NHE-1: A molecular target for signalling and cell matrix interactions

Connective Tissue Research

Volumn 49, Issue 3-4, 2008, Pages 157-161

  Koliakos, George ^a   Paletas, Konstantinos ^a   Kaloyianni, Martha ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CALMODULIN; CARBONATE DEHYDRATASE II; EZRIN; FOCAL ADHESION KINASE; HEAT SHOCK PROTEIN 70; HERMES ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MOESIN; PROTEIN INHIBITOR; PROTEIN P160; PROTEIN P90; PROTON; RADIXIN; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; SODIUM PROTON EXCHANGE PROTEIN 1 INHIBITOR; VINCULIN;

APOPTOSIS; ARTICLE; ATAXIA; BINDING AFFINITY; BINDING SITE; CALCIUM CELL LEVEL; CANCER CELL; CELL ADHESION; CELL CYCLE PROGRESSION; CELL DEATH; CELL DIFFERENTIATION; CELL MIGRATION; CELL PH; CELL PROLIFERATION; CELL VOLUME; CYTOSKELETON; DRUG EFFICACY; DRUG MECHANISM; EXTRACELLULAR MATRIX; HEART FAILURE; HEART HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; NONHUMAN; PATHOGENESIS; PRIMARY PREVENTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEIZURE; SIGNAL TRANSDUCTION;

ANIMALS; CELL ADHESION; CELL DEATH; CELL MOVEMENT; CELL PROLIFERATION; CYTOSKELETON; HUMANS; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; SIGNAL TRANSDUCTION; SODIUM-HYDROGEN ANTIPORTER;

EID: 48549106230     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.1080/03008200802151581     Document Type: Article

References (64)

1. Putney, L., Denker, S. and Barber, D. (2002) The changing face of the Na+/H+ exchanger, NHE1: Structure, regulation, and cellular actions. 42, pp. 527-552.
2. Orlowski, J. and Grinstein, S. (2004) Diversity of the mammalian sodium/ proton exchanger SLC9 gene family. 447:5, pp. 549-565.
3. Fliegel, L. (2005) The Na+/H+ exchanger isoform 1. 37, pp. 33-37.
4. Wakabayashi, S., Pang, T., Su, X. and Shigekawa, M. (2000) A novel topology model o the human Na+/H +exchanger isoform 1. 275, pp. 7942-7949.
5. Khaled, A., Moor, A., Li, A., Kim, K., Ferris, D. Muegge, K. et al. (2001) Trophic factor withdrawal: P-38 mitogen-activator protein kinase activates NHE1, which induces intracellular alklinization. 21, pp. 7545-7557.
6. Moor, A., Gan, X., Karmazyn, M. and Fliegel, L. (2001) Protein kinase mediated regulation of the Na+/H+ exchanger isoform 1 (NHE1) in ischemic and ischemic/reperfused rat heart. 27, pp. 16113-16122.
7. Tominanga, T. and Barber, D. (1998) NHE1 acts downstream of RhoA to regulate integrin induced cell adhesion and spreading. 9, pp. 2287-2303.
8. Avkiran, M. and Haworth, R. (2003) Regulatory effects of G protein-coupled receptors on cardiac sorcolemmal Na+/H+ exchanger activity: Signalling and significance. 57, pp. 942-952.
9. Shrode, L., Tapper, H. and Grinstein, S. (1997) Role of intracellular pH in proliferation, transformation, and apoptosis. 29, pp. 393-399.
10. Delvaux, M., Bastie, M., Chentoufi, J., Cragoe, E., Vaysse, N. and Ribet, A. (1990) Amiloride and analogues inhibit Na+/H+ exchange and cell proliferation in AR42J pancreatic cell line. 259, pp. G842-G849.
11. Kapus, A., Gristein, S., Wasan, S., Kandasamy, R. and Orlowski, J. (1994) Functional characterization of three isoforms of the Na+/H+ exchanger stably expressed in Chinese hamster ovary cells. ATP dependence, osmotic sensitivity, and role of cell proliferation. 269, pp. 23544-23552.
12. Madshus, I. (1988) Regulation of intracellular pH in eukaryotic cells. 250, pp. 1-8.
13. O'Neill, W. (1999) Physiological significance of volume-regulatory transporters. 276, pp. C995-C1011.
14. Rouzaire-Dubois, B., O'Regan, S. and Dubois, J. (2005) Cell size-dependent and independent proliferation of rodent neuroblastoma x glioma cells. 203, pp. 243-250.
15. Dmitrieva, N., Michea, L., Rocha, G. and Burg, M. (2001) Cell cycle delay and apoptosis in response to osmotic stress. 130, pp. 411-420.
16. Wang, D., Balkovetz, D. and Wornock, D. (1995) Mutational analysis of transmembrane histidines in the amiloride sensitive Na+/H+ exchanger. 269, pp. C392-C402.
17. Bell, S., Schreiner, C., Schultheis, P., Miller, M. Evans, R. et al. (1999) Targeted disruption of the murine NHE1 locus induces ataxia, growth retardation and seizures. 276, pp. C788-C795.
18. Leist, M. and Jaattela, M. (2001) Four deaths and a funeral: From caspases to alternative mechanisms. 2, pp. 589-598.
19. Lang, F., Madlung, J., Bock, J., Lukewille, U., Kaltenbach, S. Lang, K. et al. (2000) Inhibition of Jurkat-T-lymphocyte Na+/H+ exchanger by CD95 (Fas/Apo-1)-receptor stimulation. 440, pp. 902-907.
20. Wu, K., Khan, S., Lajhe-Reddy, S., Wang, L., Jarad, J. Miller, R. et al. (2003) Renal tubular epithelial cell apoptosis is associated with caspase cleavage of the NHE-2 Na+/H +exchanger. 284, pp. F829-F839.
21. Cho, Y., Lee, K., Lee, S., Namkoong, S., Kim, Y. Lee, H. et al. (2005) Amiloride potentiates TRAIL-induced tumor cell apoptosis by intracellular acidification-dependent Akt inactivation. 326, pp. 752-758.
22. Nylandsted, J., Jaattela, M., Hoffmann, E. and Pedersen, S. (2004) Hsp70 protects fibrosarcoma cells against shrinkage-induced programmed cell death via mechanism independent of effects on cell volume-regulatory membrane transport proteins. 449, pp. 175-185.
23. Rich, I., Worthington-White, D., Garden, O. and Musk, P. (2000) Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na+/H+ exchanger. 95, pp. 1427-1434.
24. Thangarayu, M., Sharma, K., Liu, D., Shen, S. and Srikant, C. (1999) Interdependent regulation of intracellular acidification and SHP-1 in apoptosis. 59, pp. 1649-1654.
25. Matsuyama, S., Llopis, J., Deveraux, Q., Tsien, R. and Reed, J. (2000) Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis. 2, pp. 318-325.
26. Bortner, C. and Cidlowski, J. (1996) Absence of volume regulatory mechanisms contributes to the rapid activation of apoptosis in thymocytes. 271, pp. C950-C961.
27. Friis, M., Friborg, C., Schneider, L., Nielsen, M., Lambert, I. Christensen, S. et al. (2005) Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts. 567, pp. 427-443.
28. Pedersen, S., O'Donnell, M., Anderson, S. and Cala, P. (2006) Electroneutral Na +transport in health and disease: Role Na+/H+ exchange and a Na+, K+, 2Cl- cotransport. 291, p. R1.
29. Askenasy, N., Vivi, A., Tassini, M. and Navon, G. (1996) The relation between cellular sodium, pH and volumes and the activity of Na+/H+ antiport during hypothermic ischemia: Multinuclear NMR studies of rat hearts. 28, pp. 589-601.
30. Kintner, D., Su, G., Lenart, B., Ballard, A., Meyer, J. Ng, L. et al. (2004) Increased tolerance to oxygen and glucose deprivation in astrocytes from Na+/H+exchanger isoform 1 null mice. 287, pp. C12-C21.
31. Otani, H., Uchiyama, T., Yamamura, T., Nakao, Y., Hattori, R. Ninomiya, H. et al. (2000) Effects of Na+/H+ exchange inhibitor cariporide (HOE 642) on cardiac function and cardiomyocyte cell death in rat ischemic-reperfused heart. 27, pp. 387-393.
32. Chakrabarti, S., Hoque, A. and Karmazyn, M. (1997) A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). 29, pp. 3169-3174.
33. Teshima, Y., Akao, M., Jones, S. and Marban, E. (2003) Cariporide, a selective Na+/H +exchange inhibitor, inhibits the mitochondrial death pathway. 27, pp. 729-742.
34. Stock, C. and Schwab, A. (2006) Role of the Na+/H+ exchanger NHE1 in cell migration. 187, pp. 149-157.
35. Mitchison, T. and Cramer, L. (1996) Actin-based cell motility and cell locomotion. 84, pp. 371-379.
36. Diez, S., Gerisch, G., Anderson, K., Miller-Taubenberger, A. and Bretschneider, T. (2005) Subsecond reorganization of the actin network in cell motility and chemotaxis. 102, pp. 7601-7606.
37. Bretscher, M. and Aguado-Velasco, C. (1998) Membrane traffic during cell locomotion. 10, pp. 537-541.
38. Beningo, K., Dembo, M., Kaverina, I., Small, J. and Wang, Y. (2001) Nascent focal adhesions are responsible for the generation of strong propulsive forces in migrating fibroblasts. 153, pp. 881-887.
39. Jalali, S., Del Pozo, M., Chen, K., Miao, H., Li, Y. Schwartz, M. et al. (2001) Integrin-mediated mechanotranduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. 98, pp. 1042-1046.
40. Webb, D., Parsons, J. and Horwitz, A. (2002) Adhesion assembly, disassembly and turnover in migrating cell-over and over and over again. 4, pp. E97-E100.
41. Kostidou, E., Koliakos, G., Alamdari, D., Paletas, K., Tsapas, A. and Kaloyianni, M. (2007) Enhanced laminin carbonylation by monocytes in diabetes mellitus. 40, pp. 671-679.
42. Koliakos, G., Trachana, V., Gaitatzi, M. and Dimitriadou, A. (2001) Phosphorylation of laminin-1 by protein kinase C. 11, pp. 179-185.
43. Verfaillie, C., Benis, A., Iida, J., McGlave, P. and McCarthy, J. (1994) Adhesion of committed human hematopoietic progenitors to synthetic peptides from the C-terminal heparin-binding domain of fibronectin: cooperation between the integrin alpha2beta1 and the CD44 adhesion receptor. 84, pp. 1802-1811.
44. Stock, C. G. B., Hauck, C. R., Arnold, H., Mally, S., Eble, J. A., Dieterich, P. and Schwab, A. (2005) Migration of human melanoma cells depends on extracellular pH and Na+/H +exchange. 567, pp. 225-238.
45. Reshkin, S., Bellizzi, A., Albarani, V., Guerra, L., Tommasino, M. Paradiso, A. et al. (2000) Phosphoinositide 3-kinase is involved in th tumor-specific activation of human breast cancer cell Na+/H+ exchange, motility, and invasion induced by serum deprivation. 275, pp. 5361-5369.
46. McHardy, L., Sinotte, R., Troussard, A., Sheldon, C. Church, J. et al. (2004) The tumor invasion inhibitor dihydromotuporamine C activates Rho, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange. 64, pp. 1468-1474.
47. Paradiso, A., Cardone, R., Bellizzi, A. Bagorda, A. et al. (2004) The Na+/H+ exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells. 6, pp. R616-R628.
48. Bussolino, F., Wang, J., Turrini, F. Alessi, D. et al. (1989) Stimulation of Na+/H +exchanger in human endothelial cells activated by granulocyte-macrophage-colony-stimulating factor. Evidence for a role in proliferation and migration. 264, pp. 18284-18287.
49. Roesengren, S., Henson, P. and Worthen, G. (1994) Migration associated volume changes in neutrophils facilitate the migratory process in vitro. 267, pp. C1623-C1632.
50. Denker, S. and Barber, D. (2002) The changing face of Na/H exchanger. NHE1: Structure, regulation and cellular actions. 42, pp. 527-552.
51. Denker, S. and Barber, D. (2002) Cell migration requires both ion translocation and cytoskeletal anchoring by them Na-H exchanger NHE1. 159, pp. 1087-1096.
52. Yan, W., Nehrke, K., Choi, J. and Barber, D. (2001) The Nck interactive kinase (NIK) phosphorylates NHE1 and regulates NHE1 activation by platelet-derived growth factor. 276, pp. 31349-31356.
53. Aharonovitz, O., Zaum, H., Balla, T., York, J., Orlowski, J. and Grinstein, S. (2000) Intracellular pH regulation by NHE requires phosphatidylinositol 4,5 bisphospate. 150, pp. 213-224.
54. Pang, T., Su, X., Wakabayashi, S. and Shigekawa, M. (2001) Calcineurin homologous protein as an essential cofactor for NHE. 276, pp. 17367-17372.
55. Rohatgi, R., Nollau, P., Ho, H., Kirschner, M. and Mayer, B. (2001) Nck and phospatidylinositol 3.4 bisphosphate synergistically activate actin polymerization through the N-WASP Arp2/3 pathway. 276, pp. 26448-26452.
56. Lehoux, S., Abe, J., Florian, J. and Berk, B. (2001) 14-3-3 binding to NHE isoform 1 is associated with serum-dependent activation of NHE1. 276, pp. 15794-15800.
57. Silva, N., Haworth, R., Singh, D. and Fliegel, L. (1995) The carbonyl-terminal region of NHHE1 interacts with mammalin heat shock protein. 34, pp. 10412-10420.
58. Li, X., Alvarez, B., Casey, J., Reithmeier, R. and Fliegel, L. (2002) Carbonic anhydrase II binds to and anhances the activity of NHE1. 277, pp. 36085-36091.
59. Coupaye-Gerard, B., Bookstein, C., Duncan, P., Chen, X., Smith, P. Musch, M. et al. (1996) Biosynthesis and cell surface delivery of NHE1 isoform in A6 cells. 271, pp. C2951-C2959.
60. Grinstein, S., Woodside, M., Waddell, T., Downey, G., Orlowski, J. Poyssegour, J. et al. (1993) Focal localization of NHE1 isoform: Effects on intracellular pH. 12, pp. 5209-5218.
61. Baumgartner, M., Patel, H. and Barber, D. (2004) NHE1 as plasma membrane scaffold in the assembly of signaling complexes. 287, pp. C844-C850.
62. Cingolani, H., Perez, N., Aiello, E. and Camilion de Hurtado, M. (2005) Intracellular signaling following myocardial stretch: An autocrine/ paracrine loop. 128, pp. 211-220.
63. Allen, D. and Xiao, X. (2003) Role of cardiac Na+/H+ exchanger during ischemia and reperfusion. 57, pp. 934-941.
64. Stagg, M. and Terracciano, C. (2005) Less Na+/H+ exchanger to treat heart failure: A simple solution for a complex problem. 65, pp. 10-12.