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Volumn 343, Issue 3, 2012, Pages 215-219

Ghrelin inhibits insulin release by regulating the expression of inwardly rectifying potassium channel 6.2 in islets

Author keywords

Expression; Ghrelin; Insulin; KATP channel; Kir

Indexed keywords

GHRELIN; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; INSULIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MESSENGER RNA; SULFONYLUREA RECEPTOR 1;

EID: 84863234403     PISSN: 00029629     EISSN: 15382990     Source Type: Journal    
DOI: 10.1097/MAJ.0b013e31824390b9     Document Type: Article
Times cited : (12)

References (41)
  • 1
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone releasing acylated peptide from stomach. Nature 1999;402:656-60.
    • (1999) Nature , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3
  • 2
    • 0036106519 scopus 로고    scopus 로고
    • Ghrelin in neonatal rats: Distribution in stomach and its possible role
    • Hayashida T, Nakahara K, Mondal MS, et al. Ghrelin in neonatal rats: distribution in stomach and its possible role. J Endocrinol 2002;173:239-45.
    • (2002) J Endocrinol , vol.173 , pp. 239-245
    • Hayashida, T.1    Nakahara, K.2    Mondal, M.S.3
  • 3
    • 1842480284 scopus 로고    scopus 로고
    • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor
    • Sun Y, Wang P, Zheng H, et al. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci USA 2004;101:4679-84.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 4679-4684
    • Sun, Y.1    Wang, P.2    Zheng, H.3
  • 4
    • 33745210354 scopus 로고    scopus 로고
    • Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility
    • Dixit VD, Weeraratna AT, Yang H, et al. Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility. J Biol Chem 2006;281:16681-90.
    • (2006) J Biol Chem , vol.281 , pp. 16681-16690
    • Dixit, V.D.1    Weeraratna, A.T.2    Yang, H.3
  • 5
    • 0344394262 scopus 로고    scopus 로고
    • Intracellular signaling mechanisms mediating ghrelin-stimulated growth hormone release in somatotropes
    • Malagón MM, Luque RM, Ruiz-Guerrero E, et al. Intracellular signaling mechanisms mediating ghrelin-stimulated growth hormone release in somatotropes. Endocrinology 2003;144:5372-80.
    • (2003) Endocrinology , vol.144 , pp. 5372-5380
    • Malagón, M.M.1    Luque, R.M.2    Ruiz-Guerrero, E.3
  • 6
    • 4544318339 scopus 로고    scopus 로고
    • The cholinergic system controls ghrelin release and ghrelin-induced growth hormone release in humans
    • Maier C, Schaller G, Buranyi B, et al. The cholinergic system controls ghrelin release and ghrelin-induced growth hormone release in humans. J Clin Endocrinol Metab 2004;89:4729-33.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 4729-4733
    • Maier, C.1    Schaller, G.2    Buranyi, B.3
  • 7
    • 23844451142 scopus 로고    scopus 로고
    • Endogenous ghrelin regulates episodic growth hormone (GH) secretion by amplifying GH pulse amplitude: Evidence from antagonism of the GH secretagogue-R1a receptor
    • Zizzari P, Halem H, Taylor J, et al. Endogenous ghrelin regulates episodic growth hormone (GH) secretion by amplifying GH pulse amplitude: evidence from antagonism of the GH secretagogue-R1a receptor. Endocrinology 2005;146:3836-42.
    • (2005) Endocrinology , vol.146 , pp. 3836-3842
    • Zizzari, P.1    Halem, H.2    Taylor, J.3
  • 8
    • 0033711116 scopus 로고    scopus 로고
    • The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion
    • Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000;141:4325-8.
    • (2000) Endocrinology , vol.141 , pp. 4325-4328
    • Wren, A.M.1    Small, C.J.2    Ward, H.L.3
  • 9
    • 33645857375 scopus 로고    scopus 로고
    • Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor
    • Toshinai K, Yamaguchi H, Sun Y, et al. Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology 2006;147:2306-14.
    • (2006) Endocrinology , vol.147 , pp. 2306-2314
    • Toshinai, K.1    Yamaguchi, H.2    Sun, Y.3
  • 10
    • 1042275336 scopus 로고    scopus 로고
    • Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor
    • Thompson NM, Gill DA, Davies R, et al. Ghrelin and des-octanoyl ghrelin promote adipogenesis directly in vivo by a mechanism independent of the type 1a growth hormone secretagogue receptor. Endocrinology 2004;145:234-42.
    • (2004) Endocrinology , vol.145 , pp. 234-242
    • Thompson, N.M.1    Gill, D.A.2    Davies, R.3
  • 11
    • 0037373522 scopus 로고    scopus 로고
    • The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis
    • Choi K, Roh SG, Hong YH, et al. The role of ghrelin and growth hormone secretagogues receptor on rat adipogenesis. Endocrinology 2003;144:754-9.
    • (2003) Endocrinology , vol.144 , pp. 754-759
    • Choi, K.1    Roh, S.G.2    Hong, Y.H.3
  • 12
    • 10744231780 scopus 로고    scopus 로고
    • Ghrelin administration affects circulating pituitary and gastro-entero-pancreatic hormones in acromegaly
    • Arosio M, Ronchi CL, Gebbia C, et al. Ghrelin administration affects circulating pituitary and gastro-entero-pancreatic hormones in acromegaly. Eur J Endocrinol 2004;150:27-32.
    • (2004) Eur J Endocrinol , vol.150 , pp. 27-32
    • Arosio, M.1    Ronchi, C.L.2    Gebbia, C.3
  • 13
    • 32844466699 scopus 로고    scopus 로고
    • Ghrelin does not influence gastric emptying in obese subjects
    • Valera Mora ME, Scarfone A, Valenza V, et al. Ghrelin does not influence gastric emptying in obese subjects. Obes Res 2005;13:739-44.
    • (2005) Obes Res , vol.13 , pp. 739-744
    • Valera Mora, M.E.1    Scarfone, A.2    Valenza, V.3
  • 14
    • 27744441026 scopus 로고    scopus 로고
    • Ghrelin enhances gastric emptying in diabetic gastroparesis: A double blind, placebo controlled, crossover study
    • Murray CD, Martin NM, Patterson M, et al. Ghrelin enhances gastric emptying in diabetic gastroparesis: a double blind, placebo controlled, crossover study. Gut 2005;54:1693-8.
    • (2005) Gut , vol.54 , pp. 1693-1698
    • Murray, C.D.1    Martin, N.M.2    Patterson, M.3
  • 15
    • 0036083505 scopus 로고    scopus 로고
    • Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat
    • Trudel L, Tomasetto C, Rio MC, et al. Ghrelin/motilin-related peptide is a potent prokinetic to reverse gastric postoperative ileus in rat. Am J Physiol Gastrointest Liver Physiol 2002;282:G948-52.
    • (2002) Am J Physiol Gastrointest Liver Physiol , vol.282
    • Trudel, L.1    Tomasetto, C.2    Rio, M.C.3
  • 16
    • 0037225643 scopus 로고    scopus 로고
    • Ghrelin protects against ethanolinduced gastric ulcers in rats: Studies on the mechanisms of action
    • Sibilia V, Rindi G, Pagani F, et al. Ghrelin protects against ethanolinduced gastric ulcers in rats: studies on the mechanisms of action. Endocrinology 2003;144:353-9.
    • (2003) Endocrinology , vol.144 , pp. 353-359
    • Sibilia, V.1    Rindi, G.2    Pagani, F.3
  • 17
    • 3042735648 scopus 로고    scopus 로고
    • The tissue distribution of the mRNA of and ghrelin and subtypes of its receptor, GHS-R, in humans
    • Gnanapavan S, Kola B, Bustin SA, et al. The tissue distribution of the mRNA of and ghrelin and subtypes of its receptor, GHS-R, in humans. J Clin Endocrinol Metab 2002;87:2988-91.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 2988-2991
    • Gnanapavan, S.1    Kola, B.2    Bustin, S.A.3
  • 18
    • 10744220319 scopus 로고    scopus 로고
    • Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors
    • Gaytan F, Barreiro ML, Caminos JE, et al. Expression of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in normal human testis and testicular tumors. J Clin Endocrinol Metab 2004;89:400-9.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 400-409
    • Gaytan, F.1    Barreiro, M.L.2    Caminos, J.E.3
  • 19
    • 0037329049 scopus 로고    scopus 로고
    • Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary
    • Gaytan F, Barreiro ML, Chopin LK, et al. Immunolocalization of ghrelin and its functional receptor, the type 1a growth hormone secretagogue receptor, in the cyclic human ovary. J Clin Endocrinol Metab 2003;88:879-87.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 879-887
    • Gaytan, F.1    Barreiro, M.L.2    Chopin, L.K.3
  • 20
    • 0037387132 scopus 로고    scopus 로고
    • Expression of ghrelin in the cyclic and pregnant rat ovary
    • Caminos JE, Tena-Sempere M, Gaytán F, et al. Expression of ghrelin in the cyclic and pregnant rat ovary. Endocrinology 2003;144:1594-602.
    • (2003) Endocrinology , vol.144 , pp. 1594-1602
    • Caminos, J.E.1    Tena-Sempere, M.2    Gaytán, F.3
  • 21
    • 0036959760 scopus 로고    scopus 로고
    • Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors
    • Volante M, Allìa E, Gugliotta P, et al. Expression of ghrelin and of the GH secretagogue receptor by pancreatic islet cells and related endocrine tumors. J Clin Endocrinol Metab 2002;87:1300-8.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1300-1308
    • Volante, M.1    Allìa, E.2    Gugliotta, P.3
  • 22
    • 3843070931 scopus 로고    scopus 로고
    • Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: Effect of maternal fasting
    • Chanoine JP, Wong AC. Ghrelin gene expression is markedly higher in fetal pancreas compared with fetal stomach: effect of maternal fasting. Endocrinology 2004;145:3813-20.
    • (2004) Endocrinology , vol.145 , pp. 3813-3820
    • Chanoine, J.P.1    Wong, A.C.2
  • 23
    • 0037372044 scopus 로고    scopus 로고
    • Dose-dependent inhibition by ghrelin of insulin secretion in the mouse
    • Reimer MK, Pacini G, Ahrén B. Dose-dependent inhibition by ghrelin of insulin secretion in the mouse. Endocrinology 2003;144:916-21.
    • (2003) Endocrinology , vol.144 , pp. 916-921
    • Reimer, M.K.1    Pacini, G.2    Ahrén, B.3
  • 24
    • 1242318803 scopus 로고    scopus 로고
    • Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells
    • Wierup N, Yang S, McEvilly RJ, et al. Ghrelin is expressed in a novel endocrine cell type in developing rat islets and inhibits insulin secretion from INS-1 (832/13) cells. J Histochem Cytochem 2004;52:301-10.
    • (2004) J Histochem Cytochem , vol.52 , pp. 301-310
    • Wierup, N.1    Yang, S.2    McEvilly, R.J.3
  • 25
    • 33845534952 scopus 로고    scopus 로고
    • Blockade of pancreatic isletderived ghrelin enhances insulin secretion to prevent high-fat dietinduced glucose intolerance
    • Dezaki K, Sone H, Koizumi M, et al. Blockade of pancreatic isletderived ghrelin enhances insulin secretion to prevent high-fat dietinduced glucose intolerance. Diabetes 2006;55:3486-93.
    • (2006) Diabetes , vol.55 , pp. 3486-3493
    • Dezaki, K.1    Sone, H.2    Koizumi, M.3
  • 26
    • 33646365060 scopus 로고    scopus 로고
    • Ghrelin enhances glucose-induced insulin secretion in scheduled meal-fed sheep
    • Takahashi H, Kurose Y, Kobayashi S, et al. Ghrelin enhances glucose-induced insulin secretion in scheduled meal-fed sheep. J Endocrinol 2006;189:67-75.
    • (2006) J Endocrinol , vol.189 , pp. 67-75
    • Takahashi, H.1    Kurose, Y.2    Kobayashi, S.3
  • 27
    • 9444223977 scopus 로고    scopus 로고
    • + channels as metabolic sensors studies of Kir6.x null mice
    • + channels as metabolic sensors studies of Kir6.x null mice. Diabetes 2004;53:S176-80.
    • (2004) Diabetes , vol.53
    • Minami, K.1    Miki, T.2    Kadowaki, T.3
  • 29
    • 0036155789 scopus 로고    scopus 로고
    • Intracellular Ca(2+) modulation of ATP-sensitive K(+) channel activity in acetylcholine-induced activation of rat pancreatic beta-cells
    • Nakano K, Suga S, Takeo T, et al. Intracellular Ca(2+) modulation of ATP-sensitive K(+) channel activity in acetylcholine-induced activation of rat pancreatic beta-cells. Endocrinology 2002;143:569-76.
    • (2002) Endocrinology , vol.143 , pp. 569-576
    • Nakano, K.1    Suga, S.2    Takeo, T.3
  • 30
    • 0036905897 scopus 로고    scopus 로고
    • Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation
    • Kanno T, Rorsman P, Göpel SO. Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by K(ATP)-channel modulation. J Physiol 2002;545:501-7.
    • (2002) J Physiol , vol.545 , pp. 501-507
    • Kanno, T.1    Rorsman, P.2    Göpel, S.O.3
  • 31
    • 33748753770 scopus 로고    scopus 로고
    • Oscillatory membrane potential response to glucose in islet beta-cells: A comparison of islet-cell electrical activity in mouse and rat
    • Manning Fox JE, Gyulkhandanyan AV, Satin LS, et al. Oscillatory membrane potential response to glucose in islet beta-cells: a comparison of islet-cell electrical activity in mouse and rat. Endocrinology 2006;147:4655-63.
    • (2006) Endocrinology , vol.147 , pp. 4655-4663
    • Manning Fox, J.E.1    Gyulkhandanyan, A.V.2    Satin, L.S.3
  • 32
    • 53749091796 scopus 로고    scopus 로고
    • Effect of N. sativa oil on impaired glucose tolerance and insulin insensitivity induced by high-fat-diet and turpentine-induced trauma
    • Alsaif MA. Effect of N. sativa oil on impaired glucose tolerance and insulin insensitivity induced by high-fat-diet and turpentine-induced trauma. Pak J Biol Sci 2008;11:1093-9.
    • (2008) Pak J Biol Sci , vol.11 , pp. 1093-1099
    • Alsaif, M.A.1
  • 33
    • 52149088330 scopus 로고    scopus 로고
    • Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats
    • Rachoń D, Vortherms T, Seidlová-Wuttke D, et al. Effects of black cohosh extract on body weight gain, intra-abdominal fat accumulation, plasma lipids and glucose tolerance in ovariectomized Sprague-Dawley rats. Maturitas 2008;60:209-15.
    • (2008) Maturitas , vol.60 , pp. 209-215
    • Rachoń, D.1    Vortherms, T.2    Seidlová-Wuttke, D.3
  • 34
    • 52049099639 scopus 로고    scopus 로고
    • Chromium supplementation improves glucose tolerance in diabetic Goto-Kakizaki rats
    • Abdourahman A, Edwards JG. Chromium supplementation improves glucose tolerance in diabetic Goto-Kakizaki rats. IUBMB Life 2008; 60:541-8.
    • (2008) IUBMB Life , vol.60 , pp. 541-548
    • Abdourahman, A.1    Edwards, J.G.2
  • 35
    • 34548436635 scopus 로고    scopus 로고
    • Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: Novel signal transduction of ghrelin
    • Dezaki K, Kakei M, Yada T. Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin. Diabetes 2007;56:2319-27.
    • (2007) Diabetes , vol.56 , pp. 2319-2327
    • Dezaki, K.1    Kakei, M.2    Yada, T.3
  • 36
    • 0035114908 scopus 로고    scopus 로고
    • Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells
    • Moritz W, Leech CA, Ferrer J, et al. Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells. Endocrinology 2001;142:129-38.
    • (2001) Endocrinology , vol.142 , pp. 129-138
    • Moritz, W.1    Leech, C.A.2    Ferrer, J.3
  • 37
    • 0036326795 scopus 로고    scopus 로고
    • Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells
    • Buschard K, Høy M, Bokvist K, et al. Sulfatide controls insulin secretion by modulation of ATP-sensitive K(+)-channel activity and Ca(2+)-dependent exocytosis in rat pancreatic beta-cells. Diabetes 2002;51:2514-21.
    • (2002) Diabetes , vol.51 , pp. 2514-2521
    • Buschard, K.1    Høy, M.2    Bokvist, K.3
  • 38
    • 0142029955 scopus 로고    scopus 로고
    • Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues
    • Dabrowski M, Larsen T, Ashcroft FM, et al. Potent and selective activation of the pancreatic beta-cell type K(ATP) channel by two novel diazoxide analogues. Diabetologia 2003;46:1375-82.
    • (2003) Diabetologia , vol.46 , pp. 1375-1382
    • Dabrowski, M.1    Larsen, T.2    Ashcroft, F.M.3
  • 39
    • 2342633204 scopus 로고    scopus 로고
    • Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes
    • Gloyn AL, Pearson ER, Antcliff JF, et al. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 2004;350:1838-49.
    • (2004) N Engl J Med , vol.350 , pp. 1838-1849
    • Gloyn, A.L.1    Pearson, E.R.2    Antcliff, J.F.3
  • 40
    • 53049105327 scopus 로고    scopus 로고
    • Regulation of KATP channel expression and activity by the SUR1 nucleotide binding fold 1
    • Masia R, Caputa G, Nichols CG. Regulation of KATP channel expression and activity by the SUR1 nucleotide binding fold 1. Channels (Austin) 2007;1:315-23.
    • (2007) Channels (Austin) , vol.1 , pp. 315-323
    • Masia, R.1    Caputa, G.2    Nichols, C.G.3
  • 41
    • 1442327747 scopus 로고    scopus 로고
    • Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose
    • Ritzel RA, Hansen JB, Veldhuis JD, et al. Induction of beta-cell rest by a Kir6.2/SUR1-selective K(ATP)-channel opener preserves beta-cell insulin stores and insulin secretion in human islets cultured at high (11 mM) glucose. J Clin Endocrinol Metab 2004;89:795-805.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 795-805
    • Ritzel, R.A.1    Hansen, J.B.2    Veldhuis, J.D.3


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