The cholinergic system controls ghrelin release and ghrelin-induced growth hormone release in humans

Journal of Clinical Endocrinology and Metabolism

Volumn 89, Issue 9, 2004, Pages 4729-4733

  Maier, Christina ^a   Schaller, Georg ^a   Buranyi, Barbara ^a   Nowotny, Peter ^a   Geyer, Georg ^a   Wolzt, Michael ^a   Luger, Anton ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE INHIBITOR; GHRELIN; GLUCOSE; GROWTH HORMONE; INSULIN; PYRIDOSTIGMINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CHOLINERGIC SYSTEM; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE RELEASE; HORMONAL REGULATION; HORMONE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ATROPINE; BLOOD GLUCOSE; BLOOD PRESSURE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; HUMAN GROWTH HORMONE; HUMANS; INSULIN; MALE; PARASYMPATHETIC NERVOUS SYSTEM; PEPTIDE HORMONES; PULSE; PYRIDOSTIGMINE BROMIDE;

EID: 4544318339     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-0656     Document Type: Article

References (33)

1. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K 1999 Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402:656-660
2. Murray CD, Kamm MA, Bloom SR, Emmanuel AV 2003 Ghrelin for the gastroenterologist: history and potential. Gastroenterology 125:1492-1502
3. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, Taheri S, Kennedy AR, Roberts GH, Morgan DG, Ghatei MA, Bloom SR 2000 The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141:4325-4328
4. Tschop M, Smiley DL, Heiman ML 2000 Ghrelin induces adiposity in rodents. Nature 407:908-913
5. Shiiya T, Nakazato M, Mizuta M, Date Y, Mondai MS, Tanaka M, Nozoe S, Hosoda H, Kangawa K, Matsukura S 2002 Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion. J Clin Endocrinol Metab 87:240-244
6. Cummings DE, Purnell JC, Frayo RS, Schmidova K, Wisse BE, Weigle DS 2001 A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50:1714-1719
7. Sugino T, Yamaura J, Yamagishi M, Kurose Y, Kojima M, Kangawa K, Hasegawa Y, Terashima Y 2003 Involvement of cholinergic neurons in the regulation of the ghrelin secretory response to feeding in sheep. Biochem Biophys Res Commun 304:308-312
8. Asakawa A, Inui A, Kaga T, Yuzuriha H, Nagata T, Ueno N, Makino S, Fujimiya M, Niijima A, Fujino MA, Kasuga M 2001 Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 120:337-345
9. Date Y, Murakami N, Toshinai K, Matsukura S, Niijima A, Matsuo H, Kangawa K, Nakazato M 2002 The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 123:1120-1128
10. Williams DL, Grill HJ, Cummings DE, Kaplan JM 2003 Vagotomy dissociates short- and long-term controls of circulating ghrelin. Endocrinology 144:5184-5187
11. Ahren B, Holst JJ 2001 The cephalic insulin response to meal ingestion in humans is dependent on both cholinergic and noncholinergic mechanisms and is important for postprandial glycemia. Diabetes 50:1030-1038
12. Schaller G, Schmidt A, Pleiner J, Woloszczuk W, Wolzt M, Luger A 2003 Plasma ghrelin concentrations are not regulated by glucose or insulin: a double-blind, placebo-controlled crossover clamp study. Diabetes 52:16-20
13. Di Vito L, Broglio F, Benso A, Gottero C, Prodam F, Papotti M, Muccioli G, Dieguez C, Casanueva FF, Deghenghi R, Ghigo E, Arvat E 2002 The GH-releasing effect of ghrelin, a natural GH secretagogue, is only blunted by the infusion of exogenous somatostatin in humans. Clin Endocrinol (Oxf) 56: 643-648
14. Muller EE, Locatelli V, Cocchi D 1999 Neuroendocrine control of growth hormone secretion. Physiol Rev 79:511-607
15. Penalva A, Muruais C, Casanueva FF, Dieguez C 1999 Effect of enhancement of endogenous cholinergic tone with pyridostigmine on the dose-response relationships of growth hormone (GH)-releasing hormone-induced GH secretion in normal subjects. J Clin Endocrinol Metab 70:324-327
16. Locatelli V, Torsello A, Redaelli M, Ghigo E, Massare F, Muller EE 1986 Cholinergic agonist and antagonist drugs modulate the growth hormone response to growth hormone-releasing hormone in the rat: evidence for mediation by somatostatin. J Endocrinol 111:271-278
17. De Vries WR, Abdesselam SA, Sehers TJ, Maas HC, Osman-Dualeh M, Maitimu I, Koppeschaar HP 2002 Complete inhibition of hypothalamic somatostatin activity is only partially responsible for the growth hormone response to strenuous exercise. Metabolism 51:1093-1096
18. Massara F, Ghigo E, Demislis K, Tangolo D, Mazza E, Locatelli V, Muller EE, Molinatti GM, Camanni F 1986 Cholinergic involvement in the growth hormone releasing hormone-induced growth hormone release: studies in normal and acromegalic subjects. Neuroendocrinology 43:670-675
19. Casanueva FF, Villanueva L, Dieguez C, Cabranes JA, Diaz Y, Szoke B, Scanlon MF, Schally AV, Fernandez-Cruz A 1986 Atropine blockade of growth hormone (GH)-releasing hormone-induced GH secretion in man is not exerted at pituitary level. J Clin Endocrinol Metab 62:186-191
20. Pietschmann P, Schernthaner G, Luger A 1986 Effect of cholinergic muscarinic receptor blockade on human growth hormone (GH)-releasing hormone-(1-44)-induced GH secretion in acromegaly and type I diabetes mellitus. J Clin Endocrinol Metab 63:389-393
21. Broglio F, Gottero C, Benso A, Prodam F, Casanueva FF, Dieguez C, van der Lely AJ, Deghenghi R, Arvat E, Ghigo E 2003 Acetylcholine does not play a major role in mediating the endocrine responses to ghrelin, a natural ligand of the GH secretagogue receptor, in humans. Clin Endocrinol (Oxf) 58:92-98
22. Heller Brown J, Taylor P 2001 Muscarinic receptor agonists and antagonists. In: Hardman JG, Limbird LE, Gilman AG, eds. Goodman, Gilman's the pharmacological basis of therapeutics. New York: McGraw-Hill Professional; 155-174
23. Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR 2003 Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349:941-948
24. Hakanson R, Vallgren S, Ekelund M, Rehfeld JF, Sundler F 1984 The vagus exerts trophic control of the stomach in the rat. Gastroenterology 86:28-32
25. Broglio F, Gottero C, Van Koetsveld P, Prodam F, Destefanis S, Benso A, Gauna C, Hofland L, Arvat E, van der Lely AJ, Ghigo E 2004 Acetylcholine regulates ghrelin secretion in humans. J Clin Endocrinol Metab 89:2429-2433
26. Wren AM, Small CJ, Fribbens CV, Neary NM, Ward HL, Seal LJ, Ghatei MA, Bloom SR 2002 The hypothalamic mechanisms of the hypophysiotropic action of ghrelin. Neuroendocrinology 76:316-324
27. Popovic V, Miljic D, Micic D, Damjanovic S, Arvat E, Ghigo E, Dieguez C, Casanueva FF 2003 Ghrelin main action on the regulation of growth hormone release is exerted at hypothalamic level. J Clin Endocrinol Metab 88:3450-3453
28. Jaffe CA, DeMott-Friberg R, Barkan AL 1996 Endogenous growth hormone (GH)-releasing hormone is required for GH responses to pharmacological stimuli. J Clin Invest 97:934-940
29. Pöykkö SM, Kellokoski E, Hörkkö S, Kauma HY, Kesäniemi A, Ukkola O 2003 Low plasma ghrelin is associated with insulin resistance, hypertension, and the prevalence of type 2 diabetes. Diabetes 52:2546-2553
30. Colombo M, Gregersen S, Xiao J, Hermansen K 2003 Effects of ghrelin and other neuropeptides (CART, MCH, orexin A and B, and GLP-1) on the release of insulin from isolated rat islets. Pancreas 27:161-166
31. Reimer MK, Pacini G, Ahren B 2003 Dose-dependent inhibition by ghrelin of insulin secretion in the mouse. Endocrinology 144:916-922
32. Arosio M, Ronchi CL, Gebbia C, Cappiello V, Beck-Peccoz P, Peracchi M 2003 Stimulatory effects of ghrelin on circulating somatostatin and pancreatic polypeptide levels. J Clin Endocrinol Metab 88:701-704
33. Murata M, Okimura Y, Iida K, Matsumoto M, Sowa H, Kaji H, Kojima M, Kangawa K, Chihara K 2002 Ghrelin modulates the downstream molecules of insulin signaling in hepatoma cells. J Biol Chem 277:5667-5674