inhibitor of spleen tyrosine kinase

Journal of Biological Chemistry

Volumn 287, Issue 10, 2012, Pages 7717-7727

  Hall, Justin ^a   Aulabaugh, Ann ^a   Rajamohan, Francis ^a   Liu, Shenping ^a   Kaila, Neelu ^a   Wan, Zhao Kui ^a   Ryan, Mark ^a   Magyar, Rachelle ^a   Qiu, Xiayang ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOSTERIC INHIBITOR; B CELL RECEPTOR; CYTOSOLIC; DRUG CANDIDATES; EXTRACELLULAR STIMULATION; IMMUNE RESPONSE; INHIBITION MECHANISMS; KINASE DOMAINS; KINETIC METHOD; MAST CELLS; PROTEIN KINASE; RECEPTOR ACTIVATION; REGULATORY INTERACTIONS; SPLEEN TYROSINE KINASE; SUBSTRATE PEPTIDES;

AMINO ACIDS; ANTIGENS; CELL MEMBRANES; ENZYME ACTIVITY; IMMUNOLOGY; PATHOLOGY;

DISEASE CONTROL;

PROTEIN KINASE LYNB; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; PROTEIN SH2; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; BIOPHYSICS; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME BINDING; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RADIATION SCATTERING; SUICIDE SUBSTRATE; ULTRACENTRIFUGATION;

ALLOSTERIC REGULATION; AUTOIMMUNE DISEASES; DRUG DESIGN; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; SRC HOMOLOGY DOMAINS;

EID: 84863244750     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.311993     Document Type: Article

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