Effect of thymoquinone on cytosolic pH and Na/H + exchanger activity in mouse dendritic cells

Cellular Physiology and Biochemistry

Volumn 29, Issue 1-2, 2012, Pages 21-30

  Yang, Wenting ^a   Bhandaru, Madhuri ^a   Pasham, Venkanna ^a   Bobbala, Diwakar ^a   Zelenak, Christine ^a   Jilani, Kashif ^a   Rotte, Anand ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cell volume; LPS; Nigella sativa; Reactive oxygen species; TNF

Indexed keywords

CARIPORIDE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; LIPOPOLYSACCHARIDE; PROTON; REACTIVE OXYGEN METABOLITE; SODIUM ION; SODIUM PROTON EXCHANGE PROTEIN; TERT BUTYL HYDROPEROXIDE; THYMOQUINONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BLACK CUMIN; CELL CULTURE; CELL MIGRATION; CELL PH; CELL VOLUME; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE RELEASE; CYTOSOL; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTER; MOUSE; NONHUMAN; PRIORITY JOURNAL;

MURINAE; NIGELLA SATIVA;

EID: 84863241150     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000337583     Document Type: Article

References (60)

1. Badary OA, Abd-Ellah MF, El Mahdy MA, Salama SA, Hamada FM: Anticlastogenic activity of thymoquinone against benzo(a)pyrene in mice. Food Chem Toxicol 2007;45:88-92.
2. Khader M, Bresgen N, Eckl PM: In vitro toxicological properties of thymoquinone. Food Chem Toxicol 2009;47:129-133.
3. Aggarwal BB, Kunnumakkara AB, Harikumar KB, Tharakan ST, Sung B, Anand P: Potential of spice-derived phytochemicals for cancer prevention. Planta Med 2008;74:1560-1569.
4. Ali BH, Blunden G: Pharmacological and toxicological properties of Nigella sativa. Phytother Res 2003;17:299-305.
5. Gali-Muhtasib H, Roessner A, Schneider- Stock R: Thymoquinone: A promising anti-cancer drug from natural sources. Int J Biochem Cell Biol 2006;38:1249-1253.
6. Gali-Muhtasib H, Ocker M, Kuester D, Krueger S, El Hajj Z, Diestel A, Evert M, El Najjar N, Peters B, Jurjus A, Roessner A, Schneider-Stock R: Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. J Cell Mol Med 2008;12:330-342.
7. Mohamed A, Shoker A, Bendjelloul F, Mare A, Alzrigh M, Benghuzzi H, Desin T: Improvement of experimental allergic encephalomyelitis (EAE) by thymoquinone; an oxidative stress inhibitor. Biomed Sci Instrum 2003;39:440-445.
8. Salem ML: Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 2005;5:1749-1770.
9. El Gazzar M, El Mezayen R, Nicolls MR, Marecki JC, Dreskin SC: Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma. Biochim Biophys Acta 2006;1760:1088-1095.
10. El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC: Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int Immunopharmacol 2006;6:1135-1142.
11. El Gazzar MA: Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation. Inflamm Res 2007;56:345-351.
12. El Gazzar MA, El Mezayen R, Nicolls MR, Dreskin SC: Thymoquinone attenuates proinflammatory responses in lipopolysaccharide- activated mast cells by modulating NF-kappaB nuclear transactivation. Biochim Biophys Acta 2007;1770:556-564.
13. El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, Nomiyama H: Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. Immunol Lett 2006;106:72-81.
14. Sethi G, Ahn KS, Aggarwal BB: Targeting nuclear factor-kappa B activation pathway by thymoquinone: Role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res 2008;6:1059-1070.
15. Tekeoglu I, Dogan A, Ediz L, Budancamanak M, Demirel A: Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models. Phytother Res 2007;21:895-897.
16. Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al Hmaira J, Hartig R, Roessner A, Schneider-Stock R: Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol 2004;25:857-866.
17. Roepke M, Diestel A, Bajbouj K, Walluscheck D, Schonfeld P, Roessner A, Schneider-Stock R, Gali-Muhtasib H: Lack of p53 augments thymoquinoneinduced apoptosis and caspase activation in human osteosarcoma cells. Cancer Biol Ther 2007;6:160-169.
18. Rooney S, Ryan MF: Effects of alphahederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer Res 2005;25:2199-2204.
19. Shoieb AM, Elgayyar M, Dudrick PS, Bell JL, Tithof PK: In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int J Oncol 2003;22:107-113.
20. Yi T, Cho SG, Yi Z, Pang X, Rodriguez M, Wang Y, Sethi G, Aggarwal BB, Liu M: Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signalregulated kinase signaling pathways. Mol Cancer Ther 2008;7:1789-1796.
21. Rooney S, Ryan MF: Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells. Anticancer Res 2005;25:4255-4259.
22. El Mahdy MA, Zhu Q, Wang QE, Wani G, Wani AA: Thymoquinone induces apoptosis through activation of caspase- 8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. Int J Cancer 2005;117:409-417.
23. Xuan NT, Shumilina E, Qadri SM, Gotz F, Lang F: Effect of thymoquinone on mouse dendritic cells. Cell Physiol Biochem 2010;25:307-314.
24. Adler HS, Steinbrink K: Tolerogenic dendritic cells in health and disease: Friend and foe! Eur J Dermatol 2007;17:476-491.
25. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K: Immunobiology of dendritic cells. Annu Rev Immunol 2000;18:767-811.
26. van Duivenvoorde LM, Han WG, Bakker AM, Louis-Plence P, Charbonnier LM, Apparailly F, van der Voort EI, Jorgensen C, Huizinga TW, Toes RE: Immunomodulatory dendritic cells inhibit Th1 responses and arthritis via different mechanisms. J Immunol 2007;179:1506-1515.
27. Chorny A, Gonzalez-Rey E, Delgado M: Regulation of dendritic cell differentiation by vasoactive intestinal peptide: Therapeutic applications on autoimmunity and transplantation. Ann N Y Acad Sci 2006;1088:187-194.
28. Gelin C, Sloma I, Charron D, Mooney N: Regulation of MHC II and CD1 antigen presentation: From ubiquity to security. J Leukoc Biol 2009;85:215-224.
29. Remondo C, Cereda V, Mostbock S, Sabzevari H, Franzusoff A, Schlom J, Tsang KY: Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen. Vaccine 2009;27:987-994.
30. Schuurhuis DH, Fu N, Ossendorp F, Melief CJ: Ins and outs of dendritic cells. Int Arch Allergy Immunol 2006;140:53-72.
31. Tarbell KV, Yamazaki S, Steinman RM: The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity. Semin Immunol 2006;18:93-102.
32. Blanco P, Palucka AK, Pascual V, Banchereau J: Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev 2008;19:41-52.
33. Lehner T: Special regulatory T cell review: The resurgence of the concept of contrasuppression in immunoregulation. Immunology 2008;123:40-44.
34. Li MO, Flavell RA: Contextual regulation of inflammation: A duet by transforming growth factor-beta and interleukin-10. Immunity 2008;28:468-476.
35. Cerovic V, McDonald V, Nassar MA, Paulin SM, Macpherson GG, Milling SW: New insights into the roles of dendritic cells in intestinal immunity and tolerance. Int Rev Cell Mol Biol 2009;272:33-105.
36. Edelman SM, Kasper DL: Symbiotic commensal bacteria direct maturation of the host immune system. Curr Opin Gastroenterol 2008;24:720-724.
37. Rescigno M, Lopatin U, Chieppa M: Interactions among dendritic cells, macrophages, and epithelial cells in the gut: Implications for immune tolerance. Curr Opin Immunol 2008;20:669-675.
38. Rotte A, Pasham V, Eichenmuller M, Mahmud H, Xuan NT, Shumilina E, Gotz F, Lang F: Effect of bacterial lipopolysaccharide on Na/H+ exchanger activity in dendritic cells. Cell Physiol Biochem 2010;26:553-562.
39. Rotte A, Pasham V, Yang W, Eichenmuller M, Bhandaru M, Shumilina E, Lang F: Phosphoinositide 3-kinasedependent regulation of Na+/H+ exchanger in dendritic cells. Pflugers Arch 2010;460:1087-1096.
40. Aki D, Minoda Y, Yoshida H, Watanabe S, Yoshida R, Takaesu G, Chinen T, Inaba T, Hikida M, Kurosaki T, Saeki K, Yoshimura A: Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells. Genes Cells 2008;13:199-208.
41. Matzner N, Zemtsova IM, Nguyen TX, Duszenko M, Shumilina E, Lang F: Ion channels modulating mouse dendritic cell functions. J Immunol 2008;181:6803-6809.
42. Xuan NT, Shumilina E, Matzner N, Zemtsova IM, Biedermann T, Goetz F, Lang F: Ca2+-dependent functions in peptidoglycan- stimulated mouse dendritic cells. Cell Physiol Biochem 2009;24:167-176.
43. Xuan NT, Shumilina E, Nasir O, Bobbala D, Gotz F, Lang F: Stimulation of mouse dendritic cells by Gum Arabic. Cell Physiol Biochem 2010;25:641-648.
44. Sinha A, Singh A, Satchidanandam V, Natarajan K: Impaired generation of reactive oxygen species during differentiation of dendritic cells (DCs) by Mycobacterium tuberculosis secretory antigen (MTSA) and subsequent activation of MTSA-DCs by mycobacteria results in increased intracellular survival. J Immunol 2006;177:468-478.
45. Waisbren SJ, Geibel J, Boron WF, Modlin IM: Luminal perfusion of isolated gastric glands. Am J Physiol 1994;266:C1013-C1027.
46. Roos A, Boron WF: Intracellular pH. Physiol Rev 1981;61:296-434.
47. Boyarsky G, Ganz MB, Sterzel RB, Boron WF: pH regulation in single glomerular mesangial cells. II. Na+-dependent and -independent Cl-. Am J Physiol 1988;255:C857-C869.
48. Hoffmann EK, Lambert IH, Pedersen SF: Physiology of cell volume regulation in vertebrates. Physiol Rev 2009;89:193-277.
49. Lang F, Busch GL, Ritter M, Volkl H, Waldegger S, Gulbins E, Haussinger D: Functional significance of cell volume regulatory mechanisms. Physiol Rev 1998;78:247-306.
50. Henderson LM, Chappell JB, Jones OT: Internal pH changes associated with the activity of NADPH oxidase of human neutrophils. Further evidence for the presence of an H+ conducting channel. Biochem J 1988;251:563-567.
51. Swallow CJ, Grinstein S, Rotstein OD: Regulation of cytoplasmic pH in resident and activated peritoneal macrophages. Biochim Biophys Acta 1990;1022:203-210.
52. Grinstein S, Cohen S, Goetz JD, Rothstein A: Na+/H+ exchange in volume regulation and cytoplasmic pH homeostasis in lymphocytes. Fed Proc 1985;44:2508-2512.
53. Khalife KH, Lupidi G: Reduction of hypervalent states of myoglobin and hemoglobin to their ferrous forms by thymoquinone: The role of GSH, NADH and NADPH. Biochim Biophys Acta 2008;1780:627-637.
54. Cutaia M, Parks N: Oxidant stress decreases Na+/H+ antiport activity in bovine pulmonary artery endothelial cells. Am J Physiol 1994;267:L649-L659.
55. Elsing C, Voss A, Herrmann T, Kaiser I, Huebner CA, Schlenker T: Oxidative stress reduces Na+/H+ exchange (NHE) activity in a biliary epithelial cancer cell line (Mz-Cha-1). Anticancer Res 2011;31:459-465.
56. Rada BK, Geiszt M, Kaldi K, Timar C, Ligeti E: Dual role of phagocytic NADPH oxidase in bacterial killing. Blood 2004;104:2947-2953.
57. Choi CH, Patel H, Barber DL: Expression of actin-interacting protein 1 suppresses impaired chemotaxis of Dictyostelium cells lacking the Na+-H+ exchanger NHE1. Mol Biol Cell 2010;21:3162-3170.
58. Koliakos G, Paletas K, Kaloyianni M: NHE-1: A molecular target for signalling and cell matrix interactions. Connect Tissue Res 2008;49:157-161.
59. Zolota Z, Koliakos G, Paletas K, Kaloyianni M: NHE-1 and beta 1 integrin dependent monocyte adhesion and migration after glucose, insulin or PPARgamma stimulation. Cell Adh Migr 2011;5:258-265.
60. Gali-Muhtasib HU, Abou Kheir WG, Kheir LA, Darwiche N, Crooks PA: Molecular pathway for thymoquinone-induced cellcycle arrest and apoptosis in neoplastic keratinocytes. Anticancer Drugs 2004;15:389-399.