Regulation of MHC II and CD1 antigen presentation:from ubiquity to security

Journal of Leukocyte Biology

Volumn 85, Issue 2, 2009, Pages 215-224

  Gelin, Catherine ^a,b   Sloma, Ivan ^a   Charron, Dominique ^a   Mooney, Nuala ^a  

^a INSERM   (France)

^b SAINT LOUIS HOSPITAL   (France)

Author keywords

Cell surface molecules; Dendritic cells

Indexed keywords

CD1 ANTIGEN; CELL SURFACE PROTEIN; CYTOSKELETON PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE PROTEIN; TETRASPANIN;

ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; B LYMPHOCYTE; CELL MEMBRANE; CYTOSKELETON; DENDRITIC CELL; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; EXTRACELLULAR MATRIX; MAJOR HISTOCOMPATIBILITY COMPLEX; MONOCYTE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; UBIQUITINATION;

ANIMALS; ANTIGEN PRESENTATION; ANTIGENS, CD1; EXTRACELLULAR SPACE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; MEMBRANE MICRODOMAINS;

EID: 59649098505     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0308206     Document Type: Review

References (114)

1. Benvenuti, F., Lagaudriere-Gesbert, C., Grandjean, I., Jancic, C., Hivroz, C., Trautmann, A., Lantz, O., Amigorena, S. (2004) Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes. J. Immunol. 172, 292-301.
2. Sumen, C., Mempel, T. R., Mazo, I. B., von Andrian, U. H. (2004) Intravital microscopy: visualizing immunity in context. Immunity 21, 315-329.
3. Reichardt, P., Dornbach, B., Gunzer, M. (2007) The molecular makeup and function of regulatory and effector synapses. Immunol. Rev. 218,165-177.
4. Dascher, C. C., Brenner, M. B. (2003) Evolutionary constraints on CD1 structure: insights from comparative genomic analysis. Trends Immunol. 24, 412-418.
5. Zhang, Q., Tector, M., Salter, R. D. (1995) Calnexin recognizes carbohydrate and protein determinants of class I major histocompatibility complex molecules. J. Biol. Chem. 270, 3944-3948.
6. Huttinger, R., Staffler, G., Majdic, O., Stockinger, H. (1999) Analysis of the early biogenesis of CD1b: involvement of the chaperones calnexin and calreticulin, the proteasome and β(2)-microglobulin. Int. Immunol. 11, 1615-1623.
7. Kang, S. J., Cresswell, P. (2002) Calnexin, calreticulin, and ERp57 cooperate in disulfide bond formation in human CD1d heavy chain. J. Biol. Chem. 277, 44838-44844.
8. Barral, D. C., Cavallari, M., McCormick, P. J., Garg, S., Magee, A. I., Bonifacino, J. S., De Libero, G., Brenner, M. B. (2008) CD1a and MHC class I follow a similar endocytic recycling pathway. Traffic 9, 1446-1457.
9. McMichael, A. J., Pilch, J. R., Galfre, G., Mason, D. Y., Fabre, J. W., Milstein, C. (1979) A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody. Eur. J. Immunol. 9, 205-210.
10. Porcelli, S., Brenner, M. B., Greenstein, J. L., Balk, S. P., Terhorst, C., Bleicher, P. A. (1989) Recognition of cluster differentiation 1 antigens by human CD4-CD8-cytolytic T lymphocytes. Nature 341, 447-450.
11. Beckman, E. M., Porcelli, S., Morita, C., Behar, S. M., Furlong, S. T., Brenner, M. B. (1994) Recognition of a lipid antigen by CD1-restricted αβ+ T cells. Nature 372, 691-694.
12. Behar, S. M., Porcelli, S. A. (2007) CD1-restricted T cells in host defense to infectious diseases. Curr. Top. Microbiol. Immunol. 314, 215-250.
13. De Libero, G., Mori, L. (2003) Self glycosphingolipids: new antigens recognized by autoreactive T lymphocytes. News Physiol. Sci. 18, 71-76.
14. Miyake, S., Yamamura, T. (2007) NKT cells and autoimmune diseases: unraveling the complexity. Curr. Top. Microbiol. Immunol. 314, 251-267.
15. Swann, J. B., Coquet, J. M., Smyth, M. J., Godfrey, D. I. (2007) CD1-restricted T cells and tumor immunity. Curr. Top. Microbiol. Immunol.314, 293-323.
16. Sriram, V., Du, W., Gervay-Hague, J., Brutkiewicz, R. R. (2005) Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d-specific ligands for NKT cells. Eur. J. Immunol. 35, 1692-1701.
17. Mattner, J., Debord, K. L., Ismail, N., Goff, R. D., Cantu III, C., Zhou, D., Saint-Mezard, P., Wang, V., Gao, Y., Yin, N., Hoebe, K., Schneewind, O., Walker, D., Beutler, B., Teyton, L., Savage, P. B., Bendelac, A.(2005) Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434, 525-529.
18. Kinjo, Y., Tupin, E., Wu, D., Fujio, M., Garcia-Navarro, R., Benhnia, M. R., Zajonc, D. M., Ben-Menachem, G., Ainge, G. D., Painter, G. F., Khurana, A., Hoebe, K., Behar, S. M., Beutler, B., Wilson, I. A., Tsuji, M., Sellati, T. J., Wong, C. H., Kronenberg, M. (2006) Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat. Immunol. 7, 978-986.
19. Barral, D. C., Brenner, M. B. (2007) CD1 antigen presentation: how it works. Nat. Rev. Immunol. 7, 929-941.
20. Stronge, V. S., Salio, M., Jones, E. Y., Cerundolo, V. (2007) A closer look at CD1d molecules: new horizons in studying NKT cells. Trends Immunol. 28, 455-462.
21. Sullivan, B. A., Nagarajan, N. A., Kronenberg, M. (2005) CD1 and MHC II find different means to the same end. Trends Immunol. 26, 282-288.
22. Schutze, M. P., Peterson, P. A., Jackson, M. R. (1994) An N-terminal double-arginine motif maintains type II membrane proteins in the endo-plasmic reticulum. EMBO J. 13, 1696-1705.
23. Stumptner, P., Benaroch, P. (1997) Interaction of MHC class II molecules with the invariant chain: role of the invariant chain (81-90) region.EMBO J. 16, 5807-5818.
24. Romagnoli, P., Germain, R. N. (1994) The CLIP region of invariant chain plays a critical role in regulating major histocompatibility complex class II folding, transport, and peptide occupancy. J. Exp. Med. 180, 1107-1113.
25. Roche, P. A., Cresswell, P. (1990) Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding. Nature 345,615-618.
26. Benaroch, P., Yilla, M., Raposo, G., Ito, K., Miwa, K., Geuze, H. J.,Ploegh, H. L. (1995) How MHC class II molecules reach the endocytic pathway. EMBO J. 14, 37-49.
27. Lindner, R. (2002) Transient surface delivery of invariant chain-MHC II complexes via endosomes: a quantitative study. Traffic 3, 133-146.
28. Pond, L., Watts, C. (1999) Functional early endosomes are required for maturation of major histocompatibility complex class II molecules in human B lymphoblastoid cells. J. Biol. Chem. 274, 18049-18054.
29. Brachet, V., Pehau-Arnaudet, G., Desaymard, C., Raposo, G., Amigo-rena, S. (1999) Early endosomes are required for major histocompatiblity complex class II transport to peptide-loading compartments. Mol. Biol.Cell 10, 2891-2904.
30. Hsing, L. C., Rudensky, A. Y. (2005) The lysosomal cysteine proteases in MHC class II antigen presentation. Immunol. Rev. 207, 229-241.
31. Busch, R., Rinderknecht, C. H., Roh, S., Lee, A. W., Harding, J. J., Burster, T., Hornell, T. M., Mellins, E. D. (2005) Achieving stability through editing and chaperoning: regulation of MHC class II peptide binding and expression. Immunol. Rev. 207, 242-260.
32. Cella, M., Sallusto, F., Lanzavecchia, A. (1997) Origin, maturation and antigen presenting function of dendritic cells. Curr. Opin. Immunol. 9,10-16.
33. Saudrais, C., Spehner, D., de la Salle, H., Bohbot, A., Cazenave, J. P., Goud, B., Hanau, D., Salamero, J. (1998) Intracellular pathway for the generation of functional MHC class II peptide complexes in immature human dendritic cells. J. Immunol. 160, 2597-2607.
34. Dugast, M., Toussaint, H., Dousset, C., Benaroch, P. (2005) AP2 clathrin adaptor complex, but not AP1, controls the access of the major histo-compatibility complex (MHC) class II to endosomes. J. Biol. Chem. 280,19656-19664.
35. McCormick, P. J., Martina, J. A., Bonifacino, J. S. (2005) Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments. Proc. Natl. Acad. Sci. USA 102,7910-7915.
36. De Gassart, A., Camosseto, V., Thibodeau, J., Ceppi, M., Catalan, N.,Pierre, P., Gatti, E. (2008) MHC class II stabilization at the surface of human dendritic cells is the result of maturation-dependent MARCH I down-regulation. Proc. Natl. Acad. Sci. USA 105, 3491-3496.
37. Briken, V., Jackman, R. M., Dasgupta, S., Hoening, S., Porcelli, S. A. (2002) Intracellular trafficking pathway of newly synthesized CD1b molecules. EMBO J. 21, 825-834.
38. Jayawardena-Wolf, J., Benlagha, K., Chiu, Y. H., Mehr, R., Bendelac, A. (2001) CD1d endosomal trafficking is independently regulated by an intrinsic CD1d-encoded tyrosine motif and by the invariant chain. Immunity 15, 897-908.
39. Shamshiev, A., Gober, H. J., Donda, A., Mazorra, Z., Mori, L., De Libero, G.(2002) Presentation of the same glycolipid by different CD1 molecules. J. Exp. Med. 195, 1013-1021.
40. Manolova, V., Kistowska, M., Paoletti, S., Baltariu, G. M., Bausinger, H., Hanau, D., Mori, L., De Libero, G. (2006) Functional CD1a is stabilized by exogenous lipids. Eur. J. Immunol. 36, 1083-1092.
41. Bonifacino, J. S., Dell'Angelica, E. C. (1999) Molecular bases for the recognition of tyrosine-based sorting signals. J. Cell Biol. 145, 923-926.
42. Briken, V., Jackman, R. M., Watts, G. F., Rogers, R. A., Porcelli, S. A. (2000) Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens. J. Exp. Med. 192, 281-288.
43. Sugita, M., Grant, E. P., van Donselaar, E., Hsu, V. W., Rogers, R. A., Peters, P. J., Brenner, M. B. (1999) Separate pathways for antigen presentation by CD1 molecules. Immunity 11, 743-752.
44. Sugita, M., Cao, X., Watts, G. F., Rogers, R. A., Bonifacino, J. S., Brenner, M. B. (2002) Failure of trafficking and antigen presentation by CD1 in AP-3-deficient cells. Immunity 16, 697-706.
45. Elewaut, D., Lawton, A. P., Nagarajan, N. A., Maverakis, E., Khurana, A., Honing, S., Benedict, C. A., Sercarz, E., Bakke, O., Kronenberg, M., Prigozy, T. I. (2003) The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosphingolipids and development of Vα14i NKT cells. J. Exp. Med. 198, 1133-1146.
46. Angenieux, C., Salamero, J., Fricker, D., Cazenave, J. P., Goud, B., Hanau, D., de La Salle, H. (2000) Characterization of CD1e, a third type of CD1 molecule expressed in dendritic cells. J. Biol. Chem. 275,37757-37764.
47. Maître, B., Angénieux, C., Salamero, J., Hanau, D., Fricker, D., Sig-norino, F., Proamer, F., Cazenave, J. P., Goud, B., Tourne, S., de la Salle,H.(2008) Control of the intracellular pathway of CD1e. Traffic 9,431-445.
48. Angenieux, C., Fraisier, V., Maitre, B., Racine, V., van der Wel, N., Fricker, D., Proamer, F., Sachse, M., Cazenave, J. P., Peters, P., Goud, B., Hanau, D., Sibarita, J. B., Salamero, J., de la Salle, H. (2005) The cellular pathway of CD1e in immature and maturing dendritic cells. Traffic 6, 286-302.
49. de la Salle, H., Mariotti, S., Angenieux, C., Gilleron, M., Garcia-Alles, L. F., Malm, D., Berg, T., Paoletti, S., Maitre, B., Mourey, L., Salamero, J., Cazenave, J. P., Hanau, D., Mori, L., Puzo, G., De Libero, G. (2005) Assistance of microbial glycolipid antigen processing by CD1e. Science 310, 1321-1324.
50. Alfonso, C., Karlsson, L. (2000) Nonclassical MHC class II molecules. Annu. Rev. Immunol. 18, 113-142.
51. Kang, S. J., Cresswell, P. (2002) Regulation of intracellular trafficking of human CD1d by association with MHC class II molecules. EMBO J. 21, 1650-1660.
52. Chiu, Y. H., Park, S. H., Benlagha, K., Forestier, C., Jayawardena-Wolf, J., Savage, P. B., Teyton, L., Bendelac, A. (2002) Multiple defects in antigen presentation and T cell development by mice expressing cyto-plasmic tail-truncated CD1d. Nat. Immunol. 3, 55-60.
53. Riese, R. J., Shi, G. P., Villadangos, J., Stetson, D., Driessen, C., Lennon-Dumenil, A. M., Chu, C. L., Naumov, Y., Behar, S. M., Ploegh, H., Locksley, R., Chapman, H. A. (2001) Regulation of CD1 function and NK1.1(+) T cell selection and maturation by cathepsin S. Immunity 15,909-919.
54. Honey, K., Nakagawa, T., Peters, C., Rudensky, A. (2002) Cathepsin Lregulates CD4+ T cell selection independently of its effect on invariant
55. chain: a role in the generation of positively selecting peptide ligands. J. Exp. Med. 195, 1349-1358.
56. Sloma, I., Zilber, M. T., Vasselon, T., Setterblad, N., Cavallari, M., Mori, L., De Libero, G., Charron, D., Mooney, N., Gelin, C. (2008) Regulation of CD1a surface expression and antigen presentation by invariant chain and lipid rafts. J. Immunol. 180, 980-987.
57. Chen, X., Wang, X., Keaton, J. M., Reddington, F., Illarionov, P. A., Besra, G. S., Gumperz, J. E. (2007) Distinct endosomal trafficking requirements for presentation of autoantigens and exogenous lipids by human CD1d molecules. J. Immunol. 178, 6181-6190.
58. Strubin, M., Berte, C., Mach, B. (1986) Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain. EMBO J. 5, 3483-3488.
59. Becker-Herman, S., Arie, G., Medvedovsky, H., Kerem, A., Shachar, I.(2005) CD74 is a member of the regulated intramembrane proteolysis-processed protein family. Mol. Biol. Cell 16, 5061-5069.
60. Leng, L., Metz, C. N., Fang, Y., Xu, J., Donnelly, S., Baugh, J., Delohery,T., Chen, Y., Mitchell, R. A., Bucala, R. (2003) MIF signal transduction initiated by binding to CD74. J. Exp. Med. 197, 1467-1476.
61. Roberts, T. J., Sriram, V., Spence, P. M., Gui, M., Hayakawa, K., Bacik, I., Bennink, J. R., Yewdell, J. W., Brutkiewicz, R. R. (2002) Recycling CD1d1 molecules present endogenous antigens processed in an endo-cytic compartment to NKT cells. J. Immunol. 168, 5409-5414.
62. Al-Daccak, R., Mooney, N., Charron, D. (2004) MHC class II signaling in antigen-presenting cells. Curr. Opin. Immunol. 16, 108-113.
63. Gregory, S., Zilber, M. T., Choqueux, C., Mooney, N., Charron, D., Gelin, C. (2000) Role of the CD1a molecule in the superantigen-induced activation of MHC class II negative human thymocytes. Hum. Immunol.61, 427-437.
64. Barois, N., Forquet, F., Davoust, J. (1998) Actin microfilaments control the MHC class II antigen presentation pathway in B cells. J. Cell Sci. 111, 1791-1800.
65. Chia, C. P., Khrebtukova, I., McCluskey, J., Wade, W. F. (1994) MHC class II molecules that lack cytoplasmic domains are associated with the cytoskeleton. J. Immunol. 153, 3398-3407.
66. El Fakhry, Y., Bouillon, M., Leveille, C., Brunet, A., Khalil, H., Thi-bodeau, J., Mourad, W. (2004) Delineation of the HLA-DR region and the residues involved in the association with the cytoskeleton. J. Biol. Chem. 279, 18472-18480.
67. Vogt, A. B., Spindeldreher, S., Kropshofer, H. (2002) Clustering of MHC-peptide complexes prior to their engagement in the immunological synapse: lipid raft and tetraspan microdomains. Immunol. Rev. 189,136-151.
68. Hemler, M. E. (2005) Tetraspanin functions and associated microdo-mains. Nat. Rev. Mol. Cell Biol. 6, 801-811.
69. Kijimoto-Ochiai, S., Noguchi, A., Ohnishi, T., Araki, Y. (2004) Complex formation of CD23/surface immunoglobulin and CD23/CD81/MHC class II on an EBV-transformed human B cell line and inferable role of tetraspanin. Microbiol. Immunol. 48, 417-426.
70. Rubinstein, E., Le Naour, F., Lagaudrieire-Gesbert, C., Billard, M., Conjeaud, H., Boucheix, C. (1996) CD9, CD63, CD81 and CD82 are components of a surface tetraspan network connected to HLA-DR and VLA integrins. Eur. J. Immunol. 26, 2657-2665.
71. Castaigne, J. G., Guo, W., Leveille, C., Charron, D., Al-Daccak, R. (2002) A CD18-dependent protein kinase C β-mediated alternative cell death pathway of activated monocytes. Int. Immunol. 14, 1003-1014.
72. Zilber, M. T., Setterblad, N., Vasselon, T., Doliger, C., Charron, D., Mooney, N., Gelin, C. (2005) MHC class II/CD38/CD9: a lipid-raft-dependent signaling complex in human monocytes. Blood 106, 3074-3081.
73. Naik, S. H., Metcalf, D., van Nieuwenhuijze, A., Wicks, I., Wu, L.,O'Keeffe, M., Shortman, K. (2006) Intrasplenic steady-state dendritic cell precursors that are distinct from monocytes. Nat. Immunol. 7,663-671.
74. Randolph, G. J. (2006) Migratory dendritic cells: sometimes simply ferries? Immunity 25, 15-18.
75. Unternaehrer, J. J., Chow, A., Pypaert, M., Inaba, K., Mellman, I. (2007) The tetraspanin CD9 mediates lateral association of MHC class II molecules on the dendritic cell surface. Proc. Natl. Acad. Sci. USA 104,234-239.
76. Jin, L., Waterman, P. M., Jonscher, K. R., Short, C. M., Reisdorph, N. A., Cambier, J. C. (2008) MPYS, a novel membrane tetraspanner, is associated with MHC class II and mediates transduction of apoptotic signals. Mol. Cell. Biol. 28, 5014-5026.
77. Simons, K., Ikonen, E. (1997)Functional rafts in cell membranes. Nature 387, 569-572.
78. Dykstra, M., Cherukuri, A., Sohn, H. W., Tzeng, S. J., Pierce, S. K. (2003) Location is everything: lipid rafts and immune cell signaling. Annu. Rev. Immunol. 21, 457-481.
79. Anderson, H. A., Hiltbold, E. M., Roche, P. A. (2000) Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation. Nat. Immunol. 1, 156-162.
80. Buatois, V., Baillet, M., Becart, S., Mooney, N., Leserman, L., Machy, P. (2003) MHC class II-peptide complexes in dendritic cell lipid microdo-mains initiate the CD4 Th1 phenotype. J. Immunol. 171, 5812-5819.
81. Kropshofer, H., Spindeldreher, S., Rohn, T. A., Platania, N., Grygar, C., Daniel, N., Wolpl, A., Langen, H., Horejsi, V., Vogt, A. B. (2002)Tetraspan microdomains distinct from lipid rafts enrich select peptide-MHC class II complexes. Nat. Immunol. 3, 61-68.
82. Delaguillaumie, A., Harriague, J., Kohanna, S., Bismuth, G., Rubinstein,E., Seigneuret, M., Conjeaud, H. (2004) Tetraspanin CD82 controls the association of cholesterol-dependent microdomains with the actin cy-toskeleton in T lymphocytes: relevance to co-stimulation. J. Cell Sci. 117, 5269-5282.
83. Poloso, N. J., Denzin, L. K., Roche, P. A. (2006) CDw78 defines MHC class II-peptide complexes that require Ii chain-dependent lysosomal trafficking, not localization to a specific tetraspanin membrane microdo-main. J. Immunol. 177, 5451-5458.
84. Karacsonyi, C., Knorr, R., Fulbier, A., Lindner, R. (2004) Association of major histocompatibility complex II with cholesterol- and sphingolipid-rich membranes precedes peptide loading. J. Biol. Chem. 279, 34818-34826.
85. Huby, R. D., Dearman, R. J., Kimber, I. (1999) Intracellular phospho-tyrosine induction by major histocompatibility complex class II requires co-aggregation with membrane rafts. J. Biol. Chem. 274, 22591-22596.
86. Becart, S., Setterblad, N., Ostrand-Rosenberg, S., Ono, S. J., Charron, D., Mooney, N. (2003) Intracytoplasmic domains of MHC class II molecules are essential for lipid-raft-dependent signaling. J. Cell Sci. 116, 2565-2575.
87. Setterblad, N., Roucard, C., Bocaccio, C., Abastado, J. P., Charron, D., Mooney, N. (2003) Composition of MHC class II-enriched lipid microdo-mains is modified during maturation of primary dendritic cells. J. Leukoc.Biol. 74, 40-48.
88. Hiltbold, E. M., Poloso, N. J., Roche, P. A. (2003) MHC class II-peptide complexes and APC lipid rafts accumulate at the immunological synapse. J. Immunol. 170, 1329-1338.
89. Vrljic, M., Nishimura, S. Y., Moerner, W. E., McConnell, H. M. (2005)Cholesterol depletion suppresses the translational diffusion of class II major histocompatibility complex proteins in the plasma membrane.Biophys. J. 88, 334-347.
90. Setterblad, N., Becart, S., Charron, D., Mooney, N. (2004) B cell lipid rafts regulate both peptide-dependent and peptide-independent APC-T cell interaction. J. Immunol. 173, 1876-1886.
91. Eren, E., Yates, J., Cwynarski, K., Preston, S., Dong, R., Germain, C., Lechler, R., Huby, R., Ritter, M., Lombardi, G. (2006) Location of major histocompatibility complex class II molecules in rafts on dendritic cells enhances the efficiency of T-cell activation and proliferation. Scand. J. Immunol. 63, 7-16.
92. Meyer zum Bueschenfelde, C. O., Unternaehrer, J., Mellman, I., Bot-tomly, K. (2004) Regulated recruitment of MHC class II and costimula-tory molecules to lipid rafts in dendritic cells. J. Immunol. 173, 6119-6124.
93. Lang, G. A., Exley, M. A., Lang, M. L. (2006) The CD1d-binding glycolipid α-galactosylceramide enhances humoral immunity to T-de-pendent and T-independent antigen in a CD1d-dependent manner. Immunology 119, 116-125.
94. Park, Y. K., Lee, J. W., Ko, Y. G., Hong, S., Park, S. H. (2005) Lipid rafts are required for efficient signal transduction by CD1d. Biochem. Biophys. Res. Commun. 327, 1143-1154.
95. Peng, W., Martaresche, C., Escande-Beillard, N., Cedile, O., Reynier-Vigouroux, A., Boucraut, J. (2007) Influence of lipid rafts on CD1d presentation by dendritic cells. Mol. Membr. Biol. 24, 475-484.
96. Brutkiewicz, R. R., Willard, C. A., Gillett-Heacock, K. K., Pawlak, M. R., Bailey, J. C., Khan, M. A., Nagala, M., Du, W., Gervay-Hague, J., Renukaradhya, G. J. (2007) Protein kinase C δ is a critical regulator of CD1d-mediated antigen presentation. Eur. J. Immunol. 37, 2390-2395.
97. Bertho, N., Blancheteau, V. M., Setterblad, N., Laupeze, B., Lord, J. M., Drenou, B., Amiot, L., Charron, D. J., Fauchet, R., Mooney, N. (2002) MHC class II-mediated apoptosis of mature dendritic cells proceeds by activation of the protein kinase C-δ isoenzyme. Int. Immunol. 14,935-942.
98. Drenou, B., Amiot, L., Setterblad, N., Taque, S., Guilloux, V., Charron, D., Fauchet, R., Mooney, N. (2005) MHC class II signaling function is regulated during maturation of plasmacytoid dendritic cells. J. Leukoc. Biol. 77, 560-567.
99. Majewski, M., Bose, T. O., Sille, F. C., Pollington, A. M., Fiebiger, E.,Boes, M. (2007) Protein kinase C δ stimulates antigen presentation by class II MHC in murine dendritic cells. Int. Immunol. 19, 719-732.
100. Posevitz-Fejfar, A., Smida, M., Kliche, S., Hartig, R., Schraven, B., Lindquist, J. A. (2008) A displaced PAG enhances proximal signaling and SDF-1-induced T cell migration. Eur. J. Immunol. 38, 250-259.
101. Gordy, C., Mishra, S., Rodgers, W. (2004) Visualization of antigen presentation by actin-mediated targeting of glycolipid-enriched membrane domains to the immune synapse of B cell APCs. J. Immunol. 172,2030-2038.
102. Setterblad, N., Blancheteau, V., Delaguillaumie, A., Michel, F., Becart, S., Lombardi, G., Acuto, O., Charron, D., Mooney, N. (2004) Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.J. Leukoc. Biol. 75, 1036-1044.
103. Tavano, R., Contento, R. L., Baranda, S. J., Soligo, M., Tuosto, L., Manes, S., Viola, A. (2006) CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse. Nat. Cell Biol. 8,1270-1276.
104. Gupta, N., Wollscheid, B., Watts, J. D., Scheer, B., Aebersold, R.,DeFranco, A. L. (2006) Quantitative proteomic analysis of B cell lipid rafts reveals that ezrin regulates antigen receptor-mediated lipid raft dynamics. Nat. Immunol. 7, 625-633.
105. Delaguillaumie, A., Marin-Esteban, V., Setterblad, N., Leh, L. J., Assier, E., Gelin, C., Charron, D., Galy, A., Mooney, N. (2008) Contrasting cytoskeletal regulation of MHC class II peptide presentation by human B cells or dendritic cells. Eur. J. Immunol. 38, 1096-1105.
106. Hao, S., August, A. (2005) Actin depolymerization transduces the strength of B-cell receptor stimulation. Mol. Biol. Cell 16, 2275-2284.
107. Crotta, S., Ronconi, V., Ulivieri, C., Baldari, C. T., Valiante, N. M., Abrignani, S., Wack, A. (2006) Cytoskeleton rearrangement induced by tetraspanin engagement modulates the activation of T and NK cells. Eur.J. Immunol. 36, 919-929.
108. Holowka, D., Sheets, E. D., Baird, B. (2000) Interactions between Fc(ε)RI and lipid raft components are regulated by the actin cytoskele-ton. J. Cell Sci. 113, 1009-1019.
109. Kaisho, T., Akira, S. (2006) Toll-like receptor function and signaling. J.Allergy Clin. Immunol. 117, 979-987.
110. Szatmari, I., Torocsik, D., Agostini, M., Nagy, T., Gurnell, M., Barta, E., Chatterjee, K., Nagy, L. (2007) PPARγ regulates the function of human dendritic cells primarily by altering lipid metabolism. Blood110, 3271-3280.
111. Leslie, D. S., Dascher, C. C., Cembrola, K., Townes, M. A., Hava, D. L., Hugendubler, L. C., Mueller, E., Fox, L., Roura-Mir, C., Moody, D. B.,Vincent, M. S., Gumperz, J. E., Illarionov, P. A., Besra, G. S., Reynolds,C. G., Brenner, M. B. (2008) Serum lipids regulate dendritic cell CD1 expression and function. Immunology, Epub ahead of print.
112. Gogolak, P., Rethi, B., Szatmari, I., Lanyi, A., Dezso, B., Nagy, L., Rajnavolgyi, E. (2007) Differentiation of CD1a- and CD1a+ monocyte-derived dendritic cells is biased by lipid environment and PPARγ. Blood 109, 643-652.
113. Szatmari, I., Pap, A., Ruhl, R., Ma, J. X., Illarionov, P. A., Besra, G. S.,Rajnavolgyi, E., Dezso, B., Nagy, L. (2006) PPARγ controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J. Exp. Med. 203, 2351-2362.
114. Smed-Sorensen, A., Moll, M., Cheng, T. Y., Lore, K., Norlin, A. C., Perbeck, L., Moody, D. B., Spetz, A. L., Sandberg, J. K. (2008) IgG regulates the CD1 expression profile and lipid antigen-presenting function in human dendritic cells via FcγRIIa. Blood 111, 5037-5046.